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Sisodia, Sangram S.
One or more keywords matched the following items that are connected to Sisodia, Sangram S.
Item TypeName
Concept Mice, Inbred C3H
Concept Mice, Inbred CBA
Concept Mice, Neurologic Mutants
Concept Mice, Transgenic
Concept Mice, Inbred C57BL
Concept Mice, Nude
Concept Mice, Knockout
Concept Mice
Concept Mice, Mutant Strains
Academic Article Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo.
Academic Article Transgenic models of neurodegenerative diseases.
Academic Article Evidence for phosphorylation and oligomeric assembly of presenilin 1.
Academic Article Novel neuritic clusters with accumulations of amyloid precursor protein and amyloid precursor-like protein 2 immunoreactivity in brain regions damaged by thiamine deficiency.
Academic Article Loss of functional prion protein: a role in prion disorders?
Academic Article Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the "beta-secretase" site occurs in the golgi apparatus.
Academic Article Studies on the metabolism and biological function of APLP2.
Academic Article The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry.
Academic Article Motor neuron disease and model systems: aetiologies, mechanisms and therapies.
Academic Article Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues.
Academic Article Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo.
Academic Article Mice deficient for the amyloid precursor protein gene.
Academic Article A vector for expressing foreign genes in the brains and hearts of transgenic mice.
Academic Article Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides.
Academic Article Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice.
Academic Article Mechanisms of selective motor neuron death in transgenic mouse models of motor neuron disease.
Academic Article Inherited neurodegenerative diseases and transgenic models.
Academic Article Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway.
Academic Article Evidence that levels of presenilins (PS1 and PS2) are coordinately regulated by competition for limiting cellular factors.
Academic Article Alzheimer's disease: genetic studies and transgenic models.
Academic Article An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos.
Academic Article ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions.
Academic Article Lack of requirement for presenilin1 in Notch1 signaling.
Academic Article Familial amyotrophic lateral sclerosis and Alzheimer's disease. Transgenic models.
Academic Article Endoproteolytic processing and stabilization of wild-type and mutant presenilin.
Academic Article Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins.
Academic Article Identification and characterization of a mouse homologue of the spinal muscular atrophy-determining gene, survival motor neuron.
Academic Article Genetic neurodegenerative diseases: the human illness and transgenic models.
Academic Article Effects of PS1 deficiency on membrane protein trafficking in neurons.
Academic Article Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia.
Academic Article Synaptic transmission and hippocampal long-term potentiation in transgenic mice expressing FAD-linked presenilin 1.
Academic Article Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm.
Academic Article Mutant genes in familial Alzheimer's disease and transgenic models.
Academic Article Amyloid production and deposition in mutant amyloid precursor protein and presenilin-1 yeast artificial chromosome transgenic mice.
Academic Article Neuroscience. An accomplice for gamma-secretase brought into focus.
Academic Article Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.
Academic Article Requirement for presenilin 1 in facilitating lagged 2-mediated endoproteolysis and signaling of notch 1.
Academic Article Amyotrophic lateral sclerosis and Alzheimer disease. Lessons from model systems.
Academic Article Enhanced synaptic potentiation in transgenic mice expressing presenilin 1 familial Alzheimer's disease mutation is normalized with a benzodiazepine.
Academic Article Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer's disease.
Academic Article The value of transgenic models for the study of neurodegenerative diseases.
Academic Article Altered metabolism of familial Alzheimer's disease-linked amyloid precursor protein variants in yeast artificial chromosome transgenic mice.
Academic Article Axonal transport of mutant superoxide dismutase 1 and focal axonal abnormalities in the proximal axons of transgenic mice.
Academic Article Function and dysfunction of the presenilins.
Academic Article Transgenic mouse models of Alzheimer's disease and amyotrophic lateral sclerosis.
Academic Article Biomedicine. A cargo receptor mystery APParently solved?
Academic Article Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces.
Academic Article Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression.
Academic Article Multiple effects of aspartate mutant presenilin 1 on the processing and trafficking of amyloid precursor protein.
Academic Article Accumulation of proteolytic fragments of mutant presenilin 1 and accelerated amyloid deposition are co-regulated in transgenic mice.
Academic Article Evidence that synaptically released beta-amyloid accumulates as extracellular deposits in the hippocampus of transgenic mice.
Academic Article Familial Alzheimer disease-linked presenilin 1 variants enhance production of both Abeta 1-40 and Abeta 1-42 peptides that are only partially sensitive to a potent aspartyl protease transition state inhibitor of "gamma-secretase".
Academic Article Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production.
Academic Article Cell-free generation of the notch1 intracellular domain (NICD) and APP-CTfgamma: evidence for distinct intramembranous "gamma-secretase" activities.
Academic Article Presenilin-dependent "gamma-secretase" processing of deleted in colorectal cancer (DCC).
Academic Article APP processing and synaptic function.
Academic Article Presenilin-1 regulates intracellular trafficking and cell surface delivery of beta-amyloid precursor protein.
Academic Article Regulated hyperaccumulation of presenilin-1 and the "gamma-secretase" complex. Evidence for differential intramembranous processing of transmembrane subatrates.
Academic Article DNA microarray profiling of developing PS1-deficient mouse brain reveals complex and coregulated expression changes.
Academic Article A sequence within the first transmembrane domain of PEN-2 is critical for PEN-2-mediated endoproteolysis of presenilin 1.
Academic Article Spatial segregation of gamma-secretase and substrates in distinct membrane domains.
Academic Article True and false discovery in DNA microarray experiments: transcriptome changes in the hippocampus of presenilin 1 mutant mice.
Academic Article Presenilin attenuates receptor-mediated signaling and synaptic function.
Academic Article Presenilin-1-dependent transcriptome changes.
Academic Article Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice.
Academic Article Nigrostriatal dysfunction in familial Alzheimer's disease-linked APPswe/PS1DeltaE9 transgenic mice.
Academic Article Adult neurogenesis is functionally associated with AD-like neurodegeneration.
Academic Article Expression of a familial Alzheimer's disease-linked presenilin-1 variant enhances perforant pathway lesion-induced neuronal loss in the entorhinal cortex.
Academic Article Cortical dysplasia resembling human type 2 lissencephaly in mice lacking all three APP family members.
Academic Article Accelerated Abeta deposition in APPswe/PS1deltaE9 mice with hemizygous deletions of TTR (transthyretin).
Academic Article Presenilin 1 in migration and morphogenesis in the central nervous system.
Academic Article Impairments in fast axonal transport and motor neuron deficits in transgenic mice expressing familial Alzheimer's disease-linked mutant presenilin 1.
Academic Article Molecular signatures of neurodegeneration in the cortex of PS1/PS2 double knockout mice.
Academic Article Enhanced accumulation of phosphorylated alpha-synuclein and elevated beta-amyloid 42/40 ratio caused by expression of the presenilin-1 deltaT440 mutant associated with familial Lewy body disease and variant Alzheimer's disease.
Academic Article Loss of gamma-secretase function impairs endocytosis of lipoprotein particles and membrane cholesterol homeostasis.
Academic Article P75 neurotrophin receptor regulates expression of neural cell adhesion molecule 1.
Academic Article Transcriptome differences between the frontal cortex and hippocampus of wild-type and humanized presenilin-1 transgenic mice.
Academic Article Phospholipase D1 corrects impaired betaAPP trafficking and neurite outgrowth in familial Alzheimer's disease-linked presenilin-1 mutant neurons.
Academic Article Presenilin-1 uses phospholipase D1 as a negative regulator of beta-amyloid formation.
Academic Article Abeta star: a light onto synaptic dysfunction?
Academic Article Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease.
Academic Article Non-cell-autonomous effects of presenilin 1 variants on enrichment-mediated hippocampal progenitor cell proliferation and differentiation.
Academic Article Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes.
Academic Article Identification of NEEP21 as a ß-amyloid precursor protein-interacting protein in vivo that modulates amyloidogenic processing in vitro.
Academic Article Increased expression of PS1 is sufficient to elevate the level and activity of ?-secretase in vivo.
Academic Article Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited.
Academic Article An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria.
Academic Article Expression, purification, and characterization of the Kunitz-type proteinase inhibitor domain of the amyloid beta-protein precursor-like protein-2.
Academic Article Expression of familial Alzheimer's disease-linked human presenilin 1 variants impair enrichment-induced adult hippocampal neurogenesis.
Academic Article A role for presenilins in autophagy revisited: normal acidification of lysosomes in cells lacking PSEN1 and PSEN2.
Academic Article Cellular and molecular biology of Alzheimer's disease and animal models.
Academic Article Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of ?-secretase using synthetic antibodies.
Academic Article Amyloid beta amyloidosis in Alzheimer's disease.
Academic Article Superoxide dismutase is an abundant component in cell bodies, dendrites, and axons of motor neurons and in a subset of other neurons.
Academic Article Cellular and molecular biology of Alzheimer's disease and animal models.
Academic Article Metabolism of the amyloid precursor-like protein 2 in MDCK cells. Polarized trafficking occurs independent of the chondroitin sulfate glycosaminoglycan chain.
Academic Article A mouse model for Down syndrome exhibits learning and behaviour deficits.
Academic Article The mouse APLP2 gene. Chromosomal localization and promoter characterization.
Academic Article Superoxide dismutase 1 subunits with mutations linked to familial amyotrophic lateral sclerosis do not affect wild-type subunit function.
Academic Article Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected].
Academic Article Evidence that CD147 modulation of beta-amyloid (Abeta) levels is mediated by extracellular degradation of secreted Abeta.
Academic Article Alzheimer's disease-type brain abnormalities in animal models.
Academic Article cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein.
Academic Article Hyperaccumulation of FAD-linked presenilin 1 variants in vivo.
Academic Article Stable association of presenilin derivatives and absence of presenilin interactions with APP.
Academic Article Subcellular localization of presenilins: association with a unique membrane pool in cultured cells.
Academic Article APP transgenic mice Tg2576 accumulate Abeta peptides that are distinct from the chemically modified and insoluble peptides deposited in Alzheimer's disease senile plaques.
Academic Article The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage.
Academic Article Expression of a ubiquitous, cross-reactive homologue of the mouse beta-amyloid precursor protein (APP).
Academic Article Notch and MAML signaling drives Scl-dependent interneuron diversity in the spinal cord.
Academic Article Plug-based microfluidics with defined surface chemistry to miniaturize and control aggregation of amyloidogenic peptides.
Academic Article Presenilin 1 mutants impair the self-renewal and differentiation of adult murine subventricular zone-neuronal progenitors via cell-autonomous mechanisms involving notch signaling.
Academic Article Specificity of RNA maturation pathways: RNAs transcribed by RNA polymerase III are not substrates for splicing or polyadenylation.
Academic Article Mutant presenilin 1 expression in excitatory neurons impairs enrichment-mediated phenotypes of adult hippocampal progenitor cells.
Academic Article Autoregulatory control of beta-tubulin mRNA stability is linked to translation elongation.
Academic Article Nontranscriptional role of Hif-1a in activation of ?-secretase and notch signaling in breast cancer.
Academic Article Differential release of ß-amyloid from dendrite- versus axon-targeted APP.
Academic Article Endogenous expression of FAD-linked PS1 impairs proliferation, neuronal differentiation and survival of adult hippocampal progenitors.
Academic Article Age-dependent, non-cell-autonomous deposition of amyloid from synthesis of ß-amyloid by cells other than excitatory neurons.
Academic Article Amyloid Precursor-like Protein 2 and Sortilin Do Not Regulate the PCSK9 Convertase-mediated Low Density Lipoprotein Receptor Degradation but Interact with Each Other.
Academic Article The topology of pen-2, a ?-secretase subunit, revisited: evidence for a reentrant loop and a single pass transmembrane domain.
Academic Article Antibiotic-induced perturbations in gut microbial diversity influences neuro-inflammation and amyloidosis in a murine model of Alzheimer's disease.
Academic Article Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging.
Academic Article Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1?E9 murine model of Alzheimer's disease.
Academic Article Sex-specific effects of microbiome perturbations on cerebral Aß amyloidosis and microglia phenotypes.
Academic Article Deficits in Enrichment-Dependent Neurogenesis and Enhanced Anxiety Behaviors Mediated by Expression of Alzheimer's Disease-Linked Ps1 Variants Are Rescued by Microglial Depletion.
Academic Article Synergistic depletion of gut microbial consortia, but not individual antibiotics, reduces amyloidosis in APPPS1-21 Alzheimer's transgenic mice.
Academic Article DNA-based fluorescent probes of NOS2 activity in live brains.
Academic Article An APP ectodomain mutation outside of the Aß domain promotes Aß production in vitro and deposition in vivo.
Academic Article Gut microbiota-driven brain Aß amyloidosis in mice requires microglia.
Academic Article ApoE isoform- and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy.
Academic Article Increased Type I interferon signaling and brain endothelial barrier dysfunction in an experimental model of Alzheimer's disease.
Academic Article The gut microbiome in Alzheimer's disease: what we know and what remains to be explored.
Academic Article The gut microbiome regulates astrocyte reaction to Aß amyloidosis through microglial dependent and independent mechanisms.
Academic Article Translational profiling identifies sex-specific metabolic and epigenetic reprogramming of cortical microglia/macrophages in APPPS1-21 mice with an antibiotic-perturbed-microbiome.
Academic Article Early modulation of the gut microbiome by female sex hormones alters amyloid pathology and microglial function.
Academic Article Sodium oligomannate alters gut microbiota, reduces cerebral amyloidosis and reactive microglia in a sex-specific manner.
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