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overview My lab has had a long-standing interest in understanding the basis of immunological tolerance and humoral immunity following allogeneic transplantation. We have been collaborating extensively with Dr. Marisa Alegre in studying how infections prevent the induction of transplantation tolerance or destabilize established tolerance, and understanding the fundamental mechanisms of robust transplantation tolerance. We recently have developed new approaches to track a defined population of endogenous allospecific T (CD4+effectors (Th1 and Tfh), CD4+Tregs and CD8 effector) and B cells (Class I and Class II reactive), and are now asking how each of these subsets of cells behave under conditions of rejection, memory/sensitization and tolerance, with the goal of identifying new biomarkers of tolerance and rejection. We also actively investigating the behavior of memory alloreactive B cells in the setting of transplantation, and in identifying how these cells differ from naïve B cells, with the goal of identifying immunosuppressive and tolerance inducing strategies to control this clinically important subset of cells. We are conducting these studies in experimental rodent models, and also testing our findings in humans. These studies are performed in collaboration with Dr. Roger Sciammas at UCDavis, and the clinical transplant faculty at the University of Chicago and Ohio State University. In addition, we have stretched our research into the prevention of infections through vaccination, with the long-term goal of using this strategy as an indirect but cost-effective means of stabilizing tolerance. Towards this goal, my lab has been collaborating with Dr. Chris Montgomery, a physician scientist in the Department of Pediatrics, to identify sub-unit vaccine candidates and to investigate the immunobiology of protection from Staphylococcus aureus skin infections. My lab also has a strong program of collaborative research with Dr. Joel Collier, a bioengineer at Duke University, to develop of nanoparticulate adjuvant-free vaccines that can elicit protective immune responses with minimal inflammation. Such a vaccine that elicits minimal inflammation may be ideal for tolerant patients, as we now appreciate that inflammation can destabilize established tolerance.

One or more keywords matched the following items that are connected to Chong, Anita S.

Item TypeName
Concept Acute Disease
Concept Autoimmune Diseases
Concept Graft vs Host Disease
Concept Communicable Diseases
Concept Graft Survival
Concept Chronic Disease
Concept Disease Susceptibility
Concept Drug Therapy, Combination
Concept Graft Rejection
Concept Hematopoietic Stem Cells
Concept Neuromuscular Diseases
Concept Recurrence
Concept Skin Diseases
Concept Stem Cells
Concept Tumor Stem Cell Assay
Concept Hematopoietic Stem Cell Transplantation
Concept Transplants
Concept Stem Cell Transplantation
Concept Disease Progression
Concept Pluripotent Stem Cells
Concept Pulmonary Disease, Chronic Obstructive
Concept Disease Models, Animal
Concept Pancreatic Diseases
Concept Genetic Predisposition to Disease
Academic Article Leflunomide, a novel immunomodulatory agent: in vitro analyses of the mechanism of immunosuppression.
Academic Article Complete control of humoral and cell-mediated xenoreactions with the combination of leflunomide and cyclosporine.
Academic Article Daily determinations of serum lymphotoxin allows for accurate early diagnosis of hepatic allograft rejection.
Academic Article Immunosuppressive effects of leflunomide in a cardiac allograft model.
Academic Article Granulocyte colony-stimulating factor immunomodulation in the rat cardiac transplantation model.
Academic Article Prolongation of rat islet allograft survival by the immunosuppressive agent leflunomide.
Academic Article Control and reversal of chronic xenograft rejection in hamster-to-rat cardiac transplantation.
Academic Article Delayed xenograft rejection in the concordant hamster heart into Lewis rat model.
Academic Article Effect of gene gun-mediated CTLA4IG and Fas ligand gene transfection on concordant xenogeneic islet graft rejection.
Academic Article In vivo effects of leflunomide on normal pancreatic islet and syngeneic islet graft function.
Academic Article Gene gun-mediated gene transfer and expression in rat islets.
Academic Article Effect of anti-CD4 monoclonal antibody combined with human CTLA4Ig on the survival of hamster liver and heart xenografts in Lewis rats.
Academic Article Anti-CD4 therapy in combined heart-kidney, heart-liver, and heart-small bowel allotransplants in high-responder rats.
Academic Article Successful xenotransplantation of adult porcine islets in NOD and BALB/c mice with leflunomide and cyclosporine.
Academic Article Leflunomide-based immunosuppression for porcine islet xenotransplantation.
Academic Article In vitro and in vivo mechanisms of action of the antiproliferative and immunosuppressive agent, brequinar sodium.
Academic Article Leflunomide, a potential immunosuppressant for pancreatic islet transplantation.
Academic Article In vivo activity of leflunomide: pharmacokinetic analyses and mechanism of immunosuppression.
Academic Article Control of lymphoproliferative and autoimmune disease in MRL-lpr/lpr mice by brequinar sodium: mechanisms of action.
Academic Article Differential effect of leflunomide on concordant xenogeneic islet graft rejection and recurrence of autoimmune diabetes.
Academic Article Immunosuppression preventing concordant xenogeneic islet graft rejection is not sufficient to prevent recurrence of autoimmune diabetes in nonobese diabetic mice.
Academic Article Modification of humoral responses by the combination of leflunomide and cyclosporine in Lewis rats transplanted with hamster hearts.
Academic Article Tolerance of T-independent xeno-antibody responses in the hamster-to-rat xenotransplantation model is species-restricted but not tissue-specific.
Academic Article Anti-galactose-alpha(1,3)Galactose antibody production in alpha1, 3-galactosyltransferase gene knockout mice after xeno- and allotransplantation.
Academic Article Non-depleting anti-CD4, but not anti-CD8, antibody induces long-term survival of xenogeneic and allogeneic hearts in alpha1,3-galactosyltransferase knockout (GT-Ko) mice.
Academic Article Protective effect of ischemic preconditioning on liver preservation-reperfusion injury in rats.
Academic Article FK506 treatment in combination with leflunomide in hamster-to-rat heart and liver xenograft transplantation.
Academic Article Differential immune response to carbohydrate epitopes on allo- and xenografts: implications for accommodation.
Academic Article Histological characterization and pharmacological control of chronic rejection in xenogeneic and allogeneic heart transplantation.
Academic Article Onset of accumulation of PrPres in murine ME7 scrapie in relation to pathological and PrP immunohistochemical changes.
Academic Article Acute xenograft rejection mediated by antibodies produced independently of TH1/TH2 cytokine profiles.
Academic Article Nondepleting anti-CD4 but not anti-CD8 antibody induces long-term survival of xenogeneic and allogeneic hearts in alpha1, 3-galactosyl-transferase knock-out mice.
Academic Article Intact active bone transplantation synergizes with anti-CD40 ligand therapy to induce B cell tolerance.
Academic Article CTLA-41g in combination with anti-CD40L prolongs xenograft survival and inhibits anti-gal ab production in GT-Ko mice.
Academic Article Combination of antilymphocyte globulin and leflunomide leads to superior grafts.
Academic Article Allograft tolerance induced by intact active bone co-transplantation and anti-CD40L monoclonal antibody therapy.
Academic Article The in vitro and in vivo effects of anti-galactose antibodies on endothelial cell activation and xenograft rejection.
Academic Article Skin graft survival in genetically identical cloned pigs.
Academic Article Role of CD4+ and CD8+ T cells in the rejection of concordant pancreas xenografts.
Academic Article Mouse-heart grafts expressing an incompatible carbohydrate antigen. II. Transition from accommodation to tolerance.
Academic Article Cutting Edge: NK cells mediate IgG1-dependent hyperacute rejection of xenografts.
Academic Article Reversal of diabetes in non-obese diabetic mice without spleen cell-derived beta cell regeneration.
Academic Article Liver ischemia contributes to early islet failure following intraportal transplantation: benefits of liver ischemic-preconditioning.
Academic Article Hyperacute rejection by anti-Gal IgG1, IgG2a, and IgG2b is dependent on complement and Fc-gamma receptors.
Academic Article Cellular therapies for type 1 diabetes.
Academic Article Toll-like receptor signaling in transplantation.
Academic Article Mechanistic study of malononitrileamide FK778 in cardiac transplantation and CMV infection in rats.
Academic Article The multiple facets of toll-like receptors in transplantation biology.
Academic Article Toll-like receptors (TLRs) in transplantation.
Academic Article TLR signals promote IL-6/IL-17-dependent transplant rejection.
Academic Article Concurrent antiviral and immunosuppressive activities of leflunomide in vivo.
Academic Article Decreased percentage of CD4+FoxP3+ cells in bronchoalveolar lavage from lung transplant recipients correlates with development of bronchiolitis obliterans syndrome.
Academic Article Seeing is believing: how the MIP-luc mouse can advance the field of islet transplantation and ß-cell regeneration.
Academic Article Alloantibodies prevent the induction of transplantation tolerance by enhancing alloreactive T cell priming.
Academic Article Bacterial infections, alloimmunity, and transplantation tolerance.
Academic Article CD4+ T cells are sufficient to elicit allograft rejection and major histocompatibility complex class I molecule is required to induce recurrent autoimmune diabetes after pancreas transplantation in mice.
Academic Article The Mll partial tandem duplication: differential, tissue-specific activity in the presence or absence of the wild-type allele.
Academic Article Memory alloreactive B cells and alloantibodies prevent anti-CD154-mediated allograft acceptance.
Academic Article Expression of complement regulatory proteins in accommodated xenografts induced by anti-alpha-Gal IgG1 in a rat-to-mouse model.
Academic Article Matchmaking the B-cell signature of tolerance to regulatory B cells.
Academic Article Making a B-line for transplantation tolerance.
Academic Article IL-6 induced by Staphylococcus aureus infection prevents the induction of skin allograft acceptance in mice.
Academic Article Experimental models of B cell tolerance in transplantation.
Academic Article Plasma cell densities and glomerular filtration rates predict renal allograft outcomes following acute rejection.
Academic Article Splanchnic transplantation.
Academic Article The impact of infection and tissue damage in solid-organ transplantation.
Academic Article "Tip-toeing" to an assay for transplantation tolerance?
Academic Article TLR engagement prevents transplantation tolerance.
Academic Article Pharmacologically induced regression of chronic transplant rejection.
Academic Article American society of transplantation symposium on B cells in transplantation: harnessing humoral immunity from rodent models to clinical practice.
Academic Article Effect of leflunomide in control of acute rejection in hamster-to-rat cardiac xenografts.
Academic Article Improved viability of hepatic allografts from fasted donors is associated with decreased peripheral TNF activity.
Academic Article Leflunomide immunosuppression in rat small intestinal transplantation.
Academic Article Prevention of allograft tolerance by bacterial infection with Listeria monocytogenes.
Academic Article Long-term control of alloreactive B cell responses by the suppression of T cell help.
Academic Article Leflunomide in experimental transplantation. Control of rejection and alloantibody production, reversal of acute rejection, and interaction with cyclosporine.
Academic Article Infection with the intracellular bacterium, Listeria monocytogenes, overrides established tolerance in a mouse cardiac allograft model.
Academic Article Inactivation of Kupffer cells after prolonged donor fasting improves viability of transplanted hepatic allografts.
Academic Article Effect of leflunomide and cyclosporine on concordant xenogeneic islet transplantation in streptozotocin-induced and autoimmune diabetic mice.
Academic Article In vivo mechanism by which leflunomide controls lymphoproliferative and autoimmune disease in MRL/MpJ-lpr/lpr mice.
Academic Article Quantitation of the changes in splenic architecture during the rejection of cardiac allografts or xenografts.
Academic Article Leflunomide controls rejection in hamster to rat cardiac xenografts.
Academic Article Induction of species-specific host accommodation in the hamster-to-rat xenotransplantation model.
Academic Article Efficacy of FK506, leflunomide, anti-CD4, and CTLA4IG treatments in rat to mouse pancreas xenograft transplantation.
Academic Article Anti-galactose-alpha(1,3) galactose antibody production in alpha1,3-galactosyltransferase gene knockout mice after xeno and allo transplantation.
Academic Article Lewis rat pancreas, but not cardiac xenografts, are resistant to anti-gal antibody mediated hyperacute rejection.
Academic Article Antagonistic effect of toll-like receptor signaling and bacterial infections on transplantation tolerance.
Academic Article Allograft ultraviolet-B irradiation in rat small intestinal transplantation.
Academic Article T cell immunodeficiency in dyskeratosis congenita.
Academic Article Receptors that turn on and turn off natural killer cells.
Academic Article Local inflammation exacerbates the severity of Staphylococcus aureus skin infection.
Academic Article Natural killer cell cytotoxicity and the multidrug resistance gene.
Academic Article Impact of immunosuppression on recall immune responses to influenza vaccination in stable renal transplant recipients.
Academic Article Transplantation tolerance and its outcome during infections and inflammation.
Academic Article Lessons and limits of mouse models.
Academic Article Microbes and allogeneic transplantation.
Academic Article The influence of the microbiota on the immune response to transplantation.
Academic Article Transplantation: molecular phenotyping of T-cell-mediated rejection.
Academic Article Memory B cells in transplantation.
Academic Article B cells assist allograft rejection in the deficiency of protein kinase c-theta.
Academic Article Reversing endogenous alloreactive B cell GC responses with anti-CD154 or CTLA-4Ig.
Academic Article Mechanisms and consequences of injury and repair in older organ transplants.
Academic Article AST Cutting Edge of Transplantation 2013 Meeting Report: a comprehensive look at B cells and antibodies in transplantation.
Academic Article New kid on the pretransplant block: IgG recognizing apoptotic cells.
Academic Article Spontaneous restoration of transplantation tolerance after acute rejection.
Academic Article Proteomic Identification of saeRS-Dependent Targets Critical for Protective Humoral Immunity against Staphylococcus aureus Skin Infection.
Academic Article Cutting Edge: CTLA-4Ig Inhibits Memory B Cell Responses and Promotes Allograft Survival in Sensitized Recipients.
Academic Article High-Fat Diet-Induced Obesity Enhances Allograft Rejection.
Academic Article The composition of the microbiota modulates allograft rejection.
Academic Article Cytotoxicity of prion protein peptide (PrP106-126) differs in mechanism from the cytotoxic activity of the Alzheimer's disease amyloid peptide, A beta 25-35.
Academic Article Delayed Cytotoxic T Lymphocyte-Associated Protein 4-Immunoglobulin Treatment Reverses Ongoing Alloantibody Responses and Rescues Allografts From Acute Rejection.
Academic Article Tracing Donor-MHC Class II Reactive B cells in Mouse Cardiac Transplantation: Delayed CTLA4-Ig Treatment Prevents Memory Alloreactive B-Cell Generation.
Academic Article From Pipe Dream to Donor-Specific PC Elimination: Novel Ways to Target Alloantibodies.
Academic Article Adoptive Transfer of Tracer-Alloreactive CD4+ T Cell Receptor Transgenic T Cells Alters the Endogenous Immune Response to an Allograft.
Academic Article Virtual Global Transplant Laboratory Standard Operating Protocol for Donor Alloantigen-specific Interferon-gamma ELISPOT Assay.
Academic Article Transplantation tolerance after allograft rejection.
Academic Article Erosion of Transplantation Tolerance After Infection.
Academic Article Transplantation tolerance: don't forget about the B cells.
Academic Article Tracking of TCR-Transgenic T Cells Reveals That Multiple Mechanisms Maintain Cardiac Transplant Tolerance in Mice.
Academic Article Evolving Approaches in the Identification of Allograft-Reactive T and B Cells in Mice and Humans.
Academic Article Modification of the clonogenic assay for the detection of lymphokine activated killer cell activity.
Academic Article Equal Expansion of Endogenous Transplant-Specific Regulatory T Cell and Recruitment Into the Allograft During Rejection and Tolerance.
Academic Article New insights into the development of B cell responses: Implications for solid organ transplantation.
Academic Article Heterogeneity of memory B cells.
Academic Article Distinct Graft-Specific TCR Avidity Profiles during Acute Rejection and Tolerance.
Academic Article The pursuit of transplantation tolerance: new mechanistic insights.
Academic Article Outstanding questions in transplantation: B cells, alloantibodies, and humoral rejection.
Academic Article Urinary nanosensors of early transplant rejection.
Academic Article Fifty Shades of Tolerance: Beyond a Binary Tolerant/Non-Tolerant Paradigm.
Academic Article Desensitization in the Era of Precision Medicine: Moving From the Bench to Bedside.
Academic Article Skin-restricted commensal colonization accelerates skin graft rejection.
Academic Article ITS finally here! The first International Transplant Science meeting jointly organized by AST, ESOT, and TTS.
Academic Article Resilience of T cell-intrinsic dysfunction in transplantation tolerance.
Academic Article Recommended Treatment for Antibody-mediated Rejection After Kidney Transplantation: The 2019 Expert Consensus From the Transplantion Society Working Group.
Academic Article The First International Transplant Science (ITS) Meeting.
Academic Article B cells as antigen-presenting cells in transplantation rejection and tolerance.
Academic Article Reversing donor-specific antibody responses and antibody-mediated rejection with bortezomib and belatacept in mice and kidney transplant recipients.
Academic Article Inhibition of protective immunity against Staphylococcus aureus infection by MHC-restricted immunodominance is overcome by vaccination.
Academic Article Sensitization in transplantation: Assessment of risk (STAR) 2019 Working Group Meeting Report.
Academic Article The First ITS Meeting.
Academic Article Desensitizing highly sensitized heart transplant candidates with the combination of belatacept and proteasome inhibition.
Academic Article Mechanisms of organ transplant injury mediated by B cells and antibodies: Implications for antibody-mediated rejection.
Academic Article Innate-like self-reactive B cells infiltrate human renal allografts during transplant rejection.
Academic Article A taste of honey.
Academic Article Toward an understanding of allogeneic conflict in pregnancy and transplantation.
Academic Article Oral alloantigen exposure promotes donor-specific tolerance in a mouse model of minor-mismatched skin transplantation.
Academic Article Linked sensitization by memory CD4+ T cells prevents costimulation blockade-induced transplantation tolerance.
Academic Article Host-versus-commensal immune responses participate in the rejection of colonized solid organ transplants.

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