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One or more keywords matched the following properties of He, Tong-Chuan
PropertyValue
keywords Cancer metastasis
keywords Cancer drug resistance
overview I direct the Molecular Oncology Laboratory in the Department of Orthopaedic Surgery and Rehabilitation Medicine. Our lab consists of a dynamic group of basic science investigators and physician scientists, who have diverse expertise and a broad range of research interests. Our shared long-term objective is to better understand the molecular pathogenesis of bone and musculoskeletal diseases and to translate basic discoveries into potential therapies and/or preventive measures in clinical settings. Specifically, we focus on the following areas: LINEAGE COMMITMENT AND TERMINAL DIFFERENTIATION OF MESENCHYMAL STEM CELLS (MSCS) Multipotency of MSCs MSCs are pluripotent and capable of differentiating into osteogenic, chondrogenic, myogenic or adipogenic lineage. Understanding the molecular mechanisms of bone formation is pivotal for studying the pathogenesis of bone diseases. We are interested in elucidating the molecular mechanisms through which regulate the proliferation and differentiation of osteoblasts, chondrocytes, and adipocytes. Both Wnt/beta-catenin and bone morphogenetic proteins (BMPs) have been considered as important regulators of osteogenic differentiation of mesenchymal stem cells. We are investigating the biological functions of BMPs and Wnt/beta-catenin signaling in regulating the osteoblast differentiation of MSCs. We have therefore conducted a comprehensive analysis of BMP and Wnt3A-induced osteoblast differentiation of MSCs. Our findings indicate that osteoblast differentiation is a well-regulated process in normal progenitor cells, while osteosarcoma cells are refractory to osteogenic differentiation signal. BMP-9 is one of the most potent regulators of osteogenic differentiation The bone-forming osteoblasts are derived from pluripotent bone marrow fibroblasts (a.k.a., MSCs). Although the molecular mechanisms underlying bone formation remain to be defined, BMPs seem to play an important role in osteoblast differentiation. At least 15 types of BMPs have been identified in mice and humans. However, the ability of BMPs to induce osteoblast differentiation of mesenchymal stem cells has not been comprehensively investigated, mostly due to the fact that recombinant proteins are either not biologically active or not available for all BMPs. Through a comprehensive analysis, we found that BMP2, BMP6, and BMP9 (to a much lesser extent, BMP4 and BMP7) exhibited the greatest ability to induce osteoblast differentiation, whereas BMP3 was shown to inhibit osteogenesis, both in vitro and in vivo. Our findings about BMP9 as one of the most potent inducers of osteoblast differentiation are novel and particularly intriguing because BMP9 is one of the least characterized BMPs and its functions are largely unknown. Thus, many questions regarding BMP9 signaling need to be answered: What are the type I and type II TGFbeta/BMP receptors involved in BMP9 binding? What Smads are required for BMP9 signaling? How are the downstream targets regulated by BMP9? More importantly, what are the roles of BMP9 during embryonic and/or skeletal development? We are interested in addressing these questions. Critical mediators of BMP-induced differentiation of MSCs We have identified several potentially important signaling mediators of BMP-induced osteogenic differentiation. These targets include the Inhibitors of DNA binding/Differentiation helix-loop-helix (a.k.a., Id proteins) and CTGF. Interestingly, both Ids and CTGF have been shown to overexpress in human tumors. Our findings suggest that Ids and CTGF may play an important role in promoting the proliferation of early osteoblast progenitor cells and that their expression must be down-regulated during the terminal differentiation of committed osteoblasts, suggesting that a balanced regulation of their expression may be critical to BMP-induced osteoblast lineage-specific differentiation of MSCs. We are currently dissecting the functional roles of the important downstream mediators in BMP-induced osteogenic signaling. We are also interested in identifying the molecular switches that control the lineage-specific differentiation of osteoblasts, chondrocytes, and adipocytes in MSCs. We are especially interested in understanding at what stage osteogenic BMPs (e.g., BMP2 or BMP9)-induced osteogenic and adipogenic differentiation diverges. What are the potential regulators that control this lineage divergence? It has been long postulated that a disrupted balance between osteogenesis and adipogenesis may cause musculoskeletal diseases, such as osteoporosis. Wnts regulate osteogenic differentiation of mesenchymal stem cells Our earlier studies demonstrated that Wnt/beta-catenin signaling is de-regulated in over 70% of human osteosarcoma. Recent studies also suggest that Wnt signaling may play an important role in regulating bone density, and one of the Wnt signaling antagonists Dkk1 may be implicated in the development of osteolytic lesion in multiple myeloma patients. We demonstrated that Wnt3A can induce the early osteogenic marker alkaline phosphatase in MSCs. Upon analyzing the gene expression profile of MSCs that were stimulated with Wnt3A, we found that three members of the CCN family, CCN1/Cyr61, CCN2/CTGF, and CCN5/WISP2, were among the most significantly up-regulated genes. Further studies demonstrate that CTGF is a mutual target of Wnt and BMP-9, and plays an important role in regulating osteogenic differentiation. However, more questions remain to be answered. We are currently investigating how osteogenic differentiation of MSCs is regulated by canonical and non-canonical Wnt signaling. MOLECULAR BASES OF BONE AND SOFT TISSUE SARCOMAS Sarcomas represent a heterogeneous group of malignant mesenchymal tumors with numerous histologic subtypes and complex cytogenetic abnormalities. Unlike other common solid tumors, sarcomas are relatively uncommon and their molecular pathogenesis, in general, are poorly understood. We mainly focus on understanding the molecular biology of primary bone tumor (a.k.a., osteosarcoma, OS). Osteosarcoma is the most common primary malignancy of bone, and is among the most common non-hematological primary tumors of bone in both children and adults. The peak incidence occurs in the second decade. With preoperative chemotherapy, the five-year survival rate of patients with non-metastatic tumors has improved significantly to approximately 60-70%. However, cases with local recurrence and/or pulmonary metastasis are usually less sensitive, if not resistant, to conventional chemotherapies. Several cytogenetic studies suggest that certain chromosomal regions may be amplified, rearranged, or deleted in some, but not all, human osteosarcomas. Unfortunately, the low incidence of this disease and the absence of any familial predisposition have complicated efforts to identify osteosarcoma-associated genes. Thus, we are taking a comprehensive approach to elucidate the molecular mechanisms underlying the development of osteosarcoma. Wnt/beta-catenin signaling in the development of human osteosarcoma Aberrant activation of Wnt/beta-catenin signaling by inactivating APC tumor suppressor or oncogenic activation of beta-catenin plays an important role in colorectal tumorigenesis. Oncogenic activation of beta-catenin has also been reported in several types of human solid tumors. We found that beta-catenin signaling is de-regulated in about 70% of human osteosarcoma without beta-catenin mutations. As in many other types of non-colon cancer, little is known about how Wnt/beta-catenin signaling pathway is activated. Therefore, we are interested in elucidating the upstream regulatory mechanisms that may underline of the beta-catenin signaling pathway. We are also interested in investigating the possible pathogenic role of beta-catenin deregulation in bone and soft tissue tumors. Furthermore, we are investigating the potential roles of EF-hand calcium-binding S100 proteins in osteosarcoma progression and the development of pulmonary metastasis. Clinically relevant osteosarcoma animal model In order to investigate the pathogenesis of human osteosarcoma, there is a great need to develop a clinically relevant animal model. We have developed such an orthotopic animal model of osteosarcoma using several human osteosarcoma lines. This clinically relevant model of human osteosarcoma provides varying degrees of tumor growth at the primary site and of metastatic potential. Thus, this orthotopic model is being used as a valuable tool to investigate factors that promote or inhibit osteosarcoma growth and/or metastasis. For instance, we are now using this model to investigate the roles of genes that are known to promote cell proliferation and inhibit differentiation, and genes that potentially promote or inhibit cancer metastasis. This orthotopic model can also be used to test anti-tumor small molecules or other targeted therapies. Osteosarcoma is a differentiation disease We believe that understanding the molecular events behind normal osteoblast differentiation of MSCs may provide important clues to osteosarcoma development. Stem cell differentiation and tumorigenesis share some strikingly similar characteristics. Both normal stem cells and cancer stem cells have the ability to self-renew. Although stem cells are often the target of genetic events that are necessary or sufficient for malignant transformation, in some cases restricted progenitors or even differentiated cells may become transformed. Thus, cancer stem cells may be derived from tissue-specific stem cells or progenitors, such as MSCs. Although cancer stem cells for osteosarcoma remain to be identified, OS cells indeed exhibit the characteristics of undifferentiated osteoblasts, and we have shown that differentiation-promoting agents can inhibit OS proliferation. Accordingly, we found that human osteosarcoma cells are in general refractory to osteogenic BMPs and exhibit no signs of terminal differentiation upon osteogenic BMP stimulation. Thus, we hypothesize that osteosarcoma development is caused by molecular/genetic disruptions of the osteogenic differentiation pathway. We are investigating and identifying the possible defects in osteogenic pathway, including the possible roles of the early target genes of BMP-induced osteoblast lineage-specific differentiation of MSCs. MOLECULAR BIOLOGY OF CANCER METASTASIS Cancer metastasis is an often overlooked and least understood problem. Metastasis is defined as the progressive growth of tumor cells at a site that is discontinuous from the primary tumor. Although not an efficient process, colonization at distant tissues by tumor cells represents the most dangerous attribute of cancer, because metastases, rather than primary tumors, are responsible for most cancer deaths. Metastatic cells are a subset of primary tumor cells that have acquired the ability to complete a multi-step metastatic cascade, including migration, dissemination, extravasation, and eventual proliferation at a discontinuous secondary site. Understanding the molecular biology of cancer metastasis may provide novel intervention strategies to control/contain metastatic lesions, and/or to improve the quality of life for the patients with these advanced diseases. Pulmonary metastasis of primary bone tumors Lung metastasis is the leading cause of OS mortality. Our orthotopic tumor model of human OS provides a unique opportunity for us to investigate the molecular events underlying osteosarcoma pulmonary metastasis. Using this model, we have conducted serial selections of highly metastatic human OS sublines, which were otherwise non-metastatic. Using microarray analysis, we have compared the gene expression profiles between these sublines and the parental lines in search for gene(s) that may cause or be associated with osteosarcoma metastasis. In an alternative approach, we are conducting functional selection assays, in which an RNAi library has been introduced into the non-metastatic or less metastatic human osteosarcoma cells to recover lung metastases and to identify potential metastasis suppressors of human osteosarcoma. Metastatic bone tumors Bone is one of the most frequently targeted organs for cancer metastasis, and bone is the most common site for distant relapse of most cancers. The bone microenvironment is unique among metastatic target tissues because it is subjected to continuous remodeling under the influence circulating hormones and local bone-derived factors. Interactions between the bone microenvironment and the cancer cells can give rise to osteolytic (bone resorbing) or osteoblastic (bone forming) metastasis. Osteolytic bone metastasis are characteristic for most malignancies, such as breast cancer and lung cancer, while osteoblastic metastasis is mostly associated with prostate cancer. We are investigating the molecular mechanisms through which the interactions between metastatic (breast and prostate) cancer cells and bone microenvironment are regulated. NOVEL THERAPEUTIC AND/OR PREVENTIVE STRATEGIES FOR BONE AND MUSCULOSKELETAL DISEASES The ultimate goal of biomedical research is to develop innovative diagnostic, therapeutic, and/or preventive strategies for human diseases. We are interested in developing innovative approaches for local or systemic delivery of therapeutic genes as effective treatment for bone and musculoskeletal diseases. We are investigating the use of osteogenic BMPs for bone regeneration, enhancing fracture healing, repairing segmental defects, promoting spinal fusion, and preventing implant wear particle-induced osteolysis. We have recently demonstrated the potential use of some of the BMPs in promoting biomechanical features of healing tendons/ligaments. We also demonstrated that Sox9, a master regulator of chondrogenesis, may be used in gene therapy to treat intervertebral disc degeneration and articular cartilage injuries. These lines of investigation reflect our commitment to the true spirit of translational research in bone and musculoskeletal disorders.
One or more keywords matched the following items that are connected to He, Tong-Chuan
Item TypeName
Concept Breast Neoplasms
Concept Bone Neoplasms
Concept Urinary Bladder Neoplasms
Concept Femoral Neoplasms
Concept Colonic Neoplasms
Concept Uterine Cervical Neoplasms
Concept Kidney Neoplasms
Concept Mammary Neoplasms, Experimental
Concept Liver Neoplasms
Concept Pancreatic Neoplasms
Concept Ovarian Neoplasms
Concept Lung Neoplasms
Concept Prostatic Neoplasms
Concept Head and Neck Neoplasms
Concept Drug Resistance, Neoplasm
Concept Meningeal Neoplasms
Concept Neoplasms, Experimental
Concept Penile Neoplasms
Concept Stomach Neoplasms
Concept Skin Neoplasms
Concept Colorectal Neoplasms
Concept Brain Neoplasms
Concept Neoplasms
Concept Neoplasms, Glandular and Epithelial
Academic Article Nuclear receptor agonists as potential differentiation therapy agents for human osteosarcoma.
Academic Article Tyrosine kinase inhibitor STI-571/Gleevec down-regulates the beta-catenin signaling activity.
Academic Article Cytoplasmic and/or nuclear accumulation of the beta-catenin protein is a frequent event in human osteosarcoma.
Academic Article Elevated protein expression of cyclin D1 and Fra-1 but decreased expression of c-Myc in human colorectal adenocarcinomas overexpressing beta-catenin.
Academic Article An orthotopic model of human osteosarcoma growth and spontaneous pulmonary metastasis.
Academic Article Is cytomegalovirus associated with human colorectal tumorigenesis?
Academic Article Steamed American ginseng berry: ginsenoside analyses and anticancer activities.
Academic Article Myoid differentiation and prognosis in adult pleomorphic sarcomas of the extremity: an analysis of 92 cases.
Academic Article Notoginseng enhances anti-cancer effect of 5-fluorouracil on human colorectal cancer cells.
Academic Article Characterization of gene expression regulated by American ginseng and ginsenoside Rg3 in human colorectal cancer cells.
Academic Article S100A6 expression and function in human osteosarcoma.
Academic Article Tyrosine kinase inhibitor STI-571: the new wonder drug of cancer therapy.
Academic Article Antiproliferative effects of different plant parts of Panax notoginseng on SW480 human colorectal cancer cells.
Academic Article In vitro and in vivo anticancer effects of American ginseng berry: exploring representative compounds.
Academic Article American ginseng berry enhances chemopreventive effect of 5-FU on human colorectal cancer cells.
Academic Article Synergistic antitumor effect of the activated PPARgamma and retinoid receptors on human osteosarcoma.
Academic Article Establishment and characterization of a new highly metastatic human osteosarcoma cell line.
Academic Article A traditional Chinese medicine formulation consisting of Rhizoma Corydalis and Rhizoma Curcumae exerts synergistic anti-tumor activity.
Academic Article Immunosuppressive cyclosporin A activates AKT in keratinocytes through PTEN suppression: implications in skin carcinogenesis.
Academic Article Tetrandrine inhibits Wnt/ß-catenin signaling and suppresses tumor growth of human colorectal cancer.
Academic Article Chemopreventive effects of Panax notoginseng and its major constituents on SW480 human colorectal cancer cells.
Academic Article Ginsenoside Rg3 inhibits colorectal tumor growth through the down-regulation of Wnt/ß-catenin signaling.
Academic Article Antioxidants potentiate American ginseng-induced killing of colorectal cancer cells.
Academic Article BMP9 inhibits the proliferation and invasiveness of breast cancer cells MDA-MB-231.
Academic Article LIGHT delivery to tumors by mesenchymal stem cells mobilizes an effective antitumor immune response.
Academic Article The CCN proteins: important signaling mediators in stem cell differentiation and tumorigenesis.
Academic Article Chemopreventive effects of heat-processed Panax quinquefolius root on human breast cancer cells.
Academic Article Enhancement of canonical Wnt/ß-catenin signaling activity by HCV core protein promotes cell growth of hepatocellular carcinoma cells.
Academic Article Lysophosphatidic acid acyltransferase ß (LPAATß) promotes the tumor growth of human osteosarcoma.
Academic Article Osteosarcoma development and stem cell differentiation.
Academic Article Oncolytic adenoviral vectors which employ the survivin promoter induce glioma oncolysis via a process of beclin-dependent autophagy.
Academic Article Wnt/beta-catenin signaling pathway as a novel cancer drug target.
Academic Article Increased expression of S100A6 is associated with decreased metastasis and inhibition of cell migration and anchorage independent growth in human osteosarcoma.
Academic Article Osteosarcoma and osteoblastic differentiation: a new perspective on oncogenesis.
Academic Article RNA interference-mediated gene silencing of vascular endothelial growth factor in colon cancer cells.
Academic Article Ginsenoside Rh2 induces apoptosis and paraptosis-like cell death in colorectal cancer cells through activation of p53.
Academic Article Caspase-mediated pro-apoptotic interaction of panaxadiol and irinotecan in human colorectal cancer cells.
Academic Article Compound K, a Ginsenoside Metabolite, Inhibits Colon Cancer Growth via Multiple Pathways Including p53-p21 Interactions.
Academic Article The synergistic apoptotic interaction of panaxadiol and epigallocatechin gallate in human colorectal cancer cells.
Academic Article Ginseng saponin metabolite 20(S)-protopanaxadiol inhibits tumor growth by targeting multiple cancer signaling pathways.
Academic Article Paraptosis and NF-?B activation are associated with protopanaxadiol-induced cancer chemoprevention.
Academic Article Genistein induces G2/M cell cycle arrest and apoptosis via ATM/p53-dependent pathway in human colon cancer cells.
Academic Article IGFBP5 domains exert distinct inhibitory effects on the tumorigenicity and metastasis of human osteosarcoma.
Academic Article Tetrandrine Suppresses Cancer Angiogenesis and Metastasis in 4T1 Tumor Bearing Mice.
Academic Article TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal.
Academic Article Regulation of cell proliferation and migration by p62 through stabilization of Twist1.
Academic Article BMP9 regulates cross-talk between breast cancer cells and bone marrow-derived mesenchymal stem cells.
Academic Article S100A8 and S100A9 are associated with colorectal carcinoma progression and contribute to colorectal carcinoma cell survival and migration via Wnt/ß-catenin pathway.
Academic Article Dihydroartemisinin inhibits tumor growth of human osteosarcoma cells by suppressing Wnt/ß-catenin signaling.
Academic Article Protopanaxadiol, an active ginseng metabolite, significantly enhances the effects of fluorouracil on colon cancer.
Academic Article TRAIL pathway is associated with inhibition of colon cancer by protopanaxadiol.
Academic Article BMP9 inhibits the bone metastasis of breast cancer cells by downregulating CCN2 (connective tissue growth factor, CTGF) expression.
Academic Article Exomic analysis of myxoid liposarcomas, synovial sarcomas, and osteosarcomas.
Academic Article BMP9 inhibits proliferation and metastasis of HER2-positive SK-BR-3 breast cancer cells through ERK1/2 and PI3K/AKT pathways.
Academic Article Targeting BMP9-promoted human osteosarcoma growth by inactivation of notch signaling.
Academic Article Bone morphogenetic protein 2 inhibits the proliferation and growth of human colorectal cancer cells.
Academic Article S100A9 promotes the proliferation and invasion of HepG2 hepatocellular carcinoma cells via the activation of the MAPK signaling pathway.
Academic Article The Anthelmintic Drug Niclosamide Inhibits the Proliferative Activity of Human Osteosarcoma Cells by Targeting Multiple Signal Pathways.
Academic Article Biological roles of human bone morphogenetic protein 9 in the bone microenvironment of human breast cancer MDA-MB-231 cells.
Academic Article High intensity focused ultrasound enhances anti-tumor immunity by inhibiting the negative regulatory effect of miR-134 on CD86 in a murine melanoma model.
Academic Article Antibiotic monensin synergizes with EGFR inhibitors and oxaliplatin to suppress the proliferation of human ovarian cancer cells.
Academic Article All-trans retinoic acid inhibits proliferation, migration, invasion and induces differentiation of hepa1-6 cells through reversing EMT in vitro.
Academic Article The evolving roles of canonical WNT signaling in stem cells and tumorigenesis: implications in targeted cancer therapies.
Academic Article Red ginseng and cancer treatment.
Academic Article Coffee consumption and risk of gastric cancer: an updated meta-analysis.
Academic Article A Blockade of IGF Signaling Sensitizes Human Ovarian Cancer Cells to the Anthelmintic Niclosamide-Induced Anti-Proliferative and Anticancer Activities.
Academic Article Hypoxia pathway and hypoxia-mediated extensive extramedullary hematopoiesis are involved in ursolic acid's anti-metastatic effect in 4T1 tumor bearing mice.
Academic Article Insider information: Testing cancer drug sensitivity for personalized therapy.
Academic Article Molecular basis of differentiation therapy for soft tissue sarcomas.
Academic Article Wnt/ß-catenin signaling plays an ever-expanding role in stem cell self-renewal, tumorigenesis and cancer chemoresistance.
Academic Article The Current and Future Therapies for Human Osteosarcoma.
Academic Article High intensity focused ultrasound inhibits melanoma cell migration and metastasis through attenuating microRNA-21-mediated PTEN suppression.
Academic Article Anthelmintic mebendazole enhances cisplatin's effect on suppressing cell proliferation and promotes differentiation of head and neck squamous cell carcinoma (HNSCC).
Academic Article Inhibitory effects of BMP9 on breast cancer cells by regulating their interaction with pre-adipocytes/adipocytes.
Academic Article Transition to resistance: An unexpected role of the EMT in cancer chemoresistance.
Academic Article Epimedin C Promotes Vascularization during BMP2-Induced Osteogenesis and Tumor-Associated Angiogenesis.
Academic Article CDX2 is mutated in a colorectal cancer with normal APC/beta-catenin signaling.
Academic Article The beta-catenin binding domain of adenomatous polyposis coli is sufficient for tumor suppression.
Academic Article 14-3-3sigma is a p53-regulated inhibitor of G2/M progression.
Academic Article Genetic determinants of p53-induced apoptosis and growth arrest.
Academic Article Converting cancer genes into killer genes.
Academic Article Role of intestinal microbiome in American ginseng-mediated colon cancer prevention in high fat diet-fed AOM/DSS mice [corrected].
Academic Article Identification of c-MYC as a target of the APC pathway.
Academic Article PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs.
Academic Article Correction to: Role of intestinal microbiome in American ginseng-mediated colon cancer prevention in high fat diet-fed AOM/DSS mice.
Academic Article Breast cancer development and progression: Risk factors, cancer stem cells, signaling pathways, genomics, and molecular pathogenesis.
Academic Article [Twist regulates proliferation, migration and invasion of osteosarcoma cells in vitro].
Academic Article LncRNA ITGB2-AS1 Could Promote the Migration and Invasion of Breast Cancer Cells through Up-Regulating ITGB2.
Academic Article Niclosamide Exhibits Potent Anticancer Activity and Synergizes with Sorafenib in Human Renal Cell Cancer Cells.
Academic Article Inhibitor of ß-catenin and TCF (ICAT) promotes cervical cancer growth and metastasis by disrupting E-cadherin/ß-catenin complex.
Academic Article Epigenetic silencing of SFRP5 promotes the metastasis and invasion of chondrosarcoma by expression inhibition and Wnt signaling pathway activation.
Academic Article BMP9 Promotes the Proliferation and Migration of Bladder Cancer Cells through Up-Regulating lncRNA UCA1.
Academic Article Monensin inhibits cell proliferation and tumor growth of chemo-resistant pancreatic cancer cells by targeting the EGFR signaling pathway.
Academic Article A simplified system for the effective expression and delivery of functional mature microRNAs in mammalian cells.
Academic Article [Clinical observation of partial pancreatectomy as part of primary cytoreductive surgery in advanced epithelial ovarian cancer].
Academic Article ARRB1-Promoted NOTCH1 Degradation Is Suppressed by OncomiR miR-223 in T-cell Acute Lymphoblastic Leukemia.
Academic Article Cytotoxicity and Preliminary Analysis of the Pro-apoptotic and Cell Cycle Arrest Effects of Lantana ukambensis Against Colorectal Cancer Cells.
Academic Article Blockade of IGF/IGF-1R signaling axis with soluble IGF-1R mutants suppresses the cell proliferation and tumor growth of human osteosarcoma.
Academic Article Upregulation of polycistronic microRNA-143 and microRNA-145 in colonocytes suppresses colitis and inflammation-associated colon cancer.
Academic Article SP1-induced long non-coding RNA SNHG6 facilitates the carcinogenesis of chondrosarcoma through inhibiting KLF6 by recruiting EZH2.
Academic Article The inhibition of BRAF activity sensitizes chemoresistant human ovarian cancer cells to paclitaxel-induced cytotoxicity and tumor growth inhibition.
Academic Article SNHG3 promotes migration, invasion, and epithelial-mesenchymal transition of breast cancer cells through the miR-186-5p/ZEB1 axis.
Academic Article BMP4 augments the survival of hepatocellular carcinoma (HCC) cells under hypoxia and hypoglycemia conditions by promoting the glycolysis pathway.
Academic Article Antiparasitic mebendazole (MBZ) effectively overcomes cisplatin resistance in human ovarian cancer cells by inhibiting multiple cancer-associated signaling pathways.
Academic Article Integrative analysis of immune-related multi-omics profiles identifies distinct prognosis and tumor microenvironment patterns in osteosarcoma.
Academic Article LncRNA SNHG3 regulates the BMSC osteogenic differentiation in bone metastasis of breast cancer by modulating the miR-1273g-3p/BMP3 axis.
Academic Article Ferroptosis as a novel form of regulated cell death: Implications in the pathogenesis, oncometabolism and treatment of human cancer.
Academic Article Pyrvinium doubles against WNT-driven cancer.
Academic Article The HPV16 E6, E7/miR-23b-3p/ICAT signaling axis promotes proliferation, migration, invasion and EMT of cervical cancer cells.
Academic Article Effect of antibiotic monensin on cell proliferation and IGF1R signaling pathway in human colorectal cancer cells.
Grant A genomewide discovery of chemoresistance-associated noncoding RNAs in human cancers
Grant Regulation of beta-Catenin Signaling by Tyrosine Phosphorylation
Academic Article Erratum: BMP4 augments the survival of hepatocellular carcinoma (HCC) cells under hypoxia and hypoglycemia conditions by promoting the glycolysis pathway.
Academic Article Niclosamide (NA) overcomes cisplatin resistance in human ovarian cancer.
Academic Article Long noncoding RNA (lncRNA) H19: An essential developmental regulator with expanding roles in cancer, stem cell differentiation, and metabolic diseases.
Academic Article BMP4 upregulates glycogen synthesis through the SMAD/SLC2A1 (GLUT1) signaling axis in hepatocellular carcinoma (HCC) cells.
Academic Article Erratum: SNHG3 promotes migration, invasion, and epithelial-mesenchymal transition of breast cancer cells through the miR-186-5p/ZEB1 axis.
Academic Article Twenty years of Gendicine® rAd-p53 cancer gene therapy: The first-in-class human cancer gene therapy in the era of personalized oncology.
Academic Article Collagen type X expression and chondrocyte hypertrophic differentiation during OA and OS development.
Academic Article Targeting the lipid kinase PIKfyve upregulates surface expression of MHC class I to augment cancer immunotherapy.
Academic Article Targeting PIKfyve-driven lipid homeostasis as a metabolic vulnerability in pancreatic cancer.
Academic Article Clinicopathologic Features and Survival Outcomes for Primary Renal Neuroendocrine Neoplasms.
Academic Article Efficacy of Intra-Arterial Plus Intravesical Chemotherapy for High-Risk Non-Muscle-Invasive Bladder Cancer: A Pooled Analysis.
Academic Article Proxalutamide reduces SARS-CoV-2 infection and associated inflammatory response.
Academic Article Targeting the mSWI/SNF Complex in POU2F-POU2AF Transcription Factor-Driven Malignancies.
Academic Article PMEPA1 Is a Prognostic Biomarker That Correlates With Cell Malignancy and the Tumor Microenvironment in Bladder Cancer.
Academic Article Effect of goal-directed fluid therapy based on both stroke volume variation and delta stroke volume on the incidence of composite postoperative complications among individuals undergoing meningioma resection.
Academic Article A nomogram incorporating PD-L1, NLR, and clinicopathologic features to predict inguinal lymph node metastasis in penile squamous cell carcinoma.
Academic Article p300/CBP degradation is required to disable the active AR enhanceosome in prostate cancer.
Academic Article PIKfyve, expressed by CD11c-positive cells, controls tumor immunity.
Academic Article Targeting the mSWI/SNF complex in POU2F-POU2AF transcription factor-driven malignancies.
Academic Article Smoking status and pathological response to neoadjuvant chemotherapy among patients with bladder cancer: a pooled analysis.
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  • Cancer
  • drug resistance