The University of Chicago Header Logo

Search Result Details

This page shows the details of why an item matched the keywords from your search.
One or more keywords matched the following properties of Claud, Erika C.
keywords Intestinal Development
overview Dr. Claud is a physician scientist who intended to be a full time clinician but discovered a passion for answering questions through laboratory investigation. She is committed to the questions being explored in her laboratory but also to encouraging medical students and trainees to consider research as an essential and feasible means of improving patient care. Dr. Claud is a Professor in the Department of Pediatrics, Section of Neonatology, and the Department of Medicine, Section of Gastroenterology. She received her combined undergraduate and medical degree at Northwestern University through the six year Honors Program in Medical Education, and then completed her Residency in Pediatrics at Children’s Memorial Hospital in Chicago. After spending 18 months in rural Kenya as a missionary physician, she returned to Chicago to complete her Neonatology Fellowship at Children’s Memorial Hospital. Following her clinical fellowship she was recruited to Harvard Medical School where she held a clinical position at The Boston Children’s Hospital and completed a research fellowship at Massachusetts General Hospital. She joined the faculty of the University of Chicago in 2004. She is NIH funded to investigate the role of microbes in intestinal development of the preterm infant and leads the MIND (Microbiome in Neonatal Development) cohort. The interaction between the intestine and its resident microbiota is a complex relationship with risk and benefit for the host. Perturbations in environmental cues or altered patterns of microbial selection can affect health and increase risk of disease in susceptible individuals. The simple microbial communities and limited environmental variation of the preterm infant provide a unique model in which to investigate microbial perturbations. Her laboratory utilizes state-of-the-art experimental approaches including: 16S rRNA and shotgun metagenomic analyses of the microbiome, gnotobiotic mouse models, rodent models of Neonatal Necrotizing Enterocolitis, as well as cell culture models of immature and mature intestine to investigate the health impact of the microbiome on health outcomes of preterm infants. She is co-director of the Basic Science Track within the Scholarship and Discovery Program of the Pritzker School of Medicine and Faculty Co-Chair Pritzker School of Medicine Summer Research Program. She is also Director of Neonatology Research and a member of the Faculty Leadership Cabinet for the Duchossois Family Institute.
One or more keywords matched the following items that are connected to Claud, Erika C.
Item TypeName
Concept Child Development
Concept Intestinal Absorption
Concept Intestinal Mucosa
Concept Gene Expression Regulation, Developmental
Academic Article Developmentally regulated IkappaB expression in intestinal epithelium and susceptibility to flagellin-induced inflammation.
Academic Article Flagellin is required for salmonella-induced expression of heat shock protein Hsp25 in intestinal epithelium.
Academic Article Platelet-activating factor-induced chloride channel activation is associated with intracellular acidosis and apoptosis of intestinal epithelial cells.
Academic Article Salmonella type III effector AvrA stabilizes cell tight junctions to inhibit inflammation in intestinal epithelial cells.
Academic Article Developmentally regulated tumor necrosis factor-alpha induced nuclear factor-kappaB activation in intestinal epithelium.
Academic Article Erythropoietin protects intestinal epithelial barrier function and lowers the incidence of experimental neonatal necrotizing enterocolitis.
Academic Article The mechanism of excessive intestinal inflammation in necrotizing enterocolitis: an immature innate immune response.
Academic Article Bacteria-free solution derived from Lactobacillus plantarum inhibits multiple NF-kappaB pathways and inhibits proteasome function.
Academic Article Salmonella typhimurium infection increases p53 acetylation in intestinal epithelial cells.
Academic Article Regional differences in colonic mucosa-associated microbiota determine the physiological expression of host heat shock proteins.
Academic Article Axin1 prevents Salmonella invasiveness and inflammatory response in intestinal epithelial cells.
Academic Article Mother's milk-induced Hsp70 expression preserves intestinal epithelial barrier function in an immature rat pup model.
Academic Article Platelet-activating factor regulates chloride transport in colonic epithelial cell monolayers.
Academic Article Modulation of human intestinal epithelial cell IL-8 secretion by human milk factors.
Academic Article Lubiprostone decreases mouse colonic inner mucus layer thickness and alters intestinal microbiota.
Academic Article Synergistic protection of combined probiotic conditioned media against neonatal necrotizing enterocolitis-like intestinal injury.
Academic Article Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis.
Academic Article Differential expression of 26S proteasome subunits and functional activity during neonatal development.
Academic Article Oral administration of transforming growth factor-ß1 (TGF-ß1) protects the immature gut from injury via Smad protein-dependent suppression of epithelial nuclear factor ?B (NF-?B) signaling and proinflammatory cytokine production.
Academic Article Erythropoietin protects epithelial cells from excessive autophagy and apoptosis in experimental neonatal necrotizing enterocolitis.
Academic Article Transcriptional modulation of intestinal innate defense/inflammation genes by preterm infant microbiota in a humanized gnotobiotic mouse model.
Academic Article Tight junction CLDN2 gene is a direct target of the vitamin D receptor.
Academic Article Administration of defined microbiota is protective in a murine Salmonella infection model.
Academic Article Preterm infant gut microbiota affects intestinal epithelial development in a humanized microbiome gnotobiotic mouse model.
Academic Article Rebooting the microbiome.
Academic Article Neonatal Necrotizing Enterocolitis -Inflammation and Intestinal Immaturity.
Grant Early Enterocyte Injury in Neonatal Necrotizing Enterocolitis
Academic Article Connection between gut microbiome and brain development in preterm infants.
Academic Article Microbiota influence the development of the brain and behaviors in C57BL/6J mice.
Academic Article Effects of Intestinal Microbiota on Brain Development in Humanized Gnotobiotic Mice.
Grant Immature intestinal NF-kB regulation, probiotics, and necrotizing enterocolitis
Grant The microbiome as a potential mediator of socio-economic disparities in preterm infant neurodevelopmental trajectories from NICU discharge to school age
Grant Preterm infant susceptibility to NEC due to early intestinal microbiome function
Grant Regulation of Inflammation in Immature Intestine
Grant Use of Probiotic Conditioned Media to Protect Against Necrotizing Enterocolitis
Academic Article Impact of Developmental Age, Necrotizing Enterocolitis Associated Stress, and Oral Therapeutic Intervention on Mucus Barrier Properties.
Academic Article Maternal administration of probiotics promotes brain development and protects offspring's brain from postnatal inflammatory insults in C57/BL6J mice.
Academic Article Childhood Development and the Microbiome-The Intestinal Microbiota in Maintenance of Health and Development of Disease During Childhood Development.
Academic Article Necrotizing enterocolitis intestinal barrier function protection by antenatal dexamethasone and surfactant-D in a rat model.
Academic Article The Role of Childhood Asthma in Obesity Development: A Nationwide US Multicohort Study.
Academic Article Bacteroidota and Lachnospiraceae integration into the gut microbiome at key time points in early life are linked to infant neurodevelopment.
Academic Article The Impact of Maternal Probiotics on Intestinal Vitamin D Receptor Expression in Early Life.
Search Criteria
  • Intestinal
  • Development