| Item Type | Name |
|
Concept
|
Myosin-Light-Chain Kinase
|
|
Concept
|
Protein-Tyrosine Kinases
|
|
Concept
|
Phosphotransferases (Alcohol Group Acceptor)
|
|
Concept
|
Mitogen-Activated Protein Kinases
|
|
Concept
|
Receptor Protein-Tyrosine Kinases
|
|
Concept
|
eIF-2 Kinase
|
|
Concept
|
Cyclin-Dependent Kinase 4
|
|
Concept
|
Mitogen-Activated Protein Kinase 3
|
|
Concept
|
Cyclin-Dependent Kinase Inhibitor p16
|
|
Concept
|
Mitogen-Activated Protein Kinase Kinases
|
|
Concept
|
Cyclin-Dependent Kinase Inhibitor p21
|
|
Concept
|
Protein Kinase C
|
|
Concept
|
Receptor-Interacting Protein Serine-Threonine Kinase 2
|
|
Concept
|
Receptor Tyrosine Kinase-like Orphan Receptors
|
|
Concept
|
Class I Phosphatidylinositol 3-Kinases
|
|
Concept
|
MAP Kinase Kinase 6
|
|
Concept
|
Cyclin-Dependent Kinase Inhibitor p15
|
|
Concept
|
CDC2 Protein Kinase
|
|
Concept
|
Mitogen-Activated Protein Kinase 1
|
|
Concept
|
Calcium-Calmodulin-Dependent Protein Kinases
|
|
Concept
|
Phosphatidylinositol 3-Kinases
|
|
Concept
|
MAP Kinase Signaling System
|
|
Concept
|
JNK Mitogen-Activated Protein Kinases
|
|
Concept
|
Extracellular Signal-Regulated MAP Kinases
|
|
Concept
|
Cyclin-Dependent Kinase Inhibitor p27
|
|
Concept
|
Cyclin-Dependent Kinase 6
|
|
Concept
|
fms-Like Tyrosine Kinase 3
|
|
Concept
|
Lim Kinases
|
|
Concept
|
Protein Kinase Inhibitors
|
|
Concept
|
p38 Mitogen-Activated Protein Kinases
|
|
Concept
|
Cyclin-Dependent Kinase 2
|
|
Concept
|
Cyclin-Dependent Kinase 5
|
|
Academic Article
|
Gene-expression profiles of human tumor xenografts in nude mice treated orally with the EGFR tyrosine kinase inhibitor ZD1839.
|
|
Academic Article
|
A nonsynonymous SNP in PRKCH (protein kinase C eta) increases the risk of cerebral infarction.
|
|
Academic Article
|
Activation of WD repeat and high-mobility group box DNA binding protein 1 in pulmonary and esophageal carcinogenesis.
|
|
Academic Article
|
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease.
|
|
Academic Article
|
Inactivation of fibroblast growth factor binding protein 3 causes anxiety-related behaviors.
|
|
Academic Article
|
Impact of LIMK1, MMP2 and TNF-a variations for intracranial aneurysm in Japanese population.
|
|
Academic Article
|
Common variants on 14q32 and 13q12 are associated with DLBCL susceptibility.
|
|
Academic Article
|
Possible involvement of NEDD4 in keloid formation; its critical role in fibroblast proliferation and collagen production.
|
|
Academic Article
|
Disruption of fibroblast growth factor signal pathway inhibits the growth of synovial sarcomas: potential application of signal inhibitors to molecular target therapy.
|
|
Academic Article
|
A genome-wide association study identifies genetic variants in the CDKN2BAS locus associated with endometriosis in Japanese.
|
|
Academic Article
|
A genome-wide association study identifies four genetic markers for hematological toxicities in cancer patients receiving gemcitabine therapy.
|
|
Academic Article
|
Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations.
|
|
Academic Article
|
Genome-wide association study for intracranial aneurysm in the Japanese population identifies three candidate susceptible loci and a functional genetic variant at EDNRA.
|
|
Academic Article
|
Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population.
|
|
Academic Article
|
IL28 variation affects expression of interferon stimulated genes and peg-interferon and ribavirin therapy.
|
|
Academic Article
|
A genome-wide association study in the Japanese population confirms 9p21 and 14q23 as susceptibility loci for primary open angle glaucoma.
|
|
Academic Article
|
Dual-specificity phosphatase 5 (DUSP5) as a direct transcriptional target of tumor suppressor p53.
|
|
Academic Article
|
Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.
|
|
Academic Article
|
MELK inhibitor, novel molecular targeted therapeutics for human cancer stem cells.
|
|
Academic Article
|
Association of the RIP2 gene with childhood atopic asthma.
|
|
Academic Article
|
ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms.
|
|
Academic Article
|
Overexpression of the potential kinase serine/ threonine/tyrosine kinase 1 (STYK 1) in castration-resistant prostate cancer.
|
|
Academic Article
|
Phosphorylation and activation of cell division cycle associated 5 by mitogen-activated protein kinase play a crucial role in human lung carcinogenesis.
|
|
Academic Article
|
Critical roles of LGN/GPSM2 phosphorylation by PBK/TOPK in cell division of breast cancer cells.
|
|
Academic Article
|
Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer.
|
|
Academic Article
|
Prediction of sensitivity of advanced non-small cell lung cancers to gefitinib (Iressa, ZD1839).
|
|
Academic Article
|
Indazole-based potent and cell-active Mps1 kinase inhibitors: rational design from pan-kinase inhibitor anthrapyrazolone (SP600125).
|
|
Academic Article
|
WHSC1 promotes oncogenesis through regulation of NIMA-related kinase-7 in squamous cell carcinoma of the head and neck.
|
|
Academic Article
|
Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family.
|
|
Academic Article
|
RASEF is a novel diagnostic biomarker and a therapeutic target for lung cancer.
|
|
Academic Article
|
Involvement of FKHR-dependent TRADD expression in chemotherapeutic drug-induced apoptosis.
|
|
Academic Article
|
Preclinical efficacy of maternal embryonic leucine-zipper kinase (MELK) inhibition in acute myeloid leukemia.
|
|
Academic Article
|
A polymorphism in MAPKAPK3 affects response to interferon therapy for chronic hepatitis C.
|
|
Academic Article
|
Genetic variants associated with angiotensin-converting enzyme inhibitor-associated angioedema.
|
|
Academic Article
|
Activation of Holliday junction recognizing protein involved in the chromosomal stability and immortality of cancer cells.
|
|
Academic Article
|
Demethylation of RB regulator MYPT1 by histone demethylase LSD1 promotes cell cycle progression in cancer cells.
|
|
Academic Article
|
A single nucleotide polymorphism in activated Cdc42 associated tyrosine kinase 1 influences the interferon therapy in hepatitis C patients.
|
|
Academic Article
|
Phosphorylation and activation of cell division cycle associated 8 by aurora kinase B plays a significant role in human lung carcinogenesis.
|
|
Academic Article
|
Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcoma.
|
|
Academic Article
|
ESE-3, an Ets family transcription factor, is up-regulated in cellular senescence.
|
|
Academic Article
|
A unique hinge binder of extremely selective aminopyridine-based Mps1 (TTK) kinase inhibitors with cellular activity.
|
|
Academic Article
|
Gamma-aminobutyric acid (GABA) stimulates pancreatic cancer growth through overexpressing GABAA receptor pi subunit.
|
|
Academic Article
|
Overexpression of cohesion establishment factor DSCC1 through E2F in colorectal cancer.
|
|
Academic Article
|
Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B.
|
|
Academic Article
|
ANLN plays a critical role in human lung carcinogenesis through the activation of RHOA and by involvement in the phosphoinositide 3-kinase/AKT pathway.
|
|
Academic Article
|
Critical roles of T-LAK cell-originated protein kinase in cytokinesis.
|
|
Academic Article
|
The histone methyltransferase Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) is involved in human carcinogenesis.
|
|
Academic Article
|
VAV3 mediates resistance to breast cancer endocrine therapy.
|
|
Academic Article
|
The histone demethylase JMJD2B plays an essential role in human carcinogenesis through positive regulation of cyclin-dependent kinase 6.
|
|
Academic Article
|
Identification of a nuclear protein, LRRC42, involved in lung carcinogenesis.
|
|
Academic Article
|
Detection of novel cancer-testis antigen-specific T-cell responses in TIL, regional lymph nodes, and PBL in patients with esophageal squamous cell carcinoma.
|
|
Academic Article
|
Identification of p53-46F as a super p53 with an enhanced ability to induce p53-dependent apoptosis.
|
|
Academic Article
|
Heterozygous TGFBR2 mutations in Marfan syndrome.
|
|
Academic Article
|
Identification of human leukocyte antigen-A24-restricted epitope peptides derived from gene products upregulated in lung and esophageal cancers as novel targets for immunotherapy.
|
|
Academic Article
|
Dysregulation of AKT Pathway by SMYD2-Mediated Lysine Methylation on PTEN.
|
|
Academic Article
|
PDZ-binding kinase/T-LAK cell-originated protein kinase, a putative cancer/testis antigen with an oncogenic activity in breast cancer.
|
|
Academic Article
|
TOPK inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition of cytokinesis.
|
|
Academic Article
|
PRMT6 increases cytoplasmic localization of p21CDKN1A in cancer cells through arginine methylation and makes more resistant to cytotoxic agents.
|
|
Academic Article
|
T-LAK cell-originated protein kinase presents a novel therapeutic target in FLT3-ITD mutated acute myeloid leukemia.
|
|
Academic Article
|
SUV420H1 enhances the phosphorylation and transcription of ERK1 in cancer cells.
|
|
Academic Article
|
Discovery of imidazo[1,2-b]pyridazine derivatives: selective and orally available Mps1 (TTK) kinase inhibitors exhibiting remarkable antiproliferative activity.
|
|
Academic Article
|
Toxoplasma gondii exploits UHRF1 and induces host cell cycle arrest at G2 to enable its proliferation.
|
|
Academic Article
|
Effective growth-suppressive activity of maternal embryonic leucine-zipper kinase (MELK) inhibitor against small cell lung cancer.
|
|
Academic Article
|
Eradication of Large Solid Tumors by Gene Therapy with a T-Cell Receptor Targeting a Single Cancer-Specific Point Mutation.
|
|
Academic Article
|
Afatinib Activity in Platinum-Refractory Metastatic Urothelial Carcinoma in Patients With ERBB Alterations.
|
|
Academic Article
|
Oncogenic roles of TOPK and MELK, and effective growth suppression by small molecular inhibitors in kidney cancer cells.
|
|
Academic Article
|
Preclinical evaluation of biomarkers associated with antitumor activity of MELK inhibitor.
|
|
Academic Article
|
Anti-myeloma activity of MELK inhibitor OTS167: effects on drug-resistant myeloma cells and putative myeloma stem cell replenishment of malignant plasma cells.
|
|
Academic Article
|
p53RFP, a p53-inducible RING-finger protein, regulates the stability of p21WAF1.
|
|
Academic Article
|
T-LAK Cell-Originated Protein Kinase (TOPK) as a Prognostic Factor and a Potential Therapeutic Target in Ovarian Cancer.
|
|
Academic Article
|
Diaminopyridine-based potent and selective mps1 kinase inhibitors binding to an unusual flipped-Peptide conformation.
|
|
Academic Article
|
WHSC1L1 drives cell cycle progression through transcriptional regulation of CDC6 and CDK2 in squamous cell carcinoma of the head and neck.
|
|
Academic Article
|
TOPK (T-LAK cell-originated protein kinase) inhibitor exhibits growth suppressive effect on small cell lung cancer.
|
|
Academic Article
|
WHSC1L1-mediated EGFR mono-methylation enhances the cytoplasmic and nuclear oncogenic activity of EGFR in head and neck cancer.
|
|
Academic Article
|
Effects of SMYD2-mediated EML4-ALK methylation on the signaling pathway and growth in non-small-cell lung cancer cells.
|
|
Academic Article
|
Maternal Embryonic Leucine Zipper Kinase (MELK), a Potential Therapeutic Target for Neuroblastoma.
|
|
Academic Article
|
MELK inhibition targets cancer stem cells through downregulation of SOX2 expression in head and neck cancer cells.
|
|
Academic Article
|
Potent anti-myeloma activity of the TOPK inhibitor OTS514 in pre-clinical models.
|
|
Academic Article
|
Clinical significance of gene mutation in ctDNA analysis for hormone receptor-positive metastatic breast cancer.
|
|
Academic Article
|
High expression of maternal embryonic leucine-zipper kinase (MELK) impacts clinical outcomes in patients with ovarian cancer and its inhibition suppresses ovarian cancer cells growth ex vivo.
|
|
Academic Article
|
Anti-cancer immunotherapy using cancer-derived multiple epitope-peptides cocktail vaccination clinical studies in patients with refractory/persistent disease of uterine cervical cancer and ovarian cancer [phase 2].
|
|
Academic Article
|
Serial circulating tumor DNA monitoring of CDK4/6 inhibitors response in metastatic breast cancer.
|
|
Concept
|
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
|
|
Concept
|
NIMA-Related Kinases
|
|
Concept
|
Protein Kinase C-theta
|
|
Concept
|
Aurora Kinase B
|
|
Concept
|
Aurora Kinases
|
|
Concept
|
3-Phosphoinositide-Dependent Protein Kinases
|
|
Concept
|
Death-Associated Protein Kinases
|
|
Concept
|
Myotonin-Protein Kinase
|