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overview Signaling mechanism in inflammation, cancer and neuronal degenerative disease My laboratory has a long-standing interest in understanding how the intracellular signaling network is integrated in response to a variety of extracellular signals, thereby controlling proliferation, programmed cell death and transformation. Our recent work focuses on elucidating the signaling mechanism in inflammatory disease, such as severe sepsis and colitis-associated cancer, and neuronal degenerative disease like Alzheimer’s disease, using a multifaceted experimental approach involving biochemistry, molecular cell biology, proteomics, computational modeling and animal models. Our long-term goal is to identify potential therapeutic targets for prevention and treatment of inflammatory and infectious disease, cancer and neuronal degenerative disease.
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