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One or more keywords matched the following properties of Rust, Michael J.
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overview Bacteria are an ancient form of life that occupies almost every conceivable niche, from pathogenesis to commensal existence with an animal host to primary production in oceans and lake. Despite their apparent simplicity, bacteria possess sophisticated biochemical networks that dynamically store information about the size and status of the cell and conditions in the external environment. These biochemical systems allow precise decision making that allow microbes to thrive in challenging conditions. Our lab is interested in the design principles of these reaction networks. We use a multidisciplinary approach: biochemical reconstitution of the underlying interactions, single cell microscopy to study function, and mathematical modeling to rebuild systems in silico. A major focus area is bacterial circadian rhythms, which allow single cells to predict the time of day.
One or more keywords matched the following items that are connected to Rust, Michael J.
Item TypeName
Concept Bacterial Proteins
Concept Chromosomes, Bacterial
Concept Genes, Bacterial
Concept Gene Expression Regulation, Bacterial
Academic Article Orderly wheels of the cyanobacterial clock.
Academic Article Light-driven changes in energy metabolism directly entrain the cyanobacterial circadian oscillator.
Academic Article Ordered phosphorylation governs oscillation of a three-protein circadian clock.
Academic Article Robust and tunable circadian rhythms from differentially sensitive catalytic domains.
Academic Article Mixtures of opposing phosphorylations within hexamers precisely time feedback in the cyanobacterial circadian clock.
Academic Article The cyanobacterial clock and metabolism.
Academic Article Rhythms in energy storage control the ability of the cyanobacterial circadian clock to reset.
Academic Article Circadian rhythms. A protein fold switch joins the circadian oscillator to clock output in cyanobacteria.
Academic Article Controlling the Cyanobacterial Clock by Synthetically Rewiring Metabolism.
Academic Article The cyanobacterial circadian clock follows midday in vivo and in vitro.
Academic Article High protein copy number is required to suppress stochasticity in the cyanobacterial circadian clock.
Academic Article Molecular dynamics simulations of nucleotide release from the circadian clock protein KaiC reveal atomic-resolution functional insights.
Academic Article Biophysical clocks face a trade-off between internal and external noise resistance.
Academic Article Bayesian modeling reveals metabolite-dependent ultrasensitivity in the cyanobacterial circadian clock.
Academic Article The circadian clock ensures successful DNA replication in cyanobacteria.
Academic Article KidA, a multi-PAS domain protein, tunes the period of the cyanobacterial circadian oscillator.
Search Criteria
  • Bacterial
  • pathogenesis