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One or more keywords matched the following properties of Karczmar, Gregory
PropertyValue
keywords Breast cancer screening with MRI
keywords Prostate cancer screening with MRI
overview I have developed new approaches to functional and anatomic magnetic resonance imaging for over 30 years. I’ve applied these methods to improve detection and accurate diagnosis of cancer, and monitor cancer response to therapy. I am the Director of Magnetic Resonance Imaging Research at the University of Chicago, and Co-Director of the Advanced Imaging Program of the University of Chicago Comprehensive Cancer center. I’ve collaborated with our outstanding mammographic group and medical physics colleagues for many years to build internationally recognized research program in quantitative breast cancer MR imaging – which parallels and compliments a leading clinical program in breast cancer diagnosis and management. Similarly, I’ve collaborated with Dr. Oto and others to develop a leading translational research program focused on improving prostate cancer screening with MRI, and using MRI to guide therapye. With these collaborators, I’ve made pioneering contributions to MRI methods that improve prostate and breast cancer diagnosis and treatment. My research includes use of pre-clinical methods for breast and prostate cancer to improve understanding of cancer biology and guide the development of improved clinical methods.
One or more keywords matched the following items that are connected to Karczmar, Gregory
Item TypeName
Concept Breast Neoplasms
Concept Endocrine Gland Neoplasms
Concept Colonic Neoplasms
Concept Uterine Cervical Neoplasms
Concept Kidney Neoplasms
Concept Mammary Neoplasms, Experimental
Concept Liver Neoplasms
Concept Lung Neoplasms
Concept Prostatic Neoplasms
Concept Head and Neck Neoplasms
Concept Uterine Neoplasms
Concept Soft Tissue Neoplasms
Concept Neoplasms, Experimental
Concept Colorectal Neoplasms
Concept Mammary Neoplasms, Animal
Concept Early Detection of Cancer
Concept Muscle Neoplasms
Concept Neoplasms
Academic Article Fast spectroscopic imaging of water and fat resonances to improve the quality of MR images.
Academic Article Dynamic contrast measurements in rodent model tumors.
Academic Article In vivo imaging of extraction fraction of low molecular weight MR contrast agents and perfusion rate in rodent tumors.
Academic Article Applications of magnetic resonance in model systems: cancer therapeutics.
Academic Article Correlation of magnetic resonance and oxygen microelectrode measurements of carbogen-induced changes in tumor oxygenation.
Academic Article Uptake of a superparamagnetic contrast agent imaged by MR with high spectral and spatial resolution.
Academic Article Differentiation of nonmetastatic and metastatic rodent prostate tumors with high spectral and spatial resolution MRI.
Academic Article A new method for imaging perfusion and contrast extraction fraction: input functions derived from reference tissues.
Academic Article Imaging spin probe distribution in the tumor of a living mouse with 250 MHz EPR: correlation with BOLD MRI.
Academic Article Spectrally inhomogeneous effects of contrast agents in breast lesion detected by high spectral and spatial resolution MRI.
Academic Article MRI of the tumor microenvironment.
Academic Article Breast MR imaging with high spectral and spatial resolutions: preliminary experience.
Academic Article Functional and anatomic imaging of tumor vasculature: high-resolution MR spectroscopic imaging combined with a superparamagnetic contrast agent.
Academic Article Selective depletion of tumor ATP by 2-deoxyglucose and insulin, detected by 31P magnetic resonance spectroscopy.
Academic Article The effect of varying spectral resolution on the quality of high spectral and spatial resolution magnetic resonance images of the breast.
Academic Article Effect of carbogen on tumor oxygenation: combined fluorine-19 and proton MRI measurements.
Academic Article Quantitative tumor oxymetric images from 4D electron paramagnetic resonance imaging (EPRI): methodology and comparison with blood oxygen level-dependent (BOLD) MRI.
Academic Article Using high spectral and spatial resolution bold MRI to choose the optimal oxygenating treatment for individual cancer patients.
Academic Article Semiquantitative analysis of dynamic contrast enhanced MRI in cancer patients: Variability and changes in tumor tissue over time.
Academic Article Multi-slice DCE-MRI data using P760 distinguishes between metastatic and non-metastatic rodent prostate tumors.
Academic Article A selective small molecule inhibitor of c-Met, PHA665752, inhibits tumorigenicity and angiogenesis in mouse lung cancer xenografts.
Academic Article High spectral and spatial resolution MRI of breast lesions: preliminary clinical experience.
Academic Article MRI of perfluorocarbon emulsion kinetics in rodent mammary tumours.
Academic Article Fat suppression with spectrally selective inversion vs. high spectral and spatial resolution MRI of breast lesions: qualitative and quantitative comparisons.
Academic Article Differentiation between benign and malignant breast lesions detected by bilateral dynamic contrast-enhanced MRI: a sensitivity and specificity study.
Academic Article Phase II study of the Flk-1 tyrosine kinase inhibitor SU5416 in advanced melanoma.
Academic Article Multiple reference tissue method for contrast agent arterial input function estimation.
Academic Article Quantitative analysis of water proton spectral lineshape: a novel source of contrast in MRI.
Academic Article DCEMRI of breast lesions: is kinetic analysis equally effective for both mass and nonmass-like enhancement?
Academic Article New model for analysis of dynamic contrast-enhanced MRI data distinguishes metastatic from nonmetastatic transplanted rodent prostate tumors.
Academic Article Detection of in situ mammary cancer in a transgenic mouse model: in vitro and in vivo MRI studies demonstrate histopathologic correlation.
Academic Article P-31 spectroscopy study of response of superficial human tumors to therapy.
Academic Article Dynamic contrast-enhanced magnetic resonance imaging pharmacodynamic biomarker study of sorafenib in metastatic renal carcinoma.
Academic Article Magnetic resonance imaging of the natural history of in situ mammary neoplasia in transgenic mice: a pilot study.
Academic Article Relating dose of contrast media administered to uptake and washout of malignant lesions on DCEMRI of the breast.
Academic Article Reproducibility assessment of a multiple reference tissue method for quantitative dynamic contrast enhanced-MRI analysis.
Academic Article Kinetic curves of malignant lesions are not consistent across MRI systems: need for improved standardization of breast dynamic contrast-enhanced MRI acquisition.
Academic Article Ductal carcinoma in situ: X-ray fluorescence microscopy and dynamic contrast-enhanced MR imaging reveals gadolinium uptake within neoplastic mammary ducts in a murine model.
Academic Article Comparison of high-resolution echo-planar spectroscopic imaging with conventional MR imaging of prostate tumors in mice.
Academic Article Characterization of response to radiation mediated gene therapy by means of multimodality imaging.
Academic Article Clinical implementation of a multislice high spectral and spatial resolution-based MRI sequence to achieve unilateral full-breast coverage.
Academic Article Fourier component imaging of water resonance in the human breast provides markers for malignancy.
Academic Article Prostate cancer: differentiation of central gland cancer from benign prostatic hyperplasia by using diffusion-weighted and dynamic contrast-enhanced MR imaging.
Academic Article Characterizing early contrast uptake of ductal carcinoma in situ with high temporal resolution dynamic contrast-enhanced MRI of the breast: a pilot study.
Academic Article Diagnosis of suspicious breast lesions using an empirical mathematical model for dynamic contrast-enhanced MRI.
Academic Article New vanadium-based magnetic resonance imaging probes: clinical potential for early detection of cancer.
Academic Article Normal parenchymal enhancement patterns in women undergoing MR screening of the breast.
Academic Article Early metabolic response to tumor necrosis factor in mouse sarcoma: a phosphorus-31 nuclear magnetic resonance study.
Academic Article The diverse pathology and kinetics of mass, nonmass, and focus enhancement on MR imaging of the breast.
Academic Article T(2)* relaxation times of intraductal murine mammary cancer, invasive mammary cancer, and normal mammary gland.
Academic Article High-resolution MRI of excised human prostate specimens acquired with 9.4T in detection and identification of cancers: validation of a technique.
Academic Article Diffusion-weighted and dynamic contrast-enhanced MRI of prostate cancer: correlation of quantitative MR parameters with Gleason score and tumor angiogenesis.
Academic Article Imaging vascular function for early stage clinical trials using dynamic contrast-enhanced magnetic resonance imaging.
Academic Article Can DCEMRI assess the effect of green tea on the angiogenic properties of rodent prostate tumors?
Academic Article Comparison of quantitative parameters in cervix cancer measured by dynamic contrast-enhanced MRI and CT.
Academic Article In vivo MRI of early stage mammary cancers and the normal mouse mammary gland.
Academic Article Comparing post-operative human breast specimen radiograph and MRI in lesion margin and volume assessment.
Academic Article Hepatic cancers and their response to chemoembolization therapy. Quantitative image-guided 31P magnetic resonance spectroscopy.
Academic Article Clinical magnetic resonance spectroscopy of brain, heart, liver, kidney, and cancer. A quantitative approach.
Academic Article Non-contrast enhanced MRI for evaluation of breast lesions: comparison of non-contrast enhanced high spectral and spatial resolution (HiSS) images versus contrast enhanced fat-suppressed images.
Academic Article Dynamic contrast-enhanced MR imaging findings of bone metastasis in patients with prostate cancer.
Academic Article Changes in T2*-weighted images during hyperoxia differentiate tumors from normal tissue.
Academic Article Effects of hyperoxia on T2* and resonance frequency weighted magnetic resonance images of rodent tumours.
Academic Article The use of a reference tissue arterial input function with low-temporal-resolution DCE-MRI data.
Academic Article Measurement of differences in pO2 in response to perfluorocarbon/carbogen in FSa and NFSa murine fibrosarcomas with low-frequency electron paramagnetic resonance oximetry.
Academic Article Spectroscopic imaging of the water resonance with short repetition time to study tumor response to hyperoxia.
Academic Article Magnetic resonance measurement of response to hyperoxia differentiates tumors from normal tissue and may be sensitive to oxygen consumption.
Academic Article Magnetic resonance imaging of rodent tumors using radiofrequency gradient echoes.
Academic Article Spectrally inhomogeneous BOLD contrast changes detected in rodent tumors with high spectral and spatial resolution MRI.
Academic Article Pure ductal carcinoma in situ: kinetic and morphologic MR characteristics compared with mammographic appearance and nuclear grade.
Academic Article High spectral and spatial resolution MRI of age-related changes in murine prostate.
Academic Article Sensitivity to tumor microvasculature without contrast agents in high spectral and spatial resolution MR images.
Academic Article Response of tumors to therapy studied by 31P magnetic resonance spectroscopy.
Academic Article HiSStology: high spectral and spatial resolution magnetic resonance imaging detection of vasculature validated by histology and micro-computed tomography.
Academic Article Safety limitations of MR-HIFU treatment near interfaces: a phantom validation.
Academic Article Hyperthermically induced changes in high spectral and spatial resolution MR images of tumor tissue--a pilot study.
Academic Article MR imaging-guided focal laser ablation for prostate cancer: phase I trial.
Academic Article Monitoring anti-angiogenic therapy in colorectal cancer murine model using dynamic contrast-enhanced MRI: comparing pixel-by-pixel with region of interest analysis.
Academic Article Do we really need contrast agents?
Academic Article Classification of breast lesions pre-contrast injection using water resonance lineshape analysis.
Academic Article The renin-angiotensin system mediates EGF receptor-vitamin d receptor cross-talk in colitis-associated colon cancer.
Academic Article Mammary cancer initiation and progression studied with magnetic resonance imaging.
Academic Article X-ray fluorescence microscopy demonstrates preferential accumulation of a vanadium-based magnetic resonance imaging contrast agent in murine colonic tumors.
Academic Article Hybrid multidimensional T(2) and diffusion-weighted MRI for prostate cancer detection.
Academic Article Potential of computer-aided diagnosis of high spectral and spatial resolution (HiSS) MRI in the classification of breast lesions.
Academic Article Comparison of dynamic contrast-enhanced MRI parameters of breast lesions at 1.5 and 3.0?T: a pilot study.
Academic Article Prostate volumes derived from MRI and volume-adjusted serum prostate-specific antigen: correlation with Gleason score of prostate cancer.
Academic Article Dynamic contrast-enhanced MR imaging features of the normal central zone of the prostate.
Academic Article High-resolution diffusion-weighted imaging of the prostate.
Academic Article Residual analysis of the water resonance signal in breast lesions imaged with high spectral and spatial resolution (HiSS) MRI: a pilot study.
Academic Article Preliminary assessment of dispersion versus absorption analysis of high spectral and spatial resolution magnetic resonance images in the diagnosis of breast cancer.
Academic Article Correlation of In Vivo and Ex Vivo ADC and T2 of In Situ and Invasive Murine Mammary Cancers.
Academic Article MRI accurately identifies early murine mammary cancers and reliably differentiates between in situ and invasive cancer: correlation of MRI with histology.
Academic Article Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis.
Academic Article Short-term reproducibility of apparent diffusion coefficient estimated from diffusion-weighted MRI of the prostate.
Academic Article Arterial input functions (AIFs) measured directly from arteries with low and standard doses of contrast agent, and AIFs derived from reference tissues.
Academic Article Benign Conditions That Mimic Prostate Carcinoma: MR Imaging Features with Histopathologic Correlation.
Academic Article Ultrafast Bilateral DCE-MRI of the Breast with Conventional Fourier Sampling: Preliminary Evaluation of Semi-quantitative Analysis.
Academic Article Pilot Study of the Use of Hybrid Multidimensional T2-Weighted Imaging-DWI for the Diagnosis of Prostate Cancer and Evaluation of Gleason Score.
Academic Article Dynamic Contrast-Enhanced Magnetic Resonance Imaging as a Pharmacodynamic Biomarker for Pazopanib in Metastatic Renal Carcinoma.
Academic Article Kinetic Analysis of Benign and Malignant Breast Lesions With Ultrafast Dynamic Contrast-Enhanced MRI: Comparison With Standard Kinetic Assessment.
Academic Article Fast bilateral breast coverage with high spectral and spatial resolution (HiSS) MRI at 3T.
Academic Article Value of breast MRI for patients with a biopsy showing atypical ductal hyperplasia (ADH).
Academic Article MRI ductography of contrast agent distribution and leakage in normal mouse mammary ducts and ducts with in situ cancer.
Academic Article MRI reveals increased tumorigenesis following high fat feeding in a mouse model of triple-negative breast cancer.
Academic Article Multiparametric MRI Features and Pathologic Outcome of Wedge-Shaped Lesions in the Peripheral Zone on T2-Weighted Images of the Prostate.
Academic Article Performance of T2 Maps in the Detection of Prostate Cancer.
Academic Article Diagnosis of Prostate Cancer with Noninvasive Estimation of Prostate Tissue Composition by Using Hybrid Multidimensional MR Imaging: A Feasibility Study.
Academic Article Performance of Ultrafast DCE-MRI for Diagnosis of Prostate Cancer.
Academic Article Feasibility of Dynamic Contrast-Enhanced Magnetic Resonance Imaging Using Low-Dose Gadolinium: Comparative Performance With Standard Dose in Prostate Cancer Diagnosis.
Academic Article MRI Findings After MRI-Guided Focal Laser Ablation of Prostate Cancer.
Academic Article Ultrafast Dynamic Contrast-Enhanced Breast MRI: Kinetic Curve Assessment Using Empirical Mathematical Model Validated with Histological Microvessel Density.
Academic Article Quantitative analysis of vascular properties derived from ultrafast DCE-MRI to discriminate malignant and benign breast tumors.
Academic Article Comparison of arterial input functions measured from ultra-fast dynamic contrast enhanced MRI and dynamic contrast enhanced computed tomography in prostate cancer patients.
Academic Article Comparison of region-of-interest-averaged and pixel-averaged analysis of DCE-MRI data based on simulations and pre-clinical experiments.
Academic Article Fast Temporal Resolution Dynamic Contrast-Enhanced MRI: Histogram Analysis Versus Visual Analysis for Differentiating Benign and Malignant Breast Lesions.
Academic Article Evaluation of Focal Laser Ablation of Prostate Cancer Using High Spectral and Spatial Resolution Imaging: A Pilot Study.
Academic Article Intensive Surveillance with Biannual Dynamic Contrast-Enhanced Magnetic Resonance Imaging Downstages Breast Cancer in BRCA1 Mutation Carriers.
Academic Article Comparison of T2-Weighted Imaging, DWI, and Dynamic Contrast-Enhanced MRI for Calculation of Prostate Cancer Index Lesion Volume: Correlation With Whole-Mount Pathology.
Academic Article Magnetic Resonance Angiography Shows Increased Arterial Blood Supply Associated with Murine Mammary Cancer.
Academic Article Revisiting quantitative multi-parametric MRI of benign prostatic hyperplasia and its differentiation from transition zone cancer.
Academic Article Diagnosis of Prostate Cancer by Use of MRI-Derived Quantitative Risk Maps: A Feasibility Study.
Academic Article A compact solution for estimation of physiological parameters from ultrafast prostate dynamic contrast enhanced MRI.
Academic Article Use of Indicator Dilution Principle to Evaluate Accuracy of Arterial Input Function Measured With Low-Dose Ultrafast Prostate Dynamic Contrast-Enhanced MRI.
Academic Article Low-dose imaging technique (LITE) MRI: initial experience in breast imaging.
Academic Article Effect of Echo Times on Prostate Cancer Detection on T2-Weighted Images.
Academic Article Patient-Specific Characterization of Breast Cancer Hemodynamics Using Image-Guided Computational Fluid Dynamics.
Academic Article Discrimination of benign from malignant breast lesions in dense breasts with model-based analysis of regions-of-interest using directional diffusion-weighted images.
Academic Article T2*-weighted MRI as a non-contrast-enhanced method for assessment of focal laser ablation zone extent in prostate cancer thermotherapy.
Academic Article Magnetic resonance angiography reveals increased arterial blood supply and tumorigenesis following high fat feeding in a mouse model of triple-negative breast cancer.
Academic Article Signal intensity form of the Tofts model for quantitative analysis of prostate dynamic contrast enhanced MRI data.
Academic Article Comparison of DCE-MRI of murine model cancers with a low dose and high dose of contrast agent.
Academic Article Improving Tumor Hypoxia Location in 18F-Misonidazole PET with Dynamic Contrast-enhanced MRI Using Quantitative Electron Paramagnetic Resonance Partial Oxygen Pressure Images.
Academic Article High spectral and spatial resolution MRI of prostate cancer: a pilot study.
Grant MR Virtual Pathology of the Prostate
Academic Article Robustness of radiomic features of benign breast lesions and hormone receptor positive/HER2-negative cancers across DCE-MR magnet strengths.
Academic Article Effectiveness of Dynamic Contrast Enhanced MRI with a Split Dose of Gadoterate Meglumine for Detection of Prostate Cancer.
Academic Article Can Pre-treatment Quantitative Multi-parametric MRI Predict the Outcome of Radiotherapy in Patients with Prostate Cancer?
Academic Article Enhancement-constrained acceleration: A robust reconstruction framework in breast DCE-MRI.
Academic Article Validation of Prostate Tissue Composition by Using Hybrid Multidimensional MRI: Correlation with Histologic Findings.
Academic Article Histological validation of prostate tissue composition measurement using hybrid multi-dimensional MRI: agreement with pathologists' measures.
Academic Article Differences Between Ipsilateral and Contralateral Early Parenchymal Enhancement Kinetics Predict Response of Breast Cancer to Neoadjuvant Therapy.
Academic Article Towards Patient-Specific Optimization of Neoadjuvant Treatment Protocols for Breast Cancer Based on Image-Guided Fluid Dynamics.
Academic Article Physically implausible signals as a quantitative quality assessment metric in prostate diffusion-weighted MR imaging.
Academic Article Directional and inter-acquisition variability in diffusion-weighted imaging and editing for restricted diffusion.
Academic Article Comparing Radiologist Performance in Diagnosing Clinically Significant Prostate Cancer with Multiparametric versus Hybrid Multidimensional MRI.
Academic Article Safely reducing unnecessary benign breast biopsies by applying non-mass and DWI directional variance filters to ADC thresholding.
Academic Article Parametric maps of spatial two-tissue compartment model for prostate dynamic contrast enhanced MRI - comparison with the standard Tofts model in the diagnosis of prostate cancer.
Academic Article Comparison of synthesized and acquired high b -value diffusion-weighted MRI for detection of prostate cancer.
Concept Triple Negative Breast Neoplasms
Grant Quantitative MRI for Predicting Response of Breast Cancer to Neoadjuvant Therapy
Grant Detection of prostate Cancer Specific Signals with Hybrid Multi-Dimensional MRI
Grant Microvessel Density With High Spectral/Spatial MRI
Grant Assessment of Breast Cancer Risk with High Spectral and Spatial Resolution MRI
Grant Microvessel Density With High Spectral/Spatial MRI
Grant High Spectral &Spatial Resolution MRI of Rodent Tumors
Grant 3T MRI Scanner for multidisciplinary imaging and image-guided therapy
Grant Fast Spectroscopic MR Imaging of Breast Cancer
Grant MRI of Early Non-invasive Rodent Mammary Cancers
Grant High Spectral/Spatial Resolution Imaging Breast Cancer
Grant Breast Cancer Screening with Quantitative Ultra-Fast DCEMRI and Clinical Risk Assessment
Grant UPGRADE FOR 4.7 TESLA MR SCANNER
Grant EFFECTS OF RADIOSENSITIZERS MEASURED BY MRI
Grant Quantitative DCEMRI of Prostate Cancer Correlation with Gold Standards
Grant A 7 Tesla magnet for the University of Chicago MRI research scanner
Academic Article An Interactive App with Multi-parametric MRI - Whole-Mount Histology Correlation for Enhanced Prostate MRI Training of Radiology Residents.
Academic Article Improving reader accuracy and specificity with the addition of hybrid multidimensional-MRI to multiparametric-MRI in diagnosing clinically significant prostate cancers.
Academic Article Pharmacokinetic Analysis of Enhancement-Constrained Acceleration (ECA) reconstruction-based high temporal resolution breast DCE-MRI.
Academic Article Parametric maps of spatial two-tissue compartment model for prostate dynamic contrast enhanced MRI - comparison with the standard tofts model in the diagnosis of prostate cancer.
Academic Article Four-quadrant vector mapping of hybrid multidimensional MRI data for the diagnosis of prostate cancer.
Academic Article Bilateral asymmetry of quantitative parenchymal kinetics at ultrafast DCE-MRI predict response to neoadjuvant chemotherapy in patients with HER2+ breast cancer.
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  • Cancer