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Search Results to Gregory Karczmar

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overview I have developed new approaches to functional and anatomic magnetic resonance imaging for over 30 years. I’ve applied these methods to improve detection and accurate diagnosis of cancer, and monitor cancer response to therapy. I am the Director of Magnetic Resonance Imaging Research at the University of Chicago, and Co-Director of the Advanced Imaging Program of the University of Chicago Comprehensive Cancer center. I’ve collaborated with our outstanding mammographic group and medical physics colleagues for many years to build internationally recognized research program in quantitative breast cancer MR imaging – which parallels and compliments a leading clinical program in breast cancer diagnosis and management. Similarly, I’ve collaborated with Dr. Oto and others to develop a leading translational research program focused on improving prostate cancer screening with MRI, and using MRI to guide therapye. With these collaborators, I’ve made pioneering contributions to MRI methods that improve prostate and breast cancer diagnosis and treatment. My research includes use of pre-clinical methods for breast and prostate cancer to improve understanding of cancer biology and guide the development of improved clinical methods.

One or more keywords matched the following items that are connected to Karczmar, Gregory

Item TypeName
Concept Diffusion Magnetic Resonance Imaging
Concept Magnetic Resonance Imaging, Interventional
Concept Magnetic Resonance Imaging
Academic Article Radiofrequency magnetic field gradient echoes have reduced sensitivity to susceptibility gradients.
Academic Article Fast spectroscopic imaging of water and fat resonances to improve the quality of MR images.
Academic Article Dynamic contrast measurements in rodent model tumors.
Academic Article In vivo imaging of extraction fraction of low molecular weight MR contrast agents and perfusion rate in rodent tumors.
Academic Article Differentiating between T1 and T2* changes caused by gadopentetate dimeglumine in the kidney by using a double-echo dynamic MR imaging sequence.
Academic Article Applications of magnetic resonance in model systems: cancer therapeutics.
Academic Article Uptake of a superparamagnetic contrast agent imaged by MR with high spectral and spatial resolution.
Academic Article A new method for imaging perfusion and contrast extraction fraction: input functions derived from reference tissues.
Academic Article Imaging spin probe distribution in the tumor of a living mouse with 250 MHz EPR: correlation with BOLD MRI.
Academic Article Spectrally inhomogeneous effects of contrast agents in breast lesion detected by high spectral and spatial resolution MRI.
Academic Article MRI measurements correctly predict the relative effects of tumor oxygenating agents on hypoxic fraction in rodent BA1112 tumors.
Academic Article MRI of the tumor microenvironment.
Academic Article Breast MR imaging with high spectral and spatial resolutions: preliminary experience.
Academic Article Functional and anatomic imaging of tumor vasculature: high-resolution MR spectroscopic imaging combined with a superparamagnetic contrast agent.
Academic Article Effect of carbogen on tumor oxygenation: combined fluorine-19 and proton MRI measurements.
Academic Article Quantitative tumor oxymetric images from 4D electron paramagnetic resonance imaging (EPRI): methodology and comparison with blood oxygen level-dependent (BOLD) MRI.
Academic Article Effects of constant frequency noise in magnetic resonance imaging with nonuniform k-space sampling.
Academic Article Using high spectral and spatial resolution bold MRI to choose the optimal oxygenating treatment for individual cancer patients.
Academic Article Semiquantitative analysis of dynamic contrast enhanced MRI in cancer patients: Variability and changes in tumor tissue over time.
Academic Article Fourier components of inhomogeneously broadened water resonances in breast: a new source of MRI contrast.
Academic Article Multi-slice DCE-MRI data using P760 distinguishes between metastatic and non-metastatic rodent prostate tumors.
Academic Article Magnetic resonance imaging of muscle electroporation injury.
Academic Article MRI of perfluorocarbon emulsion kinetics in rodent mammary tumours.
Academic Article Fat suppression with spectrally selective inversion vs. high spectral and spatial resolution MRI of breast lesions: qualitative and quantitative comparisons.
Academic Article Comparison and evaluation of mouse cardiac MRI acquired with open birdcage, single loop surface and volume birdcage coils.
Academic Article Differentiation between benign and malignant breast lesions detected by bilateral dynamic contrast-enhanced MRI: a sensitivity and specificity study.
Academic Article Phase II study of the Flk-1 tyrosine kinase inhibitor SU5416 in advanced melanoma.
Academic Article Multiple reference tissue method for contrast agent arterial input function estimation.
Academic Article Quantitative analysis of water proton spectral lineshape: a novel source of contrast in MRI.
Academic Article DCEMRI of breast lesions: is kinetic analysis equally effective for both mass and nonmass-like enhancement?
Academic Article New model for analysis of dynamic contrast-enhanced MRI data distinguishes metastatic from nonmetastatic transplanted rodent prostate tumors.
Academic Article Detection of in situ mammary cancer in a transgenic mouse model: in vitro and in vivo MRI studies demonstrate histopathologic correlation.
Academic Article Estimating the arterial input function using two reference tissues in dynamic contrast-enhanced MRI studies: fundamental concepts and simulations.
Academic Article A new approach to analysis of the impulse response function (IRF) in dynamic contrast-enhanced MRI (DCEMRI): a simulation study.
Academic Article Anatomical and functional brain imaging using high-resolution echo-planar spectroscopic imaging at 1.5 Tesla.
Academic Article Dynamic contrast-enhanced magnetic resonance imaging pharmacodynamic biomarker study of sorafenib in metastatic renal carcinoma.
Academic Article Magnetic resonance imaging of the natural history of in situ mammary neoplasia in transgenic mice: a pilot study.
Academic Article Relating dose of contrast media administered to uptake and washout of malignant lesions on DCEMRI of the breast.
Academic Article Kinetic curves of malignant lesions are not consistent across MRI systems: need for improved standardization of breast dynamic contrast-enhanced MRI acquisition.
Academic Article Ductal carcinoma in situ: X-ray fluorescence microscopy and dynamic contrast-enhanced MR imaging reveals gadolinium uptake within neoplastic mammary ducts in a murine model.
Academic Article Comparison of high-resolution echo-planar spectroscopic imaging with conventional MR imaging of prostate tumors in mice.
Academic Article Magnetic resonance imaging of changes in muscle tissues after membrane trauma.
Academic Article Characterization of response to radiation mediated gene therapy by means of multimodality imaging.
Academic Article Quantitative analysis of dynamic contrast enhanced MRI for assessment of bowel inflammation in Crohn's disease pilot study.
Academic Article Echo-planar spectroscopic imaging (EPSI) of the water resonance structure in human breast using sensitivity encoding (SENSE).
Academic Article Clinical implementation of a multislice high spectral and spatial resolution-based MRI sequence to achieve unilateral full-breast coverage.
Academic Article Prostate cancer: differentiation of central gland cancer from benign prostatic hyperplasia by using diffusion-weighted and dynamic contrast-enhanced MR imaging.
Academic Article High-resolution magnetic resonance colonography and dynamic contrast-enhanced magnetic resonance imaging in a murine model of colitis.
Academic Article Characterizing early contrast uptake of ductal carcinoma in situ with high temporal resolution dynamic contrast-enhanced MRI of the breast: a pilot study.
Academic Article Granular convection observed by magnetic resonance imaging.
Academic Article Diagnosis of suspicious breast lesions using an empirical mathematical model for dynamic contrast-enhanced MRI.
Academic Article New vanadium-based magnetic resonance imaging probes: clinical potential for early detection of cancer.
Academic Article Normal parenchymal enhancement patterns in women undergoing MR screening of the breast.
Academic Article The diverse pathology and kinetics of mass, nonmass, and focus enhancement on MR imaging of the breast.
Academic Article T(2)* relaxation times of intraductal murine mammary cancer, invasive mammary cancer, and normal mammary gland.
Academic Article High-resolution MRI of excised human prostate specimens acquired with 9.4T in detection and identification of cancers: validation of a technique.
Academic Article Diffusion-weighted and dynamic contrast-enhanced MRI of prostate cancer: correlation of quantitative MR parameters with Gleason score and tumor angiogenesis.
Academic Article Imaging vascular function for early stage clinical trials using dynamic contrast-enhanced magnetic resonance imaging.
Academic Article Nuclear magnetic resonance imaging-guided phosphorus-31 spectroscopy of the human heart.
Academic Article Evaluation of diffusion-weighted MR imaging for detection of bowel inflammation in patients with Crohn's disease.
Academic Article Can DCEMRI assess the effect of green tea on the angiogenic properties of rodent prostate tumors?
Academic Article Comparison of quantitative parameters in cervix cancer measured by dynamic contrast-enhanced MRI and CT.
Academic Article In vivo MRI of early stage mammary cancers and the normal mouse mammary gland.
Academic Article Use of a reference tissue and blood vessel to measure the arterial input function in DCEMRI.
Academic Article Comparing post-operative human breast specimen radiograph and MRI in lesion margin and volume assessment.
Academic Article Non-contrast enhanced MRI for evaluation of breast lesions: comparison of non-contrast enhanced high spectral and spatial resolution (HiSS) images versus contrast enhanced fat-suppressed images.
Academic Article Changes in T2*-weighted images during hyperoxia differentiate tumors from normal tissue.
Academic Article Effects of hyperoxia on T2* and resonance frequency weighted magnetic resonance images of rodent tumours.
Academic Article Prospects for assessment of the effects of electrical injury by magnetic resonance.
Academic Article Image-guided 31P magnetic resonance spectroscopy of normal and transplanted human kidneys.
Academic Article The use of a reference tissue arterial input function with low-temporal-resolution DCE-MRI data.
Academic Article Measurement of differences in pO2 in response to perfluorocarbon/carbogen in FSa and NFSa murine fibrosarcomas with low-frequency electron paramagnetic resonance oximetry.
Academic Article Use of radio-frequency field gradients to image blood flow and perfusion in vivo.
Academic Article Magnetic resonance measurement of response to hyperoxia differentiates tumors from normal tissue and may be sensitive to oxygen consumption.
Academic Article Magnetic resonance imaging of rodent tumors using radiofrequency gradient echoes.
Academic Article Spectrally inhomogeneous BOLD contrast changes detected in rodent tumors with high spectral and spatial resolution MRI.
Academic Article Pure ductal carcinoma in situ: kinetic and morphologic MR characteristics compared with mammographic appearance and nuclear grade.
Academic Article Comparison of 31P MRS and 1H MRI at 1.5 and 2.0 T.
Academic Article High spectral and spatial resolution MRI of age-related changes in murine prostate.
Academic Article Sensitivity to tumor microvasculature without contrast agents in high spectral and spatial resolution MR images.
Academic Article HiSStology: high spectral and spatial resolution magnetic resonance imaging detection of vasculature validated by histology and micro-computed tomography.
Academic Article Safety limitations of MR-HIFU treatment near interfaces: a phantom validation.
Academic Article Hyperthermically induced changes in high spectral and spatial resolution MR images of tumor tissue--a pilot study.
Academic Article MR imaging-guided focal laser ablation for prostate cancer: phase I trial.
Academic Article Monitoring anti-angiogenic therapy in colorectal cancer murine model using dynamic contrast-enhanced MRI: comparing pixel-by-pixel with region of interest analysis.
Academic Article Do we really need contrast agents?
Academic Article Classification of breast lesions pre-contrast injection using water resonance lineshape analysis.
Academic Article High resolution 3D MRI of mouse mammary glands with intra-ductal injection of contrast media.
Academic Article Mammary cancer initiation and progression studied with magnetic resonance imaging.
Academic Article 3D high spectral and spatial resolution imaging of ex vivo mouse brain.
Academic Article X-ray fluorescence microscopy demonstrates preferential accumulation of a vanadium-based magnetic resonance imaging contrast agent in murine colonic tumors.
Academic Article Hybrid multidimensional T(2) and diffusion-weighted MRI for prostate cancer detection.
Academic Article Potential of computer-aided diagnosis of high spectral and spatial resolution (HiSS) MRI in the classification of breast lesions.
Academic Article Comparison of dynamic contrast-enhanced MRI parameters of breast lesions at 1.5 and 3.0?T: a pilot study.
Academic Article Prostate volumes derived from MRI and volume-adjusted serum prostate-specific antigen: correlation with Gleason score of prostate cancer.
Academic Article MRI of neonatal necrotizing enterocolitis in a rodent model.
Academic Article Dynamic contrast-enhanced MR imaging features of the normal central zone of the prostate.
Academic Article Quantitative evaluation of internal marks made using MRgFUS as seen on MRI, CT, US, and digital color images - a pilot study.
Academic Article High-resolution diffusion-weighted imaging of the prostate.
Academic Article Residual analysis of the water resonance signal in breast lesions imaged with high spectral and spatial resolution (HiSS) MRI: a pilot study.
Academic Article Correlation of In Vivo and Ex Vivo ADC and T2 of In Situ and Invasive Murine Mammary Cancers.
Academic Article MRI accurately identifies early murine mammary cancers and reliably differentiates between in situ and invasive cancer: correlation of MRI with histology.
Academic Article IV Administered Gadodiamide Enters the Lumen of the Prostatic Glands: X-Ray Fluorescence Microscopy Examination of a Mouse Model.
Academic Article Short-term reproducibility of apparent diffusion coefficient estimated from diffusion-weighted MRI of the prostate.
Academic Article Benign Conditions That Mimic Prostate Carcinoma: MR Imaging Features with Histopathologic Correlation.
Academic Article Cavernosal nerve functionality evaluation after magnetic resonance imaging-guided transurethral ultrasound treatment of the prostate.
Academic Article B1 and T1 mapping of the breast with a reference tissue method.
Academic Article Ultrafast Bilateral DCE-MRI of the Breast with Conventional Fourier Sampling: Preliminary Evaluation of Semi-quantitative Analysis.
Academic Article Pilot Study of the Use of Hybrid Multidimensional T2-Weighted Imaging-DWI for the Diagnosis of Prostate Cancer and Evaluation of Gleason Score.
Academic Article Dynamic Contrast-Enhanced Magnetic Resonance Imaging as a Pharmacodynamic Biomarker for Pazopanib in Metastatic Renal Carcinoma.
Academic Article Kinetic Analysis of Benign and Malignant Breast Lesions With Ultrafast Dynamic Contrast-Enhanced MRI: Comparison With Standard Kinetic Assessment.
Academic Article Spectral characterization of tissues in high spectral and spatial resolution MR images: Implications for a classification-based synthetic CT algorithm.
Academic Article Fast bilateral breast coverage with high spectral and spatial resolution (HiSS) MRI at 3T.
Academic Article Value of breast MRI for patients with a biopsy showing atypical ductal hyperplasia (ADH).
Academic Article MRI ductography of contrast agent distribution and leakage in normal mouse mammary ducts and ducts with in situ cancer.
Academic Article X-Ray Fluorescence Microscopy Demonstrates Preferential Accumulation of a Vanadium-Based Magnetic Resonance Imaging Contrast Agent in Murine Colonic Tumors.
Academic Article MRI reveals increased tumorigenesis following high fat feeding in a mouse model of triple-negative breast cancer.
Academic Article Multiparametric MRI Features and Pathologic Outcome of Wedge-Shaped Lesions in the Peripheral Zone on T2-Weighted Images of the Prostate.
Academic Article Performance of T2 Maps in the Detection of Prostate Cancer.
Academic Article Diagnosis of Prostate Cancer with Noninvasive Estimation of Prostate Tissue Composition by Using Hybrid Multidimensional MR Imaging: A Feasibility Study.
Academic Article Performance of Ultrafast DCE-MRI for Diagnosis of Prostate Cancer.
Academic Article Feasibility of Dynamic Contrast-Enhanced Magnetic Resonance Imaging Using Low-Dose Gadolinium: Comparative Performance With Standard Dose in Prostate Cancer Diagnosis.
Academic Article MRI Findings After MRI-Guided Focal Laser Ablation of Prostate Cancer.
Academic Article Magnetic Resonance Imaging and Molecular Characterization of a Hormone-Mediated Murine Model of Prostate Enlargement and Bladder Outlet Obstruction.
Academic Article Ultrafast Dynamic Contrast-Enhanced Breast MRI: Kinetic Curve Assessment Using Empirical Mathematical Model Validated with Histological Microvessel Density.
Academic Article Dynamic field-of-view imaging to increase temporal resolution in the early phase of contrast media uptake in breast DCE-MRI: A feasibility study.
Academic Article Quantitative analysis of vascular properties derived from ultrafast DCE-MRI to discriminate malignant and benign breast tumors.
Academic Article The effects of variations in tissue microstructure from postmortem rat brain on the asymmetry of the water proton resonance.
Academic Article Comparison of arterial input functions measured from ultra-fast dynamic contrast enhanced MRI and dynamic contrast enhanced computed tomography in prostate cancer patients.
Academic Article Magnetic resonance spectroscopy detects differential lipid composition in mammary glands on low fat, high animal fat versus high fructose diets.
Academic Article Comparison of region-of-interest-averaged and pixel-averaged analysis of DCE-MRI data based on simulations and pre-clinical experiments.
Academic Article Fast Temporal Resolution Dynamic Contrast-Enhanced MRI: Histogram Analysis Versus Visual Analysis for Differentiating Benign and Malignant Breast Lesions.
Academic Article Evaluation of Focal Laser Ablation of Prostate Cancer Using High Spectral and Spatial Resolution Imaging: A Pilot Study.
Academic Article Intensive Surveillance with Biannual Dynamic Contrast-Enhanced Magnetic Resonance Imaging Downstages Breast Cancer in BRCA1 Mutation Carriers.
Academic Article Comparison of T2-Weighted Imaging, DWI, and Dynamic Contrast-Enhanced MRI for Calculation of Prostate Cancer Index Lesion Volume: Correlation With Whole-Mount Pathology.
Academic Article Revisiting quantitative multi-parametric MRI of benign prostatic hyperplasia and its differentiation from transition zone cancer.
Academic Article Diagnosis of Prostate Cancer by Use of MRI-Derived Quantitative Risk Maps: A Feasibility Study.
Academic Article A compact solution for estimation of physiological parameters from ultrafast prostate dynamic contrast enhanced MRI.
Academic Article Use of Indicator Dilution Principle to Evaluate Accuracy of Arterial Input Function Measured With Low-Dose Ultrafast Prostate Dynamic Contrast-Enhanced MRI.
Academic Article Low-dose imaging technique (LITE) MRI: initial experience in breast imaging.

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