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overview Awad was recruited in 2010 to lead the Neurovascular Surgery Program at the University of Chicago Medicine, and is currently tenured in the Biological Sciences Division. He is the John Harper Seeley Professor of Neurological Sciences and Professor of Neurological Surgery, Neurology, the Grossman Institute of Neuroscience, Quantitative Biology and Human Behavior, and the (PhD granting) Committee on Neurobiology. He is a Senior Faculty Scholar at the Bucksbaum Institute for Clinical Excellence and directs the Safadi Program of Excellence in Clinical and Translational Neurosciences. Dr Awad is active in numerous professional and learned societies. He has served on the Executive Committee of the American Stroke Association, and on the Board of Governors of the American College of Surgeons. He was the Chairman of the Joint Cerebrovascular Section of the American Association of Neurological Surgeons and the Congress of Neurological Surgeons, he has directed the Annual Course on Research Update in Neuroscience for Neurosurgeons, and he served as the 51st President of the Congress of Neurological Surgeons. Dr Awad is the Founding past-President of the World Association of Lebanese Neurosurgeons, and the Founding Chairman of Scientific Advisory Board of the patient advocacy group Angioma Alliance. Dr Awad has authored over 350 scientific papers and book chapters, and edited twelve books dealing with cerebrovascular surgery and other aspects of neurological surgery. He has presented over 500 papers and lectures at major meetings and symposia, has been a visiting professor at numerous institutions in the United States and abroad, was recognized among America’s Best Doctors, Best Teachers, and is the recipient of the Bucy Award for Excellence in Neurosurgical Education, the Arnold Award for Mentoring at Pritzker School of Medicine, and numerous other honors. Dr Awad has made numerous scientific contributions including the characterization of subcortical ischemic lesions in the aged, advances in the understanding of the natural history and biologic behavior of vascular malformations of the brain, numerous technical advances in neurovascular and epilepsy surgery, and is a recognized expert in the treatment of neurovascular disease, hemorrhagic stroke and neurosurgical critical care. His research has been cited by other researchers more than 79,000 times (H-index 91). Current research focuses on molecular mechanisms, biomarkers and therapeutic targets in cavernous angiomas (cerebral vascular malformations), the pathobiology of brain hemorrhage, and minimally invasive techniques for treating hemorrhagic stroke. Dr. Awad's research has been funded continuously from the National Institutes of Health since 1998, including a prestigious midcareer development grant in patient-oriented research (2000-2005), and current active R01, P01 and U01 funding through 2025. From 2016 to 2020, he served on the United States National Advisory Council for Neurological Disorders and Stroke. In 2019, he was elected to the Association of American Physicians. www.issamawad.com www.uchicagomedicine.org/ccm www.uchicagomedicine.org/hht http://safadiprogram.uchicago.edu

One or more keywords matched the following items that are connected to Awad, Issam

Item TypeName
Concept Abnormalities, Radiation-Induced
Concept Acute Disease
Concept Alcoholism
Concept Arteriovenous Malformations
Concept Aneurysm
Concept Congenital Abnormalities
Concept Abnormalities, Multiple
Concept Acromegaly
Concept Blood Pressure
Concept Brain Diseases
Concept Carotid Artery Diseases
Concept Intracranial Aneurysm
Concept Aneurysm, Infected
Concept Aphasia
Concept Angiomatosis
Concept Arnold-Chiari Malformation
Concept Intracranial Embolism and Thrombosis
Concept Cerebral Infarction
Concept Brain Edema
Concept Brain Injuries
Concept Calcinosis
Concept Epilepsy, Temporal Lobe
Concept Ischemic Attack, Transient
Concept Cerebrovascular Disorders
Concept Colitis
Concept Cerebellar Diseases
Concept Cerebellar Neoplasms
Concept Intracranial Arteriosclerosis
Concept Carotid Artery Thrombosis
Concept Cerebral Arterial Diseases
Concept Coronary Disease
Concept Constriction, Pathologic
Concept Chorea
Concept Hematoma
Concept Coronary Artery Disease
Concept Dementia
Concept Cysts
Concept Consciousness Disorders
Concept Dizziness
Concept Cushing Syndrome
Concept Epilepsy
Concept Dilatation, Pathologic
Concept Cerebral Hemorrhage
Concept Edema, Cardiac
Concept Encephalitis
Concept Hemangioma
Concept Hemiplegia
Concept Hypertension
Concept Hypertension, Renovascular
Concept Chronic Disease
Concept Eyelid Neoplasms
Concept Depression
Concept Epilepsies, Partial
Concept Glioma
Concept Neoplasms, Radiation-Induced
Concept Neovascularization, Pathologic
Concept Nevus of Ota
Concept Gliosis
Concept Fibromuscular Dysplasia
Concept Inflammation
Concept Headache
Concept Functional Laterality
Concept Movement Disorders
Concept Muscular Diseases
Concept Pain
Concept Migraine Disorders
Concept Hemangioma, Cavernous
Concept Intervertebral Disc Displacement
Concept Nervous System Diseases
Concept Neoplastic Syndromes, Hereditary
Concept Pain, Postoperative
Concept Sensation Disorders
Concept Peripheral Nervous System Diseases
Concept Nocardia Infections
Concept Paraplegia
Concept Thromboembolism
Concept Pulmonary Edema
Concept Genetic Markers
Concept Hodgkin Disease
Concept Hamartoma
Concept Rupture, Spontaneous
Concept Vertebrobasilar Insufficiency
Concept Vision Disorders
Concept Creutzfeldt-Jakob Syndrome
Concept Polycystic Kidney Diseases
Concept Spinal Cord Injuries
Concept Spinal Neoplasms
Concept Subarachnoid Hemorrhage
Concept Respiration Disorders
Concept Respiratory Insufficiency
Concept Respiratory Paralysis
Concept Spondylolisthesis
Concept Hernia
Concept Sturge-Weber Syndrome
Concept Spinal Cord Compression
Concept Spinal Stenosis
Concept Thrombosis
Concept Syndrome
Concept Ulcer
Concept Syringomyelia
Concept Telangiectasia, Hereditary Hemorrhagic
Concept Intracranial Hypertension
Concept Head Injuries, Penetrating
Concept Vascular Diseases
Concept Central Nervous System Neoplasms
Concept Wounds, Gunshot
Concept Memory Disorders
Concept Meningioma
Concept Carotid Stenosis
Concept Melanoma
Concept Meningeal Neoplasms
Concept Neoplasm Recurrence, Local
Concept Panic Disorder
Concept Aneurysm, Ruptured
Concept Sequence Deletion
Concept Recovery of Function
Concept Infarction, Middle Cerebral Artery
Concept Vasospasm, Intracranial
Concept Intracranial Hemorrhage, Hypertensive
Concept Epilepsy, Complex Partial
Concept Brain Stem Infarctions
Concept Genetic Association Studies
Concept Fatal Outcome
Concept Chronic Pain
Concept Incidental Findings
Concept Hemangioma, Capillary
Concept Intracranial Arterial Diseases
Concept Intracranial Thrombosis
Concept Hemangioma, Cavernous, Central Nervous System
Concept Postoperative Complications
Concept Pseudotumor Cerebri
Concept Surgical Wound Dehiscence
Concept Leukoaraiosis
Concept Cerebral Small Vessel Diseases
Concept Skin Neoplasms
Concept Spinal Cord Diseases
Concept Spinal Cord Neoplasms
Concept Polycystic Kidney, Autosomal Dominant
Concept Intracranial Hypotension
Concept Intracranial Hemorrhages
Concept Stroke
Concept Postoperative Hemorrhage
Concept Thrombophilia
Concept Carotid Artery Injuries
Concept Chromosome Disorders
Concept Arterial Occlusive Diseases
Concept Arteriosclerosis
Concept Brain Neoplasms
Concept Intracranial Arteriovenous Malformations
Concept Brain Ischemia
Concept Chromosome Aberrations
Concept Disease Models, Animal
Concept Encephalocele
Concept Facial Paralysis
Concept Hemorrhage
Concept Hydrocephalus
Concept Hypersensitivity, Delayed
Concept Intraoperative Complications
Concept Neoplasms
Concept Osteomyelitis
Concept Renal Artery Obstruction
Concept Sclerosis
Concept Seizures
Concept Spinal Injuries
Concept Germinoma
Concept Neoplasm, Residual
Concept Central Nervous System Vascular Malformations
Academic Article Mixed vascular malformations of the brain: clinical and pathogenetic considerations.
Academic Article Factors predisposing to clinical disability in patients with cavernous malformations of the brain.
Academic Article Comparison of the clinical presentation of symptomatic arteriovenous malformations (angiographically visualized) and occult vascular malformations.
Academic Article Misdiagnosis of symptomatic cerebral aneurysm. Prevalence and correlation with outcome at four institutions.
Academic Article Intracranial cavernous malformations: lesion behavior and management strategies.
Academic Article A comparison of the clinical profile of cavernous malformations with and without associated venous malformations.
Academic Article A quality-of-life instrument for young hemorrhagic stroke patients.
Academic Article Multilocus linkage identifies two new loci for a mendelian form of stroke, cerebral cavernous malformation, at 7p15-13 and 3q25.2-27.
Academic Article Recommendations for the management of patients with unruptured intracranial aneurysms: A Statement for healthcare professionals from the Stroke Council of the American Heart Association.
Academic Article Hemorrhagic lesion at the tentorial incisura in a patient with facial nevus.
Academic Article Stereotactic computed tomographic-guided aspiration and thrombolysis of intracerebral hematoma : protocol and preliminary experience.
Academic Article AHA Scientific Statement: Recommendations for the management of intracranial arteriovenous malformations: a statement for healthcare professionals from a special writing group of the Stroke Council, American Stroke Association.
Academic Article Pathobiology of human cerebrovascular malformations: basic mechanisms and clinical relevance.
Academic Article Biallelic somatic and germ line CCM1 truncating mutations in a cerebral cavernous malformation lesion.
Academic Article Intracranial dural arteriovenous malformations: factors predisposing to an aggressive neurological course.
Academic Article Hemorrhage from cavernous malformations of the brain: definition and reporting standards. Angioma Alliance Scientific Advisory Board.
Academic Article Intraventricular hemorrhage secondary to intranidal aneurysm rupture-successful management by arteriovenous malformation embolization followed by intraventricular tissue plasminogen activator: case report.
Academic Article Drainage efficiency with dual versus single catheters in severe intraventricular hemorrhage.
Academic Article Ventricular catheter location and the clearance of intraventricular hemorrhage.
Academic Article Resolution of intraventricular hemorrhage varies by ventricular region and dose of intraventricular thrombolytic: the Clot Lysis: Evaluating Accelerated Resolution of IVH (CLEAR IVH) program.
Academic Article Fatal "hypertensive" intracerebral hemorrhage associated with a cerebral cavernous angioma: case report.
Academic Article Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease.
Academic Article Clinical vasospasm after subarachnoid hemorrhage: response to hypervolemic hemodilution and arterial hypertension.
Academic Article Thrombolytic evacuation of intracerebral and intraventricular hemorrhage.
Academic Article Subarachnoid hemorrhage and choir singing.
Academic Article Incidental subcortical lesions identified on magnetic resonance imaging in the elderly. I. Correlation with age and cerebrovascular risk factors.
Academic Article Incidental subcortical lesions identified on magnetic resonance imaging in the elderly. II. Postmortem pathological correlations.
Academic Article Extracranial-intracranial bypass surgery: a critical analysis in light of the International Cooperative Study.
Academic Article Radiosurgery and venous malformations.
Academic Article Galen's anecdote of the fallen sophist: on the certainty of science through anatomy.
Academic Article Outcome predictors and spectrum of treatment eligibility with prospective protocolized management of intracerebral hemorrhage.
Academic Article Genetic heterogeneity of inherited cerebral cavernous malformation.
Academic Article Occipital lobe vascular malformations: prevalence of visual field deficits and prognosis after therapeutic intervention.
Academic Article Toward more rational prediction of outcome in patients with high-grade subarachnoid hemorrhage.
Academic Article Reporting terminology for brain arteriovenous malformation clinical and radiographic features for use in clinical trials.
Academic Article Natural history of the cavernous angioma.
Academic Article Ruptured superior cerebellar artery aneurysm in a child with bilateral fibromuscular hyperplasia of the renal arteries: case report and review of the literature.
Academic Article Preliminary report of the clot lysis evaluating accelerated resolution of intraventricular hemorrhage (CLEAR-IVH) clinical trial.
Academic Article Low-dose recombinant tissue-type plasminogen activator enhances clot resolution in brain hemorrhage: the intraventricular hemorrhage thrombolysis trial.
Academic Article External ventricular drainage for intraventricular hemorrhage.
Academic Article Occurrence and impact of intracranial pressure elevation during treatment of severe intraventricular hemorrhage.
Academic Article Intensive care management of acute hemorrhagic leukoencephalitis with favorable neurologic outcome.
Academic Article Intracarotid amobarbital procedure: I. Prediction of decreased modality-specific memory scores after temporal lobectomy.
Academic Article Application of magnetic resonance angiography to neurosurgical practice: a critical review of 150 cases.
Academic Article Perioperative management and outcome after surgical treatment of anterior cerebral artery aneurysms.
Academic Article Proton magnetic resonance imaging in ischemic cerebrovascular disease.
Academic Article Neurologic surgery.
Academic Article Magnetic resonance diffusion-weighted imaging: sensitivity and apparent diffusion constant in stroke.
Academic Article Intracarotid amobarbital procedure as a predictor of material-specific memory change after anterior temporal lobectomy.
Academic Article Endovascular therapeutic approach to peripheral aneurysms of the superior cerebellar artery.
Academic Article Intracranial cavernous angioma: a practical review of clinical and biological aspects.
Academic Article Surgery for intracerebral hemorrhage.
Academic Article Protocols and critical pathways for stroke care.
Academic Article Cerebral cavernous malformations and epilepsy.
Academic Article Current updates in perioperative management of intracerebral hemorrhage.
Academic Article Parenchymal perianeurysmal cystic changes in the brain: report of five cases.
Academic Article [Etiologic spectrum of intracerebral hemorrhage in young patients].
Academic Article Advances in the genetics of cerebrovascular disease and stroke.
Academic Article [Genetic factors related to intracranial arteriovenous malformations].
Academic Article The Modified Graeb Score: an enhanced tool for intraventricular hemorrhage measurement and prediction of functional outcome.
Academic Article Primary intracerebral hemorrhage and subarachnoid hemorrhage.
Academic Article Radiosurgery for angiographically occult vascular malformations.
Academic Article Minimally invasive surgery plus recombinant tissue-type plasminogen activator for intracerebral hemorrhage evacuation decreases perihematomal edema.
Academic Article Hemorrhagic stroke: introduction.
Academic Article Surgical trials in intracerebral hemorrhage.
Academic Article Current updates in perioperative management of intracerebral hemorrhage.
Academic Article When blood tickles the brain: where is the argument?
Academic Article Recommendations for the management of patients with unruptured intracranial aneurysms: A statement for healthcare professionals from the Stroke Council of the American Heart Association.
Academic Article Management of incidental cavernous malformations: a review.
Academic Article DBS reduced hemichorea associated with a developmental venous anomaly and microbleeding in STN.
Academic Article Spontaneous intracerebral and intraventricular hemorrhage: advances in minimally invasive surgery and thrombolytic evacuation, and lessons learned in recent trials.
Academic Article A multicenter, randomized, double-blinded, placebo-controlled phase III study of Clot Lysis Evaluation of Accelerated Resolution of Intraventricular Hemorrhage (CLEAR III).
Academic Article Bleeding and infection with external ventricular drainage: a systematic review in comparison with adjudicated adverse events in the ongoing Clot Lysis Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III (CLEAR-III IHV) trial.
Academic Article Prediction of cognitive change as a function of preoperative ability status among temporal lobectomy patients seen at 6-month follow-up.
Academic Article Determinants of external ventricular drain placement and associated outcomes in patients with spontaneous intraventricular hemorrhage.
Academic Article Extent of resection in temporal lobectomy for epilepsy. II. Memory changes and neurologic complications.
Academic Article Accuracy of the ABC/2 Score for Intracerebral Hemorrhage: Systematic Review and Analysis of MISTIE, CLEAR-IVH, and CLEAR III.
Academic Article Quantitative Susceptibility Mapping in Cerebral Cavernous Malformations: Clinical Correlations.
Academic Article Safety and efficacy of minimally invasive surgery plus alteplase in intracerebral haemorrhage evacuation (MISTIE): a randomised, controlled, open-label, phase 2 trial.
Academic Article Thrombolytic removal of intraventricular haemorrhage in treatment of severe stroke: results of the randomised, multicentre, multiregion, placebo-controlled CLEAR III trial.
Academic Article Spontaneous Intracerebral and Intraventricular Hemorrhage: Advances in Minimally Invasive Surgery and Thrombolytic Evacuation, and Lessons Learned in Recent Trials.
Academic Article Recombinant Human Coagulation Factor VIIa for Intracerebral Hemorrhage.
Academic Article Demographic Risk Factors for Vascular Lesions as Etiology of Intraventricular Hemorrhage in Prospectively Screened Cases.
Academic Article Surgical Performance in Minimally Invasive Surgery Plus Recombinant Tissue Plasminogen Activator for Intracerebral Hemorrhage Evacuation Phase III Clinical Trial.
Academic Article Permanent CSF shunting after intraventricular hemorrhage in the CLEAR III trial.
Academic Article CSF inflammatory response after intraventricular hemorrhage.
Academic Article Quantitative susceptibility mapping as a monitoring biomarker in cerebral cavernous malformations with recent hemorrhage.
Academic Article The Incidence of Catheter Tract Hemorrhage and Catheter Placement Accuracy in the CLEAR III Trial.
Academic Article Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice.
Academic Article Trial Readiness in Cavernous Angiomas With Symptomatic Hemorrhage (CASH).
Academic Article Symptomatic Hemorrhagic Complications in Clot Lysis: Evaluation of Accelerated Resolution of Intraventricular Hemorrhage Phase III Clinical Trial (CLEAR III): A Posthoc Root-Cause Analysis.
Academic Article Influence of Bleeding Pattern on Ischemic Lesions After Spontaneous Hypertensive Intracerebral Hemorrhage with Intraventricular Hemorrhage.
Academic Article Plasma Biomarkers of Inflammation Reflect Seizures and Hemorrhagic Activity of Cerebral Cavernous Malformations.
Academic Article Atorvastatin Treatment of Cavernous Angiomas with Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial.
Academic Article Plasma Biomarkers of Inflammation and Angiogenesis Predict Cerebral Cavernous Malformation Symptomatic Hemorrhage or Lesional Growth.
Academic Article African American Screening and Enrollment in (Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage III) CLEAR III.
Academic Article Efficacy and safety of minimally invasive surgery with thrombolysis in intracerebral haemorrhage evacuation (MISTIE III): a randomised, controlled, open-label, blinded endpoint phase 3 trial.
Academic Article Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease.
Academic Article Surgical Performance Determines Functional Outcome Benefit in the Minimally Invasive Surgery Plus Recombinant Tissue Plasminogen Activator for Intracerebral Hemorrhage Evacuation (MISTIE) Procedure.
Academic Article A randomized 500-subject open-label phase 3 clinical trial of minimally invasive surgery plus alteplase in intracerebral hemorrhage evacuation (MISTIE III).
Academic Article Intracranial Hypertension and Cerebral Perfusion Pressure Insults in Adult Hypertensive Intraventricular Hemorrhage: Occurrence and Associations With Outcome.
Academic Article Biomarkers of cavernous angioma with symptomatic hemorrhage.
Academic Article Surgery for intracerebral haemorrhage - Authors' reply.
Academic Article In Reply: Surgical Performance Determines Functional Outcome Benefit in the Minimally Invasive Surgery Plus Recombinant Tissue Plasminogen Activator for Intracerebral Hemorrhage Evacuation (MISTIE) Procedure.
Academic Article Symptomatic Brain Hemorrhages from Cavernous Angioma After Botulinum Toxin Injections, a Role of TLR/MEKK3 Mechanism? Case Report and Review of the Literature.
Academic Article Relationship of White Matter Lesions with Intracerebral Hemorrhage Expansion and Functional Outcome: MISTIE II and CLEAR III.
Academic Article Primary intraventricular hemorrhage outcomes in the CLEAR III trial.
Academic Article Subclinical imaging changes in cerebral cavernous angiomas during prospective surveillance.
Academic Article Antibodies in cerebral cavernous malformations react with cytoskeleton autoantigens in the lesional milieu.
Academic Article Role of Temporal Sequence in Treating Intracerebral Hemorrhage.
Academic Article Novel Murine Models of Cerebral Cavernous Malformations.
Academic Article A Pooled Analysis of Diffusion-Weighted Imaging Lesions in Patients With Acute Intracerebral Hemorrhage.
Academic Article 3D Deep Neural Network Segmentation of Intracerebral Hemorrhage: Development and Validation for Clinical Trials.
Academic Article Thrombolysis for Evacuation of Intracerebral and Intraventricular Hemorrhage: A Guide to Surgical Protocols With Practical Lessons Learned From the MISTIE and CLEAR Trials.
Academic Article Impact of Intracranial Pressure Monitor-Guided Therapy on Neurologic Outcome After Spontaneous Nontraumatic Intracranial Hemorrhage.
Academic Article Temporal Evolution and Outcomes of Non-Traumatic Intracerebral Hemorrhage in Hospitalized Patients.
Academic Article A Roadmap for Developing Plasma Diagnostic and Prognostic Biomarkers of Cerebral Cavernous Angioma With Symptomatic Hemorrhage (CASH).
Academic Article Intracerebral Hemorrhage Volume Reduction and Timing of Intervention Versus Functional Benefit and Survival in the MISTIE III and STICH Trials.
Academic Article Leukocyte dynamics after intracerebral hemorrhage in a living patient reveal rapid adaptations to tissue milieu.
Academic Article Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage.
Academic Article Perfusion and permeability as diagnostic biomarkers of cavernous angioma with symptomatic hemorrhage.
Academic Article Post-Trial Enhanced Deployment and Technical Performance with the MISTIE Procedure per Lessons Learned.
Academic Article In Reply: Intracerebral Hemorrhage Volume Reduction and Timing of Intervention Versus Functional Benefit and Survival in the MISTIE III and STICH Trials.
Academic Article CSF and serum inflammatory response and association with outcomes in spontaneous intracerebral hemorrhage with intraventricular extension: an analysis of the CLEAR-III Trial.
Academic Article Post-Stroke Depression in Patients with Large Spontaneous Intracerebral Hemorrhage.
Academic Article COVID-19 in a Hemorrhagic Neurovascular Disease, Cerebral Cavernous Malformation.
Academic Article Baseline Characteristics of Patients With Cavernous Angiomas With Symptomatic Hemorrhage in Multisite Trial Readiness Project.
Academic Article Intracranial Pressure and Cerebral Perfusion Pressure in Large Spontaneous Intracranial Hemorrhage and Impact of Minimally Invasive Surgery.
Academic Article Perfusion and Permeability MRI Predicts Future Cavernous Angioma Hemorrhage and Growth.
Academic Article Association Between Intraventricular Alteplase Use and Parenchymal Hematoma Volume in Patients With Spontaneous Intracerebral Hemorrhage and Intraventricular Hemorrhage.
Academic Article Cerebral Microbleeds and Acute Hematoma Characteristics in the ATACH-2 and MISTIE III Trials.
Academic Article Intraventricular Hemorrhage Expansion in the CLEAR III Trial: A Post Hoc Exploratory Analysis.
Academic Article Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions.
Academic Article Bayesian deep learning outperforms clinical trial estimators of intracerebral and intraventricular hemorrhage volume.

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