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One or more keywords matched the following properties of Awad, Issam
overview Awad was recruited in 2010 to lead the Neurovascular Surgery Program at the University of Chicago Medicine, and is currently tenured in the Biological Sciences Division. He is the John Harper Seeley Professor of Neurological Sciences and Professor of Neurological Surgery, Neurology, the Grossman Institute of Neuroscience, Quantitative Biology and Human Behavior, and the (PhD granting) Committee on Neurobiology. He is a Senior Faculty Scholar at the Bucksbaum Institute for Clinical Excellence and directs the Safadi Program of Excellence in Clinical and Translational Neurosciences. Dr Awad is active in numerous professional and learned societies. He has served on the Executive Committee of the American Stroke Association, and on the Board of Governors of the American College of Surgeons. He was the Chairman of the Joint Cerebrovascular Section of the American Association of Neurological Surgeons and the Congress of Neurological Surgeons, he has directed the Annual Course on Research Update in Neuroscience for Neurosurgeons, and he served as the 51st President of the Congress of Neurological Surgeons. Dr Awad is the Founding past-President of the World Association of Lebanese Neurosurgeons, and the Founding Chairman of Scientific Advisory Board of the patient advocacy group Angioma Alliance. Dr Awad has authored over 350 scientific papers and book chapters, and edited twelve books dealing with cerebrovascular surgery and other aspects of neurological surgery. He has presented over 500 papers and lectures at major meetings and symposia, has been a visiting professor at numerous institutions in the United States and abroad, was recognized among America’s Best Doctors, Best Teachers, and is the recipient of the Bucy Award for Excellence in Neurosurgical Education, the Arnold Award for Mentoring at Pritzker School of Medicine, and numerous other honors. Dr Awad has made numerous scientific contributions including the characterization of subcortical ischemic lesions in the aged, advances in the understanding of the natural history and biologic behavior of vascular malformations of the brain, numerous technical advances in neurovascular and epilepsy surgery, and is a recognized expert in the treatment of neurovascular disease, hemorrhagic stroke and neurosurgical critical care. His research has been cited by other researchers more than 79,000 times (H-index 91). Current research focuses on molecular mechanisms, biomarkers and therapeutic targets in cavernous angiomas (cerebral vascular malformations), the pathobiology of brain hemorrhage, and minimally invasive techniques for treating hemorrhagic stroke. Dr. Awad's research has been funded continuously from the National Institutes of Health since 1998, including a prestigious midcareer development grant in patient-oriented research (2000-2005), and current active R01, P01 and U01 funding through 2025. From 2016 to 2020, he served on the United States National Advisory Council for Neurological Disorders and Stroke. In 2019, he was elected to the Association of American Physicians.
One or more keywords matched the following items that are connected to Awad, Issam
Item TypeName
Concept Brain Diseases
Concept Brain Edema
Concept Brain Injuries
Concept Brain
Concept Brain Mapping
Concept Brain Stem
Concept Blood-Brain Barrier
Concept Brain Stem Infarctions
Concept Deep Brain Stimulation
Concept Brain Neoplasms
Concept Brain Ischemia
Academic Article Mixed vascular malformations of the brain: clinical and pathogenetic considerations.
Academic Article Factors predisposing to clinical disability in patients with cavernous malformations of the brain.
Academic Article Comparison of the clinical presentation of symptomatic arteriovenous malformations (angiographically visualized) and occult vascular malformations.
Academic Article Intracranial cavernous malformations: lesion behavior and management strategies.
Academic Article A founder mutation as a cause of cerebral cavernous malformation in Hispanic Americans.
Academic Article A comparison of the clinical profile of cavernous malformations with and without associated venous malformations.
Academic Article Ultrastructural pathological features of cerebrovascular malformations: a preliminary report.
Academic Article Comparative localization of auditory comprehension by using functional magnetic resonance imaging and cortical stimulation.
Academic Article Failure of the hypotensive provocative test during temporary balloon test occlusion of the internal carotid artery to predict delayed hemodynamic ischemia after therapeutic carotid occlusion.
Academic Article Endothelial cell culture from human cerebral cavernous malformations.
Academic Article Hemorrhagic lesion at the tentorial incisura in a patient with facial nevus.
Academic Article Further study of CD31 protein and messenger ribonucleic acid expression in human cerebral vascular malformations.
Academic Article Pathobiology of human cerebrovascular malformations: basic mechanisms and clinical relevance.
Academic Article Multiple spinal cavernous malformations with atypical phenotype after prior irradiation: case report.
Academic Article Differential gene expression in human cerebrovascular malformations.
Academic Article Hemorrhage from cavernous malformations of the brain: definition and reporting standards. Angioma Alliance Scientific Advisory Board.
Academic Article Oligoclonal immune response in cerebral cavernous malformations. Laboratory investigation.
Academic Article Second operation after the failure of previous resection for epilepsy.
Academic Article Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity.
Academic Article Prostacyclin in experimental ischemic models.
Academic Article Spread of malignant gliomas.
Academic Article Vascular pressures and cortical blood flow in cavernous angioma of the brain.
Academic Article Periventricular lesions on MRI. Facts and theories.
Academic Article From mutant mice to "vascular permeability therapy" in cavernous angiomas?
Academic Article Treatment of acute focal cerebral ischemia with prostacyclin.
Academic Article Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease.
Academic Article Magnetic resonance imaging evaluation of cerebral cavernous malformations with susceptibility-weighted imaging.
Academic Article Focal parenchymal lesions in transient ischemic attacks: correlation of computed tomography and magnetic resonance imaging.
Academic Article Incidental subcortical lesions identified on magnetic resonance imaging in the elderly. I. Correlation with age and cerebrovascular risk factors.
Academic Article Incidental subcortical lesions identified on magnetic resonance imaging in the elderly. II. Postmortem pathological correlations.
Academic Article Cerebral cavernous malformations: clinical insights from genetic studies.
Academic Article Modification of focal cerebral ischemia by prostacyclin and indomethacin.
Academic Article Mapping a gene causing cerebral cavernous malformation to 7q11.2-q21.
Academic Article Pathological heterogeneity of angiographically occult vascular malformations of the brain.
Academic Article Intracranial hypertension after resection of cerebral arteriovenous malformations. Predisposing factors and management strategy.
Academic Article Radiosurgery and venous malformations.
Academic Article Brainstem cavernous malformations.
Academic Article Incidental lesions noted on magnetic resonance imaging of the brain: prevalence and clinical significance in various age groups.
Academic Article Changes in intracranial stenotic lesions after extracranial-intracranial bypass surgery.
Academic Article Genetic heterogeneity of inherited cerebral cavernous malformation.
Academic Article Expression of angiogenic factors and structural proteins in central nervous system vascular malformations.
Academic Article Sensitivity of magnetic resonance diffusion-weighted imaging and regional relationship between the apparent diffusion coefficient and cerebral blood flow in rat focal cerebral ischemia.
Academic Article Reporting terminology for brain arteriovenous malformation clinical and radiographic features for use in clinical trials.
Academic Article Patterns of functional magnetic resonance imaging activation in association with structural lesions in the rolandic region: a classification system.
Academic Article Coronary risk evaluation in patients with transient ischemic attack and ischemic stroke: a scientific statement for healthcare professionals from the Stroke Council and the Council on Clinical Cardiology of the American Heart Association/American Stroke Association.
Academic Article Natural history of the cavernous angioma.
Academic Article Pathogenesis of subcortical hyperintense lesions on magnetic resonance imaging of the brain. Observations in patients undergoing controlled therapeutic internal carotid artery occlusion.
Academic Article Biology of vascular malformations of the brain.
Academic Article Low-dose recombinant tissue-type plasminogen activator enhances clot resolution in brain hemorrhage: the intraventricular hemorrhage thrombolysis trial.
Academic Article Correlation of clinical and angiographic findings in brain ischemia with regional cerebral blood flow measured by the xenon inhalation technique.
Academic Article Natural history of recurrent seizures after resective surgery for epilepsy.
Academic Article Intractable epilepsy and structural lesions of the brain: mapping, resection strategies, and seizure outcome.
Academic Article Reoperation for intractable seizures.
Academic Article Further observations on the pathology of subcortical lesions identified on magnetic resonance imaging.
Academic Article Epilepsy surgery: introduction and overview.
Academic Article Perioperative management and outcome after surgical treatment of anterior cerebral artery aneurysms.
Academic Article Sclerosing vasculopathy of the central nervous system in nonelderly demented patients.
Academic Article Proton magnetic resonance imaging in ischemic cerebrovascular disease.
Academic Article Ischemic stroke and intracranial multifocal cerebral arteriopathy in Williams syndrome.
Academic Article Neurologic surgery.
Academic Article Magnetic resonance diffusion-weighted imaging: sensitivity and apparent diffusion constant in stroke.
Academic Article Expression of basement membrane and endothelial cell adhesion molecules in vascular malformations of the brain: preliminary observations and working hypothesis.
Academic Article Therapeutic carotid occlusion: current management paradigms.
Academic Article Vascular malformations and epilepsy: clinical considerations and basic mechanisms.
Academic Article Intracranial cavernous angioma: a practical review of clinical and biological aspects.
Academic Article Cerebral cavernous malformations and epilepsy.
Academic Article Current updates in perioperative management of intracerebral hemorrhage.
Academic Article Parenchymal perianeurysmal cystic changes in the brain: report of five cases.
Academic Article The Modified Graeb Score: an enhanced tool for intraventricular hemorrhage measurement and prediction of functional outcome.
Academic Article Radiosurgery for angiographically occult vascular malformations.
Academic Article Coronary risk evaluation in patients with transient ischemic attack and ischemic stroke: a scientific statement for healthcare professionals from the Stroke Council and the Council on Clinical Cardiology of the American Heart Association/American Stroke Association.
Academic Article Minimally invasive surgery plus recombinant tissue-type plasminogen activator for intracerebral hemorrhage evacuation decreases perihematomal edema.
Academic Article When blood tickles the brain: where is the argument?
Academic Article MRI-guided stereotactic placement of depth electrodes in temporal lobe epilepsy.
Academic Article Epilepsy surgery in children and adults.
Academic Article DBS reduced hemichorea associated with a developmental venous anomaly and microbleeding in STN.
Academic Article Evaluation of iron content in human cerebral cavernous malformation using quantitative susceptibility mapping.
Academic Article Subdural electrodes in the presurgical evaluation for surgery of epilepsy.
Academic Article A new class of electrodes of 'intermediate invasiveness': preliminary experience with epidural pegs and foramen ovale electrodes in the mapping of seizure foci.
Academic Article Brainstem cavernous malformations: 1390 surgical cases from the literature.
Academic Article Dynamic permeability and quantitative susceptibility: related imaging biomarkers in cerebral cavernous malformations.
Academic Article Functional anatomy of the human supplementary sensorimotor area: results of extraoperative electrical stimulation.
Academic Article Vascular permeability in cerebral cavernous malformations.
Academic Article Quantitative Susceptibility Mapping in Cerebral Cavernous Malformations: Clinical Correlations.
Academic Article Micro-computed tomography in murine models of cerebral cavernous malformations as a paradigm for brain disease.
Academic Article RhoA Kinase Inhibition With Fasudil Versus Simvastatin in Murine Models of Cerebral Cavernous Malformations.
Academic Article Vascular permeability and iron deposition biomarkers in longitudinal follow-up of cerebral cavernous malformations.
Academic Article Quantitative susceptibility mapping as a monitoring biomarker in cerebral cavernous malformations with recent hemorrhage.
Academic Article Phenotypic characterization of murine models of cerebral cavernous malformations.
Academic Article Influence of Bleeding Pattern on Ischemic Lesions After Spontaneous Hypertensive Intracerebral Hemorrhage with Intraventricular Hemorrhage.
Academic Article A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis.
Academic Article A Brain-Targeted Orally Available ROCK2 Inhibitor Benefits Mild and Aggressive Cavernous Angioma Disease.
Academic Article Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation.
Academic Article Symptomatic Brain Hemorrhages from Cavernous Angioma After Botulinum Toxin Injections, a Role of TLR/MEKK3 Mechanism? Case Report and Review of the Literature.
Academic Article Subclinical imaging changes in cerebral cavernous angiomas during prospective surveillance.
Academic Article Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma.
Academic Article Common transcriptome, plasma molecules, and imaging signatures in the aging brain and a Mendelian neurovascular disease, cerebral cavernous malformation.
Academic Article Novel Murine Models of Cerebral Cavernous Malformations.
Academic Article 3D Deep Neural Network Segmentation of Intracerebral Hemorrhage: Development and Validation for Clinical Trials.
Academic Article Cerebrovascular Complications in Early Survivors of Civilian Penetrating Brain Injury.
Academic Article A Roadmap for Developing Plasma Diagnostic and Prognostic Biomarkers of Cerebral Cavernous Angioma With Symptomatic Hemorrhage (CASH).
Academic Article Longitudinal transcriptomics define the stages of myeloid activation in the living human brain after intracerebral hemorrhage.
Academic Article Abortive intussusceptive angiogenesis causes multi-cavernous vascular malformations.
Academic Article Perfusion and permeability as diagnostic biomarkers of cavernous angioma with symptomatic hemorrhage.
Academic Article Baseline Characteristics of Patients With Cavernous Angiomas With Symptomatic Hemorrhage in Multisite Trial Readiness Project.
Academic Article Case Report: Management of Traumatic Carotid-Cavernous Fistulas in the Acute Setting of Penetrating Brain Injury.
Academic Article Propranolol as therapy for cerebral cavernous malformations: a cautionary note.
Grant Biomarkers of Cerebral Cavernous Angioma with Symptomatic Hemorrhage (CASH)
Grant Genesis and Progression of Cerebral Cavernous Malformations
Grant Development of BA-1049 for treatment of cerebral cavernous malformation
Academic Article Underlying intracranial atherosclerotic disease is associated with worse outcomes in acute large vessel occlusion undergoing endovascular thrombectomy.
Academic Article Inflammatory Mechanisms in a Neurovascular Disease: Cerebral Cavernous Malformation.
Academic Article Mechanistic Evaluation of Diffusion Weighted Hyperintense Lesions After Large Spontaneous Intracerebral Hemorrhage: A Subgroup Analysis of MISTIE III.
Academic Article Pathologic features of brain hemorrhage after radiation treatment: case series with somatic mutation analysis.
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