The University of Chicago Header Logo

Search Result Details

This page shows the details of why an item matched the keywords from your search.
One or more keywords matched the following properties of Awad, Issam
overview Awad was recruited in 2010 to lead the Neurovascular Surgery Program at the University of Chicago Medicine, and is currently tenured in the Biological Sciences Division. He is the John Harper Seeley Professor of Neurological Sciences and Professor of Neurological Surgery, Neurology, the Grossman Institute of Neuroscience, Quantitative Biology and Human Behavior, and the (PhD granting) Committee on Neurobiology. He is a Senior Faculty Scholar at the Bucksbaum Institute for Clinical Excellence and directs the Safadi Program of Excellence in Clinical and Translational Neurosciences. Dr Awad is active in numerous professional and learned societies. He has served on the Executive Committee of the American Stroke Association, and on the Board of Governors of the American College of Surgeons. He was the Chairman of the Joint Cerebrovascular Section of the American Association of Neurological Surgeons and the Congress of Neurological Surgeons, he has directed the Annual Course on Research Update in Neuroscience for Neurosurgeons, and he served as the 51st President of the Congress of Neurological Surgeons. Dr Awad is the Founding past-President of the World Association of Lebanese Neurosurgeons, and the Founding Chairman of Scientific Advisory Board of the patient advocacy group Angioma Alliance. Dr Awad has authored over 350 scientific papers and book chapters, and edited twelve books dealing with cerebrovascular surgery and other aspects of neurological surgery. He has presented over 500 papers and lectures at major meetings and symposia, has been a visiting professor at numerous institutions in the United States and abroad, was recognized among America’s Best Doctors, Best Teachers, and is the recipient of the Bucy Award for Excellence in Neurosurgical Education, the Arnold Award for Mentoring at Pritzker School of Medicine, and numerous other honors. Dr Awad has made numerous scientific contributions including the characterization of subcortical ischemic lesions in the aged, advances in the understanding of the natural history and biologic behavior of vascular malformations of the brain, numerous technical advances in neurovascular and epilepsy surgery, and is a recognized expert in the treatment of neurovascular disease, hemorrhagic stroke and neurosurgical critical care. His research has been cited by other researchers more than 79,000 times (H-index 91). Current research focuses on molecular mechanisms, biomarkers and therapeutic targets in cavernous angiomas (cerebral vascular malformations), the pathobiology of brain hemorrhage, and minimally invasive techniques for treating hemorrhagic stroke. Dr. Awad's research has been funded continuously from the National Institutes of Health since 1998, including a prestigious midcareer development grant in patient-oriented research (2000-2005), and current active R01, P01 and U01 funding through 2025. From 2016 to 2020, he served on the United States National Advisory Council for Neurological Disorders and Stroke. In 2019, he was elected to the Association of American Physicians.
One or more keywords matched the following items that are connected to Awad, Issam
Item TypeName
Concept Emergency Treatment
Concept Combined Modality Therapy
Concept Embolization, Therapeutic
Concept Therapeutic Irrigation
Concept Treatment Outcome
Concept Laser Therapy
Concept Genetic Therapy
Concept Withholding Treatment
Concept Thrombolytic Therapy
Academic Article Intracranial cavernous malformations: lesion behavior and management strategies.
Academic Article Cerebral vascular malformations adjacent to sensorimotor and visual cortex. Functional magnetic resonance imaging studies before and after therapeutic intervention.
Academic Article Intraoperative endovascular treatment as an adjunct to microsurgical clipping of paraclinoid aneurysms.
Academic Article Failure of the hypotensive provocative test during temporary balloon test occlusion of the internal carotid artery to predict delayed hemodynamic ischemia after therapeutic carotid occlusion.
Academic Article Stereotactic computed tomographic-guided aspiration and thrombolysis of intracerebral hematoma : protocol and preliminary experience.
Academic Article Impact of Guglielmi detachable coils on outcomes of patients with intracranial aneurysms treated by a multidisciplinary team at a single institution.
Academic Article AHA Scientific Statement: Recommendations for the management of intracranial arteriovenous malformations: a statement for healthcare professionals from a special writing group of the Stroke Council, American Stroke Association.
Academic Article On COURAGE and lessons from the heart.
Academic Article Surrogate measures of outcome in clinical trials: clues worth examining?
Academic Article Intraventricular hemorrhage secondary to intranidal aneurysm rupture-successful management by arteriovenous malformation embolization followed by intraventricular tissue plasminogen activator: case report.
Academic Article Drainage efficiency with dual versus single catheters in severe intraventricular hemorrhage.
Academic Article Ventricular catheter location and the clearance of intraventricular hemorrhage.
Academic Article Resolution of intraventricular hemorrhage varies by ventricular region and dose of intraventricular thrombolytic: the Clot Lysis: Evaluating Accelerated Resolution of IVH (CLEAR IVH) program.
Academic Article From mutant mice to "vascular permeability therapy" in cavernous angiomas?
Academic Article Treatment of acute focal cerebral ischemia with prostacyclin.
Academic Article Thrombolytic evacuation of intracerebral and intraventricular hemorrhage.
Academic Article Radiosurgery and venous malformations.
Academic Article Outcome predictors and spectrum of treatment eligibility with prospective protocolized management of intracerebral hemorrhage.
Academic Article Occipital lobe vascular malformations: prevalence of visual field deficits and prognosis after therapeutic intervention.
Academic Article Toward more rational prediction of outcome in patients with high-grade subarachnoid hemorrhage.
Academic Article Reporting terminology for brain arteriovenous malformation clinical and radiographic features for use in clinical trials.
Academic Article Pathogenesis of subcortical hyperintense lesions on magnetic resonance imaging of the brain. Observations in patients undergoing controlled therapeutic internal carotid artery occlusion.
Academic Article Preliminary report of the clot lysis evaluating accelerated resolution of intraventricular hemorrhage (CLEAR-IVH) clinical trial.
Academic Article Low-dose recombinant tissue-type plasminogen activator enhances clot resolution in brain hemorrhage: the intraventricular hemorrhage thrombolysis trial.
Academic Article External ventricular drainage for intraventricular hemorrhage.
Academic Article Occurrence and impact of intracranial pressure elevation during treatment of severe intraventricular hemorrhage.
Academic Article Intensive care management of acute hemorrhagic leukoencephalitis with favorable neurologic outcome.
Academic Article Perioperative management and outcome after surgical treatment of anterior cerebral artery aneurysms.
Academic Article Therapeutic carotid occlusion: current management paradigms.
Academic Article Giant aneurysms of the anterior circle of Willis: management outcome of open microsurgical treatment.
Academic Article Endovascular therapeutic approach to peripheral aneurysms of the superior cerebellar artery.
Academic Article Protocols and critical pathways for stroke care.
Academic Article Cerebral cavernous malformations and epilepsy.
Academic Article Temporary and permanent occlusion of cervical and cerebral arteries.
Academic Article A randomized trial of brief treatment of early- stage Hodgkin lymphoma: Is it effective?
Academic Article Which aneurysms should be referred for endovascular therapy?
Academic Article Radiosurgery for angiographically occult vascular malformations.
Academic Article What genes can teach us about human cerebrovascular malformations.
Academic Article Minimally invasive surgery plus recombinant tissue-type plasminogen activator for intracerebral hemorrhage evacuation decreases perihematomal edema.
Academic Article Surgical trials in intracerebral hemorrhage.
Academic Article Recommendations for the management of patients with unruptured intracranial aneurysms: A statement for healthcare professionals from the Stroke Council of the American Heart Association.
Academic Article DBS reduced hemichorea associated with a developmental venous anomaly and microbleeding in STN.
Academic Article Spontaneous intracerebral and intraventricular hemorrhage: advances in minimally invasive surgery and thrombolytic evacuation, and lessons learned in recent trials.
Academic Article A multicenter, randomized, double-blinded, placebo-controlled phase III study of Clot Lysis Evaluation of Accelerated Resolution of Intraventricular Hemorrhage (CLEAR III).
Academic Article Brainstem cavernous malformations: 1390 surgical cases from the literature.
Academic Article Bleeding and infection with external ventricular drainage: a systematic review in comparison with adjudicated adverse events in the ongoing Clot Lysis Evaluating Accelerated Resolution of Intraventricular Hemorrhage Phase III (CLEAR-III IHV) trial.
Academic Article Determinants of external ventricular drain placement and associated outcomes in patients with spontaneous intraventricular hemorrhage.
Academic Article Safety and efficacy of minimally invasive surgery plus alteplase in intracerebral haemorrhage evacuation (MISTIE): a randomised, controlled, open-label, phase 2 trial.
Academic Article Thrombolytic removal of intraventricular haemorrhage in treatment of severe stroke: results of the randomised, multicentre, multiregion, placebo-controlled CLEAR III trial.
Academic Article Surgical Performance in Minimally Invasive Surgery Plus Recombinant Tissue Plasminogen Activator for Intracerebral Hemorrhage Evacuation Phase III Clinical Trial.
Academic Article Permanent CSF shunting after intraventricular hemorrhage in the CLEAR III trial.
Academic Article Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations.
Academic Article Symptomatic Hemorrhagic Complications in Clot Lysis: Evaluation of Accelerated Resolution of Intraventricular Hemorrhage Phase III Clinical Trial (CLEAR III): A Posthoc Root-Cause Analysis.
Academic Article Atorvastatin Treatment of Cavernous Angiomas with Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial.
Academic Article Efficacy and safety of minimally invasive surgery with thrombolysis in intracerebral haemorrhage evacuation (MISTIE III): a randomised, controlled, open-label, blinded endpoint phase 3 trial.
Academic Article Surgical Performance Determines Functional Outcome Benefit in the Minimally Invasive Surgery Plus Recombinant Tissue Plasminogen Activator for Intracerebral Hemorrhage Evacuation (MISTIE) Procedure.
Academic Article A randomized 500-subject open-label phase 3 clinical trial of minimally invasive surgery plus alteplase in intracerebral hemorrhage evacuation (MISTIE III).
Academic Article Intracranial Hypertension and Cerebral Perfusion Pressure Insults in Adult Hypertensive Intraventricular Hemorrhage: Occurrence and Associations With Outcome.
Grant Atorvastatin Treatment of Cavernous Angiomas with Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Trial
Academic Article Surgery for intracerebral haemorrhage - Authors' reply.
Academic Article Primary intraventricular hemorrhage outcomes in the CLEAR III trial.
Academic Article Stereotactic laser interstitial thermal therapy for epilepsy associated with solitary and multiple cerebral cavernous malformations.
Academic Article Role of Temporal Sequence in Treating Intracerebral Hemorrhage.
Academic Article Prior antiplatelet therapy and haematoma expansion after primary intracerebral haemorrhage: an individual patient-level analysis of CLEAR III, MISTIE III and VISTA-ICH.
Academic Article Thrombolysis for Evacuation of Intracerebral and Intraventricular Hemorrhage: A Guide to Surgical Protocols With Practical Lessons Learned From the MISTIE and CLEAR Trials.
Academic Article Impact of Intracranial Pressure Monitor-Guided Therapy on Neurologic Outcome After Spontaneous Nontraumatic Intracranial Hemorrhage.
Academic Article Temporal Evolution and Outcomes of Non-Traumatic Intracerebral Hemorrhage in Hospitalized Patients.
Academic Article Intracerebral Hemorrhage Volume Reduction and Timing of Intervention Versus Functional Benefit and Survival in the MISTIE III and STICH Trials.
Academic Article Cerebral Cavernous Malformation: From Mechanism to Therapy.
Academic Article Commentary: Feasibility and Morbidity of Magnetic Resonance Imaging-Guided Stereotactic Laser Ablation of Deep Cerebral Cavernous Malformations: A Report of 4 Cases.
Academic Article Post-Trial Enhanced Deployment and Technical Performance with the MISTIE Procedure per Lessons Learned.
Academic Article In Reply: Intracerebral Hemorrhage Volume Reduction and Timing of Intervention Versus Functional Benefit and Survival in the MISTIE III and STICH Trials.
Academic Article CSF and serum inflammatory response and association with outcomes in spontaneous intracerebral hemorrhage with intraventricular extension: an analysis of the CLEAR-III Trial.
Academic Article Association Between Intraventricular Alteplase Use and Parenchymal Hematoma Volume in Patients With Spontaneous Intracerebral Hemorrhage and Intraventricular Hemorrhage.
Academic Article Propranolol as therapy for cerebral cavernous malformations: a cautionary note.
Academic Article Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions.
Academic Article Association of Intraventricular Fibrinolysis With Clinical Outcomes in Intracerebral Hemorrhage: An Individual Participant Data Meta-Analysis.
Academic Article ß1 integrin monoclonal antibody treatment ameliorates cerebral cavernous malformations.
Concept Time-to-Treatment
Grant Rock Inhibition as Therapy for Cerebral Cavernous Malformation
Grant Biomarkers of Cerebral Cavernous Angioma with Symptomatic Hemorrhage (CASH)
Grant Genesis and Progression of Cerebral Cavernous Malformations
Grant Development of BA-1049 for treatment of cerebral cavernous malformation
Academic Article Underlying intracranial atherosclerotic disease is associated with worse outcomes in acute large vessel occlusion undergoing endovascular thrombectomy.
Academic Article Catheter Tract Hemorrhages and Intracerebral Hemorrhage Outcomes in the Clot Lysis: Evaluating Accelerated Resolution of Intraventricular Hemorrhage Trial.
Academic Article Minimally Invasive Surgery With Thrombolysis for Intracerebral Hemorrhage Evacuation: Bayesian Reanalysis of a Randomized Controlled Trial.
Academic Article Trial Readiness of Cavernous Malformations With Symptomatic Hemorrhage, Part I: Event Rates and Clinical Outcome.
Academic Article Association Between Hematoma Volume and Risk of Subsequent Ischemic Stroke: A MISTIE III and ATACH-2 Analysis.
Academic Article Antithrombotic Therapy in Cerebral Cavernous Malformations: A Systematic Review, Meta-Analysis, and Network Meta-Analysis.
Academic Article Pathologic Features of Brain Hemorrhage After Radiation Treatment: Case Series with Somatic Mutation Analysis.
Search Criteria
  • Therapeutics