| Item Type | Name |
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Concept
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Blood Proteins
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Concept
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DNA-Binding Proteins
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Concept
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Eye Proteins
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Concept
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Membrane Proteins
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Concept
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Nerve Tissue Proteins
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Concept
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Monosaccharide Transport Proteins
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Concept
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Muscle Proteins
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Concept
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Proto-Oncogene Proteins
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Concept
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Proteins
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Concept
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Repressor Proteins
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Concept
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Extracellular Matrix Proteins
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Concept
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Milk Proteins
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Concept
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Proto-Oncogene Proteins c-fos
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Concept
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RNA-Binding Proteins
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Concept
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Immediate-Early Proteins
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Concept
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ras Proteins
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Concept
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Qa-SNARE Proteins
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Concept
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HMGB Proteins
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Concept
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Mitochondrial Proteins
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Concept
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Intercellular Signaling Peptides and Proteins
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Concept
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Green Fluorescent Proteins
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Concept
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Mutant Chimeric Proteins
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Concept
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Proto-Oncogene Proteins c-raf
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Concept
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SNARE Proteins
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Concept
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Cell Cycle Proteins
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Concept
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rab3 GTP-Binding Proteins
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Concept
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Bone Morphogenetic Proteins
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Concept
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I-kappa B Proteins
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Concept
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Saccharomyces cerevisiae Proteins
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Concept
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Recombinant Proteins
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Concept
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Shc Signaling Adaptor Proteins
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Concept
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Adaptor Proteins, Signal Transducing
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Concept
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R-SNARE Proteins
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Concept
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HSP40 Heat-Shock Proteins
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Concept
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Viral Proteins
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Concept
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GTP-Binding Proteins
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Concept
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Antimicrobial Cationic Peptides
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Concept
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Homeodomain Proteins
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Concept
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Cation Transport Proteins
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Concept
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Monomeric GTP-Binding Proteins
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Concept
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GTPase-Activating Proteins
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Concept
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Insulin Receptor Substrate Proteins
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Concept
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Intracellular Signaling Peptides and Proteins
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Concept
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Suppressor of Cytokine Signaling Proteins
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Concept
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ADAM Proteins
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Concept
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Calcium-Binding Proteins
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Concept
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Carrier Proteins
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Concept
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Cytoskeletal Proteins
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Concept
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Luminescent Proteins
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Concept
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Nuclear Proteins
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Concept
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Recombinant Fusion Proteins
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Concept
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Membrane Transport Proteins
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Concept
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Vesicular Transport Proteins
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Concept
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Adaptor Proteins, Vesicular Transport
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Concept
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Proto-Oncogene Proteins c-akt
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Academic Article
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A novel regulatory mechanism for trimeric GTP-binding proteins in the membrane and secretory granule fractions of human and rodent beta cells.
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Academic Article
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Insulin-stimulated translocation of GLUT4 glucose transporters requires SNARE-complex proteins.
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Academic Article
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A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth.
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Academic Article
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Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1).
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Academic Article
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Synaptotagmin III isoform is compartmentalized in pancreatic beta-cells and has a functional role in exocytosis.
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Academic Article
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Glycerol-stimulated proinsulin biosynthesis in isolated pancreatic rat islets via adenoviral-induced expression of glycerol kinase is mediated via mitochondrial metabolism.
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Academic Article
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Cysteine string protein (CSP) is an insulin secretory granule-associated protein regulating beta-cell exocytosis.
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Academic Article
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Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells.
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Academic Article
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Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: signal transduction via janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediated mitogenic signalling.
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Academic Article
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Pancreatic beta-cell growth and survival--a role in obesity-linked type 2 diabetes?
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Academic Article
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Fatty acid and phorbol ester-mediated interference of mitogenic signaling via novel protein kinase C isoforms in pancreatic beta-cells (INS-1).
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Academic Article
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Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic beta-cells.
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Academic Article
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Phosphoinositide 3 kinase mediates Toll-like receptor 4-induced activation of NF-kappa B in endothelial cells.
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Academic Article
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Syncollin inhibits regulated corticotropin secretion from AtT-20 cells through a reduction in the secretory vesicle population.
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Academic Article
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A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli.
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Academic Article
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Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells.
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Academic Article
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Fluorescent cargo proteins in pancreatic beta-cells: design determines secretion kinetics at exocytosis.
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Academic Article
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Differential activation mechanisms of Erk-1/2 and p70(S6K) by glucose in pancreatic beta-cells.
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Academic Article
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Insulin receptor substrate 2 plays diverse cell-specific roles in the regulation of glucose transport.
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Academic Article
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Glucagon-like peptide-1 protects beta cells from cytokine-induced apoptosis and necrosis: role of protein kinase B.
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Academic Article
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Type 2 diabetes-a matter of beta-cell life and death?
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Academic Article
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Actin and non-muscle myosin II facilitate apical exocytosis of tear proteins in rabbit lacrimal acinar epithelial cells.
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Academic Article
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Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet beta-cells.
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Academic Article
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Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes.
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Academic Article
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Insulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiation.
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Academic Article
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Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons.
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Academic Article
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Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?
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Academic Article
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Decreasing IRS-2 expression in pancreatic beta-cells (INS-1) promotes apoptosis, which can be compensated for by introduction of IRS-4 expression.
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Academic Article
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Proinsulin maturation, misfolding, and proteotoxicity.
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Academic Article
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A cis-element in the 5' untranslated region of the preproinsulin mRNA (ppIGE) is required for glucose regulation of proinsulin translation.
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Academic Article
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Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells.
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Academic Article
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Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element.
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Academic Article
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[Biogenesis of the insulin secretion granule].
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Academic Article
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Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells.
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Academic Article
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Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death.
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Academic Article
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The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion.
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Academic Article
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Arf nucleotide binding site opener [ARNO] promotes sequential activation of Arf6, Cdc42 and Rac1 and insulin secretion in INS 832/13 ß-cells and rat islets.
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Academic Article
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Regulation of the biosynthesis of insulin-secretory-granule proteins. Co-ordinate translational control is exerted on some, but not all, granule matrix constituents.
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Academic Article
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Leptin action via neurotensin neurons controls orexin, the mesolimbic dopamine system and energy balance.
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Academic Article
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Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3ß independent of JNK activation.
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Academic Article
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Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells.
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Academic Article
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Degradation of islet amyloid polypeptide by neprilysin.
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Academic Article
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FoxO feedback control of basal IRS-2 expression in pancreatic ß-cells is distinct from that in hepatocytes.
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Academic Article
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A Kex2-related endopeptidase activity present in rat liver specifically processes the insulin proreceptor.
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Academic Article
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Specific glucose-induced control of insulin receptor substrate-2 expression is mediated via Ca2+-dependent calcineurin/NFAT signaling in primary pancreatic islet ß-cells.
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Academic Article
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Free fatty acid-induced inhibition of glucose and insulin-like growth factor I-induced deoxyribonucleic acid synthesis in the pancreatic beta-cell line INS-1.
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Academic Article
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Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation.
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Academic Article
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Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1).
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Academic Article
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IRS-3 inhibits IRS-2-mediated signaling in pancreatic beta-cells.
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Academic Article
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Glucagon-like peptide-1 prevents beta cell glucolipotoxicity.
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Academic Article
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Direct imaging shows that insulin granule exocytosis occurs by complete vesicle fusion.
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Academic Article
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Intragranular targeting of syncollin, but not a syncollinGFP chimera, inhibits regulated insulin exocytosis in pancreatic beta-cells.
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Academic Article
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Glycogen synthase kinase 3 beta mediates high glucose-induced ubiquitination and proteasome degradation of insulin receptor substrate 1.
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Academic Article
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Rab3A effector domain peptides induce insulin exocytosis via a specific interaction with a cytosolic protein doublet.
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Academic Article
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Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation.
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Academic Article
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Suppressor of cytokine signalling-3 inhibits Tumor necrosis factor-alpha induced apoptosis and signalling in beta cells.
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Academic Article
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Intracellular signalling. Key enzyme in leptin-induced anorexia.
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Academic Article
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A potential role for hypothalamomedullary POMC projections in leptin-induced suppression of food intake.
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Academic Article
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Islet autoantigens: structure, function, localization, and regulation.
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Academic Article
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Characterization of the promoter for the rat and human link protein gene.
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Academic Article
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Direct innervation and modulation of orexin neurons by lateral hypothalamic LepRb neurons.
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Academic Article
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Developmental expression of the translocator protein 18 kDa (TSPO) in testicular germ cells.
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Academic Article
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Aberrant chloride intracellular channel 4 expression contributes to endothelial dysfunction in pulmonary arterial hypertension.
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Academic Article
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Pancreatic ß-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function.
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Academic Article
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Control of food intake and energy expenditure by Nos1 neurons of the paraventricular hypothalamus.
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Academic Article
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Neurturin and a GLP-1 Analogue Act Synergistically to Alleviate Diabetes in Zucker Diabetic Fatty Rats.
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Academic Article
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Ca(2+)-regulated serine protease associated with the nuclear scaffold.
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Academic Article
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Dominant-negative PKC-epsilon impairs apical actin remodeling in parallel with inhibition of carbachol-stimulated secretion in rabbit lacrimal acini.
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Academic Article
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The c-propeptide of type II procollagen binds to the enhancer region of the type II procollagen gene and regulates its transcription.
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Academic Article
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Characterization of a glucocorticoid responsive element and identification of an AT-rich element that regulate the link protein gene.
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Academic Article
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Leptin-receptor-expressing neurons in the dorsomedial hypothalamus and median preoptic area regulate sympathetic brown adipose tissue circuits.
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Academic Article
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Leptin action in the forebrain regulates the hindbrain response to satiety signals.
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Academic Article
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Reduced plasma levels of small HDL particles transporting fibrinolytic proteins in pulmonary arterial hypertension.
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Academic Article
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Spatial organization of EphA2 at the cell-cell interface modulates trans-endocytosis of ephrinA1.
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Academic Article
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Iron deficiency and raised hepcidin in idiopathic pulmonary arterial hypertension: clinical prevalence, outcomes, and mechanistic insights.
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Academic Article
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Alternative splicing generates two different mRNA species for rat link protein.
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Academic Article
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Plasma proteome analysis in patients with pulmonary arterial hypertension: an observational cohort study.
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Academic Article
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Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1.
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Academic Article
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PACE4 is a member of the mammalian propeptidase family that has overlapping but not identical substrate specificity to PACE.
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Academic Article
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Identification of rare sequence variation underlying heritable pulmonary arterial hypertension.
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Academic Article
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Unsuitability of indoxyl acetate as a substrate for the assay of testicular hyaluronidase.
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Academic Article
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Proteomic Analysis of Restored Insulin Production and Trafficking in Obese Diabetic Mouse Pancreatic Islets Following Euglycemia.
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Academic Article
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Targeted Measurements of O- and N-Glycopeptides Show That Proteins in High Density Lipoprotein Particles Are Enriched with Specific Glycosylation Compared to Plasma.
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Academic Article
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Characterization of GDF2 Mutations and Levels of BMP9 and BMP10 in Pulmonary Arterial Hypertension.
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Academic Article
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The mouse slalom mutant demonstrates a role for Jagged1 in neuroepithelial patterning in the organ of Corti.
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Academic Article
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A fluorescent timer reporter enables sorting of insulin secretory granules by age.
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Academic Article
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Mining the Plasma Proteome for Insights into the Molecular Pathology of Pulmonary Arterial Hypertension.
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Concept
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Serrate-Jagged Proteins
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Grant
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Metabolic Control of Insulin Exocytosis
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Grant
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Metabolic Control of Proinsulin Biosynthesis Translation
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Grant
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Metabolic Control of Proinsulin Biosynthesis Translation
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Academic Article
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SOX17 Enhancer Variants Disrupt Transcription Factor Binding And Enhancer Inactivity Drives Pulmonary Hypertension.
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Academic Article
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Blood DNA methylation profiling identifies cathepsin Z dysregulation in pulmonary arterial hypertension.
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