Item Type | Name |
Concept
|
Diabetes Mellitus, Experimental
|
Concept
|
Diabetes Mellitus, Type 1
|
Concept
|
Diabetes Mellitus, Type 2
|
Concept
|
Insulin
|
Concept
|
Insulin-Like Growth Factor I
|
Concept
|
Mutation
|
Concept
|
Receptor, Insulin
|
Concept
|
Insulin Resistance
|
Concept
|
Insulin-Like Growth Factor Binding Protein 1
|
Concept
|
Mutation, Missense
|
Concept
|
Insulin-Secreting Cells
|
Concept
|
Insulin Receptor Substrate Proteins
|
Concept
|
Diabetes Mellitus
|
Concept
|
Insulin, Regular, Human
|
Academic Article
|
Glucose-regulated translational control of proinsulin biosynthesis with that of the proinsulin endopeptidases PC2 and PC3 in the insulin-producing MIN6 cell line.
|
Academic Article
|
Processing of proopiomelanocortin by insulin secretory granule proinsulin processing endopeptidases.
|
Academic Article
|
A novel regulatory mechanism for trimeric GTP-binding proteins in the membrane and secretory granule fractions of human and rodent beta cells.
|
Academic Article
|
Specific co-ordinated regulation of PC3 and PC2 gene expression with that of preproinsulin in insulin-producing beta TC3 cells.
|
Academic Article
|
Insulin-stimulated translocation of GLUT4 glucose transporters requires SNARE-complex proteins.
|
Academic Article
|
Preferential cleavage of des-31,32-proinsulin over intact proinsulin by the insulin secretory granule type II endopeptidase. Implication of a favored route for prohormone processing.
|
Academic Article
|
Insulin-secreting non-islet cells are resistant to autoimmune destruction.
|
Academic Article
|
The ratio of mouse insulin I:insulin II does not reflect that of the corresponding preproinsulin mRNAs.
|
Academic Article
|
Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo : a specific vascular action of insulin.
|
Academic Article
|
Acute stimulation with long chain acyl-CoA enhances exocytosis in insulin-secreting cells (HIT T-15 and NMRI beta-cells).
|
Academic Article
|
Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation.
|
Academic Article
|
A specific increased expression of insulin receptor substrate 2 in pancreatic beta-cell lines is involved in mediating serum-stimulated beta-cell growth.
|
Academic Article
|
Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1).
|
Academic Article
|
Cooperativity between the preproinsulin mRNA untranslated regions is necessary for glucose-stimulated translation.
|
Academic Article
|
How is the insulin content regulated in nondiabetic hyperinsulinaemic, insulin resistant states? Study of spontaneously hypertensive rats.
|
Academic Article
|
Synaptotagmin III isoform is compartmentalized in pancreatic beta-cells and has a functional role in exocytosis.
|
Academic Article
|
Glycerol-stimulated proinsulin biosynthesis in isolated pancreatic rat islets via adenoviral-induced expression of glycerol kinase is mediated via mitochondrial metabolism.
|
Academic Article
|
Cysteine string protein (CSP) is an insulin secretory granule-associated protein regulating beta-cell exocytosis.
|
Academic Article
|
Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic beta-cell proliferation.
|
Academic Article
|
A distinct difference in the metabolic stimulus-response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moieties.
|
Academic Article
|
Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells.
|
Academic Article
|
Changes in cytoplasmic ATP concentration parallels changes in ATP-regulated K+-channel activity in insulin-secreting cells.
|
Academic Article
|
Succinate is a preferential metabolic stimulus-coupling signal for glucose-induced proinsulin biosynthesis translation.
|
Academic Article
|
Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: signal transduction via janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediated mitogenic signalling.
|
Academic Article
|
Pancreatic beta-cell growth and survival--a role in obesity-linked type 2 diabetes?
|
Academic Article
|
Induction of endothelin-1 expression by glucose: an effect of protein kinase C activation.
|
Academic Article
|
A low-affinity Ca2+-dependent association of calmodulin with the Rab3A effector domain inversely correlates with insulin exocytosis.
|
Academic Article
|
Insulin secretory deficiency and glucose intolerance in Rab3A null mice.
|
Academic Article
|
Gene and cell-replacement therapy in the treatment of type 1 diabetes: how high must the standards be set?
|
Academic Article
|
Ca2+-dependent dephosphorylation of kinesin heavy chain on beta-granules in pancreatic beta-cells. Implications for regulated beta-granule transport and insulin exocytosis.
|
Academic Article
|
Fatty acid and phorbol ester-mediated interference of mitogenic signaling via novel protein kinase C isoforms in pancreatic beta-cells (INS-1).
|
Academic Article
|
Signal transducer and activator of transcription 5 activation is sufficient to drive transcriptional induction of cyclin D2 gene and proliferation of rat pancreatic beta-cells.
|
Academic Article
|
Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide.
|
Academic Article
|
Glucose-induced translational control of proinsulin biosynthesis is proportional to preproinsulin mRNA levels in islet beta-cells but not regulated via a positive feedback of secreted insulin.
|
Academic Article
|
A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli.
|
Academic Article
|
Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells.
|
Academic Article
|
Fluorescent cargo proteins in pancreatic beta-cells: design determines secretion kinetics at exocytosis.
|
Academic Article
|
Differential activation mechanisms of Erk-1/2 and p70(S6K) by glucose in pancreatic beta-cells.
|
Academic Article
|
Insulin receptor substrate 2 plays diverse cell-specific roles in the regulation of glucose transport.
|
Academic Article
|
Type 2 diabetes-a matter of beta-cell life and death?
|
Academic Article
|
10th EASD/JDRF Oxford Workshop. What is a beta-cell and can we improve it?
|
Academic Article
|
Specific regulation of IRS-2 expression by glucose in rat primary pancreatic islet beta-cells.
|
Academic Article
|
Insulin action in the brain contributes to glucose lowering during insulin treatment of diabetes.
|
Academic Article
|
Insulin-like growth factor 1 receptor signaling regulates skin development and inhibits skin keratinocyte differentiation.
|
Academic Article
|
Impact of defined matrix interactions on insulin production by cultured human beta-cells: effect on insulin content, secretion, and gene transcription.
|
Academic Article
|
Inositol (1,4,5)-trisphosphate dynamics and intracellular calcium oscillations in pancreatic beta-cells.
|
Academic Article
|
Leptin regulates insulin sensitivity via phosphatidylinositol-3-OH kinase signaling in mediobasal hypothalamic neurons.
|
Academic Article
|
Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein kinase B in the Akt?
|
Academic Article
|
Decreasing IRS-2 expression in pancreatic beta-cells (INS-1) promotes apoptosis, which can be compensated for by introduction of IRS-4 expression.
|
Academic Article
|
Beta-cell regeneration: epithelial mesenchymal transition pre-EMTpted by lineage tracing?
|
Academic Article
|
A cis-element in the 5' untranslated region of the preproinsulin mRNA (ppIGE) is required for glucose regulation of proinsulin translation.
|
Academic Article
|
Regulated autophagy controls hormone content in secretory-deficient pancreatic endocrine beta-cells.
|
Academic Article
|
Insulin regulates glucagon-like peptide-1 secretion from the enteroendocrine L cell.
|
Academic Article
|
Glucagon-like peptide-1 regulates proliferation and apoptosis via activation of protein kinase B in pancreatic INS-1 beta cells.
|
Academic Article
|
Glycogen synthase kinase-3 regulates IGFBP-1 gene transcription through the thymine-rich insulin response element.
|
Academic Article
|
Stimulation by ATP of proinsulin to insulin conversion in isolated rat pancreatic islet secretory granules. Association with the ATP-dependent proton pump.
|
Academic Article
|
Proalbumin to albumin conversion by a proinsulin processing endopeptidase of insulin secretory granules.
|
Academic Article
|
[Biogenesis of the insulin secretion granule].
|
Academic Article
|
Involvement of Per-Arnt-Sim Kinase and extracellular-regulated kinases-1/2 in palmitate inhibition of insulin gene expression in pancreatic beta-cells.
|
Academic Article
|
Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death.
|
Academic Article
|
The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion.
|
Academic Article
|
Exendin 4 controls insulin production in rat islet beta cells predominantly by potentiation of glucose-stimulated proinsulin biosynthesis at the translational level.
|
Academic Article
|
Arf nucleotide binding site opener [ARNO] promotes sequential activation of Arf6, Cdc42 and Rac1 and insulin secretion in INS 832/13 ß-cells and rat islets.
|
Academic Article
|
Regulation of the biosynthesis of insulin-secretory-granule proteins. Co-ordinate translational control is exerted on some, but not all, granule matrix constituents.
|
Academic Article
|
The balance between proinsulin biosynthesis and insulin secretion: where can imbalance lead?
|
Academic Article
|
Glucose and fatty acids synergize to promote B-cell apoptosis through activation of glycogen synthase kinase 3ß independent of JNK activation.
|
Academic Article
|
Protein farnesylation-dependent Raf/extracellular signal-related kinase signaling links to cytoskeletal remodeling to facilitate glucose-induced insulin secretion in pancreatic beta-cells.
|
Academic Article
|
Newly synthesized proinsulin/insulin and stored insulin are released from pancreatic B cells predominantly via a regulated, rather than a constitutive, pathway.
|
Academic Article
|
Effect of human lymphoblastoid interferon on insulin synthesis and secretion in isolated human pancreatic islets.
|
Academic Article
|
Pancreatic regeneration in type 1 diabetes: dreams on a deserted islet?
|
Academic Article
|
AMP-activated protein kinase attenuates nitric oxide-induced beta-cell death.
|
Academic Article
|
Glucolipotoxicity age-dependently impairs beta cell function in rats despite a marked increase in beta cell mass.
|
Academic Article
|
Increased phagocyte-like NADPH oxidase and ROS generation in type 2 diabetic ZDF rat and human islets: role of Rac1-JNK1/2 signaling pathway in mitochondrial dysregulation in the diabetic islet.
|
Academic Article
|
Formation of a human ß-cell population within pancreatic islets is set early in life.
|
Academic Article
|
Degradation of islet amyloid polypeptide by neprilysin.
|
Academic Article
|
High-performance liquid chromatography (HPLC): a rapid, flexible and sensitive method for separating islet proinsulin and insulin.
|
Academic Article
|
How does type 1 diabetes develop?: the notion of homicide or ß-cell suicide revisited.
|
Academic Article
|
Glucose stimulates the biosynthesis of rat I and II insulin to an equal extent in isolated pancreatic islets.
|
Academic Article
|
FoxO feedback control of basal IRS-2 expression in pancreatic ß-cells is distinct from that in hepatocytes.
|
Academic Article
|
A Kex2-related endopeptidase activity present in rat liver specifically processes the insulin proreceptor.
|
Academic Article
|
What beta-cell defect could lead to hyperproinsulinemia in NIDDM? Some clues from recent advances made in understanding the proinsulin-processing mechanism.
|
Academic Article
|
Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus.
|
Academic Article
|
Co-secretion of carboxypeptidase H and insulin from isolated rat islets of Langerhans.
|
Academic Article
|
PKC-dependent stimulation of exocytosis by sulfonylureas in pancreatic beta cells.
|
Academic Article
|
Mechanism of action of glucagon-like peptide-2 to increase IGF-I mRNA in intestinal subepithelial fibroblasts.
|
Academic Article
|
Specific glucose-induced control of insulin receptor substrate-2 expression is mediated via Ca2+-dependent calcineurin/NFAT signaling in primary pancreatic islet ß-cells.
|
Academic Article
|
The intracellular handling of insulin-related peptides in isolated pancreatic islets. Evidence for differential rates of degradation of insulin and C-peptide.
|
Academic Article
|
Long-term biochemical changes in the islets of Langerhans in mice following infection with encephalomyocarditis virus.
|
Academic Article
|
Free fatty acid-induced inhibition of glucose and insulin-like growth factor I-induced deoxyribonucleic acid synthesis in the pancreatic beta-cell line INS-1.
|
Academic Article
|
Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation.
|
Academic Article
|
Molecular insights into insulin action and secretion.
|
Academic Article
|
Protein kinase B/Akt prevents fatty acid-induced apoptosis in pancreatic beta-cells (INS-1).
|
Academic Article
|
Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis.
|
Academic Article
|
IRS-3 inhibits IRS-2-mediated signaling in pancreatic beta-cells.
|
Academic Article
|
Diazoxide attenuates glucose-induced defects in first-phase insulin release and pulsatile insulin secretion in human islets.
|
Academic Article
|
Direct imaging shows that insulin granule exocytosis occurs by complete vesicle fusion.
|
Academic Article
|
The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species.
|
Academic Article
|
Intragranular targeting of syncollin, but not a syncollinGFP chimera, inhibits regulated insulin exocytosis in pancreatic beta-cells.
|
Academic Article
|
Effect of interferon and double-stranded RNA on B-cell function in mouse islets of Langerhans.
|
Academic Article
|
Hypothalamic leptin signaling regulates hepatic insulin sensitivity via a neurocircuit involving the vagus nerve.
|
Academic Article
|
Glycogen synthase kinase 3 beta mediates high glucose-induced ubiquitination and proteasome degradation of insulin receptor substrate 1.
|
Academic Article
|
Effects of glucose and D-3-hydroxybutyrate on human pancreatic islet cell function.
|
Academic Article
|
Rab3A effector domain peptides induce insulin exocytosis via a specific interaction with a cytosolic protein doublet.
|
Academic Article
|
Proinsulin endopeptidase substrate specificities defined by site-directed mutagenesis of proinsulin.
|
Academic Article
|
Glucose or diabetes activates p38 mitogen-activated protein kinase via different pathways.
|
Academic Article
|
Correction of diet-induced hyperglycemia, hyperinsulinemia, and skeletal muscle insulin resistance by moderate hyperleptinemia.
|
Academic Article
|
IGF-I and GH post-receptor signaling mechanisms for pancreatic beta-cell replication.
|
Academic Article
|
Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation.
|
Academic Article
|
Suppressor of cytokine signalling-3 inhibits Tumor necrosis factor-alpha induced apoptosis and signalling in beta cells.
|
Academic Article
|
Intracellular signalling. Key enzyme in leptin-induced anorexia.
|
Academic Article
|
ß1 integrin is a crucial regulator of pancreatic ß-cell expansion.
|
Academic Article
|
Islet autoantigens: structure, function, localization, and regulation.
|
Academic Article
|
Direct autocrine action of insulin on ß-cells: does it make physiological sense?
|
Academic Article
|
ß-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.
|
Academic Article
|
ß-cell failure in type 2 diabetes: postulated mechanisms and prospects for prevention and treatment.
|
Academic Article
|
Monomethylated-adenines potentiate glucose-induced insulin production and secretion via inhibition of phosphodiesterase activity in rat pancreatic islets.
|
Academic Article
|
Pancreatic ß-Cell Adaptive Plasticity in Obesity Increases Insulin Production but Adversely Affects Secretory Function.
|
Academic Article
|
SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed ß cells.
|
Academic Article
|
The Brain-to-Pancreatic Islet Neuronal Map Reveals Differential Glucose Regulation From Distinct Hypothalamic Regions.
|
Academic Article
|
40th EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004.
|
Academic Article
|
Free Fatty Acid-Induced Inhibition of Glucose and Insulin-Like Growth Factor I-Induced Deoxyribonucleic Acid Synthesis in the Pancreatic ß-Cell Line INS-1* * This work was supported by grants from the NIH (GK-55267), the Juvenile Diabetes Foundation International, the German Research Society, and BetaGene, Inc.
|
Academic Article
|
Neurturin and a GLP-1 Analogue Act Synergistically to Alleviate Diabetes in Zucker Diabetic Fatty Rats.
|
Academic Article
|
Codependence of Bone Morphogenetic Protein Receptor 2 and Transforming Growth Factor-ß in Elastic Fiber Assembly and Its Perturbation in Pulmonary Arterial Hypertension.
|
Academic Article
|
Expansion of the Knockdown Resistance Frequency Map for Human Head Lice (Phthiraptera: Pediculidae) in the United States Using Quantitative Sequencing.
|
Academic Article
|
Persistence of Pancreatic Insulin mRNA Expression and Proinsulin Protein in Type 1 Diabetes Pancreata.
|
Academic Article
|
Activation of mammalian target of rapamycin (mTOR) by insulin is associated with stimulation of 4EBP1 binding to dimeric mTOR complex 1.
|
Academic Article
|
ß-Cell Control of Insulin Production During Starvation-Refeeding in Male Rats.
|
Academic Article
|
The dynamic plasticity of insulin production in ß-cells.
|
Academic Article
|
Identification of rare sequence variation underlying heritable pulmonary arterial hypertension.
|
Academic Article
|
Pancreatic ß-Cell Rest Replenishes Insulin Secretory Capacity and Attenuates Diabetes in an Extreme Model of Obese Type 2 Diabetes.
|
Academic Article
|
Biosynthesis and storage of insulin.
|
Academic Article
|
Human PAH is characterized by a pattern of lipid-related insulin resistance.
|
Academic Article
|
Inhibition of upper small intestinal mTOR lowers plasma glucose levels by inhibiting glucose production.
|
Academic Article
|
Combined loss of GLP-1R and Y2R does not alter progression of high-fat diet-induced obesity or response to RYGB surgery in mice.
|
Academic Article
|
Proteomic Analysis of Restored Insulin Production and Trafficking in Obese Diabetic Mouse Pancreatic Islets Following Euglycemia.
|
Academic Article
|
Characterization of GDF2 Mutations and Levels of BMP9 and BMP10 in Pulmonary Arterial Hypertension.
|
Academic Article
|
Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension.
|
Academic Article
|
The mouse slalom mutant demonstrates a role for Jagged1 in neuroepithelial patterning in the organ of Corti.
|
Academic Article
|
Characterization of Signaling Pathways Associated with Pancreatic ß-cell Adaptive Flexibility in Compensation of Obesity-linked Diabetes in db/db Mice.
|
Academic Article
|
A fluorescent timer reporter enables sorting of insulin secretory granules by age.
|
Academic Article
|
Resolution of NASH and hepatic fibrosis by the GLP-1R/GcgR dual-agonist Cotadutide via modulating mitochondrial function and lipogenesis.
|
Academic Article
|
Characterization of Signaling Pathways Associated with Pancreatic ß-cell Adaptive Flexibility in Compensation of Obesity-linked Diabetes in db/db Mice.
|
Academic Article
|
A fluorescent timer reporter enables sorting of insulin secretory granules by age.
|
Academic Article
|
Peptide-YY3-36/glucagon-like peptide-1 combination treatment of obese diabetic mice improves insulin sensitivity associated with recovered pancreatic ß-cell function and synergistic activation of discrete hypothalamic and brainstem neuronal circuitries.
|
Academic Article
|
High Plasma Levels of Soluble Lectin-like Oxidized Low-Density Lipoprotein Receptor-1 Are Associated With Inflammation and Cardiometabolic Risk Profiles in Pediatric Overweight and Obesity.
|
Academic Article
|
Physical Activity and Insulin Sensitivity Independently Attenuate the Effect of FTO rs9939609 on Obesity.
|
Grant
|
Mitogenic Signal Transduction in Pancreatic Beta-Cells
|
Grant
|
Metabolic Control of Insulin Exocytosis
|
Grant
|
Central Control of Pancreatic Islet Function
|
Grant
|
Western Region Islet Study Group
|
Grant
|
An Interdisciplinary Molecular Metabolism Training Program
|
Grant
|
Metabolic Control of Proinsulin Biosynthesis Translation
|
Grant
|
Metabolic Control of Proinsulin Biosynthesis Translation
|