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Search Results to Martin Feder

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overview My research focuses on understanding adaptation to the environment from both a mechanistic and evolutionary perspective; i.e., how organisms function in natural environments, the mechanisms underlying this function, the evolutionary origin, maintenance, and constraint of this function, the evolutionary consequences of variation in function, and how all of these aspects are encoded or reflected in the genome. Thus, my research focuses at the intersection of the four disciplinary domains shown to the left; i.e., evolutionary and ecological functional genomics. My research program addresses this suite of issues through a multidisciplinary, problem-oriented approach. My present emphasis is on ecological and evolutionary physiology of the stress response [the induction of a specific suite of proteins (stress or heat-shock proteins) by extreme temperatures and other stresses]. Several projects are underway, with a common theme: HEAT-SHOCK PROTEINS AND GENES Specifically, my laboratory investigates the heat-shock protein Hsp70, its encoding genes, and its regulation in Drosophila as a model system for understanding evolutionary adaptation. Hsp70 is a molecular chaperone that deters stress-induced protein aggregation, but has numerous other functions. Hsp70 is necessary for full-strength tolerance (in terms of survival, normal development, normal function) of high temperature. Such tolerance is critical in nature, where non-adult Drosophila undergo harmful to lethal high temperatures. In nature, Drosophila populations vary in stress tolerance and Hsp70 levels. Our current major focus is on understanding the genomic basis for this variation. The number of hsp70 gene copies and evolution of the hsp70 coding sequence are partial or inadequate explanations. Evidently cis-regulatory regions such as proximal promoters underlie intraspecific variation in Hsp70 levels. Repeated insertion of mobile genetic elements into these promoters is a recurrent mechanism of evolution.

One or more keywords matched the following items that are connected to Feder, Martin

Item TypeName
Concept Drosophila
Concept Drosophila melanogaster
Concept Drosophila Proteins
Academic Article Effect of engineering Hsp70 copy number on Hsp70 expression and tolerance of ecologically relevant heat shock in larvae and pupae of Drosophila melanogaster.
Academic Article Tissue-specific variation in Hsp70 expression and thermal damage in Drosophila melanogaster larvae.
Academic Article Overcoming cytoplasmic incompatibility in Drosophila.
Academic Article Deleterious consequences of Hsp70 overexpression in Drosophila melanogaster larvae.
Academic Article Laboratory selection at different temperatures modifies heat-shock transcription factor (HSF) activation in Drosophila melanogaster.
Academic Article A Drosophila melanogaster strain from sub-equatorial Africa has exceptional thermotolerance but decreased Hsp70 expression.
Academic Article Rapid concerted evolution via gene conversion at the Drosophila hsp70 genes.
Academic Article Response to natural and laboratory selection at the Drosophila hsp70 genes.
Academic Article Hsp70 and thermal pretreatment mitigate developmental damage caused by mitotic poisons in Drosophila.
Academic Article Evolvability of Hsp70 expression under artificial election for inducible thermotolerance in independent populations of Drosophila melanogaster.
Academic Article Evolution of thermotolerance and the heat-shock response: evidence from inter/intraspecific comparison and interspecific hybridization in the virilis species group of Drosophila. I. Thermal phenotype.
Academic Article Modification of heat-shock gene expression in Drosophila melanogaster populations via transposable elements.
Academic Article Effect of heat shock, pretreatment and hsp70 copy number on wing development in Drosophila melanogaster.
Academic Article Hsp70 duplication in the Drosophila melanogaster species group: how and when did two become five?
Academic Article Adaptive differentiation of thermotolerance in Drosophila along a microclimatic gradient.
Academic Article Dropping like flies: environmentally induced impairment and protection of locomotor performance in adult Drosophila melanogaster.
Academic Article Heat-shock promoters: targets for evolution by P transposable elements in Drosophila.
Academic Article Abundant, diverse, and consequential P elements segregate in promoters of small heat-shock genes in Drosophila populations.
Academic Article Evolution and arrangement of the hsp70 gene cluster in two closely related species of the virilis group of Drosophila.
Academic Article Unusual arrangement of the hsp68 locus in the virilis species group of Drosophila implicates evolutionary loss of an hsp68 gene.
Academic Article Naturally occurring transposable elements disrupt hsp70 promoter function in Drosophila melanogaster.
Academic Article Reverse transcriptional profiling: non-correspondence of transcript level variation and proximal promoter polymorphism.
Academic Article Phylogeny disambiguates the evolution of heat-shock cis-regulatory elements in Drosophila.
Academic Article Location of P element insertions in the proximal promoter region of Hsp70A is consequential for gene expression and correlated with fecundity in Drosophila melanogaster.
Academic Article Contrasting patterns of transposable element insertions in Drosophila heat-shock promoters.
Academic Article Ecological and evolutionary physiology of heat shock proteins and the stress response in Drosophila: complementary insights from genetic engineering and natural variation.
Academic Article Genetic evidence for adaptation-driven incipient speciation of Drosophila melanogaster along a microclimatic contrast in "Evolution Canyon," Israel.
Academic Article Remarkable site specificity of local transposition into the Hsp70 promoter of Drosophila melanogaster.
Academic Article Hsp70 and larval thermotolerance in Drosophila melanogaster: how much is enough and when is more too much?
Academic Article Natural hyperthermia and expression of the heat shock protein Hsp70 affect developmental abnormalities in Drosophila melanogaster.
Academic Article Molecular thermal telemetry of free-ranging adult Drosophila melanogaster.
Academic Article NATURAL VARIATION IN THE EXPRESSION OF THE HEAT-SHOCK PROTEIN HSP70 IN A POPULATION OF DROSOPHILA MELANOGASTER AND ITS CORRELATION WITH TOLERANCE OF ECOLOGICALLY RELEVANT THERMAL STRESS.
Academic Article HERITABILITY OF EXPRESSION OF THE 70KD HEAT-SHOCK PROTEIN IN DROSOPHILA MELANOGASTER AND ITS RELEVANCE TO THE EVOLUTION OF THERMOTOLERANCE.
Academic Article EXPERIMENTAL EVOLUTION OF HSP70 EXPRESSION AND THERMOTOLERANCE IN DROSOPHILA MELANOGASTER.
Academic Article Changes in thermotolerance and Hsp70 expression with domestication in Drosophila melanogaster.
Academic Article Engineering Candidate Genes in Studies of Adaptation: The Heat-Shock Protein Hsp70 in Drosophila melanogaster.

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