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Search Results to David A. Drummond

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overview Dr. Drummond is an Associate Professor of Biochemistry & Molecular Biology and Human Genetics. His group studies how cells respond to stress at the molecular level, focusing on formation and dissolution of large assemblies of proteins and RNA during and after stresses such as heat shock. Drummond's lab uses a wide range of techniques, including in vivo imaging, in vitro reconstitution and mechanistic biochemistry, quantitative proteomics, and molecular evolutionary analyses. Because many features of stress-triggered assembly processes are shared across eukaryotes, including humans, the group employs budding yeast, Saccharomyces cerevisiae, as a model organism.

One or more keywords matched the following items that are connected to Drummond, David A.

Item TypeName
Concept Bacterial Proteins
Concept Fungal Proteins
Concept DNA-Binding Proteins
Concept Protein Denaturation
Concept Heat-Shock Proteins
Concept Protein Conformation
Concept Protein Synthesis Inhibitors
Concept Proteins
Concept Protein Biosynthesis
Concept Protein Structure, Tertiary
Concept PII Nitrogen Regulatory Proteins
Concept Drosophila Proteins
Concept Protein Structure, Secondary
Concept Protein Folding
Concept Saccharomyces cerevisiae Proteins
Concept Recombinant Proteins
Concept Sequence Analysis, Protein
Concept Cation Transport Proteins
Concept Escherichia coli Proteins
Concept Protein Stability
Concept Luminescent Proteins
Concept Nuclear Proteins
Concept Poly(A)-Binding Proteins
Academic Article Estimating selection on synonymous codon usage from noisy experimental data.
Academic Article Misfolded proteins impose a dosage-dependent fitness cost and trigger a cytosolic unfolded protein response in yeast.
Academic Article Contact density affects protein evolutionary rate from bacteria to animals.
Academic Article Population genetics of translational robustness.
Academic Article Quantifying condition-dependent intracellular protein levels enables high-precision fitness estimates.
Academic Article A single determinant dominates the rate of yeast protein evolution.
Academic Article Why highly expressed proteins evolve slowly.
Academic Article Predicting the tolerance of proteins to random amino acid substitution.
Academic Article Signatures of protein biophysics in coding sequence evolution.
Academic Article Protein evolution: innovative chaps.
Academic Article The evolutionary consequences of erroneous protein synthesis.
Academic Article Mistranslation-induced protein misfolding as a dominant constraint on coding-sequence evolution.
Academic Article A diverse family of thermostable cytochrome P450s created by recombination of stabilizing fragments.
Academic Article Structural determinants of the rate of protein evolution in yeast.
Academic Article Why high-error-rate random mutagenesis libraries are enriched in functional and improved proteins.
Academic Article Thermodynamic prediction of protein neutrality.
Academic Article Good codons, bad transcript: large reductions in gene expression and fitness arising from synonymous mutations in a key enzyme.
Academic Article Activity of MM-398, nanoliposomal irinotecan (nal-IRI), in Ewing's family tumor xenografts is associated with high exposure of tumor to drug and high SLFN11 expression.
Academic Article A nutrient-driven tRNA modification alters translational fidelity and genome-wide protein coding across an animal genus.
Academic Article Correction: A nutrient-driven tRNA modification alters translational fidelity and genome-wide protein coding across an animal genus.
Academic Article Dying mRNA Tells a Story of Its Life.
Academic Article Reversible, Specific, Active Aggregates of Endogenous Proteins Assemble upon Heat Stress.
Academic Article Heat Shock Factor 1: From Fire Chief to Crowd-Control Specialist.
Academic Article Stress-Triggered Phase Separation Is an Adaptive, Evolutionarily Tuned Response.
Academic Article Accounting for experimental noise reveals that mRNA levels, amplified by post-transcriptional processes, largely determine steady-state protein levels in yeast.
Academic Article An Escherichia coli Nitrogen Starvation Response Is Important for Mutualistic Coexistence with Rhodopseudomonas palustris.
Academic Article Transient intracellular acidification regulates the core transcriptional heat shock response.
Academic Article Daily Cycles of Reversible Protein Condensation in Cyanobacteria.

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  • Misfolding