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Search Results to Michaela Gack

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overview Understanding host-virus interactions is an essential step in developing safe and effective antimicrobials against existing and newly emerging pathogens. The early detection of invading viruses by the host depends on a limited number of specific receptors that detect viral patterns and activate signaling cascades, thereby triggering interferon (IFN)-mediated antiviral defense mechanisms. Intracellular innate immune receptors, such as RIG-I-like receptors (RLRs) and the intracellular viral DNA sensors cGAS and IFI16, detect a variety of RNA and DNA viruses including influenza virus, measles virus, dengue virus and herpesviruses. In addition, members of the tripartite motif (TRIM) protein family play a major role in the antiviral host response. Research in the Gack laboratory seeks a better understanding of the cell-intrinsic mechanisms underlying the host innate immune response against viral infections. Another area of our research focuses on the detailed mechanisms by which viral pathogens – influenza viruses, measles virus, dengue virus and herpesviruses – suppress the innate immune system. The Gack laboratory uses an integrative approach that combines RNAi screens and proteomics with molecular, biochemical, and cell-biological approaches as well as viral infection studies including reverse genetics systems for the generation of recombinant mutant viruses.

One or more keywords matched the following items that are connected to Gack, Michaela

Item TypeName
Concept DNA-Binding Proteins
Concept Membrane Proteins
Concept Nerve Tissue Proteins
Concept Viral Structural Proteins
Concept RNA-Binding Proteins
Concept Immediate-Early Proteins
Concept Viral Nonstructural Proteins
Concept Apoptosis Regulatory Proteins
Concept rab GTP-Binding Proteins
Concept Oncogene Proteins, Viral
Concept Green Fluorescent Proteins
Concept Recombinant Proteins
Concept Adaptor Proteins, Signal Transducing
Concept Viral Proteins
Concept GTP-Binding Proteins
Concept Homeodomain Proteins
Concept Tumor Suppressor Proteins
Concept 14-3-3 Proteins
Concept Carrier Proteins
Concept Nuclear Proteins
Concept Recombinant Fusion Proteins
Concept Vesicular Transport Proteins
Concept CARD Signaling Adaptor Proteins
Academic Article Growth transformation of human T cells by herpesvirus saimiri requires multiple Tip-Lck interaction motifs.
Academic Article Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I.
Academic Article Linear ubiquitin assembly complex negatively regulates RIG-I- and TRIM25-mediated type I interferon induction.
Academic Article RIG-I-like receptor regulation in virus infection and immunity.
Academic Article Crystal structure of the TRIM25 B30.2 (PRYSPRY) domain: a key component of antiviral signalling.
Academic Article Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking.
Academic Article Species-specific inhibition of RIG-I ubiquitination and IFN induction by the influenza A virus NS1 protein.
Academic Article Antagonism of the phosphatase PP1 by the measles virus V protein is required for innate immune escape of MDA5.
Academic Article Regulation of RIG-I-like receptor signaling by host and viral proteins.
Academic Article Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction.
Academic Article Phosphorylation-mediated negative regulation of RIG-I antiviral activity.
Academic Article Negative role of RIG-I serine 8 phosphorylation in the regulation of interferon-beta production.
Academic Article RIG-I works double duty.
Academic Article Inhibition of interferon regulatory factor 7 (IRF7)-mediated interferon signal transduction by the Kaposi's sarcoma-associated herpesvirus viral IRF homolog vIRF3.
Academic Article The ubiquitin-specific protease USP15 promotes RIG-I-mediated antiviral signaling by deubiquitylating TRIM25.
Academic Article A phosphomimetic-based mechanism of dengue virus to antagonize innate immunity.
Academic Article Viral evasion of intracellular DNA and RNA sensing.
Academic Article Mechanism of TRIM25 Catalytic Activation in the Antiviral RIG-I Pathway.
Academic Article Post-translational Control of Intracellular Pathogen Sensing Pathways.
Academic Article Viral pathogenesis: Dengue virus takes on cGAS.
Academic Article TRIM23 mediates virus-induced autophagy via activation of TBK1.
Academic Article Identification of a second binding site on the TRIM25 B30.2 domain.
Academic Article The Human Papillomavirus E6 Oncoprotein Targets USP15 and TRIM25 To Suppress RIG-I-Mediated Innate Immune Signaling.
Academic Article TRIM25 Binds RNA to Modulate Cellular Anti-viral Defense.
Academic Article TRIM Proteins and Their Roles in Antiviral Host Defenses.
Academic Article TRIM proteins: New players in virus-induced autophagy.
Academic Article Centrosomal protein TRIM43 restricts herpesvirus infection by regulating nuclear lamina integrity.
Academic Article Disassembly of the TRIM23-TBK1 Complex by the Us11 Protein of Herpes Simplex Virus 1 Impairs Autophagy.
Academic Article Zika Virus NS3 Mimics a Cellular 14-3-3-Binding Motif to Antagonize RIG-I- and MDA5-Mediated Innate Immunity.
Academic Article Distinct and Orchestrated Functions of RNA Sensors in Innate Immunity.
Academic Article The antiviral activities of TRIM proteins.
Academic Article Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
Academic Article The herpesvirus accessory protein ?134.5 facilitates viral replication by disabling mitochondrial translocation of RIG-I.
Academic Article The Small t Antigen of JC Virus Antagonizes RIG-I-Mediated Innate Immunity by Inhibiting TRIM25's RNA Binding Ability.
Academic Article Herpesvirus-mediated stabilization of ICP0 expression neutralizes restriction by TRIM23.
Academic Article The US3 Kinase of Herpes Simplex Virus Phosphorylates the RNA Sensor RIG-I To Suppress Innate Immunity.

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