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One or more keywords matched the following properties of Fang, Yun
overview My research foci are mechano-transduction mechanisms by which cells sense and convert environmental mechanical stimuli into biological signaling and novel nanomedicine approaches that target dysregulated mechano-sensing pathways. Cellular mechanotransduction is instrumental to embryogenesis and physiological control of tissue homeostasis; abnormal cell responses to mechanical forces promote pathologies associated with numerous human diseases. This is especially important in the vasculature, where environmental mechanical stimuli produce cellular responses in endothelial cells at arterial curvatures and bifurcations by locally disturbed blood flow to induce atherosclerosis. A similar cascade appears to be induced in acute lung injury where it is the increased cyclic stretch that is the trigger. My research program at the University of Chicago focuses on the molecular understanding of endothelial homeostasis governed by mechanical forces, with emphasis upon regulation of non-coding genome, transcription factors, G protein signaling, and genetic variance. Another major research goal is to develop innovative nanomedicine-based therapeutic strategies to treat dysregulated mechano-sensing mechanisms causing vascular diseases. Key Words: microRNA, non-coding RNA, human genetics, enhancer biology, vascular biology, nanotechnology, nanomedicine, mechanotransduction, atherosclerosis, acute lung injury
One or more keywords matched the following items that are connected to Fang, Yun
Item TypeName
Concept Atherosclerosis
Academic Article Monocyte-targeting supramolecular micellar assemblies: a molecular diagnostic tool for atherosclerosis.
Academic Article MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitro.
Academic Article Site-specific microRNA-92a regulation of Kruppel-like factors 4 and 2 in atherosusceptible endothelium.
Academic Article Endothelial heterogeneity associated with regional athero-susceptibility and adaptation to disturbed blood flow in vivo.
Academic Article The atherosusceptible endothelium: endothelial phenotypes in complex haemodynamic shear stress regions in vivo.
Academic Article Inhibition of atherosclerosis-promoting microRNAs via targeted polyelectrolyte complex micelles.
Academic Article Mechanosensitive PPAP2B Regulates Endothelial Responses to Atherorelevant Hemodynamic Forces.
Academic Article Hypercholesterolemia-Induced Loss of Flow-Induced Vasodilation and Lesion Formation in Apolipoprotein E-Deficient Mice Critically Depend on Inwardly Rectifying K+ Channels.
Academic Article Proatherogenic Flow Increases Endothelial Stiffness via Enhanced CD36-Mediated Uptake of Oxidized Low-Density Lipoproteins.
Grant Spatial Delivery of MicroRNA Inhibitor via Targeted Polyelectrolyte Complex Micelles to Treat Atherosclerosis.
Grant Coronary artery disease locus 1p32.2 and miR92a-PPAP2B signaling in endothelial mechanobiology
Grant miR-10a regulation of regional arterial endothelial phenotypes in atherosclerosis
Academic Article The guidance receptor plexin D1 is a mechanosensor in endothelial cells.
Academic Article Targeted polyelectrolyte complex micelles treat vascular complications in vivo.
Grant miR-10a regulation of regional arterial endothelial phenotypes in atherosclerosis
Academic Article Mechanosensitive super-enhancers regulate genes linked to atherosclerosis in endothelial cells.
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  • Atherosclerosis