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One or more keywords matched the following properties of Cobey, Sarah E.
PropertyValue
keywords influenza
overview Broadly, my group investigates the coevolution of pathogens and hosts’ adaptive immunity. We use computational and mathematical tools to test hypotheses and to advance theory. Our earlier work focused on the evolutionary consequences of immune-mediated competition between different pathogen strains, including pneumococcus, human papillomavirus, and especially influenza. More recently, our focus has expanded to include the related dynamics of the host immune response. We are investigating the evolution of antibody repertoires within hosts over time, in particular to identify the roles of infection history, chance, vaccination, and host genetics in generating the diversity of B cell responses. This research involves linking epidemiological and immunological observations of B cells to the antigenic and genetic evolution of influenza viruses. Consequently, it makes extensive use of longitudinal dynamical models of individuals and birth cohorts as well as techniques from molecular evolution to investigate coevolution across scales. Understanding the dynamics of vaccination is another area of focus. We have investigated the actual and expected impacts of vaccines against pneumococcus, human papillomavirus, and influenza. With influenza, we have been investigating the impact of the vaccine on viral transmission and local evolution and how immune history might reduce the vaccine’s effectiveness and alter selective pressures. Improving vaccination strategies given hosts’ diverse immune histories and the potential for rapid evolution by the pathogen is a long-term aim of our work. Ultimately, we want to explain coevolution sufficiently well to enable prediction, or at least to determine when prediction is not feasible.
One or more keywords matched the following items that are connected to Cobey, Sarah E.
Item TypeName
Concept Influenza, Human
Concept Influenza B virus
Concept Influenza A virus
Concept Influenza Vaccines
Concept Influenza A Virus, H3N2 Subtype
Concept Influenza A Virus, H1N1 Subtype
Concept Hemagglutinin Glycoproteins, Influenza Virus
Academic Article Epochal evolution shapes the phylodynamics of interpandemic influenza A (H3N2) in humans.
Academic Article Consequences of host heterogeneity, epitope immunodominance, and immune breadth for strain competition.
Academic Article Global migration dynamics underlie evolution and persistence of human influenza A (H3N2).
Academic Article Ecological factors driving the long-term evolution of influenza's host range.
Academic Article Predicting the epidemic sizes of influenza A/H1N1, A/H3N2, and B: a statistical method.
Academic Article Improving influenza vaccine virus selection: report of a WHO informal consultation held at WHO headquarters, Geneva, Switzerland, 14-16 June 2010.
Academic Article Strength and tempo of selection revealed in viral gene genealogies.
Academic Article Anticipating the species jump: surveillance for emerging viral threats.
Academic Article Improving influenza vaccine virus selection: report of a WHO informal consultation held at WHO headquarters, Geneva, Switzerland, 14-16 June 2010.
Academic Article Explaining the geographical origins of seasonal influenza A (H3N2).
Academic Article Viral factors in influenza pandemic risk assessment.
Academic Article Immune history and influenza virus susceptibility.
Academic Article Does influenza drive absolute humidity?
Academic Article Immune History and Influenza Vaccine Effectiveness.
Academic Article Estimating Vaccine-Driven Selection in Seasonal Influenza.
Academic Article Response to Skowronski and De Serres.
Academic Article Poor Immunogenicity, Not Vaccine Strain Egg Adaptation, May Explain the Low H3N2 Influenza Vaccine Effectiveness in 2012-2013.
Academic Article Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains.
Academic Article Spec-seq unveils transcriptional subpopulations of antibody-secreting cells following influenza vaccination.
Academic Article Repeated Vaccination May Protect Children From Influenza Infection.
Academic Article Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals.
Academic Article Age-specific differences in the dynamics of protective immunity to influenza.
Academic Article Comparison of Human H3N2 Antibody Responses Elicited by Egg-Based, Cell-Based, and Recombinant Protein-Based Influenza Vaccines During the 2017-2018 Season.
Academic Article Earliest infections predict the age distribution of seasonal influenza A cases.
Academic Article Middle-aged individuals may be in a perpetual state of H3N2 influenza virus susceptibility.
Academic Article Preexisting immunity shapes distinct antibody landscapes after influenza virus infection and vaccination in humans.
Academic Article An Egg-Derived Sulfated N-Acetyllactosamine Glycan Is an Antigenic Decoy of Influenza Virus Vaccines.
Academic Article Lineage-specific protection and immune imprinting shape the age distributions of influenza B cases.
Academic Article The Potential Beneficial Effects of Vaccination on Antigenically Evolving Pathogens.
Academic Article Investigation of the Impact of Childhood Immune Imprinting on Birth Year-Specific Risk of Clinical Infection During Influenza A Virus Epidemics in Hong Kong.
Academic Article Reduced effectiveness of repeat influenza vaccination: distinguishing among within-season waning, recent clinical infection, and subclinical infection.
Academic Article Measures of population immunity can predict the dominant clade of influenza A (H3N2) and reveal age-associated differences in susceptibility and specificity.
Academic Article High-throughput sequencing-based neutralization assay reveals how repeated vaccinations impact titers to recent human H1N1 influenza strains.
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  • Influenza