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One or more keywords matched the following properties of Cobey, Sarah E.
keywords mathematical modeling
overview Broadly, my group investigates the coevolution of pathogens and hosts’ adaptive immunity. We use computational and mathematical tools to test hypotheses and to advance theory. Our earlier work focused on the evolutionary consequences of immune-mediated competition between different pathogen strains, including pneumococcus, human papillomavirus, and especially influenza. More recently, our focus has expanded to include the related dynamics of the host immune response. We are investigating the evolution of antibody repertoires within hosts over time, in particular to identify the roles of infection history, chance, vaccination, and host genetics in generating the diversity of B cell responses. This research involves linking epidemiological and immunological observations of B cells to the antigenic and genetic evolution of influenza viruses. Consequently, it makes extensive use of longitudinal dynamical models of individuals and birth cohorts as well as techniques from molecular evolution to investigate coevolution across scales. Understanding the dynamics of vaccination is another area of focus. We have investigated the actual and expected impacts of vaccines against pneumococcus, human papillomavirus, and influenza. With influenza, we have been investigating the impact of the vaccine on viral transmission and local evolution and how immune history might reduce the vaccine’s effectiveness and alter selective pressures. Improving vaccination strategies given hosts’ diverse immune histories and the potential for rapid evolution by the pathogen is a long-term aim of our work. Ultimately, we want to explain coevolution sufficiently well to enable prediction, or at least to determine when prediction is not feasible.
One or more keywords matched the following items that are connected to Cobey, Sarah E.
Item TypeName
Concept Models, Genetic
Concept Models, Theoretical
Concept Models, Immunological
Concept Models, Statistical
Concept Models, Biological
Academic Article Epochal evolution shapes the phylodynamics of interpandemic influenza A (H3N2) in humans.
Academic Article Pathogen diversity and hidden regimes of apparent competition.
Academic Article Consequences of host heterogeneity, epitope immunodominance, and immune breadth for strain competition.
Academic Article Niche and neutral effects of acquired immunity permit coexistence of pneumococcal serotypes.
Academic Article Predicting the epidemic sizes of influenza A/H1N1, A/H3N2, and B: a statistical method.
Academic Article Pathogen evolution and the immunological niche.
Academic Article Trade-offs in antibody repertoires to complex antigens.
Academic Article The evolution within us.
Academic Article Limits to Causal Inference with State-Space Reconstruction for Infectious Disease.
Academic Article Host population structure and treatment frequency maintain balancing selection on drug resistance.
Academic Article Recurring infection with ecologically distinct HPV types can explain high prevalence and diversity.
Academic Article Use of an individual-based model of pneumococcal carriage for planning a randomized trial of a whole-cell vaccine.
Academic Article Estimating Vaccine-Driven Selection in Seasonal Influenza.
Academic Article Age-specific differences in the dynamics of protective immunity to influenza.
Academic Article Modeling infectious disease dynamics.
Academic Article Earliest infections predict the age distribution of seasonal influenza A cases.
Academic Article Middle-aged individuals may be in a perpetual state of H3N2 influenza virus susceptibility.
Academic Article Practical considerations for measuring the effective reproductive number, Rt.
Academic Article Model-informed COVID-19 vaccine prioritization strategies by age and serostatus.
Academic Article Model-informed COVID-19 vaccine prioritization strategies by age and serostatus.
Academic Article Lineage-specific protection and immune imprinting shape the age distributions of influenza B cases.
Academic Article Incorporating temporal distribution of population-level viral load enables real-time estimation of COVID-19 transmission.
Academic Article Modeling comparative cost-effectiveness of SARS-CoV-2 vaccine dose fractionation in India.
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  • Modeling