Loading...
The University of Chicago Header Logo
Keywords
Last Name
Institution

Connection

Search Results to John Reinitz

This is a "connection" page, showing the details of why an item matched the keywords from your search.

                     
                     

One or more keywords matched the following properties of Reinitz, John

PropertyValue
overview My laboratory is engaged in a long term project to understand how DNA sequence specifies biological form. We are interested not only in the specification of typical form by a typical genome, but also in the effects of variability. Such variability might take the form of genetic variation in a population or intrinsic fluctuations in an individual. These problems touch on issues central to developmental and evolutionary biology, and efforts to solve them have previously led to the development of new branches of mathematics. We consider these issues in the specific context of segment determination in the fruit fly Drosophila melanogaster, but actively seek collaborations with investigators working on other organisms or with pure theoreticians. The starting point for our own investigations are quantitative data on gene expression, extracted from images of confocally scanned fixed or living embryos. We use this numerical information to find parameter sets for specific models of fundamental processes of gene regulation and pattern formation by means of large scale optimization procedures performed on parallel computers. These models may be specified in terms of DNA sequence or be more coarse-grained. They might take the form of a dynamical system, deterministic or stochastic, or simply be a complex but explicit mathematical function. Our goal is to use every tool in the toolbox—wet experiments, statistics, computational science, and mathematics—to solve a well focused scientific problem: how does a fly go from DNA sequence to a fate map of presumptive segments at single cell resolution?

One or more keywords matched the following items that are connected to Reinitz, John

Item TypeName
Concept Pattern Recognition, Automated
Concept Body Patterning
Academic Article Mechanism of eve stripe formation.
Academic Article Registration of the expression patterns of Drosophila segmentation genes by two independent methods.
Academic Article Spatio-temporal registration of the expression patterns of Drosophila segmentation genes.
Academic Article Prediction of mutant expression patterns using gene circuits.
Academic Article Transcriptional repression by the Drosophila giant protein: cis element positioning provides an alternative means of interpreting an effector gradient.
Academic Article Bicoid cooperative DNA binding is critical for embryonic patterning in Drosophila.
Academic Article Characterization of the Drosophila segment determination morphome.
Academic Article Temporal classification of Drosophila segmentation gene expression patterns by the multi-valued neural recognition method.
Academic Article Dynamic control of positional information in the early Drosophila embryo.
Academic Article A method for two-dimensional registration and construction of the two-dimensional atlas of gene expression patterns in situ.
Academic Article A database for management of gene expression data in situ.
Academic Article Removal of background signal from in situ data on the expression of segmentation genes in Drosophila.
Academic Article Turing centenary: Pattern formation.
Academic Article Stripe forming architecture of the gap gene system.
Academic Article Thoracic patterning by the Drosophila gap gene hunchback.
Academic Article Canalization of gene expression and domain shifts in the Drosophila blastoderm by dynamical attractors.
Academic Article Canalization of gene expression in the Drosophila blastoderm by gap gene cross regulation.
Academic Article Size regulation in the segmentation of Drosophila: interacting interfaces between localized domains of gene expression ensure robust spatial patterning.
Academic Article Quantitative dynamics and increased variability of segmentation gene expression in the Drosophila Krüppel and knirps mutants.
Academic Article Support vector regression applied to the determination of the developmental age of a Drosophila embryo from its segmentation gene expression patterns.
Academic Article Developmental biology: a ten per cent solution.
Academic Article Drosophila blastoderm patterning.
Academic Article A synthetic biology approach to the development of transcriptional regulatory models and custom enhancer design.
Academic Article Natural variation of the expression pattern of the segmentation gene even-skipped in melanogaster.
Academic Article An in silico analysis of robust but fragile gene regulation links enhancer length to robustness.

Search Criteria
  • Pattern
  • Formation