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Search Results to Sarah London

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One or more keywords matched the following properties of London, Sarah

overview We still don’t know what properties of the brain promote and limit the ability to learn although behaviorally, we observe individual, sex, and age differences in the long-term effects of experience. Memory formation requires that two major levels of neurobiology are coordinated 1) the presence of a subset of cells, or "ensemble," that are capable of participating in memory storage and 2) the triggering of appropriate molecular and genomic changes in response to experience. The challenges of placing molecular underpinnings of neural plasticity within cell populations that are engaged in memory formation are compounded by the need to behaviorally link cellular and molecular brain properties to the ability to learn. In the London Lab, we take advantage of a model system that has a Critical Period for sensory learning, the zebra finch songbird, to discover how epigenetic mechanisms, genomic regulation, molecular signaling, and cell subtypes contribute to the ability to learn complex natural behaviors. Because Critical Periods define restricted phases in development when an experience is optimally encoded in ways that have long-term consequences on brain function and behavioral patterns, we can meaningfully link neural properties before, during, and after the Critical Period to behavioral outcomes.

One or more keywords matched the following items that are connected to London, Sarah

Item TypeName
Concept Finches
Academic Article Social information embedded in vocalizations induces neurogenomic and behavioral responses.
Academic Article RNA-seq transcriptome analysis of male and female zebra finch cell lines.
Academic Article Steroidogenic enzymes along the ventricular proliferative zone in the developing songbird brain.
Academic Article A complex mTOR response in habituation paradigms for a social signal in adult songbirds.
Academic Article A reliable and flexible gene manipulation strategy in posthatch zebra finch brain.
Academic Article Neural expression and post-transcriptional dosage compensation of the steroid metabolic enzyme 17beta-HSD type 4.
Academic Article Developmental shifts in gene expression in the auditory forebrain during the sensitive period for song learning.
Academic Article Functional identification of sensory mechanisms required for developmental song learning.
Academic Article Developmental song learning as a model to understand neural mechanisms that limit and promote the ability to learn.
Academic Article Bidirectional manipulation of mTOR signaling disrupts socially mediated vocal learning in juvenile songbirds.
Academic Article The genome of a songbird.
Academic Article Genomic and neural analysis of the estradiol-synthetic pathway in the zebra finch.
Academic Article Epigenetic regulation of transcriptional plasticity associated with developmental song learning.
Academic Article The zebra finch neuropeptidome: prediction, detection and expression.
Academic Article Integrating genomes, brain and behavior in the study of songbirds.
Academic Article Cloning of the zebra finch androgen synthetic enzyme CYP17: a study of its neural expression throughout posthatch development.
Academic Article Proteomic analyses of zebra finch optic tectum and comparative histochemistry.
Academic Article Proteomic analyses of songbird (Zebra finch; Taeniopygia guttata) retina.
Academic Article Interhemispheric functional connectivity in the zebra finch brain, absent the corpus callosum in normal ontogeny.
Academic Article The variability of song variability in zebra finch (Taeniopygia guttata) populations.
Academic Article Inhibitory cell populations depend on age, sex, and prior experience across a neural network for Critical Period learning.

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