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Gardel, Margaret
One or more keywords matched the following properties of Gardel, Margaret
PropertyValue
keywords Cytoskeleton, Actin
overview My lab is dedicated to understanding how cell adhesion and migration is regulated by the physical behaviors and structure of the actin cytoskeleton, focal adhesions and cell-cell adhesions and how the physical behaviors of complex cytoskeletal machines emerge from their molecular constituents. We employ approaches from condensed matter physics, cell biology and biochemistry to study the physical properties of the actin cytoskeleton and focal adhesions within live cells and in reconstituted systems of purified proteins.
One or more keywords matched the following items that are connected to Gardel, Margaret
Item TypeName
Concept Actins
Concept Actin Cytoskeleton
Concept Actin Capping Proteins
Concept Actin-Related Protein 2-3 Complex
Concept Actin Depolymerizing Factors
Academic Article Assembly kinetics determine the architecture of a-actinin crosslinked F-actin networks.
Academic Article Identification and characterization of a small molecule inhibitor of formin-mediated actin assembly.
Academic Article Actin assembly factors regulate the gelation kinetics and architecture of F-actin networks.
Academic Article Myosin II-mediated focal adhesion maturation is tension insensitive.
Academic Article Distribution of directional change as a signature of complex dynamics.
Academic Article Optogenetic control of RhoA reveals zyxin-mediated elasticity of stress fibres.
Academic Article Epithelial rotation promotes the global alignment of contractile actin bundles during Drosophila egg chamber elongation.
Academic Article Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination.
Academic Article Filament turnover tunes both force generation and dissipation to control long-range flows in a model actomyosin cortex.
Academic Article Model for adhesion clutch explains biphasic relationship between actin flow and traction at the cell leading edge.
Academic Article Isoforms Confer Characteristic Force Generation and Mechanosensation by Myosin II Filaments.
Academic Article Reconstitution of contractile actomyosin arrays.
Academic Article Shear thickening of F-actin networks crosslinked with non-muscle myosin IIB.
Academic Article Dynamic and structural signatures of lamellar actomyosin force generation.
Academic Article Mechanical integration of actin and adhesion dynamics in cell migration.
Academic Article Biophysics. Clutch dynamics.
Academic Article When Is "Enough" Enough?
Academic Article Contact guidance requires spatial control of leading-edge protrusion.
Academic Article Actomyosin sliding is attenuated in contractile biomimetic cortices.
Academic Article Self-organization of myosin II in reconstituted actomyosin bundles.
Academic Article Spatiotemporal constraints on the force-dependent growth of focal adhesions.
Academic Article Stress-dependent elasticity of composite actin networks as a model for cell behavior.
Academic Article Mechanical hysteresis in actin networks.
Academic Article Dia1-dependent adhesions are required by epithelial tissues to initiate invasion.
Academic Article Liquid behavior of cross-linked actin bundles.
Academic Article Actin Mechanics and Fragmentation.
Academic Article Arp2/3 inhibition induces amoeboid-like protrusions in MCF10A epithelial cells by reduced cytoskeletal-membrane coupling and focal adhesion assembly.
Academic Article Thick filament length and isoform composition determine self-organized contractile units in actomyosin bundles.
Academic Article Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed.
Academic Article Partitioning and Enhanced Self-Assembly of Actin in Polypeptide Coacervates.
Academic Article Interplay of structure, elasticity, and dynamics in actin-based nematic materials.
Academic Article Filament rigidity and connectivity tune the deformation modes of active biopolymer networks.
Academic Article Model-based traction force microscopy reveals differential tension in cellular actin bundles.
Academic Article Determinants of fluidlike behavior and effective viscosity in cross-linked actin networks.
Academic Article F-actin buckling coordinates contractility and severing in a biomimetic actomyosin cortex.
Academic Article Contractile units in disordered actomyosin bundles arise from F-actin buckling.
Academic Article United we stand: integrating the actin cytoskeleton and cell-matrix adhesions in cellular mechanotransduction.
Academic Article Tension is required but not sufficient for focal adhesion maturation without a stress fiber template.
Academic Article A zyxin-mediated mechanism for actin stress fiber maintenance and repair.
Academic Article Conserved F-actin dynamics and force transmission at cell adhesions.
Academic Article Mechanics of the F-actin cytoskeleton.
Academic Article Chapter 19: Mechanical response of cytoskeletal networks.
Academic Article Prestressed F-actin networks cross-linked by hinged filamins replicate mechanical properties of cells.
Academic Article Scaling of F-actin network rheology to probe single filament elasticity and dynamics.
Academic Article Elastic behavior of cross-linked and bundled actin networks.
Academic Article Anomalous diffusion probes microstructure dynamics of entangled F-actin networks.
Academic Article Colloid surface chemistry critically affects multiple particle tracking measurements of biomaterials.
Academic Article Relating microstructure to rheology of a bundled and cross-linked F-actin network in vitro.
Academic Article Microrheology of entangled F-actin solutions.
Academic Article Self-organizing motors divide active liquid droplets.
Academic Article Cofilin drives rapid turnover and fluidization of entangled F-actin.
Academic Article Stress relaxation in F-actin solutions by severing.
Academic Article Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-bundling protein.
Academic Article Tuning shape and internal structure of protein droplets via biopolymer filaments.
Academic Article Evolutionarily diverse LIM domain-containing proteins bind stressed actin filaments through a conserved mechanism.
Academic Article The Actin Cytoskeleton as an Active Adaptive Material.
Academic Article Spatiotemporal control of liquid crystal structure and dynamics through activity patterning.
Academic Article Actin bundle architecture and mechanics regulate myosin II force generation.
Academic Article Actin filament alignment causes mechanical hysteresis in cross-linked networks.
Academic Article LIM domain proteins in cell mechanobiology.
Academic Article Dia1 coordinates differentiation and cell sorting in a stratified epithelium.
Academic Article Quantifying Strain-Sensing Protein Recruitment During Stress Fiber Repair.
Academic Article TES-1/Tes and ZYX-1/Zyxin protect junctional actin networks under tension during epidermal morphogenesis in the C. elegans embryo.
Grant Therapeutic Potentiation of Bronchial Dilatation
Grant Mechanical Regulation of Cell Adhesion by Dynamic Cytoskeletal Assemblies
Academic Article Author Correction: Membrane tension induces F-actin reorganization and flow in a biomimetic model cortex.
Academic Article Membrane tension induces F-actin reorganization and flow in a biomimetic model cortex.
Academic Article Limiting Pool and Actin Architecture Controls Myosin Cluster Sizes in Adherent Cells.
Academic Article Cracked actin filaments as mechanosensitive receptors.
Academic Article Measuring response functions of active materials from data.
Academic Article Reconstitution of the transition from a lamellipodia- to filopodia-like actin network with purified proteins.
Academic Article Limiting pool and actin architecture controls myosin cluster sizes in adherent cells.
Academic Article Highly flexible PEG-LifeAct constructs act as tunable biomimetic actin crosslinkers.
Search Criteria
  • Actins