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Gardel, Margaret
One or more keywords matched the following properties of Gardel, Margaret
PropertyValue
keywords Cell Mechanics
keywords Adhesion, Cell
keywords Migration, Cell
overview My lab is dedicated to understanding how cell adhesion and migration is regulated by the physical behaviors and structure of the actin cytoskeleton, focal adhesions and cell-cell adhesions and how the physical behaviors of complex cytoskeletal machines emerge from their molecular constituents. We employ approaches from condensed matter physics, cell biology and biochemistry to study the physical properties of the actin cytoskeleton and focal adhesions within live cells and in reconstituted systems of purified proteins.
One or more keywords matched the following items that are connected to Gardel, Margaret
Item TypeName
Concept Cell Communication
Concept Cell Differentiation
Concept Cell Movement
Concept Cell Membrane
Concept Cell Division
Concept Cells
Concept Cell Adhesion
Concept Cell Cycle
Concept Epithelial Cells
Concept Cell Biology
Concept HeLa Cells
Concept Cell Culture Techniques
Concept Tumor Cells, Cultured
Concept Cell Adhesion Molecules
Concept 3T3 Cells
Concept Cell Proliferation
Concept Embryonic Stem Cells
Concept NIH 3T3 Cells
Concept Caco-2 Cells
Concept Cell-Matrix Junctions
Concept Cell Surface Extensions
Concept Human Umbilical Vein Endothelial Cells
Concept Cell Polarity
Concept Endothelial Cells
Concept Cell Line, Tumor
Concept Cell Shape
Concept Cell Line
Concept Cell Survival
Concept Cells, Cultured
Academic Article Endothelial barrier disruption and recovery is controlled by substrate stiffness.
Academic Article Identification and characterization of a small molecule inhibitor of formin-mediated actin assembly.
Academic Article Myosin II-mediated focal adhesion maturation is tension insensitive.
Academic Article Attenuation of lipopolysaccharide-induced lung vascular stiffening by lipoxin reduces lung inflammation.
Academic Article Optogenetic control of RhoA reveals zyxin-mediated elasticity of stress fibres.
Academic Article Epithelial rotation promotes the global alignment of contractile actin bundles during Drosophila egg chamber elongation.
Academic Article Desmosomal cadherin association with Tctex-1 and cortactin-Arp2/3 drives perijunctional actin polymerization to promote keratinocyte delamination.
Academic Article Forcing cells into shape: the mechanics of actomyosin contractility.
Academic Article Model for adhesion clutch explains biphasic relationship between actin flow and traction at the cell leading edge.
Academic Article Dynamic and structural signatures of lamellar actomyosin force generation.
Academic Article Regulation of cell motile behavior by crosstalk between cadherin- and integrin-mediated adhesions.
Academic Article Optimization of traction force microscopy for micron-sized focal adhesions.
Academic Article Mechanical integration of actin and adhesion dynamics in cell migration.
Academic Article Biophysics. Clutch dynamics.
Academic Article High resolution traction force microscopy based on experimental and computational advances.
Academic Article Probing intracellular force distributions by high-resolution live cell imaging and inverse dynamics.
Academic Article When Is "Enough" Enough?
Academic Article Contact guidance requires spatial control of leading-edge protrusion.
Academic Article Actomyosin sliding is attenuated in contractile biomimetic cortices.
Academic Article Living matter--nexus of physics and biology in the 21st century.
Academic Article Spatiotemporal constraints on the force-dependent growth of focal adhesions.
Academic Article CD98hc (SLC3A2) participates in fibronectin matrix assembly by mediating integrin signaling.
Academic Article Stress-dependent elasticity of composite actin networks as a model for cell behavior.
Academic Article Lamellipodium is a myosin-independent mechanosensor.
Academic Article Dia1-dependent adhesions are required by epithelial tissues to initiate invasion.
Academic Article Cholesterol depletion impairs contractile machinery in neonatal rat cardiomyocytes.
Academic Article Geometry regulates traction stresses in adherent cells.
Academic Article Stressing the limits of focal adhesion mechanosensitivity.
Academic Article Arp2/3 inhibition induces amoeboid-like protrusions in MCF10A epithelial cells by reduced cytoskeletal-membrane coupling and focal adhesion assembly.
Academic Article Stiffness-controlled three-dimensional extracellular matrices for high-resolution imaging of cell behavior.
Academic Article Cell-ECM traction force modulates endogenous tension at cell-cell contacts.
Academic Article Preparation of complaint matrices for quantifying cellular contraction.
Academic Article Local cortical tension by myosin II guides 3D endothelial cell branching.
Academic Article Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed.
Academic Article Model-based traction force microscopy reveals differential tension in cellular actin bundles.
Academic Article Moving beyond molecular mechanisms.
Academic Article Cutting through the noise: the mechanics of intracellular transport.
Academic Article Protrusive activity guides changes in cell-cell tension during epithelial cell scattering.
Academic Article F-actin buckling coordinates contractility and severing in a biomimetic actomyosin cortex.
Academic Article United we stand: integrating the actin cytoskeleton and cell-matrix adhesions in cellular mechanotransduction.
Academic Article Tension is required but not sufficient for focal adhesion maturation without a stress fiber template.
Academic Article Cell-substrate interactions.
Academic Article A zyxin-mediated mechanism for actin stress fiber maintenance and repair.
Academic Article Conserved F-actin dynamics and force transmission at cell adhesions.
Academic Article Chapter 19: Mechanical response of cytoskeletal networks.
Academic Article PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility.
Academic Article Force localization modes in dynamic epithelial colonies.
Academic Article Prestressed F-actin networks cross-linked by hinged filamins replicate mechanical properties of cells.
Academic Article Margaret Gardel: at the interface of physics and biology. Interview by Caitlin Sedwick.
Academic Article Measuring the mechanical stress induced by an expanding multicellular tumor system: a case study.
Academic Article Editorial overview: Cell architecture.
Academic Article Self-organizing motors divide active liquid droplets.
Academic Article High throughput discovery of functional protein modifications by Hotspot Thermal Profiling.
Academic Article Mechanosensitive Junction Remodeling Promotes Robust Epithelial Morphogenesis.
Academic Article RhoA Mediates Epithelial Cell Shape Changes via Mechanosensitive Endocytosis.
Academic Article Optogenetic Control of RhoA to Probe Subcellular Mechanochemical Circuitry.
Academic Article Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-bundling protein.
Academic Article Adaptive viscoelasticity of epithelial cell junctions: from models to methods.
Academic Article Caveolae Spelunking: Exploring a New Modality in Tensional Homeostasis.
Academic Article Evolutionarily diverse LIM domain-containing proteins bind stressed actin filaments through a conserved mechanism.
Academic Article Cell cycle-dependent active stress drives epithelia remodeling.
Academic Article LIM domain proteins in cell mechanobiology.
Academic Article Dia1 coordinates differentiation and cell sorting in a stratified epithelium.
Academic Article Force-dependent intercellular adhesion strengthening underlies asymmetric adherens junction contraction.
Academic Article Confluence and tight junction dependence of volume regulation in epithelial tissue.
Concept Madin Darby Canine Kidney Cells
Grant Mechanical Regulation of Cell Adhesion by Dynamic Cytoskeletal Assemblies
Grant 2007 NIH Director's Pioneer Award Program (DP1)
Academic Article Zyxin is all you need: machine learning adherent cell mechanics.
Academic Article Limiting Pool and Actin Architecture Controls Myosin Cluster Sizes in Adherent Cells.
Academic Article Epithelial tissue confinement inhibits cell growth and leads to volume-reducing divisions.
Academic Article Reconstitution of the transition from a lamellipodia- to filopodia-like actin network with purified proteins.
Academic Article Limiting pool and actin architecture controls myosin cluster sizes in adherent cells.
Academic Article Machine learning interpretable models of cell mechanics from protein images.
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