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One or more keywords matched the following properties of Gardel, Margaret
keywords Cytoskeleton, Actin
overview My lab is dedicated to understanding how cell adhesion and migration is regulated by the physical behaviors and structure of the actin cytoskeleton, focal adhesions and cell-cell adhesions and how the physical behaviors of complex cytoskeletal machines emerge from their molecular constituents. We employ approaches from condensed matter physics, cell biology and biochemistry to study the physical properties of the actin cytoskeleton and focal adhesions within live cells and in reconstituted systems of purified proteins.
One or more keywords matched the following items that are connected to Gardel, Margaret
Item TypeName
Concept Cytoskeleton
Concept Actin Cytoskeleton
Academic Article Identification and characterization of a small molecule inhibitor of formin-mediated actin assembly.
Academic Article Actin assembly factors regulate the gelation kinetics and architecture of F-actin networks.
Academic Article Distribution of directional change as a signature of complex dynamics.
Academic Article Optogenetic control of RhoA reveals zyxin-mediated elasticity of stress fibres.
Academic Article Filament turnover tunes both force generation and dissipation to control long-range flows in a model actomyosin cortex.
Academic Article Model for adhesion clutch explains biphasic relationship between actin flow and traction at the cell leading edge.
Academic Article Isoforms Confer Characteristic Force Generation and Mechanosensation by Myosin II Filaments.
Academic Article Biophysics. Clutch dynamics.
Academic Article When Is "Enough" Enough?
Academic Article Living matter--nexus of physics and biology in the 21st century.
Academic Article Self-organization of myosin II in reconstituted actomyosin bundles.
Academic Article Liquid behavior of cross-linked actin bundles.
Academic Article Actin Mechanics and Fragmentation.
Academic Article Stressing the limits of focal adhesion mechanosensitivity.
Academic Article Arp2/3 inhibition induces amoeboid-like protrusions in MCF10A epithelial cells by reduced cytoskeletal-membrane coupling and focal adhesion assembly.
Academic Article Thick filament length and isoform composition determine self-organized contractile units in actomyosin bundles.
Academic Article Partitioning and Enhanced Self-Assembly of Actin in Polypeptide Coacervates.
Academic Article Interplay of structure, elasticity, and dynamics in actin-based nematic materials.
Academic Article Filament rigidity and connectivity tune the deformation modes of active biopolymer networks.
Academic Article Model-based traction force microscopy reveals differential tension in cellular actin bundles.
Academic Article Determinants of fluidlike behavior and effective viscosity in cross-linked actin networks.
Academic Article F-actin buckling coordinates contractility and severing in a biomimetic actomyosin cortex.
Academic Article United we stand: integrating the actin cytoskeleton and cell-matrix adhesions in cellular mechanotransduction.
Academic Article Tension is required but not sufficient for focal adhesion maturation without a stress fiber template.
Academic Article A zyxin-mediated mechanism for actin stress fiber maintenance and repair.
Academic Article Mechanics of the F-actin cytoskeleton.
Academic Article Chapter 19: Mechanical response of cytoskeletal networks.
Academic Article Margaret Gardel: at the interface of physics and biology. Interview by Caitlin Sedwick.
Academic Article Scaling of F-actin network rheology to probe single filament elasticity and dynamics.
Academic Article Elastic behavior of cross-linked and bundled actin networks.
Academic Article Anomalous diffusion probes microstructure dynamics of entangled F-actin networks.
Academic Article Relating microstructure to rheology of a bundled and cross-linked F-actin network in vitro.
Academic Article Microrheology of entangled F-actin solutions.
Academic Article Self-organizing motors divide active liquid droplets.
Academic Article Cofilin drives rapid turnover and fluidization of entangled F-actin.
Academic Article Stress relaxation in F-actin solutions by severing.
Academic Article Tuning molecular motor transport through cytoskeletal filament network organization.
Academic Article Dynamin regulates the dynamics and mechanical strength of the actin cytoskeleton as a multifilament actin-bundling protein.
Academic Article Tuning shape and internal structure of protein droplets via biopolymer filaments.
Academic Article The Actin Cytoskeleton as an Active Adaptive Material.
Academic Article Spatiotemporal control of liquid crystal structure and dynamics through activity patterning.
Academic Article Actin bundle architecture and mechanics regulate myosin II force generation.
Academic Article Actin filament alignment causes mechanical hysteresis in cross-linked networks.
Academic Article LIM domain proteins in cell mechanobiology.
Academic Article Quantifying Strain-Sensing Protein Recruitment During Stress Fiber Repair.
Grant 2007 NIH Director's Pioneer Award Program (DP1)
Academic Article Membrane tension induces F-actin reorganization and flow in a biomimetic model cortex.
Academic Article Measuring response functions of active materials from data.
Academic Article Reconstitution of the transition from a lamellipodia- to filopodia-like actin network with purified proteins.
Academic Article Limiting pool and actin architecture controls myosin cluster sizes in adherent cells.
Academic Article Highly flexible PEG-LifeAct constructs act as tunable biomimetic actin crosslinkers.
Academic Article Motor crosslinking augments elasticity in active nematics.
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