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overview How our brain is developed and evolved remains a major question, and abnormal development of the human brain can cause autism, epilepsy and intellectual disability. We study fundamental mechanisms of brain development and disorders, and our specific interests include: tracing cell types and lineages in mammalian brains, genetic mechanisms of neuronal type specification, and roles of mRNA isoform diversity in neural development and diseases. We develop and apply single-cell approaches, animal models, and functional genomics to address these questions.

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  • Intellectual Disability