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Barreiro, Luis

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overview	Our lab aims to understand how natural selection has contributed to the evolution of our species and to which extent past selection events impact present-day susceptibility to disease. Specifically, our group studies the genetic basis of differences in immune response among different individuals and human populations as well as the phenotypic evolution of immune responses in primates. Most projects in the lab are multidisciplinary and combine the use of cutting edge genomic techniques with immunological and evolutionary genetic tools.

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overview

Our lab aims to understand how natural selection has contributed to the evolution of our species and to which extent past selection events impact present-day susceptibility to disease. Specifically, our group studies the genetic basis of differences in immune response among different individuals and human populations as well as the phenotypic evolution of immune responses in primates. Most projects in the lab are multidisciplinary and combine the use of cutting edge genomic techniques with immunological and evolutionary genetic tools.

One or more keywords matched the following items that are connected to Barreiro, Luis

Item Type	Name
Concept	Chromosomes, Human, Pair 8
Concept	Chromosomes, Human, Pair 14
Concept	Influenza, Human
Concept	Humans
Concept	Herpesvirus 1, Human
Concept	Genome, Human
Concept	Chromosomes, Human
Academic Article	Integration of genetic and immunological insights into a model of celiac disease pathogenesis.
Academic Article	Functional comparison of innate immune signaling pathways in primates.
Academic Article	Don't move: LRRK2 arrests NFAT in the cytoplasm.
Academic Article	Deciphering the genetic architecture of variation in the immune response to Mycobacterium tuberculosis infection.
Academic Article	Human NKG2E is expressed and forms an intracytoplasmic complex with CD94 and DAP12.
Academic Article	Different selective pressures shape the evolution of Toll-like receptors in human and African great ape populations.
Academic Article	Adaptive, convergent origins of the pygmy phenotype in African rainforest hunter-gatherers.
Academic Article	Seasonal variation in human gut microbiome composition.
Academic Article	Genome-Wide Association Studies of the Human Gut Microbiota.
Academic Article	Mycobacterial infection induces a specific human innate immune response.
Academic Article	Bacterial infection remodels the DNA methylation landscape of human dendritic cells.
Academic Article	The epigenomic landscape of African rainforest hunter-gatherers and farmers.
Academic Article	Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease.
Academic Article	Molecular identification of two genotypes of mumps virus causing two regional outbreaks in Asturias, Spain.
Academic Article	Evolutionary genetics evidence of an essential, nonredundant role of the IFN-? pathway in protective immunity.
Academic Article	Evolutionary genetic dissection of human interferons.
Academic Article	Promoter and neck region length variation of DC-SIGN is not associated with susceptibility to tuberculosis in Tunisian patients.
Academic Article	Inferring the demographic history of African farmers and pygmy hunter-gatherers using a multilocus resequencing data set.
Academic Article	The contribution of admixture to primate evolution.
Academic Article	The heritage of pathogen pressures and ancient demography in the human innate-immunity CD209/CD209L region.
Academic Article	DC-SIGNR neck-region polymorphisms and HIV-1 susceptibility: From population stratification to a possible advantage of the 7/5 heterozygous genotype.
Academic Article	The macrophage IRF8/IRF1 regulome is required for protection against infections and is associated with chronic inflammation.
Academic Article	Signature-tagged transposon mutagenesis identifies novel Mycobacterium tuberculosis genes involved in the parasitism of human macrophages.
Academic Article	Alu repeats as transcriptional regulatory platforms in macrophage responses to M. tuberculosis infection.
Academic Article	Dispersals and genetic adaptation of Bantu-speaking populations in Africa and North America.
Academic Article	Natural selection has driven population differentiation in modern humans.
Academic Article	Lack of association between genetic polymorphisms in enzymes associated with folate metabolism and unexplained reduced sperm counts.
Academic Article	From evolutionary genetics to human immunology: how selection shapes host defence genes.
Academic Article	The demographic history and mutational load of African hunter-gatherers and farmers.
Academic Article	Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family.
Academic Article	Reservoir host immune responses to emerging zoonotic viruses.
Academic Article	DC-SIGN interacts with Mycobacterium leprae but sequence variation in this lectin is not associated with leprosy in the Pakistani population.
Academic Article	Holy Immune Tolerance, Batman!
Academic Article	The role played by natural selection on Mendelian traits in humans.
Academic Article	Extracellular adenosine triphosphate affects the response of human macrophages infected with Mycobacterium tuberculosis.
Academic Article	Formulating a historical and demographic model of recent human evolution based on resequencing data from noncoding regions.
Academic Article	The contribution of natural selection to present-day susceptibility to chronic inflammatory and autoimmune disease.
Academic Article	Social networks predict gut microbiome composition in wild baboons.
Academic Article	TLR3 deficiency in patients with herpes simplex encephalitis.
Academic Article	Editorial Overview: immunogenetics and transplantation: bringing evolution and genomics to human immunology.
Academic Article	Gene set signature of reversal reaction type I in leprosy patients.
Academic Article	Exploring the occurrence of classic selective sweeps in humans using whole-genome sequencing data sets.
Academic Article	Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense.
Academic Article	Genetic and evolutionary determinants of human population variation in immune responses.
Academic Article	When genetics meets epigenetics: deciphering the mechanisms controlling inter-individual variation in immune responses to infection.
Academic Article	Genetic and transcriptional analysis of human host response to healthy gut microbiota.
Academic Article	Protective role of DC-SIGN (CD209) neck-region alleles with <5 repeat units in HIV-1 transmission.
Academic Article	Characterizing 5-hydroxymethylcytosine in human prefrontal cortex at single base resolution.
Academic Article	Age-dependent association between pulmonary tuberculosis and common TOX variants in the 8q12-13 linkage region.
Academic Article	A genomic portrait of the genetic architecture and regulatory impact of microRNA expression in response to infection.
Academic Article	Length variation of DC-SIGN and L-SIGN neck-region has no impact on tuberculosis susceptibility.
Academic Article	Annexin1 regulates DC efferocytosis and cross-presentation during Mycobacterium tuberculosis infection.
Academic Article	Social status alters immune regulation and response to infection in macaques.
Academic Article	High-throughput SNP genotyping: combining tag SNPs and molecular beacons.
Academic Article	Deciphering the genetic control of gene expression following Mycobacterium leprae antigen stimulation.
Academic Article	Genetic regulatory effects modified by immune activation contribute to autoimmune disease associations.
Academic Article	Promoter variation in the DC-SIGN-encoding gene CD209 is associated with tuberculosis.
Academic Article	Signatures of purifying and local positive selection in human miRNAs.
Academic Article	bacterial infection drives the expression dynamics of microRNAs and their isomiRs.
Academic Article	Evolutionary insights into the high worldwide prevalence of MBL2 deficiency alleles.
Academic Article	Polygenic adaptation and convergent evolution on growth and cardiac genetic pathways in African and Asian rainforest hunter-gatherers.
Academic Article	Evolution of the TIR domain-containing adaptors in humans: swinging between constraint and adaptation.
Academic Article	Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans.
Academic Article	Predicting susceptibility to tuberculosis based on gene expression profiling in dendritic cells.
Academic Article	Deciphering the ancient and complex evolutionary history of human arylamine N-acetyltransferase genes.
Academic Article	Genome-wide quantification of the effects of DNA methylation on human gene regulation.
Academic Article	Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease.
Academic Article	Molecular Signature of CAID Syndrome: Noncanonical Roles of SGO1 in Regulation of TGF-ß Signaling and Epigenomics.
Academic Article	Gene activation precedes DNA demethylation in response to infection in human dendritic cells.
Academic Article	Natural selection contributed to immunological differences between hunter-gatherers and agriculturalists.
Academic Article	Genomic Evidence for Local Adaptation of Hunter-Gatherers to the African Rainforest.
Academic Article	Identification of a ?c Receptor Antagonist That Prevents Reprogramming of Human Tissue-resident Cytotoxic T Cells by IL15 and IL21.
Academic Article	Efficient and Robust NK-Cell Transduction With Baboon Envelope Pseudotyped Lentivector.
Academic Article	IL-15, gluten and HLA-DQ8 drive tissue destruction in coeliac disease.
Academic Article	Transposable elements have contributed human regulatory regions that are activated upon bacterial infection.
Academic Article	Defining trained immunity and its role in health and disease.
Academic Article	The epigenetically-encoded memory of the innate immune system.
Academic Article	GHRH proliferative action on somatotrophs is cell-type specific and dependent on Pit-1/GHF-1 expression.
Academic Article	Evolutionary and population (epi)genetics of immunity to infection.
Academic Article	Fecal microbiota transplant rescues mice from human pathogen mediated sepsis by restoring systemic immunity.
Academic Article	Herd Immunity: Understanding COVID-19.
Academic Article	Trained immunity, tolerance, priming and differentiation: distinct immunological processes.
Academic Article	Primate innate immune responses to bacterial and viral pathogens reveals an evolutionary trade-off between strength and specificity.
Academic Article	Gut microbiome heritability is nearly universal but environmentally contingent.
Academic Article	A multilayered immune system through the lens of unconventional T cells.
Academic Article	Alveolar macrophages from persons living with HIV show impaired epigenetic response to Mycobacterium tuberculosis.
Academic Article	A signature of Neanderthal introgression on molecular mechanisms of environmental responses.
Academic Article	Genetic ancestry effects on the response to viral infection are pervasive but cell type specific.
Academic Article	High molecular weight DNA extraction strategies for long-read sequencing of complex metagenomes.
Academic Article	Synchrony and idiosyncrasy in the gut microbiome of wild baboons.
Academic Article	Mitochondrial cyclophilin D promotes disease tolerance by licensing NK cell development and IL-22 production against influenza virus.
Academic Article	Aberrant T-cell exhaustion in severe combined immunodeficiency survivors with poor T-cell reconstitution after transplantation.
Academic Article	GATA4 controls regionalization of tissue immunity and commensal-driven immunopathology.
Academic Article	Evolution of immune genes is associated with the Black Death.
Academic Article	Human alveolar macrophage metabolism is compromised during Mycobacterium tuberculosis infection.
Concept	Human Migration
Grant	Stress and the Genome: Testing the Impact of Social Effects on Gene Regulation
Grant	Stress and the Genome: Testing the Impact of Social Effects on Gene Regulation
Grant	Characterizing the impact of Yersinia Pestis to the phenotypic evolution of the human immune system
Academic Article	[The Black Death, natural selection and susceptibility to auto-immune disorders].
Academic Article	Universal gut microbial relationships in the gut microbiome of wild baboons.
Academic Article	Genome graphs detect human polymorphisms in active epigenomic state during influenza infection.
Academic Article	DNA methylation-environment interactions in the human genome.
Academic Article	Antigen-driven colonic inflammation is associated with development of dysplasia in primary sclerosing cholangitis.
Academic Article	The evolutionary tale of lactase persistence in humans.
Academic Article	Mycobacterium tuberculosis infection drives differential responses in the bone marrow hematopoietic stem and progenitor cells.
Academic Article	BCG vaccination impacts the epigenetic landscape of progenitor cells in human bone marrow.
Academic Article	Developmental role of macrophages modeled in human pluripotent stem cell-derived intestinal tissue.
Academic Article	Microbial transmission in the social microbiome and host health and disease.
Academic Article	Epigenetic variation impacts individual differences in the transcriptional response to influenza infection.
Academic Article	DNA methylation-environment interactions in the human genome.
Academic Article	EpiVar Browser: advanced exploration of epigenomics data under controlled access.
Academic Article	Alendronate modulates cytokine responses in healthy young individuals after BCG vaccination.
Academic Article	Shaping immunity: The influence of natural selection on population immune diversity.
Grant	Genetic variation of N6-methyladenosine (m6A) RNA modification in immune cells and its contribution to human diseases
Academic Article	A host-directed oxadiazole compound potentiates antituberculosis treatment via zinc poisoning in human macrophages and in a mouse model of infection.
Academic Article	Sustained IFN signaling is associated with delayed development of SARS-CoV-2-specific immunity.
Academic Article	BCG vaccination alters the epigenetic landscape of progenitor cells in human bone marrow to influence innate immune responses.

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Humans