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Search Results to Luis Barreiro

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One or more keywords matched the following properties of Barreiro, Luis

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keywords Functional Genomics, Population Genetics, Natural Selection, Innate Immunity, Population Variation
overview Our lab aims to understand how natural selection has contributed to the evolution of our species and to which extent past selection events impact present-day susceptibility to disease. Specifically, our group studies the genetic basis of differences in immune response among different individuals and human populations as well as the phenotypic evolution of immune responses in primates. Most projects in the lab are multidisciplinary and combine the use of cutting edge genomic techniques with immunological and evolutionary genetic tools.

One or more keywords matched the following items that are connected to Barreiro, Luis

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Concept Selection, Genetic
Academic Article Different selective pressures shape the evolution of Toll-like receptors in human and African great ape populations.
Academic Article Adaptive, convergent origins of the pygmy phenotype in African rainforest hunter-gatherers.
Academic Article Evolutionary genetics evidence of an essential, nonredundant role of the IFN-? pathway in protective immunity.
Academic Article Evolutionary genetic dissection of human interferons.
Academic Article Natural selection has driven population differentiation in modern humans.
Academic Article From evolutionary genetics to human immunology: how selection shapes host defence genes.
Academic Article The role played by natural selection on Mendelian traits in humans.
Academic Article Formulating a historical and demographic model of recent human evolution based on resequencing data from noncoding regions.
Academic Article The contribution of natural selection to present-day susceptibility to chronic inflammatory and autoimmune disease.
Academic Article Exploring the occurrence of classic selective sweeps in humans using whole-genome sequencing data sets.
Academic Article Evolutionary dynamics of human Toll-like receptors and their different contributions to host defense.
Academic Article Genetic Ancestry and Natural Selection Drive Population Differences in Immune Responses to Pathogens.
Academic Article Signatures of purifying and local positive selection in human miRNAs.
Academic Article Evolution of the TIR domain-containing adaptors in humans: swinging between constraint and adaptation.
Academic Article Adaptively introgressed Neandertal haplotype at the OAS locus functionally impacts innate immune responses in humans.
Academic Article Natural selection contributed to immunological differences between hunter-gatherers and agriculturalists.
Academic Article Evolutionary and population (epi)genetics of immunity to infection.

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  • Selection Genetic