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overview Our lab is interested in how mechanotransduction affects endothelial cell phenotype. We recently discovered that oscillatory shear stress affects endothelial cell metabolism by turning on HIF-1alpha which turns up glycolytic pathways and suppresses mitochondrial function. This metabolic switch, induced by mechanical forces, is necessary for promoting endothelial inflammation. Currently, we are using novel FRET probes to investigate how modulating the actin cytoskeleton affects metabolism at the single cell level.

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