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Multimodal imaging of pancreatic beta cells in vivo by targeting transmembrane protein 27 (TMEM27).
Bace2 is a ? cell-enriched protease that regulates pancreatic ? cell function and mass.
Tmem27 dimerization, deglycosylation, plasma membrane depletion, and the extracellular Phe-Phe motif are negative regulators of cleavage by Bace2.