Item Type | Name |
Concept
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Iodide Peroxidase
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Academic Article
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Characterization of the nuclear factor-kappa B responsiveness of the human dio2 gene.
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Academic Article
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Neuronal hypoxia induces Hsp40-mediated nuclear import of type 3 deiodinase as an adaptive mechanism to reduce cellular metabolism.
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Academic Article
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Effects of rexinoids on thyrotrope function and the hypothalamic-pituitary-thyroid axis.
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Academic Article
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Triplets! Unexpected structural similarity among the three enzymes that catalyze initiation and termination of thyroid hormone effects.
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Academic Article
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Hypoxia-inducible factor induces local thyroid hormone inactivation during hypoxic-ischemic disease in rats.
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Academic Article
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Role of the type 2 iodothyronine deiodinase (D2) in the control of thyroid hormone signaling.
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Academic Article
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Coordination of hypothalamic and pituitary T3 production regulates TSH expression.
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Academic Article
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Type 2 deiodinase at the crossroads of thyroid hormone action.
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Academic Article
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Thyroxine 5'-deiodination mediates norepinephrine-induced lipogenesis in dispersed brown adipocytes.
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Academic Article
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Early Developmental Disruption of Type 2 Deiodinase Pathway in Mouse Skeletal Muscle Does Not Impair Muscle Function.
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Academic Article
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Adaptive activation of thyroid hormone and energy expenditure.
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Academic Article
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Type 2 iodothyronine selenodeiodinase is expressed throughout the mouse skeleton and in the MC3T3-E1 mouse osteoblastic cell line during differentiation.
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Academic Article
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The thyroid hormone-inactivating deiodinase functions as a homodimer.
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Academic Article
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The role of thyroid hormone and brown adipose tissue in energy homoeostasis.
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Academic Article
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A Common DIO2 Polymorphism and Alzheimer Disease Dementia in African and European Americans.
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Academic Article
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Thyroid Hormone Signaling in Male Mouse Skeletal Muscle Is Largely Independent of D2 in Myocytes.
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Academic Article
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Quantitation of brown adipose tissue perfusion in transgenic mice using near-infrared fluorescence imaging.
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Academic Article
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The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue.
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Academic Article
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Thyroid function disturbance and type 3 iodothyronine deiodinase induction after myocardial infarction in rats a time course study.
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Academic Article
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Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis.
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Academic Article
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Thyroid hormone activation by type 2 deiodinase mediates exercise-induced peroxisome proliferator-activated receptor-? coactivator-1a expression in skeletal muscle.
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Academic Article
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Regulation of thyroid hormone activation via the liver X-receptor/retinoid X-receptor pathway.
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Academic Article
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Selective proteolysis of human type 2 deiodinase: a novel ubiquitin-proteasomal mediated mechanism for regulation of hormone activation.
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Academic Article
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Cellular and molecular basis of deiodinase-regulated thyroid hormone signaling.
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Academic Article
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Induction of Type 2 Iodothyronine Deiodinase After Status Epilepticus Modifies Hippocampal Gene Expression in Male Mice.
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Academic Article
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The type 2 deiodinase A/G (Thr92Ala) polymorphism is associated with decreased enzyme velocity and increased insulin resistance in patients with type 2 diabetes mellitus.
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Academic Article
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Metabolic effects of thyroid hormones-beyond traditional prospects.
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Academic Article
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Ubc6p and ubc7p are required for normal and substrate-induced endoplasmic reticulum-associated degradation of the human selenoprotein type 2 iodothyronine monodeiodinase.
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Academic Article
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Deiodinases: implications of the local control of thyroid hormone action.
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Academic Article
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Substrate-induced down-regulation of human type 2 deiodinase (hD2) is mediated through proteasomal degradation and requires interaction with the enzyme's active center.
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Academic Article
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Mice with impaired extrathyroidal thyroxine to 3,5,3'-triiodothyronine conversion maintain normal serum 3,5,3'-triiodothyronine concentrations.
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Academic Article
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Thyroid hormone-related regulation of gene expression in human fatty liver.
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Academic Article
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Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity.
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Academic Article
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Bacterial lipopolysaccharide (LPS)-induced type 2 iodothyronine deiodinase (D2) activation in the mediobasal hypothalamus (MBH) is independent of the LPS-induced fall in serum thyroid hormone levels.
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Academic Article
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Atypical expression of type 2 iodothyronine deiodinase in thyrotrophs explains the thyroxine-mediated pituitary thyrotropin feedback mechanism.
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Academic Article
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Endoplasmic reticulum-associated degradation of the human type 2 iodothyronine deiodinase (D2) is mediated via an association between mammalian UBC7 and the carboxyl region of D2.
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Academic Article
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Inhibition of the type 2 iodothyronine deiodinase underlies the elevated plasma TSH associated with amiodarone treatment.
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Academic Article
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For some, L-thyroxine replacement might not be enough: a genetic rationale.
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Academic Article
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Tissue-specific inactivation of type 2 deiodinase reveals multilevel control of fatty acid oxidation by thyroid hormone in the mouse.
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Academic Article
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Maternal inheritance of an inactive type III deiodinase gene allele affects mouse pancreatic ß-cells and disrupts glucose homeostasis.
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Academic Article
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Absence of myocardial thyroid hormone inactivating deiodinase results in restrictive cardiomyopathy in mice.
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Academic Article
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Pathophysiological relevance of deiodinase polymorphism.
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Academic Article
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Triumphs of the thyroid despite lesser conversion.
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Academic Article
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The type II deiodinase is retrotranslocated to the cytoplasm and proteasomes via p97/Atx3 complex.
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Academic Article
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Covering the base-pairs in iodothyronine deiodinase-1 biology: holes remain in the lineup.
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Academic Article
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Central role of brown adipose tissue thyroxine 5'-deiodinase on thyroid hormone-dependent thermogenic response to cold.
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Academic Article
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A Transgenic Mouse Model for Detection of Tissue-Specific Thyroid Hormone Action.
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Academic Article
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Disruption of type 2 iodothyronine deiodinase activity in cultured human glial cells by polybrominated diphenyl ethers.
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Academic Article
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Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation.
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Academic Article
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Coupling between Nutrient Availability and Thyroid Hormone Activation.
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Academic Article
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Lipopolysaccharide induces type 2 iodothyronine deiodinase in the mediobasal hypothalamus: implications for the nonthyroidal illness syndrome.
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Academic Article
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An inside job.
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Academic Article
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Type 1 iodothyronine deiodinase is a sensitive marker of peripheral thyroid status in the mouse.
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Academic Article
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The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure.
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Academic Article
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Regional physiological adaptation of the central nervous system deiodinases to iodine deficiency.
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Academic Article
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Ubiquitination-induced conformational change within the deiodinase dimer is a switch regulating enzyme activity.
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Academic Article
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Defending plasma T3 is a biological priority.
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Academic Article
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Reawakened interest in type III iodothyronine deiodinase in critical illness and injury.
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Academic Article
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Human type 3 iodothyronine selenodeiodinase is located in the plasma membrane and undergoes rapid internalization to endosomes.
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Academic Article
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The small polyphenolic molecule kaempferol increases cellular energy expenditure and thyroid hormone activation.
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Academic Article
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Prevalent polymorphism in thyroid hormone-activating enzyme leaves a genetic fingerprint that underlies associated clinical syndromes.
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Academic Article
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Mice with targeted disruption of the Dio2 gene have cold-induced overexpression of the uncoupling protein 1 gene but fail to increase brown adipose tissue lipogenesis and adaptive thermogenesis.
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Academic Article
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The thyroid hormone-inactivating type III deiodinase is expressed in mouse and human beta-cells and its targeted inactivation impairs insulin secretion.
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Academic Article
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Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes.
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Academic Article
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Deiodinase-mediated thyroid hormone inactivation minimizes thyroid hormone signaling in the early development of fetal skeleton.
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Academic Article
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Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation.
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Academic Article
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Type 2 iodothyronine deiodinase is highly expressed in germ cells of adult rat testis.
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Academic Article
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Minireview: cracking the metabolic code for thyroid hormone signaling.
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Academic Article
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The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line.
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Academic Article
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Distinct subcellular localization of transiently expressed types 1 and 2 iodothyronine deiodinases as determined by immunofluorescence confocal microscopy.
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Academic Article
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Activation and inactivation of thyroid hormone by deiodinases: local action with general consequences.
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Academic Article
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New insights into the variable effectiveness of levothyroxine monotherapy for hypothyroidism.
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Academic Article
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The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate.
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Academic Article
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Differences in hypothalamic type 2 deiodinase ubiquitination explain localized sensitivity to thyroxine.
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Academic Article
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Type 2 Deiodinase Disruption in Astrocytes Results in Anxiety-Depressive-Like Behavior in Male Mice.
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Academic Article
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Endoplasmic reticulum stress decreases intracellular thyroid hormone activation via an eIF2a-mediated decrease in type 2 deiodinase synthesis.
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Academic Article
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Disruption of thyroid hormone activation in type 2 deiodinase knockout mice causes obesity with glucose intolerance and liver steatosis only at thermoneutrality.
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Academic Article
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Chronic cardiac-specific thyrotoxicosis increases myocardial beta-adrenergic responsiveness.
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Academic Article
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Type 2 deiodinase expression is induced by peroxisomal proliferator-activated receptor-gamma agonists in skeletal myocytes.
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Academic Article
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Type 2 deiodinase polymorphism causes ER stress and hypothyroidism in the brain.
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Academic Article
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Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases.
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Academic Article
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Paracrine signaling by glial cell-derived triiodothyronine activates neuronal gene expression in the rodent brain and human cells.
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Academic Article
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In vivo dimerization of types 1, 2, and 3 iodothyronine selenodeiodinases.
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Academic Article
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The E3 ubiquitin ligase TEB4 mediates degradation of type 2 iodothyronine deiodinase.
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Academic Article
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Expression patterns of WSB-1 and USP-33 underlie cell-specific posttranslational control of type 2 deiodinase in the rat brain.
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Academic Article
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Scope and limitations of iodothyronine deiodinases in hypothyroidism.
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Academic Article
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Cardiac expression of human type 2 iodothyronine deiodinase increases glucose metabolism and protects against doxorubicin-induced cardiac dysfunction in male mice.
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Academic Article
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Cracking the code for thyroid hormone signaling.
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Academic Article
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The Deiodinase Trio and Thyroid Hormone Signaling.
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Academic Article
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3,5,3'-Triiodothyronine actively stimulates UCP in brown fat under minimal sympathetic activity.
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Academic Article
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The role of glucocorticoids in the stress-induced reduction of extrathyroidal 3,5,3'-triiodothyronine generation in rats.
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Academic Article
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Hepatic Inactivation of the Type 2 Deiodinase Confers Resistance to Alcoholic Liver Steatosis.
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Academic Article
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Paradigms of Dynamic Control of Thyroid Hormone Signaling.
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Academic Article
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Thyroid hormone inhibits lung fibrosis in mice by improving epithelial mitochondrial function.
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Academic Article
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Human Type 1 Iodothyronine Deiodinase (DIO1) Mutations Cause Abnormal Thyroid Hormone Metabolism.
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Academic Article
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Assessment of children in the autistic spectrum disorder that carry the Thr92Ala-DIO2 polymorphism.
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Academic Article
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Accelerating functional gene discovery in osteoarthritis.
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Academic Article
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Deiodinases and the Metabolic Code for Thyroid Hormone Action.
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Academic Article
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Neonatal thyroxine activation modifies epigenetic programming of the liver.
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Academic Article
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Deiodinase-3 is a thyrostat to regulate podocyte homeostasis.
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Academic Article
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Heterozygote Advantage of the Type II Deiodinase Thr92Ala Polymorphism on Intrahospital Mortality of COVID-19.
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Academic Article
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Inactivation of Type 3 Deiodinase Results in Life-long Changes in the Brown Adipose Tissue Transcriptome in the Male Mouse.
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Academic Article
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Selpercatinib-Induced Hypothyroidism Through Off-Target Inhibition of Type 2 Iodothyronine Deiodinase.
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Academic Article
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Localized T3 production modifies the transcriptome and promotes the hepatocyte-like lineage in iPSC-derived hepatic organoids.
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