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One or more keywords matched the following properties of Pincus, David
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overview David Pincus is an Assistant Professor in the Dept. of Molecular Genetics and Cell Biology. The Pincus lab is located in the Center for Physics of Evolving Systems on the 5th floor of GCIS. The Pincus Lab studies cellular adaptation at three levels: cell biological mechanisms of adaptation to environmental stress, global principles of adaptation and resource allocation in complex environments, and the intersection of physiological stress response factors and evolutionary adaptation. David is trained in approaches in biochemistry, biophysics, genetics, genomics, and molecular, cell, computational, systems and synthetic biology. The lab uses budding yeast and cultured human cells as experimental models. Key project areas: 1) Quantitative cell biology of the heat shock response 2) Single-cell transcriptomics in complex stress environments
One or more keywords matched the following items that are connected to Pincus, David
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Concept Yeasts
Academic Article Hsf1 Phosphorylation Generates Cell-to-Cell Variation in Hsp90 Levels and Promotes Phenotypic Plasticity.
Academic Article Genetic and epigenetic determinants establish a continuum of Hsf1 occupancy and activity across the yeast genome.
Academic Article Hsf1 and Hsp70 constitute a two-component feedback loop that regulates the yeast heat shock response.
Academic Article Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis.
Academic Article Specificity in endoplasmic reticulum-stress signaling in yeast entails a step-wise engagement of HAC1 mRNA to clusters of the stress sensor Ire1.
Academic Article Defining the Essential Function of Yeast Hsf1 Reveals a Compact Transcriptional Program for Maintaining Eukaryotic Proteostasis.
Academic Article Assigning quantitative function to post-translational modifications reveals multiple sites of phosphorylation that tune yeast pheromone signaling output.
Academic Article Serial Immunoprecipitation of 3xFLAG/V5-tagged Yeast Proteins to Identify Specific Interactions with Chaperone Proteins.
Academic Article Scaffold number in yeast signaling system sets tradeoff between system output and dynamic range.
Academic Article Negative feedback that improves information transmission in yeast signalling.
Academic Article Reagents for investigating MAPK signalling in model yeast species.
Academic Article Primordial super-enhancers: heat shock-induced chromatin organization in yeast.
Grant Regulatory Dynamics of the Proteostasis Network
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  • Yeasts