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Oakes, Scott
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Item TypeName
Concept Endoribonucleases
Academic Article Divergent allosteric control of the IRE1a endoribonuclease using kinase inhibitors.
Academic Article IRE1a induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress.
Academic Article IRE1a cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2.
Academic Article A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stress.
Academic Article Allosteric inhibition of the IRE1a RNase preserves cell viability and function during endoplasmic reticulum stress.
Academic Article Parallel Signaling through IRE1a and PERK Regulates Pancreatic Neuroendocrine Tumor Growth and Survival.
Academic Article Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses.
Academic Article Type I but Not Type II Calreticulin Mutations Activate the IRE1a/XBP1 Pathway of the Unfolded Protein Response to Drive Myeloproliferative Neoplasms.
Academic Article SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1a/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived Cells.
Academic Article Deletion of the Unfolded Protein Response Transducer IRE1a Is Detrimental to Aging Photoreceptors and to ER Stress-Mediated Retinal Degeneration.
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  • Endoribonucleases