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Dr. Alenghat's laboratory focuses on macrophage biology and the inflammatory processes underlying atherosclerosis. His clinical and academic interests span cardiovascular physiology and pathophysiology, with a particular emphasis on vascular biology and the role of inflammatory pathways in the development of atherosclerotic disease. In addition, Dr. Alenghat has expertise in integrin biology, mechanotransduction, and extracellular matrix biology.
His research aims to uncover fundamental mechanisms that regulate cardiovascular health and disease. A central project in his laboratory investigates how a signaling pathway activated downstream of integrins in macrophages influences atherogenesis and macrophage polarization. The lab employs a range of techniques, including mouse husbandry, tissue sample preparation, immunohistochemistry, and quantitative confocal microscopy.
Dr. Alenghat is also deeply committed to mentoring future physicians and scientists, with a broader goal of promoting health through a deeper understanding of and reduction in cardiovascular disease.
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Alenghat, Francis