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Search Results to Gokhan M. Mutlu

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One or more keywords matched the following properties of Mutlu, Gokhan M.

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keywords Fibroblast
overview Dr. Mutlu is Professor of Medicine and Chief of the Section of Pulmonary and Critical Care Medicine at the University of Chicago. He is also the principal investigator/director of the NIH T32 Research training in respiratory biology. Dr. Mutlu's research focuses on the mechanisms of acute lung injury, and pulmonary fibrosis. Specifically, his laboratory is interested in understanding the role of macrophage and fibroblast metabolism including mitochondria in the pathogenesis of acute lung injury and pulmonary fibrosis. Dr. Mutlu's laboratory has extensive expertise with in vitro cell based methods including bioenergetics and in vivo models of acute lung injury (influenza, LPS, bacterial pneumonia and particulate matter) and pulmonary fibrosis (bleomycin).

One or more keywords matched the following items that are connected to Mutlu, Gokhan M.

Item TypeName
Concept Fibroblasts
Concept Fibroblast Growth Factor 7
Academic Article Proapoptotic Bid is required for pulmonary fibrosis.
Academic Article Nuclear ß-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation.
Academic Article Keratinocyte growth factor expression is suppressed in early acute lung injury/acute respiratory distress syndrome by smad and c-Abl pathways.
Academic Article PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice.
Academic Article Proteasomal inhibition after injury prevents fibrosis by modulating TGF-ß(1) signalling.
Academic Article Toll-like receptor 4 signaling augments transforming growth factor-ß responses: a novel mechanism for maintaining and amplifying fibrosis in scleroderma.
Academic Article Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio.
Academic Article Transforming Growth Factor (TGF)-ß Promotes de Novo Serine Synthesis for Collagen Production.
Academic Article Downregulation of TGF-ß Receptor-2 Expression and Signaling through Inhibition of Na/K-ATPase.
Academic Article Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis.
Academic Article P311 Promotes Lung Fibrosis via Stimulation of Transforming Growth Factor-ß1, -ß2, and -ß3 Translation.
Academic Article Glutamine Metabolism Is Required for Collagen Protein Synthesis in Lung Fibroblasts.
Academic Article TGF-ß Promotes Metabolic Reprogramming in Lung Fibroblasts via mTORC1-dependent ATF4 Activation.
Academic Article Metabolic requirements of pulmonary fibrosis: role of fibroblast metabolism.

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  • Fibroblasts