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One or more keywords matched the following properties of Mutlu, Gokhan M.
PropertyValue
keywords Pulmonary Fibrosis
overview Dr. Mutlu is Professor of Medicine and Chief of the Section of Pulmonary and Critical Care Medicine at the University of Chicago. He is also the principal investigator/director of the NIH T32 Research training in respiratory biology. Dr. Mutlu's research focuses on the mechanisms of acute lung injury, and pulmonary fibrosis. Specifically, his laboratory is interested in understanding the role of macrophage and fibroblast metabolism including mitochondria in the pathogenesis of acute lung injury and pulmonary fibrosis. Dr. Mutlu's laboratory has extensive expertise with in vitro cell based methods including bioenergetics and in vivo models of acute lung injury (influenza, LPS, bacterial pneumonia and particulate matter) and pulmonary fibrosis (bleomycin).
One or more keywords matched the following items that are connected to Mutlu, Gokhan M.
Item TypeName
Concept Cystic Fibrosis
Concept Fibrosis
Concept Cystic Fibrosis Transmembrane Conductance Regulator
Concept Idiopathic Pulmonary Fibrosis
Academic Article Upregulation of alveolar epithelial active Na+ transport is dependent on beta2-adrenergic receptor signaling.
Academic Article Adenosine regulation of alveolar fluid clearance.
Academic Article Proteasomal regulation of pulmonary fibrosis.
Academic Article Wnt coreceptor Lrp5 is a driver of idiopathic pulmonary fibrosis.
Academic Article Proapoptotic Bid is required for pulmonary fibrosis.
Academic Article Interdependency of beta-adrenergic receptors and CFTR in regulation of alveolar active Na+ transport.
Academic Article Nuclear ß-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation.
Academic Article Proteasomal inhibition after injury prevents fibrosis by modulating TGF-ß(1) signalling.
Academic Article Lung-specific loss of a3 laminin worsens bleomycin-induced pulmonary fibrosis.
Academic Article Asbestos-induced pulmonary fibrosis is augmented in 8-oxoguanine DNA glycosylase knockout mice.
Academic Article Flow cytometric analysis of macrophages and dendritic cell subsets in the mouse lung.
Academic Article Toll-like receptor 4 signaling augments transforming growth factor-ß responses: a novel mechanism for maintaining and amplifying fibrosis in scleroderma.
Academic Article Regulation of myofibroblast differentiation by cardiac glycosides.
Academic Article SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage.
Academic Article Transforming Growth Factor (TGF)-ß Promotes de Novo Serine Synthesis for Collagen Production.
Academic Article Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span.
Academic Article Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis.
Academic Article P311 Promotes Lung Fibrosis via Stimulation of Transforming Growth Factor-ß1, -ß2, and -ß3 Translation.
Academic Article Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis.
Academic Article Metabolic requirements of pulmonary fibrosis: role of fibroblast metabolism.
Academic Article The role of metabolic reprogramming and de novo amino acid synthesis in collagen protein production by myofibroblasts: implications for organ fibrosis and cancer.
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  • Fibrosis