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Comstock, Laurie
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overview The human intestinal microbiota is a complex and dynamic consortium of microbes that is crucial for human health and disease prevention. Our lab has been studying the abundant bacterial members of this ecosystem to understand how they interact with each other both cooperatively and antagonistically to form these health-promoting communities. We use basic microbiological, genetic, biochemical, and gnotobiotic mouse analyses, combined with genomic, metagenomic and computational analyses to understand these complex interactions. We have discovered numerous classes of new antimicrobial proteins that these bacteria use to compete in their ecosystem, and we are studying their mechanisms of action, ecological properties, and how we may translate these molecules for human health benefits. Another focus of the lab is the evolution of microbes in the human gut and how genetic elements horizontally transferred between bacterial species personalize each individual’s gut microbiota and the phenotypes and community benefits conferred by these shared genetic elements.
One or more keywords matched the following items that are connected to Comstock, Laurie
Item TypeName
Concept Milk, Human
Concept Humans
Academic Article Bacterial glycans: key mediators of diverse host immune responses.
Academic Article Gut Symbiont Bacteroides fragilis Secretes a Eukaryotic-Like Ubiquitin Protein That Mediates Intraspecies Antagonism.
Academic Article Expression of phase variable surface molecules of Bacteroides species from healthy and clinical stool.
Academic Article A family of anti-Bacteroidales peptide toxins wide-spread in the human gut microbiota.
Academic Article Type VI Secretion Systems and the Gut Microbiota.
Academic Article Type VI secretion systems of human gut Bacteroidales segregate into three genetic architectures, two of which are contained on mobile genetic elements.
Academic Article The evolution of cooperation within the gut microbiota.
Academic Article Streamlined Genetic Manipulation of Diverse Bacteroides and Parabacteroides Isolates from the Human Gut Microbiota.
Academic Article Phase-variable expression of a family of glycoproteins imparts a dynamic surface to a symbiont in its human intestinal ecosystem.
Academic Article Evidence of extensive DNA transfer between bacteroidales species within the human gut.
Academic Article Intestinal microbial-derived sphingolipids are inversely associated with childhood food allergy.
Academic Article Importance of glycans to the host-bacteroides mutualism in the mammalian intestine.
Academic Article Bacteroides fragilis type VI secretion systems use novel effector and immunity proteins to antagonize human gut Bacteroidales species.
Academic Article Nanaerobic growth enables direct visualization of dynamic cellular processes in human gut symbionts.
Academic Article A New Pillar in Pilus Assembly.
Academic Article Human symbionts use a host-like pathway for surface fucosylation.
Academic Article Expression of a uniquely regulated extracellular polysaccharide confers a large-capsule phenotype to Bacteroides fragilis.
Academic Article Utilizing Ribose Compounds: How Bacteroides PUL It Off.
Academic Article A defined O-antigen polysaccharide mutant of Francisella tularensis live vaccine strain has attenuated virulence while retaining its protective capacity.
Academic Article Bacteroides fragilis NCTC9343 produces at least three distinct capsular polysaccharides: cloning, characterization, and reassignment of polysaccharide B and C biosynthesis loci.
Academic Article Trans locus inhibitors limit concomitant polysaccharide synthesis in the human gut symbiont Bacteroides fragilis.
Academic Article Extensive surface diversity of a commensal microorganism by multiple DNA inversions.
Academic Article Bacterial antagonism in host-associated microbial communities.
Academic Article Bacteroides thetaiotaomicron: a dynamic, niche-adapted human symbiont.
Academic Article Acquisition of MACPF domain-encoding genes is the main contributor to LPS glycan diversity in gut Bacteroides species.
Academic Article Niche-specific features of the intestinal bacteroidales.
Academic Article Characterization of adherent bacteroidales from intestinal biopsies of children and young adults with inflammatory bowel disease.
Academic Article Mobile Type VI secretion system loci of the gut Bacteroidales display extensive intra-ecosystem transfer, multi-species spread and geographical clustering.
Academic Article An ecological network of polysaccharide utilization among human intestinal symbionts.
Academic Article The Host Shapes the Gut Microbiota via Fecal MicroRNA.
Academic Article Bacteroidales Secreted Antimicrobial Proteins Target Surface Molecules Necessary for Gut Colonization and Mediate Competition In Vivo.
Academic Article An antimicrobial protein of the gut symbiont Bacteroides fragilis with a MACPF domain of host immune proteins.
Academic Article Analysis of a phase-variable restriction modification system of the human gut symbiont Bacteroides fragilis.
Academic Article Longitudinal analysis of the prevalence, maintenance, and IgA response to species of the order Bacteroidales in the human gut.
Academic Article Mpi recombinase globally modulates the surface architecture of a human commensal bacterium.
Academic Article Interaction of Lyme disease spirochetes with cultured eucaryotic cells.
Academic Article Microbiology: the inside story.
Academic Article Production of a-galactosylceramide by a prominent member of the human gut microbiota.
Academic Article A monoclonal antibody to OspA inhibits association of Borrelia burgdorferi with human endothelial cells.
Academic Article Characterization of Borrelia burgdorferi invasion of cultured endothelial cells.
Academic Article Penetration of endothelial cell monolayers by Borrelia burgdorferi.
Academic Article A general O-glycosylation system important to the physiology of a major human intestinal symbiont.
Academic Article Vibriocidal antibody responses in North American volunteers exposed to wild-type or vaccine Vibrio cholerae O139: specificity and relevance to immunity.
Academic Article Distribution of Zonula occludens toxin (zot) gene among clinical isolates of Vibrio cholerae O1 from Bangladesh and Africa.
Academic Article Initial clinical studies of CVD 112 Vibrio cholerae O139 live oral vaccine: safety and efficacy against experimental challenge.
Academic Article Zonula occludens toxin modulates tight junctions through protein kinase C-dependent actin reorganization, in vitro.
Academic Article Bacteroidetocins Target the Essential Outer Membrane Protein BamA of Bacteroidales Symbionts and Pathogens.
Academic Article Analysis of Effector and Immunity Proteins of the GA2 Type VI Secretion Systems of Gut Bacteroidales.
Academic Article A proteolytically activated antimicrobial toxin encoded on a mobile plasmid of Bacteroidales induces a protective response.
Academic Article Bacteroides fragilis Maintains Concurrent Capability for Anaerobic and Nanaerobic Respiration.
Academic Article A highly conserved and globally prevalent cryptic plasmid is among the most numerous mobile genetic elements in the human gut.
Academic Article Inflammation and bacteriophages affect DNA inversion states and functionality of the gut microbiota.
Academic Article A cryptic plasmid is among the most numerous genetic elements in the human gut.
Academic Article Comprehensive analyses of a large human gut Bacteroidales culture collection reveal species and strain level diversity and evolution.
Grant Contact-Dependent Antagonism in Gut Bacteroidales
Grant Regulation of the multiple polysaccharides of Bacteroides fragilis
Grant A new paradigm of respiration in the human gut Bacteroides
Grant Structural, genetic, and functional analyses of the glycoproteins of Bacteroides
Grant Regulation of the multiple polysaccharides of Bacteroides fragilis
Grant Significance of Bacteroides fragilis polysaccharide phase variation
Academic Article Mechanisms of bacterial immunity, protection, and survival during interbacterial warfare.
Academic Article Phosphorothioate DNA modification by BREX Type 4 systems in the human gut microbiome.
Academic Article Distant relatives of a eukaryotic cell-specific toxin family evolved a complement-like mechanism to kill bacteria.
Academic Article Comprehensive analyses of a large human gut Bacteroidales culture collection reveal species- and strain-level diversity and evolution.
Academic Article A ubiquitous mobile genetic element changes the antagonistic weaponry of a human gut symbiont.
Academic Article Bacteroides expand the functional versatility of a conserved transcription factor and transcribed DNA to program capsule diversity.
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  • Humans