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One or more keywords matched the following properties of He, Chuan
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keywords DNA methylation
overview Chuan He is the John T. Wilson Distinguished Service Professor in the Department of Chemistry and Department of Biochemistry and Molecular Biology at the University of Chicago.He received his B.S. (1994) from the University of Science and Technology of China. He received his Ph. D. degree from Massachusetts Institute of Technology in chemistry in 2000. After being trained as a Damon-Runyon postdoctoral fellow at Harvard University from 2000-2002, he joined the University of Chicago as an Assistant Professor, and was promoted to Associate Professor in 2008, Professor in 2010 and John T. Wilson Distinguished Service Professor in 2014. He is also a member of the Cancer Research Center at the University of Chicago. His research spans a broad range of chemical biology, RNA biology, epigenetics, biochemistry, molecular biology, and genomics. His recent research concerns reversible RNA and DNA methylation in biological regulation. His research group discovered the first RNA demethylase and showed that reversible RNA methylation significantly affects gene expression regulation.
One or more keywords matched the following items that are connected to He, Chuan
Item TypeName
Concept Methylation
Concept DNA Methylation
Academic Article Genome-wide analysis of N1-methyl-adenosine modification in human tRNAs.
Academic Article The AlkB domain of mammalian ABH8 catalyzes hydroxylation of 5-methoxycarbonylmethyluridine at the wobble position of tRNA.
Academic Article Blockade of miR-150 maturation by MLL-fusion/MYC/LIN-28 is required for MLL-associated leukemia.
Academic Article N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO.
Academic Article FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA.
Academic Article Hydroxymethylation at gene regulatory regions directs stem/early progenitor cell commitment during erythropoiesis.
Academic Article A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation.
Academic Article Gene expression regulation mediated through reversible m6A RNA methylation.
Academic Article Tet-mediated covalent labelling of 5-methylcytosine for its genome-wide detection and sequencing.
Academic Article Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase.
Academic Article Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO.
Academic Article Potential functional roles of DNA demethylation intermediates.
Academic Article Dynamic RNA modifications in posttranscriptional regulation.
Academic Article Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA.
Academic Article Nonenzymatic labeling of 5-hydroxymethylcytosine in nanopore sequencing.
Academic Article Detection of mismatched 5-hydroxymethyluracil in DNA by selective chemical labeling.
Academic Article Base-resolution maps of 5-formylcytosine and 5-carboxylcytosine reveal genome-wide DNA demethylation dynamics.
Academic Article A non-heme iron-mediated chemical demethylation in DNA and RNA.
Academic Article Nucleic acid modifications with epigenetic significance.
Academic Article Reversible RNA adenosine methylation in biological regulation.
Academic Article Syntheses of 5-formyl- and 5-carboxyl-dC containing DNA oligos as potential oxidation products of 5-hydroxymethylcytosine in DNA.
Academic Article Nucleic acid oxidation in DNA damage repair and epigenetics.
Academic Article Reading RNA methylation codes through methyl-specific binding proteins.
Academic Article Structure determination of DNA methylation lesions N1-meA and N3-meC in duplex DNA using a cross-linked protein-DNA system.
Academic Article RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation.
Academic Article Decoding the transcriptome and DNA methylome of human primordial germ cells.
Academic Article High-Resolution Mapping of N6-Methyladenosine in Transcriptome and Genome Using a Photo-Crosslinking-Assisted Strategy.
Academic Article DNA N(6)-methyladenine: a new epigenetic mark in eukaryotes?
Academic Article Detecting hepatocellular carcinoma in blood.
Academic Article The dynamic N(1)-methyladenosine methylome in eukaryotic messenger RNA.
Academic Article Nucleic Acid Modifications in Regulation of Gene Expression.
Academic Article Characterization of eukaryotic DNA N(6)-methyladenine by a highly sensitive restriction enzyme-assisted sequencing.
Academic Article Nuclear m(6)A Reader YTHDC1 Regulates mRNA Splicing.
Academic Article A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations.
Academic Article Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig.
Academic Article ALKBH1-Mediated tRNA Demethylation Regulates Translation.
Academic Article Post-transcriptional gene regulation by mRNA modifications.
Academic Article The emerging biology of RNA post-transcriptional modifications.
Academic Article FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N6-Methyladenosine RNA Demethylase.
Academic Article Nm-seq maps 2'-O-methylation sites in human mRNA with base precision.
Academic Article Chemical Modifications in the Life of an mRNA Transcript.
Academic Article RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia.
Academic Article Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm.
Academic Article m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer.
Academic Article Our views of dynamic N6-methyladenosine RNA methylation.
Academic Article Single base resolution mapping of 2'-O-methylation sites in human mRNA and in 3' terminal ends of small RNAs.
Academic Article Identifying the m6A Methylome by Affinity Purification and Sequencing.
Academic Article Author Correction: RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia.
Academic Article Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation.
Academic Article High-Resolution Mapping of N 6-Methyladenosine Using m6A Crosslinking Immunoprecipitation Sequencing (m6A-CLIP-Seq).
Grant Regulation of IL-6 and DNA and RNA methylation by PM-induced mitochondrial ROS
Academic Article Transcriptome-wide Mapping of Internal N7-Methylguanosine Methylome in Mammalian mRNA.
Academic Article Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers.
Academic Article m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade.
Academic Article 5-Hydroxymethylcytosine Profiles in Circulating Cell-Free DNA Associate with Disease Burden in Children with Neuroblastoma.
Academic Article RADAR: differential analysis of MeRIP-seq data with a random effect model.
Academic Article m6A mRNA Methylation Is Essential for Oligodendrocyte Maturation and CNS Myelination.
Academic Article N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription.
Academic Article DNA 5-Methylcytosine-Specific Amplification and Sequencing.
Academic Article N6-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA.
Academic Article Control of Early B Cell Development by the RNA N6-Methyladenosine Methylation.
Academic Article LEAD-m6 A-seq for Locus-Specific Detection of N6 -Methyladenosine and Quantification of Differential Methylation.
Academic Article Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m6A Methylation.
Academic Article N6-Adenosine Methylation of Socs1 mRNA Is Required to Sustain the Negative Feedback Control of Macrophage Activation.
Academic Article A human tissue map of 5-hydroxymethylcytosines exhibits tissue specificity through gene and enhancer modulation.
Academic Article Global Detection of RNA Methylation by Click Degradation.
Academic Article m6 A RNA methylation: from mechanisms to therapeutic potential.
Academic Article Chromatin and transcriptional regulation by reversible RNA methylation.
Academic Article Transcriptome-Wide Detection of Internal N7-Methylguanosine.
Academic Article METTL14 facilitates global genome repair and suppresses skin tumorigenesis.
Academic Article The METTL5-TRMT112 N6-methyladenosine methyltransferase complex regulates mRNA translation via 18S rRNA methylation.
Academic Article m6A RNA modifications are measured at single-base resolution across the mammalian transcriptome.
Academic Article Transcriptome-wide profiling and quantification of N6-methyladenosine by enzyme-assisted adenosine deamination.
Academic Article Mammalian DNA N6-methyladenosine: Challenges and new insights.
Grant RNA methylation and regulatory T cells
Grant Interrogation of dynamic RNA modifications in beta cells in type 1 diabetes
Grant Direct Oxidative Nucleic Acids Demethylation
Academic Article Advances in targeting RNA modifications for anticancer therapy.
Academic Article Genome-Wide Mapping Implicates 5-Hydroxymethylcytosines in Diabetes Mellitus and Alzheimer's Disease.
Academic Article METTL14 is a chromatin regulator independent of its RNA N6-methyladenosine methyltransferase activity.
Academic Article Nm-Mut-seq: a base-resolution quantitative method for mapping transcriptome-wide 2'-O-methylation.
Academic Article Analysis of genome-wide 5-hydroxymethylation of blood samples stored in different anticoagulants: opportunities for the expansion of clinical resources for epigenetic research.
Academic Article Base-resolution quantitative DAMM-seq for mapping RNA methylations in tRNA and mitochondrial polycistronic RNA.
Academic Article Base-Resolution Sequencing Methods for Whole-Transcriptome Quantification of mRNA Modifications.
Academic Article Author Correction: Light-induced LLPS of the CRY2/SPA1/FIO1 complex regulating mRNA methylation and chlorophyll homeostasis in Arabidopsis.
Academic Article Light-induced LLPS of the CRY2/SPA1/FIO1 complex regulating mRNA methylation and chlorophyll homeostasis in Arabidopsis.
Academic Article RNA m6A methylation and MDSCs: Roles and therapeutic implications for radiotherapy.
Academic Article Sequencing of N6-methyl-deoxyadenosine at single-base resolution across the mammalian genome.
Academic Article m6A RNA methylation regulates mitochondrial function.
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  • Methylation