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One or more keywords matched the following properties of Chitneni, Satish
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overview Our research focuses primarily on developing molecularly targeted radiotracers for noninvasive imaging of various diseases and disease-related biomarkers using positron emission tomography (PET) and for targeted radiopharmaceutical therapy of cancers. For this, we employ a variety of molecular scaffolds, including small molecules, peptides, and antibodies, and radiolabel them with appropriate radionuclides, such as fluorine-18, radioiodines, or zirconium-89 for imaging. Once successfully validated, the resulting imaging agents can have wide-ranging applications in the diagnosis and treatment of specific diseases and aid in new drug development. The work involves a multidisciplinary approach and collaborations with several other experts, including chemists, biologists, physicists, and physicians, to successfully advance the most promising radiopharmaceutical products for human use.
One or more keywords matched the following items that are connected to Chitneni, Satish
Item TypeName
Concept Fluorine Radioisotopes
Academic Article Fluorine-18 Labeling of the MDM2 Inhibitor RG7388 for PET Imaging: Chemistry and Preliminary Evaluation.
Academic Article Fluorine-18 labeling of an anti-HER2 VHH using a residualizing prosthetic group via a strain-promoted click reaction: Chemistry and preliminary evaluation.
Academic Article Comparison of the Hypoxia PET Tracer (18)F-EF5 to Immunohistochemical Marker EF5 in 3 Different Human Tumor Xenograft Models.
Academic Article 18F-EF5 PET imaging as an early response biomarker for the hypoxia-activated prodrug SN30000 combined with radiation treatment in a non-small cell lung cancer xenograft model.
Academic Article Preliminary validation of varicella zoster virus thymidine kinase as a novel reporter gene for PET.
Academic Article Improved synthesis and metabolic stability analysis of the dopamine transporter ligand [(18)F]FECT.
Academic Article Reply: Pharmacokinetic and Pharmacodynamic Modifiers of EF5 Uptake and Binding.
Academic Article A p-[18F]fluoroethoxyphenyl bicyclic nucleoside analogue as a potential positron emission tomography imaging agent for varicella-zoster virus thymidine kinase gene expression.
Academic Article Synthesis and evaluation of 18F- and 11C-labeled phenyl-galactopyranosides as potential probes for in vivo visualization of LacZ gene expression using positron emission tomography.
Academic Article Synthesis and preliminary evaluation of 18F- or 11C-labeled bicyclic nucleoside analogues as potential probes for imaging varicella-zoster virus thymidine kinase gene expression using positron emission tomography.
Academic Article Synthesis and evaluation of radiolabeled AGI-5198 analogues as candidate radiotracers for imaging mutant IDH1 expression in tumors.
Academic Article Synthesis and biological evaluation of a lipophilic, fluorine-18-labeled 5-ethynyl-2'-deoxyuridine derivative
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  • Fluorine