| Item Type | Name |
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Concept
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DNA Damage
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Concept
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DNA-Binding Proteins
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Concept
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DNA Repair
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Concept
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DNA Mutational Analysis
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Concept
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DNA, Neoplasm
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Concept
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DNA
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Concept
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DNA Topoisomerases, Type II
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Concept
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DNA (Cytosine-5-)-Methyltransferases
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Concept
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DNA Modification Methylases
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Concept
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Sequence Analysis, DNA
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Concept
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DNA, Complementary
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Concept
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DNA Repair Enzymes
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Concept
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DNA Copy Number Variations
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Concept
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DNA Methylation
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Concept
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DNA Mismatch Repair
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Concept
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DNA Primers
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Academic Article
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TTID: A novel gene at 5q31 encoding a protein with titin-like features.
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Academic Article
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Molecular characterization of KLHL3, a human homologue of the Drosophila kelch gene.
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Academic Article
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Expression profiling of CD34+ hematopoietic stem/ progenitor cells reveals distinct subtypes of therapy-related acute myeloid leukemia.
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Academic Article
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Transcript map and comparative analysis of the 1.5-Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q).
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Academic Article
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Cancer cells express aberrant DNMT3B transcripts encoding truncated proteins.
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Academic Article
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A phase I biological study of MG98, an oligodeoxynucleotide antisense to DNA methyltransferase 1, in patients with high-risk myelodysplasia and acute myeloid leukemia.
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Academic Article
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Epigenetic alterations differ in phenotypically distinct human neuroblastoma cell lines.
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Academic Article
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Coordinated cancer germline antigen promoter and global DNA hypomethylation in ovarian cancer: association with the BORIS/CTCF expression ratio and advanced stage.
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Academic Article
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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.
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Academic Article
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Selective chemical labeling reveals the genome-wide distribution of 5-hydroxymethylcytosine.
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Academic Article
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The use of hypomethylating agents in the treatment of hematologic malignancies.
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Academic Article
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DNA methyltransferase 1 and DNA methylation patterning contribute to germinal center B-cell differentiation.
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Academic Article
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Gene mutations, epigenetic dysregulation, and personalized therapy in myeloid neoplasia: are we there yet?
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Academic Article
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Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors.
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Academic Article
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TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis.
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Academic Article
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Characterization of NOL7 gene point mutations, promoter methylation, and protein expression in cervical cancer.
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Academic Article
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Truncated DNMT3B isoform DNMT3B7 suppresses growth, induces differentiation, and alters DNA methylation in human neuroblastoma.
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Academic Article
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Molecular biology. Preference by exclusion.
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Academic Article
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Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation.
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Academic Article
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Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia.
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Academic Article
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An integrated genomic approach to the assessment and treatment of acute myeloid leukemia.
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Academic Article
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Dnmt3a is essential for hematopoietic stem cell differentiation.
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Academic Article
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Epigenetic regulation of hypoxic sensing disrupts cardiorespiratory homeostasis.
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Academic Article
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Identification and molecular characterization of a novel 3′ mutation in RUNX1 in a family with familial platelet disorder.
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Academic Article
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5-hmC-mediated epigenetic dynamics during postnatal neurodevelopment and aging.
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Academic Article
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Profiles in leukemia.
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Academic Article
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DNMT3B7, a truncated DNMT3B isoform expressed in human tumors, disrupts embryonic development and accelerates lymphomagenesis.
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Academic Article
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Getting to the root of the stem cell in mutated chronic myeloid leukemia.
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Academic Article
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Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis.
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Academic Article
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Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability.
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Academic Article
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Absence of p53 in a mouse mammary tumor model promotes tumor cell proliferation without affecting apoptosis.
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Academic Article
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Identifying familial myelodysplastic/acute leukemia predisposition syndromes through hematopoietic stem cell transplantation donors with thrombocytopenia.
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Academic Article
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High resolution methylome analysis reveals widespread functional hypomethylation during adult human erythropoiesis.
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Academic Article
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Genome-wide variation of cytosine modifications between European and African populations and the implications for complex traits.
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Academic Article
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Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesis.
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Academic Article
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Histone-lysine methyltransferase EHMT2 is involved in proliferation, apoptosis, cell invasion, and DNA methylation of human neuroblastoma cells.
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Academic Article
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Perturbations of 5-hydroxymethylcytosine patterning in hematologic malignancies.
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Academic Article
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Hydroxymethylation at gene regulatory regions directs stem/early progenitor cell commitment during erythropoiesis.
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Academic Article
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TET1-mediated hydroxymethylation facilitates hypoxic gene induction in neuroblastoma.
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Academic Article
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Genome-wide hydroxymethylation tested using the HELP-GT assay shows redistribution in cancer.
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Academic Article
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Mechanism-based epigenetic chemosensitization therapy of diffuse large B-cell lymphoma.
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Academic Article
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New themes in the biological functions of 5-methylcytosine and 5-hydroxymethylcytosine.
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Academic Article
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DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia.
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Academic Article
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Large conserved domains of low DNA methylation maintained by Dnmt3a.
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Academic Article
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DNMT3B7 expression promotes tumor progression to a more aggressive phenotype in breast cancer cells.
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Academic Article
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The role of gene body cytosine modifications in MGMT expression and sensitivity to temozolomide.
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Academic Article
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Variability in DNA methylation defines novel epigenetic subgroups of DLBCL associated with different clinical outcomes.
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Academic Article
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A new family with a germline ANKRD26 mutation and predisposition to myeloid malignancies.
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Academic Article
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The mechanistic role of DNA methylation in myeloid leukemogenesis.
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Academic Article
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TET2 Mutations Affect Non-CpG Island DNA Methylation at Enhancers and Transcription Factor-Binding Sites in Chronic Myelomonocytic Leukemia.
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Academic Article
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5-hydroxymethylcytosine in cancer: significance in diagnosis and therapy.
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Academic Article
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Characterization of CpG sites that escape methylation on the inactive human X-chromosome.
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Academic Article
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DNA Methylation Dynamics of Germinal Center B Cells Are Mediated by AID.
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Academic Article
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Genomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia.
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Academic Article
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Epigenetic Control of Apolipoprotein E Expression Mediates Gender-Specific Hematopoietic Regulation.
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Academic Article
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Increased DNA methylation of Dnmt3b targets impairs leukemogenesis.
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Academic Article
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Novel germ line DDX41 mutations define families with a lower age of MDS/AML onset and lymphoid malignancies.
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Academic Article
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Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes.
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Academic Article
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Rigosertib versus best supportive care for patients with high-risk myelodysplastic syndromes after failure of hypomethylating drugs (ONTIME): a randomised, controlled, phase 3 trial.
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Academic Article
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Identifying Inherited and Acquired Genetic Factors Involved in Poor Stem Cell Mobilization and Donor-Derived Malignancy.
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Academic Article
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Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host.
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Academic Article
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Prognostic tumor sequencing panels frequently identify germ line variants associated with hereditary hematopoietic malignancies.
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Academic Article
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MBD4: guardian of the epigenetic galaxy.
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Academic Article
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Mitochondrial superoxide disrupts the metabolic and epigenetic landscape of CD4+ and CD8+ T-lymphocytes.
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Academic Article
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Cytokine-Regulated Phosphorylation and Activation of TET2 by JAK2 in Hematopoiesis.
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Academic Article
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Somatic mutation panels: Time to clear their names.
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Academic Article
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FouNdER mutations confer risk for leukemias.
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Academic Article
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5-Hydroxymethylcytosine Profiles in Circulating Cell-Free DNA Associate with Disease Burden in Children with Neuroblastoma.
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Academic Article
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HIF-1 directly induces TET3 expression to enhance 5-hmC density and induce erythroid gene expression in hypoxia.
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Academic Article
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Regulation of telomeric function by DNA methylation differs between humans and mice.
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Academic Article
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Identifying potential germline variants from sequencing hematopoietic malignancies.
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Academic Article
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Identifying potential germline variants from sequencing hematopoietic malignancies.
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Academic Article
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RBL2 bi-allelic truncating variants cause severe motor and cognitive impairment without evidence for abnormalities in DNA methylation or telomeric function.
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Academic Article
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The chemotherapeutic CX-5461 primarily targets TOP2B and exhibits selective activity in high-risk neuroblastoma.
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Academic Article
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MYCN and HIF-1 directly regulate TET1 expression to control 5-hmC gains and enhance neuroblastoma cell migration in hypoxia.
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Academic Article
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Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation.
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Academic Article
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(R)-2-Hydroxyglutarate Inhibits KDM5 Histone Lysine Demethylases to Drive Transformation in IDH-Mutant Cancers.
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Concept
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DNA (Cytosine-5-)-Methyltransferase 1
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Grant
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The Role of DNMT3B in the DNA Methylation of Cancer Cells
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Grant
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A chemical crosslinking strategy to determine DNA methylating protein complexes
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Grant
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Epigenetic and Genetic Dissection of Drug Response
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