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Godley, Lucy
One or more keywords matched the following items that are connected to Godley, Lucy
Item TypeName
Concept Mutation
Concept Germ-Line Mutation
Concept Point Mutation
Concept Mutation, Missense
Academic Article TTID: A novel gene at 5q31 encoding a protein with titin-like features.
Academic Article Molecular characterization of KLHL3, a human homologue of the Drosophila kelch gene.
Academic Article Therapy-related myeloid leukemia.
Academic Article Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.
Academic Article Gene mutations, epigenetic dysregulation, and personalized therapy in myeloid neoplasia: are we there yet?
Academic Article Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors.
Academic Article TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis.
Academic Article Characterization of NOL7 gene point mutations, promoter methylation, and protein expression in cervical cancer.
Academic Article Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia.
Academic Article Dnmt3a is essential for hematopoietic stem cell differentiation.
Academic Article Identification and molecular characterization of a novel 3′ mutation in RUNX1 in a family with familial platelet disorder.
Academic Article Profiles in leukemia.
Academic Article Wild-type p53 transgenic mice exhibit altered differentiation of the ureteric bud and possess small kidneys.
Academic Article Implications of FLT3 mutations in the therapy of acute myeloid leukemia.
Academic Article Getting to the root of the stem cell in mutated chronic myeloid leukemia.
Academic Article Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis.
Academic Article Defining the steps in a multistep mouse model for mammary carcinogenesis.
Academic Article Identifying familial myelodysplastic/acute leukemia predisposition syndromes through hematopoietic stem cell transplantation donors with thrombocytopenia.
Academic Article 2-Hydroxyglutarate in IDH mutant acute myeloid leukemia: predicting patient responses, minimal residual disease and correlations with methylcytosine and hydroxymethylcytosine levels.
Academic Article Perturbations of 5-hydroxymethylcytosine patterning in hematologic malignancies.
Academic Article Hydroxymethylation at gene regulatory regions directs stem/early progenitor cell commitment during erythropoiesis.
Academic Article Inherited predisposition to acute myeloid leukemia.
Academic Article DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia.
Academic Article Inherited and Somatic Defects in DDX41 in Myeloid Neoplasms.
Academic Article Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy.
Academic Article A new family with a germline ANKRD26 mutation and predisposition to myeloid malignancies.
Academic Article Familial myelodysplastic syndrome/acute leukemia syndromes: a review and utility for translational investigations.
Academic Article The mechanistic role of DNA methylation in myeloid leukemogenesis.
Academic Article TET2 Mutations Affect Non-CpG Island DNA Methylation at Enhancers and Transcription Factor-Binding Sites in Chronic Myelomonocytic Leukemia.
Academic Article Genomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia.
Academic Article Inherited mutations in cancer susceptibility genes are common among survivors of breast cancer who develop therapy-related leukemia.
Academic Article Novel germ line DDX41 mutations define families with a lower age of MDS/AML onset and lymphoid malignancies.
Academic Article Fumarate and Succinate Regulate Expression of Hypoxia-inducible Genes via TET Enzymes.
Academic Article Evaluation of Patients and Families With Concern for Predispositions to Hematologic Malignancies Within the Hereditary Hematologic Malignancy Clinic (HHMC).
Academic Article How I diagnose and manage individuals at risk for inherited myeloid malignancies.
Academic Article Germline ETV6 mutations and predisposition to hematological malignancies.
Academic Article Recognition of familial myeloid neoplasia in adults.
Academic Article Therapy-related myeloid neoplasms: when genetics and environment collide.
Academic Article Prognostic tumor sequencing panels frequently identify germ line variants associated with hereditary hematopoietic malignancies.
Academic Article Germline Lysine-Specific Demethylase 1 (LSD1/KDM1A) Mutations Confer Susceptibility to Multiple Myeloma.
Academic Article Identifying patients with genetic predisposition to acute myeloid leukemia.
Academic Article Somatic mutation panels: Time to clear their names.
Academic Article FouNdER mutations confer risk for leukemias.
Academic Article Inherited predisposition to myeloid malignancies.
Academic Article ClinGen Myeloid Malignancy Variant Curation Expert Panel recommendations for germline RUNX1 variants.
Academic Article RUNX1-mutated families show phenotype heterogeneity and a somatic mutation profile unique to germline predisposed AML.
Academic Article Breaking the spatial constraint between neighboring zinc fingers: a new germline mutation in GATA2 deficiency syndrome.
Academic Article Inherited Thrombocytopenia Caused by Germline ANKRD26 Mutation Should Be Considered in Young Patients With Suspected Myelodysplastic Syndrome.
Academic Article Telomere biology disorder prevalence and phenotypes in adults with familial hematologic and/or pulmonary presentations.
Academic Article Heterozygous germ line CSF3R variants as risk alleles for development of hematologic malignancies.
Academic Article Identifying potential germline variants from sequencing hematopoietic malignancies.
Academic Article Identifying potential germline variants from sequencing hematopoietic malignancies.
Academic Article Germline mutations in MDS/AML predisposition disorders.
Academic Article Germline variants drive myelodysplastic syndrome in young adults.
Academic Article Inherited predisposition to haematopoietic malignancies: overcoming barriers and exploring opportunities.
Academic Article Targeted gene panels identify a high frequency of pathogenic germline variants in patients diagnosed with a hematological malignancy and at least one other independent cancer.
Academic Article Study of inherited thrombocytopenia resulting from mutations in ETV6 or RUNX1 using a human pluripotent stem cell model.
Academic Article Clinical features and survival outcomes in patients with chronic myelomonocytic leukemia arising in the context of germline predisposition syndromes.
Academic Article Germline predisposition to hematopoietic malignancies.
Academic Article Feasibility and limitations of cultured skin fibroblasts for germline genetic testing in hematologic disorders.
Academic Article Clonal hematopoiesis in patients with ANKRD26 or ETV6 germline mutations.
Academic Article Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN.
Academic Article Clinical and molecular response of acute myeloid leukemia harboring non-canonical FLT3 N676K driver mutations to contemporary FLT3 inhibitors.
Academic Article Germ line DDX41 mutations define a unique subtype of myeloid neoplasms.
Academic Article Single-cell multi-omics of human clonal hematopoiesis reveals that DNMT3A R882 mutations perturb early progenitor states through selective hypomethylation.
Academic Article Germ line predisposition variants occur in myelodysplastic syndrome patients of all ages.
Academic Article DDX41-associated susceptibility to myeloid neoplasms.
Academic Article Genomic profiling for clinical decision making in myeloid neoplasms and acute leukemia.
Academic Article Significance of hereditary gene alterations for the pathogenesis of adult bone marrow failure versus myeloid neoplasia.
Academic Article (R)-2-Hydroxyglutarate Inhibits KDM5 Histone Lysine Demethylases to Drive Transformation in IDH-Mutant Cancers.
Grant The Role of DNMT3B in the DNA Methylation of Cancer Cells
Academic Article Germline loss-of-function BRCA1 and BRCA2 mutations and risk of de novo hematopoietic malignancies.
Academic Article Somatic mutational landscape of hereditary hematopoietic malignancies caused by germline variants in RUNX1, GATA2, and DDX41.
Academic Article Germline predisposition to clonal hematopoiesis.
Academic Article Sequential tumor molecular profiling identifies likely germline variants.
Academic Article Acute lymphoblastic leukemia with myeloid mutations is a high-risk disease associated with clonal hematopoiesis.
Academic Article Insights into the Molecular Mechanisms of Genetic Predisposition to Hematopoietic Malignancies: The Importance of Gene-Environment Interactions.
Academic Article Germline predisposition to myeloid neoplasms: Characteristics and management of high versus variable penetrance disorders.
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