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Roizman, Bernard
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overview Herpes simplex viruses cause two kinds of infections. On initial infection at the portal of entry into the body, the virus replicates and kills the infected cell (lytic infection). In the course of its replication, the virus infects nerve endings and is transported retrograde to neuronal nuclei of peripheral ganglia where it remains latent (silent) and does not harm the neuron. In some individuals the virus periodically reactivates, and is transported anterograde to a site near the portal of entry where it can cause recurrent lesions. The focus of the research conducted in this laboratory is on the mechanism by which herpes simplex virus with less than 100 genes takes over a human cell with more than 20,000 genes in both lytic and latent infection.
One or more keywords matched the following items that are connected to Roizman, Bernard
Item TypeName
Concept Herpesvirus 4, Human
Concept Humans
Concept Herpesvirus 1, Human
Concept Herpesvirus 2, Human
Concept Human papillomavirus 16
Academic Article The herpes simplex virus 1 U(L)34 protein interacts with a cytoplasmic dynein intermediate chain and targets nuclear membrane.
Academic Article Genetically engineered HSV in the treatment of glioma: a review.
Academic Article Redefining virology.
Academic Article Herpes simplex virus infections.
Academic Article Role of cyclin D3 in the biology of herpes simplex virus 1 ICPO.
Academic Article Bcl-2 blocks a caspase-dependent pathway of apoptosis activated by herpes simplex virus 1 infection in HEp-2 cells.
Academic Article Replication-competent herpes simplex viral vectors for cancer therapy.
Academic Article Molecular targeting of gene therapy and radiotherapy.
Academic Article Second-site mutation outside of the U(S)10-12 domain of Deltagamma(1)34.5 herpes simplex virus 1 recombinant blocks the shutoff of protein synthesis induced by activated protein kinase R and partially restores neurovirulence.
Academic Article An early regulatory function required in a cell type-dependent manner is expressed by the genomic but not the cDNA copy of the herpes simplex virus 1 gene encoding infected cell protein 0.
Academic Article E2F proteins are posttranslationally modified concomitantly with a reduction in nuclear binding activity in cells infected with herpes simplex virus 1.
Academic Article Of the three tegument proteins that package mRNA in herpes simplex virions, one (VP22) transports the mRNA to uninfected cells for expression prior to viral infection.
Academic Article Herpes simplex virus 1 open reading frames O and P are not necessary for establishment of latent infection in mice.
Academic Article Wild-type herpes simplex virus 1 blocks programmed cell death and release of cytochrome c but not the translocation of mitochondrial apoptosis-inducing factor to the nuclei of human embryonic lung fibroblasts.
Academic Article Posttranslational processing of infected cell protein 22 mediated by viral protein kinases is sensitive to amino acid substitutions at distant sites and can be cell-type specific.
Academic Article Herpes simplex virus 1 alpha regulatory protein ICP0 functionally interacts with cellular transcription factor BMAL1.
Academic Article The domains of glycoprotein D required to block apoptosis depend on whether glycoprotein D is present in the virions carrying herpes simplex virus 1 genome lacking the gene encoding the glycoprotein.
Academic Article RNAs extracted from herpes simplex virus 1 virions: apparent selectivity of viral but not cellular RNAs packaged in virions.
Academic Article The US3 protein kinase of herpes simplex virus 1 mediates the posttranslational modification of BAD and prevents BAD-induced programmed cell death in the absence of other viral proteins.
Academic Article cdc2 cyclin-dependent kinase binds and phosphorylates herpes simplex virus 1 U(L)42 DNA synthesis processivity factor.
Academic Article Dose-dependent and independent temporal patterns of gene responses to ionizing radiation in normal and tumor cells and tumor xenografts.
Academic Article The infected cell protein 0 of herpes simplex virus 1 dynamically interacts with proteasomes, binds and activates the cdc34 E2 ubiquitin-conjugating enzyme, and possesses in vitro E3 ubiquitin ligase activity.
Academic Article The role of cdc2 in the expression of herpes simplex virus genes.
Academic Article Herpes simplex virus 1-infected cell protein 0 contains two E3 ubiquitin ligase sites specific for different E2 ubiquitin-conjugating enzymes.
Academic Article The use of a genetically engineered herpes simplex virus (R7020) with ionizing radiation for experimental hepatoma.
Academic Article The nine ages of herpes simplex virus.
Academic Article Herpes simplex virus 1 activates cdc2 to recruit topoisomerase II alpha for post-DNA synthesis expression of late genes.
Academic Article U(S)3 protein kinase of herpes simplex virus 1 blocks caspase 3 activation induced by the products of U(S)1.5 and U(L)13 genes and modulates expression of transduced U(S)1.5 open reading frame in a cell type-specific manner.
Academic Article The domains of glycoprotein D required to block apoptosis induced by herpes simplex virus 1 are largely distinct from those involved in cell-cell fusion and binding to nectin1.
Academic Article Promyelocytic leukemia protein mediates interferon-based anti-herpes simplex virus 1 effects.
Academic Article The degradation of promyelocytic leukemia and Sp100 proteins by herpes simplex virus 1 is mediated by the ubiquitin-conjugating enzyme UbcH5a.
Academic Article Characterization of the novel E3 ubiquitin ligase encoded in exon 3 of herpes simplex virus-1-infected cell protein 0.
Academic Article Cell surface major histocompatibility complex class II proteins are regulated by the products of the gamma(1)34.5 and U(L)41 genes of herpes simplex virus 1.
Academic Article Herpes simplex viruses: is a vaccine tenable?
Academic Article Engineered herpes simplex virus 1 is dependent on IL13Ralpha 2 receptor for cell entry and independent of glycoprotein D receptor interaction.
Academic Article Requirements for the nuclear-cytoplasmic translocation of infected-cell protein 0 of herpes simplex virus 1.
Academic Article Herpes simplex virus 1 gene expression is accelerated by inhibitors of histone deacetylases in rabbit skin cells infected with a mutant carrying a cDNA copy of the infected-cell protein no. 0.
Academic Article Activation of NF-kappaB in cells productively infected with HSV-1 depends on activated protein kinase R and plays no apparent role in blocking apoptosis.
Academic Article The herpes simplex virus 1 UL41 gene-dependent destabilization of cellular RNAs is selective and may be sequence-specific.
Academic Article Truncated forms of glycoprotein D of herpes simplex virus 1 capable of blocking apoptosis and of low-efficiency entry into cells form a heterodimer dependent on the presence of a cysteine located in the shared transmembrane domains.
Academic Article The U(S)3 protein kinase blocks apoptosis induced by the d120 mutant of herpes simplex virus 1 at a premitochondrial stage.
Academic Article Expression of interleukin-4 but not of interleukin-10 from a replicative herpes simplex virus type 1 viral vector precludes experimental allergic encephalomyelitis.
Academic Article STAT1 is overexpressed in tumors selected for radioresistance and confers protection from radiation in transduced sensitive cells.
Academic Article Role of ICP0 in the strategy of conquest of the host cell by herpes simplex virus 1.
Academic Article Posttranslational processing of infected cell proteins 0 and 4 of herpes simplex virus 1 is sequential and reflects the subcellular compartment in which the proteins localize.
Academic Article Herpes simplex virus 1 mutant in which the ICP0 HUL-1 E3 ubiquitin ligase site is disrupted stabilizes cdc34 but degrades D-type cyclins and exhibits diminished neurotoxicity.
Academic Article Herpes simplex virus protein kinase US3 activates and functionally overlaps protein kinase A to block apoptosis.
Academic Article Prevention of restenosis by a herpes simplex virus mutant capable of controlled long-term expression in vascular tissue in vivo.
Academic Article Herpes simplex virus 1 gene products occlude the interferon signaling pathway at multiple sites.
Academic Article Infected cell protein No. 22 is subject to proteolytic cleavage by caspases activated by a mutant that induces apoptosis.
Academic Article Infectious agents and cancer: criteria for a causal relation.
Academic Article The UL41 protein of herpes simplex virus mediates selective stabilization or degradation of cellular mRNAs.
Academic Article The carboxyl-terminal domain of RNA polymerase II is phosphorylated by a complex containing cdk9 and infected-cell protein 22 of herpes simplex virus 1.
Academic Article The patterns of accumulation of cellular RNAs in cells infected with a wild-type and a mutant herpes simplex virus 1 lacking the virion host shutoff gene.
Academic Article The stress-inducible immediate-early responsive gene IEX-1 is activated in cells infected with herpes simplex virus 1, but several viral mechanisms, including 3' degradation of its RNA, preclude expression of the gene.
Academic Article Increased efficacy of an interleukin-12-secreting herpes simplex virus in a syngeneic intracranial murine glioma model.
Academic Article The first 30 minutes in the life of a virus: unREST in the nucleus.
Academic Article Sustained inhibition of experimental neointimal hyperplasia with a genetically modified herpes simplex virus.
Academic Article Herpes simplex virus 1 recombinant virions exhibiting the amino terminal fragment of urokinase-type plasminogen activator can enter cells via the cognate receptor.
Academic Article Protein kinase B/Akt is present in activated form throughout the entire replicative cycle of deltaU(S)3 mutant virus but only at early times after infection with wild-type herpes simplex virus 1.
Academic Article Herpes simplex virus 1 infected cell protein 0 forms a complex with CIN85 and Cbl and mediates the degradation of EGF receptor from cell surfaces.
Academic Article Activated MEK suppresses activation of PKR and enables efficient replication and in vivo oncolysis by Deltagamma(1)34.5 mutants of herpes simplex virus 1.
Academic Article The U(L)41 protein of herpes simplex virus 1 degrades RNA by endonucleolytic cleavage in absence of other cellular or viral proteins.
Academic Article Ionizing radiation activates late herpes simplex virus 1 promoters via the p38 pathway in tumors treated with oncolytic viruses.
Academic Article Herpes simplex virus 1 induces cytoplasmic accumulation of TIA-1/TIAR and both synthesis and cytoplasmic accumulation of tristetraprolin, two cellular proteins that bind and destabilize AU-rich RNAs.
Academic Article State and role of SRC family kinases in replication of herpes simplex virus 1.
Academic Article Proteolytic cleavage of VP1-2 is required for release of herpes simplex virus 1 DNA into the nucleus.
Academic Article U(S)3 and U(S)3.5 protein kinases of herpes simplex virus 1 differ with respect to their functions in blocking apoptosis and in virion maturation and egress.
Academic Article The virion host shutoff protein (UL41) of herpes simplex virus 1 is an endoribonuclease with a substrate specificity similar to that of RNase A.
Academic Article Separation of receptor-binding and profusogenic domains of glycoprotein D of herpes simplex virus 1 into distinct interacting proteins.
Academic Article Glycoprotein M of herpes simplex virus 1 is incorporated into virions during budding at the inner nuclear membrane.
Academic Article Mapping of key functions of the herpes simplex virus 1 U(S)3 protein kinase: the U(S)3 protein can form functional heteromultimeric structures derived from overlapping truncated polypeptides.
Academic Article In transduced cells, the US3 protein kinase of herpes simplex virus 1 precludes activation and induction of apoptosis by transfected procaspase 3.
Academic Article Temperature-sensitive mutations in the putative herpes simplex virus type 1 terminase subunits pUL15 and pUL33 preclude viral DNA cleavage/packaging and interaction with pUL28 at the nonpermissive temperature.
Academic Article Expression of gamma interferon-dependent genes is blocked independently by virion host shutoff RNase and by US3 protein kinase.
Academic Article Replication-competent herpes simplex virus 1 isolates selected from cells transfected with a bacterial artificial chromosome DNA lacking only the UL49 gene vary with respect to the defect in the UL41 gene encoding host shutoff RNase.
Academic Article An interferon-related gene signature for DNA damage resistance is a predictive marker for chemotherapy and radiation for breast cancer.
Academic Article Role of cdk9 in the optimization of expression of the genes regulated by ICP22 of herpes simplex virus 1.
Academic Article Cells lacking NF-kappaB or in which NF-kappaB is not activated vary with respect to ability to sustain herpes simplex virus 1 replication and are not susceptible to apoptosis induced by a replication-incompetent mutant virus.
Academic Article Translocation and colocalization of ICP4 and ICP0 in cells infected with herpes simplex virus 1 mutants lacking glycoprotein E, glycoprotein I, or the virion host shutoff product of the UL41 gene.
Academic Article Components of the REST/CoREST/histone deacetylase repressor complex are disrupted, modified, and translocated in HSV-1-infected cells.
Academic Article The interaction of herpes simplex virus 1 regulatory protein ICP22 with the cdc25C phosphatase is enabled in vitro by viral protein kinases US3 and UL13.
Academic Article Radioresistance of Stat1 over-expressing tumour cells is associated with suppressed apoptotic response to cytotoxic agents and increased IL6-IL8 signalling.
Academic Article Role of herpes simplex virus ICP27 in the degradation of mRNA by virion host shutoff RNase.
Academic Article Bcl-2 blocks accretion or depletion of stored calcium but has no effect on the redistribution of IP3 receptor I mediated by glycoprotein E of herpes simplex virus 1.
Academic Article The novel HSV-1 US5-1 RNA is transcribed off a domain encoding US5, US4, US3, US2 and alpha22.
Academic Article Interwoven roles of cyclin D3 and cdk4 recruited by ICP0 and ICP4 in the expression of herpes simplex virus genes.
Academic Article Systemic delivery of (gamma1)34.5-deleted herpes simplex virus-1 selectively targets and treats distant human xenograft tumors that express high MEK activity.
Academic Article The CoREST/REST repressor is both necessary and inimical for expression of herpes simplex virus genes.
Academic Article Antisense RNA directed to the human papillomavirus type 16 E7 mRNA from herpes simplex virus type 1 derived vectors is expressed in CaSki cells and downregulates E7 mRNA.
Academic Article Interaction of herpes simplex virus RNase with VP16 and VP22 is required for the accumulation of the protein but not for accumulation of mRNA.
Academic Article Increased oncolytic efficacy for high-grade gliomas by optimal integration of ionizing radiation into the replicative cycle of HSV-1.
Academic Article Herpes simplex virus-infected cell protein 0 blocks the silencing of viral DNA by dissociating histone deacetylases from the CoREST-REST complex.
Academic Article Modulation of vascular remodeling induced by a brief intraluminal exposure to the recombinant R7020 strain of Herpes simplex-1.
Academic Article The checkpoints of viral gene expression in productive and latent infection: the role of the HDAC/CoREST/LSD1/REST repressor complex.
Academic Article The histone acetyltransferase CLOCK is an essential component of the herpes simplex virus 1 transcriptome that includes TFIID, ICP4, ICP27, and ICP22.
Academic Article Molecular pathways: interferon/stat1 pathway: role in the tumor resistance to genotoxic stress and aggressive growth.
Academic Article Characterization of a recombinant herpes simplex virus 1 designed to enter cells via the IL13Ralpha2 receptor of malignant glioma cells.
Academic Article The two functions of herpes simplex virus 1 ICP0, inhibition of silencing by the CoREST/REST/HDAC complex and degradation of PML, are executed in tandem.
Academic Article The order Herpesvirales.
Academic Article Checkpoints in productive and latent infections with herpes simplex virus 1: conceptualization of the issues.
Academic Article HSV-1 gene expression from reactivated ganglia is disordered and concurrent with suppression of latency-associated transcript and miRNAs.
Academic Article US3 protein kinase of HSV-1 cycles between the cytoplasm and nucleus and interacts with programmed cell death protein 4 (PDCD4) to block apoptosis.
Academic Article Circadian CLOCK histone acetyl transferase localizes at ND10 nuclear bodies and enables herpes simplex virus gene expression.
Academic Article Overexpression of the ubiquitin-specific protease 7 resulting from transfection or mutations in the ICP0 binding site accelerates rather than depresses herpes simplex virus 1 gene expression.
Academic Article Induction of apoptosis accelerates reactivation of latent HSV-1 in ganglionic organ cultures and replication in cell cultures.
Academic Article Signal transducer and activator of transcription 1 regulates both cytotoxic and prosurvival functions in tumor cells.
Academic Article Role of cellular phosphatase cdc25C in herpes simplex virus 1 replication.
Academic Article The virion-packaged endoribonuclease of herpes simplex virus 1 cleaves mRNA in polyribosomes.
Academic Article During its nuclear phase the multifunctional regulatory protein ICP0 undergoes proteolytic cleavage characteristic of polyproteins.
Academic Article The disappearance of cyclins A and B and the increase in activity of the G(2)/M-phase cellular kinase cdc2 in herpes simplex virus 1-infected cells require expression of the alpha22/U(S)1.5 and U(L)13 viral genes.
Academic Article Small dense nuclear bodies are the site of localization of herpes simplex virus 1 U(L)3 and U(L)4 proteins and of ICP22 only when the latter protein is present.
Academic Article Identification of a novel expressed open reading frame situated between genes U(L)20 and U(L)21 of the herpes simplex virus 1 genome.
Academic Article Glycoprotein D or J delivered in trans blocks apoptosis in SK-N-SH cells induced by a herpes simplex virus 1 mutant lacking intact genes expressing both glycoproteins.
Academic Article Cation-independent mannose 6-phosphate receptor blocks apoptosis induced by herpes simplex virus 1 mutants lacking glycoprotein D and is likely the target of antiapoptotic activity of the glycoprotein.
Academic Article Overexpression of promyelocytic leukemia protein precludes the dispersal of ND10 structures and has no effect on accumulation of infectious herpes simplex virus 1 or its proteins.
Academic Article Friendly fire: redirecting herpes simplex virus-1 for therapeutic applications.
Academic Article The herpes simplex virus 1 US3 protein kinase blocks caspase-dependent double cleavage and activation of the proapoptotic protein BAD.
Academic Article Oct-1 is posttranslationally modified and exhibits reduced capacity to bind cognate sites at late times after infection with herpes simplex virus 1.
Academic Article Post-transcriptional processing of cellular RNAs in herpes simplex virus-infected cells.
Academic Article Construction and properties of a herpes simplex virus 1 designed to enter cells solely via the IL-13alpha2 receptor.
Academic Article The egress of herpesviruses from cells: the unanswered questions.
Academic Article ICP0 and the US3 protein kinase of herpes simplex virus 1 independently block histone deacetylation to enable gene expression.
Academic Article Herpes simplex virus 1 precludes replenishment of the short-lived receptor of tumor necrosis factor alpha by virion host shutoff-dependent degradation of its mRNA.
Academic Article ReVOLT: radiation-enhanced viral oncolytic therapy.
Academic Article Attenuated herpes simplex virus 1 blocks arterial apoptosis and intimal hyperplasia induced by balloon angioplasty and reduced blood flow.
Academic Article Nuclear retention of ICP0 in cells exposed to HDAC inhibitor or transfected with DNA before infection with herpes simplex virus 1.
Academic Article Engagement of the lysine-specific demethylase/HDAC1/CoREST/REST complex by herpes simplex virus 1.
Academic Article ICP0 enables and monitors the function of D cyclins in herpes simplex virus 1 infected cells.
Academic Article Role of herpes simplex virus ICP0 in the transactivation of genes introduced by infection or transfection: a reappraisal.
Academic Article HSV carrying WT REST establishes latency but reactivates only if the synthesis of REST is suppressed.
Academic Article The virion host shutoff RNase plays a key role in blocking the activation of protein kinase R in cells infected with herpes simplex virus 1.
Academic Article The herpes simplex virus host shutoff RNase degrades cellular and viral mRNAs made before infection but not viral mRNA made after infection.
Academic Article Use of biotinylated plasmid DNA as a surrogate for HSV DNA to identify proteins that repress or activate viral gene expression.
Academic Article Selective degradation of mRNAs by the HSV host shutoff RNase is regulated by the UL47 tegument protein.
Academic Article Modulation of reactivation of latent herpes simplex virus 1 in ganglionic organ cultures by p300/CBP and STAT3.
Academic Article The role of the CoREST/REST repressor complex in herpes simplex virus 1 productive infection and in latency.
Academic Article RIG-I-like receptor LGP2 protects tumor cells from ionizing radiation.
Academic Article An inquiry into the molecular basis of HSV latency and reactivation.
Academic Article Cells infected with herpes simplex virus 1 export to uninfected cells exosomes containing STING, viral mRNAs, and microRNAs.
Academic Article Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
Academic Article The nuclear-cytoplasmic shuttling of virion host shutoff RNase is enabled by pUL47 and an embedded nuclear export signal and defines the sites of degradation of AU-rich and stable cellular mRNAs.
Academic Article Tristetraprolin Recruits the Herpes Simplex Virion Host Shutoff RNase to AU-Rich Elements in Stress Response mRNAs To Enable Their Cleavage.
Academic Article HSV-1 degrades, stabilizes, requires, or is stung by STING depending on ICP0, the US3 protein kinase, and cell derivation.
Academic Article The stability of herpes simplex virus 1 ICP0 early after infection is defined by the RING finger and the UL13 protein kinase.
Academic Article Role of activating transcription factor 3 in the synthesis of latency-associated transcript and maintenance of herpes simplex virus 1 in latent state in ganglia.
Academic Article miR-H28 and miR-H29 expressed late in productive infection are exported and restrict HSV-1 replication and spread in recipient cells.
Academic Article The Maturation of a Scientist: An Autobiography.
Academic Article PML plays both inimical and beneficial roles in HSV-1 replication.
Academic Article The SP100 component of ND10 enhances accumulation of PML and suppresses replication and the assembly of HSV replication compartments.
Academic Article miRNAs Targeting ICP4 and Delivered to Susceptible Cells in Exosomes Block HSV-1 Replication in a Dose-Dependent Manner.
Academic Article Innate responses to gene knockouts impact overlapping gene networks and vary with respect to resistance to viral infection.
Academic Article PUM1 is a biphasic negative regulator of innate immunity genes by suppressing LGP2.
Academic Article GADD45? Activated Early in the Course of Herpes Simplex Virus 1 Infection Suppresses the Activation of a Network of Innate Immunity Genes.
Academic Article Herpes Simplex Virus 1 MicroRNA miR-H28 Exported to Uninfected Cells in Exosomes Restricts Cell-to-Cell Virus Spread by Inducing Gamma Interferon mRNA.
Academic Article Statement in support of the scientists, public health professionals, and medical professionals of China combatting COVID-19.
Academic Article hnRNPA2B1 Associated with Recruitment of RNA into Exosomes Plays a Key Role in Herpes Simplex Virus 1 Release from Infected Cells.
Grant Engineered HSV For Treatment of Malignant Glioma
Grant The functions of the US3 protein kinase of herpes simplex virus
Grant CONFERENCE ON CONTROL OF VIRAL LATENCY AND PERSISTENCE
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