Item Type | Name |
Concept
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RNA, Viral
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Concept
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RNA Splicing
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Concept
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RNA
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Concept
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RNA Polymerase II
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Concept
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DNA-Directed RNA Polymerases
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Concept
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RNA Processing, Post-Transcriptional
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Concept
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RNA Interference
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Concept
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RNA-Binding Proteins
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Concept
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RNA Helicases
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Concept
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RNA, Messenger
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Concept
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RNA, Antisense
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Concept
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DEAD-box RNA Helicases
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Concept
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RNA Transport
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Concept
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RNA, Small Interfering
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Concept
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RNA Stability
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Academic Article
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Redefining virology.
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Academic Article
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Second-site mutation outside of the U(S)10-12 domain of Deltagamma(1)34.5 herpes simplex virus 1 recombinant blocks the shutoff of protein synthesis induced by activated protein kinase R and partially restores neurovirulence.
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Academic Article
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An early regulatory function required in a cell type-dependent manner is expressed by the genomic but not the cDNA copy of the herpes simplex virus 1 gene encoding infected cell protein 0.
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Academic Article
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Of the three tegument proteins that package mRNA in herpes simplex virions, one (VP22) transports the mRNA to uninfected cells for expression prior to viral infection.
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Academic Article
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RNAs extracted from herpes simplex virus 1 virions: apparent selectivity of viral but not cellular RNAs packaged in virions.
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Academic Article
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Dose-dependent and independent temporal patterns of gene responses to ionizing radiation in normal and tumor cells and tumor xenografts.
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Academic Article
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The herpes simplex virus 1 UL41 gene-dependent destabilization of cellular RNAs is selective and may be sequence-specific.
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Academic Article
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The UL41 protein of herpes simplex virus mediates selective stabilization or degradation of cellular mRNAs.
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Academic Article
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The carboxyl-terminal domain of RNA polymerase II is phosphorylated by a complex containing cdk9 and infected-cell protein 22 of herpes simplex virus 1.
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Academic Article
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The patterns of accumulation of cellular RNAs in cells infected with a wild-type and a mutant herpes simplex virus 1 lacking the virion host shutoff gene.
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Academic Article
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Herpes simplex virus 1 ICP22 regulates the accumulation of a shorter mRNA and of a truncated US3 protein kinase that exhibits altered functions.
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Academic Article
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The stress-inducible immediate-early responsive gene IEX-1 is activated in cells infected with herpes simplex virus 1, but several viral mechanisms, including 3' degradation of its RNA, preclude expression of the gene.
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Academic Article
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The U(L)41 protein of herpes simplex virus 1 degrades RNA by endonucleolytic cleavage in absence of other cellular or viral proteins.
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Academic Article
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Herpes simplex virus 1 induces cytoplasmic accumulation of TIA-1/TIAR and both synthesis and cytoplasmic accumulation of tristetraprolin, two cellular proteins that bind and destabilize AU-rich RNAs.
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Academic Article
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State and role of SRC family kinases in replication of herpes simplex virus 1.
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Academic Article
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The virion host shutoff protein (UL41) of herpes simplex virus 1 is an endoribonuclease with a substrate specificity similar to that of RNase A.
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Academic Article
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Expression of gamma interferon-dependent genes is blocked independently by virion host shutoff RNase and by US3 protein kinase.
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Academic Article
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Role of cdk9 in the optimization of expression of the genes regulated by ICP22 of herpes simplex virus 1.
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Academic Article
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Role of herpes simplex virus ICP27 in the degradation of mRNA by virion host shutoff RNase.
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Academic Article
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The novel HSV-1 US5-1 RNA is transcribed off a domain encoding US5, US4, US3, US2 and alpha22.
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Academic Article
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Interwoven roles of cyclin D3 and cdk4 recruited by ICP0 and ICP4 in the expression of herpes simplex virus genes.
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Academic Article
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Antisense RNA directed to the human papillomavirus type 16 E7 mRNA from herpes simplex virus type 1 derived vectors is expressed in CaSki cells and downregulates E7 mRNA.
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Academic Article
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Interaction of herpes simplex virus RNase with VP16 and VP22 is required for the accumulation of the protein but not for accumulation of mRNA.
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Academic Article
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The histone acetyltransferase CLOCK is an essential component of the herpes simplex virus 1 transcriptome that includes TFIID, ICP4, ICP27, and ICP22.
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Academic Article
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HSV-1 gene expression from reactivated ganglia is disordered and concurrent with suppression of latency-associated transcript and miRNAs.
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Academic Article
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US3 protein kinase of HSV-1 cycles between the cytoplasm and nucleus and interacts with programmed cell death protein 4 (PDCD4) to block apoptosis.
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Academic Article
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Circadian CLOCK histone acetyl transferase localizes at ND10 nuclear bodies and enables herpes simplex virus gene expression.
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Academic Article
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Signal transducer and activator of transcription 1 regulates both cytotoxic and prosurvival functions in tumor cells.
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Academic Article
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Role of cellular phosphatase cdc25C in herpes simplex virus 1 replication.
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Academic Article
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The virion-packaged endoribonuclease of herpes simplex virus 1 cleaves mRNA in polyribosomes.
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Academic Article
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Post-transcriptional processing of cellular RNAs in herpes simplex virus-infected cells.
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Academic Article
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Herpes simplex virus 1 precludes replenishment of the short-lived receptor of tumor necrosis factor alpha by virion host shutoff-dependent degradation of its mRNA.
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Academic Article
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Disruption of HDAC/CoREST/REST repressor by dnREST reduces genome silencing and increases virulence of herpes simplex virus.
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Academic Article
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HSV carrying WT REST establishes latency but reactivates only if the synthesis of REST is suppressed.
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Academic Article
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The herpes simplex virus host shutoff RNase degrades cellular and viral mRNAs made before infection but not viral mRNA made after infection.
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Academic Article
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Use of biotinylated plasmid DNA as a surrogate for HSV DNA to identify proteins that repress or activate viral gene expression.
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Academic Article
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Selective degradation of mRNAs by the HSV host shutoff RNase is regulated by the UL47 tegument protein.
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Academic Article
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RIG-I-like receptor LGP2 protects tumor cells from ionizing radiation.
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Academic Article
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Cells infected with herpes simplex virus 1 export to uninfected cells exosomes containing STING, viral mRNAs, and microRNAs.
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Academic Article
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The nuclear-cytoplasmic shuttling of virion host shutoff RNase is enabled by pUL47 and an embedded nuclear export signal and defines the sites of degradation of AU-rich and stable cellular mRNAs.
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Academic Article
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Tristetraprolin Recruits the Herpes Simplex Virion Host Shutoff RNase to AU-Rich Elements in Stress Response mRNAs To Enable Their Cleavage.
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Academic Article
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miRNAs Targeting ICP4 and Delivered to Susceptible Cells in Exosomes Block HSV-1 Replication in a Dose-Dependent Manner.
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Academic Article
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PUM1 is a biphasic negative regulator of innate immunity genes by suppressing LGP2.
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Academic Article
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GADD45? Activated Early in the Course of Herpes Simplex Virus 1 Infection Suppresses the Activation of a Network of Innate Immunity Genes.
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Academic Article
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Herpes Simplex Virus 1 MicroRNA miR-H28 Exported to Uninfected Cells in Exosomes Restricts Cell-to-Cell Virus Spread by Inducing Gamma Interferon mRNA.
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Academic Article
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hnRNPA2B1 Associated with Recruitment of RNA into Exosomes Plays a Key Role in Herpes Simplex Virus 1 Release from Infected Cells.
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Grant
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DISSECTION OF THE FUNCTIONS OF HERPES SIMPLEX VIRUS ICPO
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Grant
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FUNCTIONS FOR HERPES SIMPLEX VIRUS ICP22 AND US1.5
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Grant
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Selective Degradation of mRNA by Herpes Simplex Virus 1
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Grant
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MECHANISMS OF VIRAL INFECTION IN RELATION TO CANCER
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Grant
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UCCRC: VIRAL ONCOLOGY PROGRAM
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