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Concept
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Receptors, Thyrotropin
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Concept
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Receptors, Thyrotropin-Releasing Hormone
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Concept
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Thyrotropin
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Concept
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Thyrotropin-Releasing Hormone
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Concept
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Thyrotropin, beta Subunit
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Academic Article
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Multiple genetic factors in the heterogeneity of thyroid hormone resistance.
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Academic Article
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Resistance to thyroid hormone caused by two mutant thyroid hormone receptors beta, R243Q and R243W, with marked impairment of function that cannot be explained by altered in vitro 3,5,3'-triiodothyroinine binding affinity.
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Academic Article
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A new family with hyperthyroxinemia caused by transthyretin Val109 misdiagnosed as thyrotoxicosis and resistance to thyroid hormone--a clinical research center study.
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Academic Article
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Thyroid dysfunction is not associated with alterations in serum leptin levels.
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Academic Article
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Resistance to thyrotropin and other abnormalities of the thyrotropin receptor.
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Academic Article
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Resistance to thyrotropin (TSH) in three families is not associated with mutations in the TSH receptor or TSH.
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Academic Article
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Thyrotropin regulation by thyroid hormone in thyroid hormone receptor beta-deficient mice.
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Academic Article
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Evaluation of pituitary and peripheral tissue markers of thyroid hormone action in an Iranian family with resistance to thyroid hormone.
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Academic Article
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Selective pituitary resistance to thyroid hormone produced by expression of a mutant thyroid hormone receptor beta gene in the pituitary gland of transgenic mice.
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Academic Article
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Structure-function relationships of two loss-of-function mutations of the thyrotropin receptor gene.
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Academic Article
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Effect of thyroid hormone on growth. Lessons from the syndrome of resistance to thyroid hormone.
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Academic Article
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Mice deficient in the steroid receptor co-activator 1 (SRC-1) are resistant to thyroid hormone.
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Academic Article
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Thyroid hormone action on liver, heart, and energy expenditure in thyroid hormone receptor beta-deficient mice.
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Academic Article
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Genetic immunization of outbred mice with thyrotropin receptor cDNA provides a model of Graves' disease.
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Academic Article
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Congenital central isolated hypothyroidism caused by a homozygous mutation in the TSH-beta subunit gene.
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Academic Article
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Low serum free thyroxine index in ambulating elderly is due to a resetting of the threshold of thyrotropin feedback suppression.
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Academic Article
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Five new families with resistance to thyroid hormone not caused by mutations in the thyroid hormone receptor beta gene.
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Academic Article
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Aberrant alternative splicing of thyroid hormone receptor in a TSH-secreting pituitary tumor is a mechanism for hormone resistance.
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Academic Article
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The hypothyroidism in an inbred kindred with congenital thyroid hormone and glucocorticoid deficiency is due to a mutation producing a truncated thyrotropin receptor.
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Academic Article
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Congenital hypothyroidism in a child with unsuspected familial dysalbuminemic hyperthyroxinemia caused by a mutation (R218H) in the human albumin gene.
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Academic Article
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Improved radioimmunoassay for measurement of mouse thyrotropin in serum: strain differences in thyrotropin concentration and thyrotroph sensitivity to thyroid hormone.
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Academic Article
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Steroid receptor coactivator-1 deficiency causes variable alterations in the modulation of T(3)-regulated transcription of genes in vivo.
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Academic Article
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Resistance to thyroid hormone caused by a new mutation (V336M) in the thyroid hormone receptor beta gene.
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Academic Article
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Type 1 iodothyronine deiodinase in the house musk shrew (Suncus murinus, Insectivora: Soricidae): cloning and characterization of complementary DNA, unique tissue distribution and regulation by T(3).
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Academic Article
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Thyroid function in mice with compound heterozygous and homozygous disruptions of SRC-1 and TIF-2 coactivators: evidence for haploinsufficiency.
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Academic Article
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Low TSH requirement and goiter in transgenic mice overexpressing IGF-I and IGF-Ir receptor in the thyroid gland.
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Academic Article
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Congenital secondary hypothyroidism caused by exon skipping due to a homozygous donor splice site mutation in the TSHbeta-subunit gene.
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Academic Article
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RXR receptor agonist suppression of thyroid function: central effects in the absence of thyroid hormone receptor.
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Academic Article
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The effect of short-term treatment with recombinant human thyroid-stimulating hormones on leydig cell function in men.
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Academic Article
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Resistance to thyrotropin.
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Academic Article
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Hypothyroidism in thyroid transcription factor 1 haploinsufficiency is caused by reduced expression of the thyroid-stimulating hormone receptor.
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Academic Article
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Regression of a large goiter in a patient with resistance to thyroid hormone by every other day treatment with triiodothyronine.
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Academic Article
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Thyroid function and effect of aging in combined hetero/homozygous mice deficient in thyroid hormone receptors alpha and beta genes.
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Academic Article
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Fetal loss associated with excess thyroid hormone exposure.
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Academic Article
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Autosomal dominant resistance to thyrotropin as a distinct entity in five multigenerational kindreds: clinical characterization and exclusion of candidate loci.
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Academic Article
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Neonatal detection of generalized resistance to thyroid hormone.
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Academic Article
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Delineation of the discontinuous-conformational epitope of a monoclonal antibody displaying full in vitro and in vivo thyrotropin activity.
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Academic Article
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The syndrome of resistance to thyroid stimulating hormone.
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Academic Article
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Effects of maternal levels of thyroid hormone (TH) on the hypothalamus-pituitary-thyroid set point: studies in TH receptor beta knockout mice.
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Academic Article
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Loss-of-function mutations in the thyrotropin receptor gene as a major determinant of hyperthyrotropinemia in a consanguineous community.
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Academic Article
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Tissue responses to thyroid hormone in a kindred with resistance to thyroid hormone harboring a commonly occurring mutation in the thyroid hormone receptor beta gene (P453T).
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Academic Article
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Clinical and molecular characterization of a novel selenocysteine insertion sequence-binding protein 2 (SBP2) gene mutation (R128X).
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Academic Article
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A thyroid hormone analog with reduced dependence on the monocarboxylate transporter 8 for tissue transport.
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Academic Article
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A new inherited abnormality of thyroxine-binding globulin (TBG-San Diego) with decreased affinity for thyroxine and triiodothyronine.
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Academic Article
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Generalized resistance to thyroid hormone associated with a mutation in the ligand-binding domain of the human thyroid hormone receptor beta.
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Academic Article
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Mice deficient in MCT8 reveal a mechanism regulating thyroid hormone secretion.
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Academic Article
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Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice.
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Academic Article
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Selenium supplementation fails to correct the selenoprotein synthesis defect in subjects with SBP2 gene mutations.
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Academic Article
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Type 3 deiodinase deficiency results in functional abnormalities at multiple levels of the thyroid axis.
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Academic Article
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A lack of thyroid hormones rather than excess thyrotropin causes abnormal skeletal development in hypothyroidism.
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Academic Article
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A single copy of the recently identified dual oxidase maturation factor (DUOXA) 1 gene produces only mild transient hypothyroidism in a patient with a novel biallelic DUOXA2 mutation and monoallelic DUOXA1 deletion.
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Academic Article
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Consecutive mutational events in a TSHR allele of Arab families with resistance to thyroid stimulating hormone.
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Academic Article
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Role of type 2 deiodinase in response to acute lung injury (ALI) in mice.
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Academic Article
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High concentration of thyrotropin-releasing hormone in pancreatic islets.
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Academic Article
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Resistance to thyroid hormone in a patient with thyroid dysgenesis.
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Academic Article
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Variant thyroxine-binding globulin in serum of Australian aborigines: a comparison with familial TBG deficiency in Caucasians and American blacks.
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Academic Article
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Induction of hypothyroidism and hypoprolactinemia by growth hormone producing rat pituitary tumors.
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Academic Article
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Mice deficient in dual oxidase maturation factors are severely hypothyroid.
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Academic Article
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Dominant role of thyrotropin-releasing hormone in the hypothalamic-pituitary-thyroid axis.
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Academic Article
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Suppression of serum thyrotropin (TSH) by L-dopa in chronic hypothyroidism: interrelationships in the regulation of TSH and prolactin secretion.
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Academic Article
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The coexistence of a novel inactivating mutant thyrotropin receptor allele with two thyroid peroxidase mutations: a genotype-phenotype correlation.
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Academic Article
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Syndromes of thyroid hormone resistance.
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Academic Article
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Mosaicism of a thyroid hormone receptor-beta gene mutation in resistance to thyroid hormone.
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Academic Article
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Defective thyroid hormone feedback regulation in the syndrome of peripheral resistance to thyroid hormone.
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Academic Article
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Ontogenetic patterns of thyrotropin-releasing hormone-like material in rat hypothalamus, pancreas, and retina: selective effect of light deprivation.
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Academic Article
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Chiari-Frommel syndrome in a patient with primary adrenocortical insufficiency.
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Academic Article
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Endemic goiter with hypothyroidism in three generations.
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Academic Article
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Loss of bioreactivity and preservation of immunoreactivity of iodothyrotropin-releasing hormone.
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Academic Article
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Thyroid function in a uremic rat model. Evidence suggesting tissue hypothyroidism.
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Academic Article
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Modulation of thyroglobulin messenger RNA accumulation in the rat thyroid.
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Academic Article
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High prevalence of thyroxine-binding globulin deficiency among Bedouin infants in southern Israel.
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Academic Article
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Resistance to thyroid hormone.
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Academic Article
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Thyroid dysfunction in chronic renal failure. A study of the pituitary-thyroid axis and peripheral turnover kinetics of thyroxine and triiodothyronine.
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Academic Article
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Preliminary studies on the immediate phase-shifting effects of light and exercise on the human circadian clock.
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Academic Article
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Pituitary-thyroid setpoint and thyrotropin receptor expression in consomic rats.
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Academic Article
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Brief report: resistance to thyrotropin caused by mutations in the thyrotropin-receptor gene.
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Academic Article
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Nocturnal exercise phase delays circadian rhythms of melatonin and thyrotropin secretion in normal men.
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Academic Article
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Interrelationships in the regulation of TSH and prolactin secretion in man: effects of L-dopa, TRH and thyroid hormone in various combinations.
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Academic Article
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Congenital neonatal hyperthyroidism caused by germline mutations in the TSH receptor gene.
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Academic Article
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The influence of percutaneous fine needle aspiration on serum thyroglobulin.
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Academic Article
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Demonstration of rapid light-induced advances and delays of the human circadian clock using hormonal phase markers.
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Academic Article
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A somatic gain-of-function mutation in the thyrotropin receptor gene producing a toxic adenoma in an infant.
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Academic Article
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In vivo interaction of steroid receptor coactivator (SRC)-1 and the activation function-2 domain of the thyroid hormone receptor (TR) beta in TRbeta E457A knock-in and SRC-1 knockout mice.
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Academic Article
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Functional characteristics of a variant thyrotropin receptor.
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Academic Article
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Multifactorial control of the 24-hour secretory profiles of pituitary hormones.
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Academic Article
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Inherited abnormality of thyroxine-binding globulin with no demonstrable thyroxine-binding activity and high serum levels of denatured thyroxine-binding globulin.
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Academic Article
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Variant thyroxine-binding globulin in serum of Australian aborigines: its physical, chemical and biological properties.
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Academic Article
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Thyrotropin controls transcription of the thyroglobulin gene.
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Academic Article
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Resistance to thyroid hormone in subjects from two unrelated families is associated with a point mutation in the thyroid hormone receptor beta gene resulting in the replacement of the normal proline 453 with serine.
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Academic Article
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Increased sensitivity to thyroid hormone in mice with complete deficiency of thyroid hormone receptor alpha.
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Academic Article
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Genetic analysis reveals different functions for the products of the thyroid hormone receptor alpha locus.
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Academic Article
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Four new cases of congenital secondary hypothyroidism due to a splice site mutation in the thyrotropin-beta gene: phenotypic variability and founder effect.
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Academic Article
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Repulsive separation of the cytoplasmic ends of transmembrane helices 3 and 6 is linked to receptor activation in a novel thyrotropin receptor mutant (M626I).
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Academic Article
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Serum thyrotropin and prolactin in the syndrome of generalized resistance to thyroid hormone: responses to thyrotropin-releasing hormone stimulation and short term triiodothyronine suppression.
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Academic Article
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Tissue-specific thyroid hormone deprivation and excess in monocarboxylate transporter (mct) 8-deficient mice.
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Academic Article
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A familial thyrotropin (TSH) receptor mutation provides in vivo evidence that the inositol phosphates/Ca2+ cascade mediates TSH action on thyroid hormone synthesis.
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Academic Article
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Generation of functional thyroid from embryonic stem cells.
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Academic Article
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Inherited heat-stable variant thyroxine-binding globulin (TBG-Chicago).
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Academic Article
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Neonatal hypothyroidism and goiter in one infant of each of two sets of twins due to maternal therapy with antithyroid drugs.
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Academic Article
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Radioimmunoassay of anterior pituitary hormones.
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Academic Article
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Abnormal thyroxine metabolism in hyposomatotrophic dwarfism and inhibition of responsiveness to TRH during GH therapy.
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Academic Article
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Reduced triiodothyronine content in liver but not pituitary of the uremic rat model: demonstration of changes compatible with thyroid hormone deficiency in liver only.
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Academic Article
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Polymorphism of a variant human thyrotropin receptor (hTSHR) gene.
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Academic Article
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Management of differentiated thyroid cancer in the presence of resistance to thyroid hormone and TSH-secreting adenomas: a report of four cases and review of the literature.
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Academic Article
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Changes in thyroid status during perinatal development of MCT8-deficient male mice.
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Academic Article
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Tissue-specific posttranslational modification allows functional targeting of thyrotropin.
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Academic Article
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Long-term outcome of loss-of-function mutations in thyrotropin receptor gene.
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Academic Article
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A TSHß Variant with Impaired Immunoreactivity but Intact Biological Activity and Its Clinical Implications.
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Academic Article
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The Thyroid Hormone Analog DITPA Ameliorates Metabolic Parameters of Male Mice With Mct8 Deficiency.
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Academic Article
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Hematopoietic Stem Cells Transplantation Can Normalize Thyroid Function in a Cystinosis Mouse Model.
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Academic Article
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Desensitization and Incomplete Recovery of Hepatic Target Genes After Chronic Thyroid Hormone Treatment and Withdrawal in Male Adult Mice.
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Academic Article
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Overexpression of Interleukin-4 in the Thyroid of Transgenic Mice Upregulates the Expression of Duox1 and the Anion Transporter Pendrin.
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Academic Article
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A Novel Mutation (S54C) of the PAX8 Gene in a Family with Congenital Hypothyroidism and a High Proportion of Affected Individuals.
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Academic Article
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DUOX2 Gene Mutation Manifesting as Resistance to Thyrotropin Phenotype.
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Academic Article
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TRH Action Is Impaired in Pituitaries of Male IGSF1-Deficient Mice.
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Academic Article
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Oncogene-induced senescence and its evasion in a mouse model of thyroid neoplasia.
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Academic Article
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Resistance to thyrotropin.
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Academic Article
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Prenatal Diagnosis of Resistance to Thyroid Hormone and Its Clinical Implications.
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Academic Article
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GLIS3 is indispensable for TSH/TSHR-dependent thyroid hormone biosynthesis and follicular cell proliferation.
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Academic Article
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Very Severe Resistance to Thyroid Hormone ß in One of Three Affected Members of a Family with a Novel Mutation in the THRB Gene.
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Academic Article
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Increased Anaplastic Lymphoma Kinase Activity Induces a Poorly Differentiated Thyroid Carcinoma in Mice.
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Academic Article
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Central Congenital Hypothyroidism Caused by a Novel Mutation, C47W, in the Cysteine Knot Region of TSHß.
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Academic Article
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Mice Hypomorphic for Keap1, a Negative Regulator of the Nrf2 Antioxidant Response, Show Age-Dependent Diffuse Goiter with Elevated Thyrotropin Levels.
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Academic Article
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Prenatal Treatment of Thyroid Hormone Cell Membrane Transport Defect Caused by MCT8 Gene Mutation.
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Academic Article
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Severe Resistance to Thyroid Hormone Beta in a Patient with Athyreosis.
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Academic Article
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Foxe1 Deletion in the Adult Mouse Is Associated With Increased Thyroidal Mast Cells and Hypothyroidism.
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Academic Article
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The Relationship Between Fetal THRB Genotype and Maternal Thyroid Function.
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Academic Article
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STR mutations on chromosome 15q cause thyrotropin resistance by activating a primate-specific enhancer of MIR7-2/MIR1179.
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