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One or more keywords matched the following items that are connected to Refetoff, Samuel
Item TypeName
Concept Receptors, Thyrotropin
Concept Receptors, Thyrotropin-Releasing Hormone
Concept Thyrotropin
Concept Thyrotropin-Releasing Hormone
Concept Thyrotropin, beta Subunit
Academic Article Multiple genetic factors in the heterogeneity of thyroid hormone resistance.
Academic Article Resistance to thyroid hormone caused by two mutant thyroid hormone receptors beta, R243Q and R243W, with marked impairment of function that cannot be explained by altered in vitro 3,5,3'-triiodothyroinine binding affinity.
Academic Article A new family with hyperthyroxinemia caused by transthyretin Val109 misdiagnosed as thyrotoxicosis and resistance to thyroid hormone--a clinical research center study.
Academic Article Thyroid dysfunction is not associated with alterations in serum leptin levels.
Academic Article Resistance to thyrotropin and other abnormalities of the thyrotropin receptor.
Academic Article Resistance to thyrotropin (TSH) in three families is not associated with mutations in the TSH receptor or TSH.
Academic Article Thyrotropin regulation by thyroid hormone in thyroid hormone receptor beta-deficient mice.
Academic Article Evaluation of pituitary and peripheral tissue markers of thyroid hormone action in an Iranian family with resistance to thyroid hormone.
Academic Article Selective pituitary resistance to thyroid hormone produced by expression of a mutant thyroid hormone receptor beta gene in the pituitary gland of transgenic mice.
Academic Article Structure-function relationships of two loss-of-function mutations of the thyrotropin receptor gene.
Academic Article Effect of thyroid hormone on growth. Lessons from the syndrome of resistance to thyroid hormone.
Academic Article Mice deficient in the steroid receptor co-activator 1 (SRC-1) are resistant to thyroid hormone.
Academic Article Thyroid hormone action on liver, heart, and energy expenditure in thyroid hormone receptor beta-deficient mice.
Academic Article Genetic immunization of outbred mice with thyrotropin receptor cDNA provides a model of Graves' disease.
Academic Article Congenital central isolated hypothyroidism caused by a homozygous mutation in the TSH-beta subunit gene.
Academic Article Low serum free thyroxine index in ambulating elderly is due to a resetting of the threshold of thyrotropin feedback suppression.
Academic Article Five new families with resistance to thyroid hormone not caused by mutations in the thyroid hormone receptor beta gene.
Academic Article Aberrant alternative splicing of thyroid hormone receptor in a TSH-secreting pituitary tumor is a mechanism for hormone resistance.
Academic Article The hypothyroidism in an inbred kindred with congenital thyroid hormone and glucocorticoid deficiency is due to a mutation producing a truncated thyrotropin receptor.
Academic Article Congenital hypothyroidism in a child with unsuspected familial dysalbuminemic hyperthyroxinemia caused by a mutation (R218H) in the human albumin gene.
Academic Article Improved radioimmunoassay for measurement of mouse thyrotropin in serum: strain differences in thyrotropin concentration and thyrotroph sensitivity to thyroid hormone.
Academic Article Steroid receptor coactivator-1 deficiency causes variable alterations in the modulation of T(3)-regulated transcription of genes in vivo.
Academic Article Resistance to thyroid hormone caused by a new mutation (V336M) in the thyroid hormone receptor beta gene.
Academic Article Type 1 iodothyronine deiodinase in the house musk shrew (Suncus murinus, Insectivora: Soricidae): cloning and characterization of complementary DNA, unique tissue distribution and regulation by T(3).
Academic Article Thyroid function in mice with compound heterozygous and homozygous disruptions of SRC-1 and TIF-2 coactivators: evidence for haploinsufficiency.
Academic Article Low TSH requirement and goiter in transgenic mice overexpressing IGF-I and IGF-Ir receptor in the thyroid gland.
Academic Article Congenital secondary hypothyroidism caused by exon skipping due to a homozygous donor splice site mutation in the TSHbeta-subunit gene.
Academic Article RXR receptor agonist suppression of thyroid function: central effects in the absence of thyroid hormone receptor.
Academic Article The effect of short-term treatment with recombinant human thyroid-stimulating hormones on leydig cell function in men.
Academic Article Resistance to thyrotropin.
Academic Article Hypothyroidism in thyroid transcription factor 1 haploinsufficiency is caused by reduced expression of the thyroid-stimulating hormone receptor.
Academic Article Regression of a large goiter in a patient with resistance to thyroid hormone by every other day treatment with triiodothyronine.
Academic Article Thyroid function and effect of aging in combined hetero/homozygous mice deficient in thyroid hormone receptors alpha and beta genes.
Academic Article Fetal loss associated with excess thyroid hormone exposure.
Academic Article Autosomal dominant resistance to thyrotropin as a distinct entity in five multigenerational kindreds: clinical characterization and exclusion of candidate loci.
Academic Article Neonatal detection of generalized resistance to thyroid hormone.
Academic Article Delineation of the discontinuous-conformational epitope of a monoclonal antibody displaying full in vitro and in vivo thyrotropin activity.
Academic Article The syndrome of resistance to thyroid stimulating hormone.
Academic Article Effects of maternal levels of thyroid hormone (TH) on the hypothalamus-pituitary-thyroid set point: studies in TH receptor beta knockout mice.
Academic Article Loss-of-function mutations in the thyrotropin receptor gene as a major determinant of hyperthyrotropinemia in a consanguineous community.
Academic Article Tissue responses to thyroid hormone in a kindred with resistance to thyroid hormone harboring a commonly occurring mutation in the thyroid hormone receptor beta gene (P453T).
Academic Article Clinical and molecular characterization of a novel selenocysteine insertion sequence-binding protein 2 (SBP2) gene mutation (R128X).
Academic Article A thyroid hormone analog with reduced dependence on the monocarboxylate transporter 8 for tissue transport.
Academic Article A new inherited abnormality of thyroxine-binding globulin (TBG-San Diego) with decreased affinity for thyroxine and triiodothyronine.
Academic Article Generalized resistance to thyroid hormone associated with a mutation in the ligand-binding domain of the human thyroid hormone receptor beta.
Academic Article Mice deficient in MCT8 reveal a mechanism regulating thyroid hormone secretion.
Academic Article Thyrotrophin receptor signaling dependence of Braf-induced thyroid tumor initiation in mice.
Academic Article Selenium supplementation fails to correct the selenoprotein synthesis defect in subjects with SBP2 gene mutations.
Academic Article Type 3 deiodinase deficiency results in functional abnormalities at multiple levels of the thyroid axis.
Academic Article A lack of thyroid hormones rather than excess thyrotropin causes abnormal skeletal development in hypothyroidism.
Academic Article A single copy of the recently identified dual oxidase maturation factor (DUOXA) 1 gene produces only mild transient hypothyroidism in a patient with a novel biallelic DUOXA2 mutation and monoallelic DUOXA1 deletion.
Academic Article Consecutive mutational events in a TSHR allele of Arab families with resistance to thyroid stimulating hormone.
Academic Article Role of type 2 deiodinase in response to acute lung injury (ALI) in mice.
Academic Article High concentration of thyrotropin-releasing hormone in pancreatic islets.
Academic Article Resistance to thyroid hormone in a patient with thyroid dysgenesis.
Academic Article Variant thyroxine-binding globulin in serum of Australian aborigines: a comparison with familial TBG deficiency in Caucasians and American blacks.
Academic Article Induction of hypothyroidism and hypoprolactinemia by growth hormone producing rat pituitary tumors.
Academic Article Mice deficient in dual oxidase maturation factors are severely hypothyroid.
Academic Article Dominant role of thyrotropin-releasing hormone in the hypothalamic-pituitary-thyroid axis.
Academic Article Suppression of serum thyrotropin (TSH) by L-dopa in chronic hypothyroidism: interrelationships in the regulation of TSH and prolactin secretion.
Academic Article The coexistence of a novel inactivating mutant thyrotropin receptor allele with two thyroid peroxidase mutations: a genotype-phenotype correlation.
Academic Article Syndromes of thyroid hormone resistance.
Academic Article Mosaicism of a thyroid hormone receptor-beta gene mutation in resistance to thyroid hormone.
Academic Article Defective thyroid hormone feedback regulation in the syndrome of peripheral resistance to thyroid hormone.
Academic Article Ontogenetic patterns of thyrotropin-releasing hormone-like material in rat hypothalamus, pancreas, and retina: selective effect of light deprivation.
Academic Article Chiari-Frommel syndrome in a patient with primary adrenocortical insufficiency.
Academic Article Endemic goiter with hypothyroidism in three generations.
Academic Article Loss of bioreactivity and preservation of immunoreactivity of iodothyrotropin-releasing hormone.
Academic Article Thyroid function in a uremic rat model. Evidence suggesting tissue hypothyroidism.
Academic Article Modulation of thyroglobulin messenger RNA accumulation in the rat thyroid.
Academic Article High prevalence of thyroxine-binding globulin deficiency among Bedouin infants in southern Israel.
Academic Article Resistance to thyroid hormone.
Academic Article Thyroid dysfunction in chronic renal failure. A study of the pituitary-thyroid axis and peripheral turnover kinetics of thyroxine and triiodothyronine.
Academic Article Preliminary studies on the immediate phase-shifting effects of light and exercise on the human circadian clock.
Academic Article Pituitary-thyroid setpoint and thyrotropin receptor expression in consomic rats.
Academic Article Brief report: resistance to thyrotropin caused by mutations in the thyrotropin-receptor gene.
Academic Article Nocturnal exercise phase delays circadian rhythms of melatonin and thyrotropin secretion in normal men.
Academic Article Interrelationships in the regulation of TSH and prolactin secretion in man: effects of L-dopa, TRH and thyroid hormone in various combinations.
Academic Article Congenital neonatal hyperthyroidism caused by germline mutations in the TSH receptor gene.
Academic Article The influence of percutaneous fine needle aspiration on serum thyroglobulin.
Academic Article Demonstration of rapid light-induced advances and delays of the human circadian clock using hormonal phase markers.
Academic Article A somatic gain-of-function mutation in the thyrotropin receptor gene producing a toxic adenoma in an infant.
Academic Article In vivo interaction of steroid receptor coactivator (SRC)-1 and the activation function-2 domain of the thyroid hormone receptor (TR) beta in TRbeta E457A knock-in and SRC-1 knockout mice.
Academic Article Functional characteristics of a variant thyrotropin receptor.
Academic Article Multifactorial control of the 24-hour secretory profiles of pituitary hormones.
Academic Article Inherited abnormality of thyroxine-binding globulin with no demonstrable thyroxine-binding activity and high serum levels of denatured thyroxine-binding globulin.
Academic Article Variant thyroxine-binding globulin in serum of Australian aborigines: its physical, chemical and biological properties.
Academic Article Thyrotropin controls transcription of the thyroglobulin gene.
Academic Article Resistance to thyroid hormone in subjects from two unrelated families is associated with a point mutation in the thyroid hormone receptor beta gene resulting in the replacement of the normal proline 453 with serine.
Academic Article Increased sensitivity to thyroid hormone in mice with complete deficiency of thyroid hormone receptor alpha.
Academic Article Genetic analysis reveals different functions for the products of the thyroid hormone receptor alpha locus.
Academic Article Four new cases of congenital secondary hypothyroidism due to a splice site mutation in the thyrotropin-beta gene: phenotypic variability and founder effect.
Academic Article Repulsive separation of the cytoplasmic ends of transmembrane helices 3 and 6 is linked to receptor activation in a novel thyrotropin receptor mutant (M626I).
Academic Article Serum thyrotropin and prolactin in the syndrome of generalized resistance to thyroid hormone: responses to thyrotropin-releasing hormone stimulation and short term triiodothyronine suppression.
Academic Article Tissue-specific thyroid hormone deprivation and excess in monocarboxylate transporter (mct) 8-deficient mice.
Academic Article A familial thyrotropin (TSH) receptor mutation provides in vivo evidence that the inositol phosphates/Ca2+ cascade mediates TSH action on thyroid hormone synthesis.
Academic Article Generation of functional thyroid from embryonic stem cells.
Academic Article Inherited heat-stable variant thyroxine-binding globulin (TBG-Chicago).
Academic Article Neonatal hypothyroidism and goiter in one infant of each of two sets of twins due to maternal therapy with antithyroid drugs.
Academic Article Radioimmunoassay of anterior pituitary hormones.
Academic Article Abnormal thyroxine metabolism in hyposomatotrophic dwarfism and inhibition of responsiveness to TRH during GH therapy.
Academic Article Reduced triiodothyronine content in liver but not pituitary of the uremic rat model: demonstration of changes compatible with thyroid hormone deficiency in liver only.
Academic Article Polymorphism of a variant human thyrotropin receptor (hTSHR) gene.
Academic Article Management of differentiated thyroid cancer in the presence of resistance to thyroid hormone and TSH-secreting adenomas: a report of four cases and review of the literature.
Academic Article Changes in thyroid status during perinatal development of MCT8-deficient male mice.
Academic Article Tissue-specific posttranslational modification allows functional targeting of thyrotropin.
Academic Article Long-term outcome of loss-of-function mutations in thyrotropin receptor gene.
Academic Article A TSHß Variant with Impaired Immunoreactivity but Intact Biological Activity and Its Clinical Implications.
Academic Article The Thyroid Hormone Analog DITPA Ameliorates Metabolic Parameters of Male Mice With Mct8 Deficiency.
Academic Article Hematopoietic Stem Cells Transplantation Can Normalize Thyroid Function in a Cystinosis Mouse Model.
Academic Article Desensitization and Incomplete Recovery of Hepatic Target Genes After Chronic Thyroid Hormone Treatment and Withdrawal in Male Adult Mice.
Academic Article Overexpression of Interleukin-4 in the Thyroid of Transgenic Mice Upregulates the Expression of Duox1 and the Anion Transporter Pendrin.
Academic Article A Novel Mutation (S54C) of the PAX8 Gene in a Family with Congenital Hypothyroidism and a High Proportion of Affected Individuals.
Academic Article DUOX2 Gene Mutation Manifesting as Resistance to Thyrotropin Phenotype.
Academic Article TRH Action Is Impaired in Pituitaries of Male IGSF1-Deficient Mice.
Academic Article Oncogene-induced senescence and its evasion in a mouse model of thyroid neoplasia.
Academic Article Resistance to thyrotropin.
Academic Article Prenatal Diagnosis of Resistance to Thyroid Hormone and Its Clinical Implications.
Academic Article GLIS3 is indispensable for TSH/TSHR-dependent thyroid hormone biosynthesis and follicular cell proliferation.
Academic Article Very Severe Resistance to Thyroid Hormone ß in One of Three Affected Members of a Family with a Novel Mutation in the THRB Gene.
Academic Article Increased Anaplastic Lymphoma Kinase Activity Induces a Poorly Differentiated Thyroid Carcinoma in Mice.
Academic Article Central Congenital Hypothyroidism Caused by a Novel Mutation, C47W, in the Cysteine Knot Region of TSHß.
Academic Article Mice Hypomorphic for Keap1, a Negative Regulator of the Nrf2 Antioxidant Response, Show Age-Dependent Diffuse Goiter with Elevated Thyrotropin Levels.
Academic Article Prenatal Treatment of Thyroid Hormone Cell Membrane Transport Defect Caused by MCT8 Gene Mutation.
Academic Article Severe Resistance to Thyroid Hormone Beta in a Patient with Athyreosis.
Academic Article Foxe1 Deletion in the Adult Mouse Is Associated With Increased Thyroidal Mast Cells and Hypothyroidism.
Grant Thyroid Physiology Studies of Inherited Disorders
Academic Article The Relationship Between Fetal THRB Genotype and Maternal Thyroid Function.
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