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Kossiakoff, Anthony

One or more keywords matched the following items that are connected to Kossiakoff, Anthony

Item Type	Name
Concept	Binding Sites, Antibody
Concept	Binding Sites
Academic Article	Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities.
Academic Article	Human growth hormone and extracellular domain of its receptor: crystal structure of the complex.
Academic Article	Ternary complex between placental lactogen and the extracellular domain of the prolactin receptor.
Academic Article	High affinity RNase S-peptide variants obtained by phage display have a novel "hot-spot" of binding energy.
Academic Article	Structure of a phage display-derived variant of human growth hormone complexed to two copies of the extracellular domain of its receptor: evidence for strong structural coupling between receptor binding sites.
Academic Article	Deciphering the role of the electrostatic interactions involving Gly70 in eglin C by total chemical protein synthesis.
Academic Article	Site2 binding energetics of the regulatory step of growth hormone-induced receptor homodimerization.
Academic Article	Functional promiscuity of squirrel monkey growth hormone receptor toward both primate and nonprimate growth hormones.
Academic Article	The functional binding epitope of a high affinity variant of human growth hormone mapped by shotgun alanine-scanning mutagenesis: insights into the mechanisms responsible for improved affinity.
Academic Article	Neutron structure of subtilisin BPN': effects of chemical environment on hydrogen-bonding geometries and the pattern of hydrogen-deuterium exchange in secondary structure elements.
Academic Article	Shotgun alanine scanning shows that growth hormone can bind productively to its receptor through a drastically minimized interface.
Academic Article	Crystal structure and site 1 binding energetics of human placental lactogen.
Academic Article	The 1.38 A crystal structure of DmsD protein from Salmonella typhimurium, a proofreading chaperone on the Tat pathway.
Academic Article	The high- and low-affinity receptor binding sites of growth hormone are allosterically coupled.
Academic Article	Alternative views of functional protein binding epitopes obtained by combinatorial shotgun scanning mutagenesis.
Academic Article	The role of protein dynamics in increasing binding affinity for an engineered protein-protein interaction established by H/D exchange mass spectrometry.
Academic Article	Exploring the capacity of minimalist protein interfaces: interface energetics and affinity maturation to picomolar KD of a single-domain antibody with a flat paratope.
Academic Article	Understanding mechanisms governing protein-protein interactions from synthetic binding interfaces.
Academic Article	Intramolecular cooperativity in a protein binding site assessed by combinatorial shotgun scanning mutagenesis.
Academic Article	Structure of bovine trypsinogen at 1.9 A resolution.
Academic Article	Crystal structure of the kringle 2 domain of tissue plasminogen activator at 2.4-A resolution.
Academic Article	The X-ray structure of a growth hormone-prolactin receptor complex.
Academic Article	Neutron diffraction identifies His 57 as the catalytic base in trypsin.
Academic Article	X-ray structures of the antigen-binding domains from three variants of humanized anti-p185HER2 antibody 4D5 and comparison with molecular modeling.
Academic Article	Comparison of the intermediate complexes of human growth hormone bound to the human growth hormone and prolactin receptors.
Academic Article	Molecular recognition in biological systems: from activation to inhibition.
Academic Article	Mechanisms of zymogen activation.
Academic Article	Determination of the energetics governing the regulatory step in growth hormone-induced receptor homodimerization.
Academic Article	The structural basis for biological signaling, regulation, and specificity in the growth hormone-prolactin system of hormones and receptors.
Academic Article	The crystal structure of a quercetin 2,3-dioxygenase from Bacillus subtilis suggests modulation of enzyme activity by a change in the metal ion at the active site(s).
Academic Article	Characterization of engineered actin binding proteins that control filament assembly and structure.
Academic Article	A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination.
Academic Article	Engineering Synthetic Antibody Inhibitors Specific for LD2 or LD4 Motifs of Paxillin.
Academic Article	A polar ring endows improved specificity to an antibody fragment.
Academic Article	Cryo-EM structure of human rhodopsin bound to an inhibitory G protein.
Academic Article	Structural basis for activation of voltage sensor domains in an ion channel TPC1.
Academic Article	Development of "Plug and Play" Fiducial Marks for Structural Studies of GPCR Signaling Complexes by Single-Particle Cryo-EM.
Academic Article	Structural basis of omega-3 fatty acid transport across the blood-brain barrier.
Academic Article	Structures of rhodopsin in complex with G-protein-coupled receptor kinase 1.
Academic Article	Isoform- and ligand-specific modulation of the adhesion GPCR ADGRL3/Latrophilin3 by a synthetic binder.
Academic Article	Cryo-EM structures of Clostridium perfringens enterotoxin bound to its human receptor, claudin-4.

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