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Kossiakoff, Anthony
One or more keywords matched the following items that are connected to
Kossiakoff, Anthony
Item Type
Name
Concept
Peptide Fragments
Concept
Receptors, Peptide
Concept
Peptide Library
Academic Article
X-ray structure of human relaxin at 1.5 A. Comparison to insulin and implications for receptor binding determinants.
Academic Article
Biosynthetic phage display: a novel protein engineering tool combining chemical and genetic diversity.
Academic Article
High affinity RNase S-peptide variants obtained by phage display have a novel "hot-spot" of binding energy.
Academic Article
Structure of a phage display-derived variant of human growth hormone complexed to two copies of the extracellular domain of its receptor: evidence for strong structural coupling between receptor binding sites.
Academic Article
The functional binding epitope of a high affinity variant of human growth hormone mapped by shotgun alanine-scanning mutagenesis: insights into the mechanisms responsible for improved affinity.
Academic Article
Engineering subtilisin and its substrates for efficient ligation of peptide bonds in aqueous solution.
Academic Article
Synthetic antibodies for specific recognition and crystallization of structured RNA.
Academic Article
Dissecting the binding energy epitope of a high-affinity variant of human growth hormone: cooperative and additive effects from combining mutations from independently selected phage display mutagenesis libraries.
Academic Article
Alternative views of functional protein binding epitopes obtained by combinatorial shotgun scanning mutagenesis.
Academic Article
Comprehensive and quantitative mapping of energy landscapes for protein-protein interactions by rapid combinatorial scanning.
Academic Article
Exploring the capacity of minimalist protein interfaces: interface energetics and affinity maturation to picomolar KD of a single-domain antibody with a flat paratope.
Academic Article
Crystal structure of the kringle 2 domain of tissue plasminogen activator at 2.4-A resolution.
Academic Article
Crystal structure of full-length KcsA in its closed conformation.
Academic Article
High-throughput generation of synthetic antibodies from highly functional minimalist phage-displayed libraries.
Academic Article
Characterization of engineered actin binding proteins that control filament assembly and structure.
Academic Article
A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination.
Academic Article
Generating conformation-specific synthetic antibodies to trap proteins in selected functional states.
Academic Article
Applications for an engineered Protein-G variant with a pH controllable affinity to antibody fragments.
Academic Article
Scalable high throughput selection from phage-displayed synthetic antibody libraries.
Academic Article
Phage display selections for affinity reagents to membrane proteins in nanodiscs.
Academic Article
Assessment of a method to characterize antibody selectivity and specificity for use in immunoprecipitation.
Academic Article
A New Versatile Immobilization Tag Based on the Ultra High Affinity and Reversibility of the Calmodulin-Calmodulin Binding Peptide Interaction.
Academic Article
Optimizing Production of Antigens and Fabs in the Context of Generating Recombinant Antibodies to Human Proteins.
Academic Article
Conformational Chaperones for Structural Studies of Membrane Proteins Using Antibody Phage Display with Nanodiscs.
Academic Article
Specific Recognition of a Single-Stranded RNA Sequence by a Synthetic Antibody Fragment.
Academic Article
Generating Conformation and Complex-Specific Synthetic Antibodies.
Academic Article
Targeted rescue of cancer-associated IDH1 mutant activity using an engineered synthetic antibody.
Academic Article
Engineered synthetic antibodies as probes to quantify the energetic contributions of ligand binding to conformational changes in proteins.
Academic Article
Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination.
Academic Article
The structure of the C-terminal domain of the nucleoprotein from the Bundibugyo strain of the Ebola virus in complex with a pan-specific synthetic Fab.
Academic Article
Development of "Plug and Play" Fiducial Marks for Structural Studies of GPCR Signaling Complexes by Single-Particle Cryo-EM.
Academic Article
Recognition of an a-helical hairpin in P22 large terminase by a synthetic antibody fragment.
Academic Article
Engineered Ultra-High Affinity Synthetic Antibodies for SARS-CoV-2 Neutralization and Detection.
Academic Article
Inhibition of Cancer Cell Adhesion, Migration and Proliferation by a Bispecific Antibody that Targets two Distinct Epitopes on av Integrins.
Academic Article
Synthetic Antibodies Detect Distinct Cellular States of Chromosome Passenger Complex Proteins.
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C Peptide