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Kossiakoff, Anthony
One or more keywords matched the following properties of Kossiakoff, Anthony
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overview The Kossiakoff Group's research interests are to provide a molecular understanding of how molecular recognition governs virtually all aspects of biological function. To study these issues our group employs a combination of X-ray crystallography and cryo-EM, site-directed mutagenesis, phage display and biophysical analysis. The Kossiakoff group has also pioneered a new technology called “chaperone-assisted” crystallography, which has facilitated the structural analyses of protein systems that had been totally recalcitrant to other approaches. The group has also been at the forefront of developing synthetic antibodies. These synthetic antibodies are much more powerful that traditional monoclonal antibodies and have the potential to completely replace them for uses in live cell imaging and proteomics.
One or more keywords matched the following items that are connected to Kossiakoff, Anthony
Item TypeName
Concept Crystallography
Concept Crystallography, X-Ray
Academic Article Hydroxyl and water molecule orientations in trypsin: comparison to molecular dynamic structures.
Academic Article Crystallization and preliminary X-ray analysis of a 1:1 complex between a designed monomeric interferon-gamma and its soluble receptor.
Academic Article Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities.
Academic Article Human growth hormone and extracellular domain of its receptor: crystal structure of the complex.
Academic Article Crystallization of ovine placental lactogen in a 1:2 complex with the extracellular domain of the rat prolactin receptor.
Academic Article Ternary complex between placental lactogen and the extracellular domain of the prolactin receptor.
Academic Article Probing intermolecular backbone H-bonding in serine proteinase-protein inhibitor complexes.
Academic Article The 2.0 A structure of bovine interferon-gamma; assessment of the structural differences between species.
Academic Article Structure of a phage display-derived variant of human growth hormone complexed to two copies of the extracellular domain of its receptor: evidence for strong structural coupling between receptor binding sites.
Academic Article The structure and activity of a monomeric interferon-gamma:alpha-chain receptor signaling complex.
Academic Article Neutron structure of subtilisin BPN': effects of chemical environment on hydrogen-bonding geometries and the pattern of hydrogen-deuterium exchange in secondary structure elements.
Academic Article The crystal structure of Aq_328 from the hyperthermophilic bacteria Aquifex aeolicus shows an ancestral histone fold.
Academic Article Dissecting the energetics of protein alpha-helix C-cap termination through chemical protein synthesis.
Academic Article Crystal structure and site 1 binding energetics of human placental lactogen.
Academic Article Synthetic antibodies for specific recognition and crystallization of structured RNA.
Academic Article X-ray structure of snow flea antifreeze protein determined by racemic crystallization of synthetic protein enantiomers.
Academic Article The 1.38 A crystal structure of DmsD protein from Salmonella typhimurium, a proofreading chaperone on the Tat pathway.
Academic Article Role of a salt bridge in the model protein crambin explored by chemical protein synthesis: X-ray structure of a unique protein analogue, [V15A]crambin-alpha-carboxamide.
Academic Article Exploring the capacity of minimalist protein interfaces: interface energetics and affinity maturation to picomolar KD of a single-domain antibody with a flat paratope.
Academic Article Mechanism of activation gating in the full-length KcsA K+ channel.
Academic Article Total chemical synthesis and X-ray crystal structure of a protein diastereomer: [D-Gln 35]ubiquitin.
Academic Article X-ray structure of native scorpion toxin BmBKTx1 by racemic protein crystallography using direct methods.
Academic Article The X-ray structure of a growth hormone-prolactin receptor complex.
Academic Article Crystal structure of full-length KcsA in its closed conformation.
Academic Article Use of the neutron diffraction--H/D exchange technique to determine the conformational dynamics of trypsin.
Academic Article The crystal structure of affinity-matured human growth hormone at 2 A resolution.
Academic Article Protein dynamics investigated by neutron diffraction.
Academic Article Neutron protein crystallography: advances in methods and applications.
Academic Article Structure of the growth hormone-receptor complex and mechanism of receptor signaling.
Academic Article The production and X-ray structure determination of perdeuterated Staphylococcal nuclease.
Academic Article Racemic crystallography of synthetic protein enantiomers used to determine the X-ray structure of plectasin by direct methods.
Academic Article The crystal structure of a quercetin 2,3-dioxygenase from Bacillus subtilis suggests modulation of enzyme activity by a change in the metal ion at the active site(s).
Academic Article Toward chaperone-assisted crystallography: protein engineering enhancement of crystal packing and X-ray phasing capabilities of a camelid single-domain antibody (VHH) scaffold.
Academic Article The application of neutron crystallography to the study of dynamic and and hydration properties of proteins.
Academic Article Protein dynamics investigated by the neutron diffraction-hydrogen exchange technique.
Academic Article A comparison of neutron diffraction and molecular dynamics structures: hydroxyl group and water molecule orientations in trypsin.
Academic Article Structure of active ß-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide.
Academic Article Nuclear pores. Architecture of the nuclear pore complex coat.
Academic Article Protein targeting. Structure of the Get3 targeting factor in complex with its membrane protein cargo.
Academic Article Structural mechanism of voltage-dependent gating in an isolated voltage-sensing domain.
Academic Article Engineering Synthetic Antibody Inhibitors Specific for LD2 or LD4 Motifs of Paxillin.
Academic Article A polar ring endows improved specificity to an antibody fragment.
Academic Article Specific Recognition of a Single-Stranded RNA Sequence by a Synthetic Antibody Fragment.
Academic Article The Preserved HTH-Docking Cleft of HIV-1 Integrase Is Functionally Critical.
Academic Article Engineered synthetic antibodies as probes to quantify the energetic contributions of ligand binding to conformational changes in proteins.
Academic Article Structural basis for activation of SAGA histone acetyltransferase Gcn5 by partner subunit Ada2.
Academic Article Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.
Academic Article The structure of the C-terminal domain of the nucleoprotein from the Bundibugyo strain of the Ebola virus in complex with a pan-specific synthetic Fab.
Academic Article Structural basis for activation of voltage sensor domains in an ion channel TPC1.
Academic Article Synthetic antibodies against BRIL as universal fiducial marks for single-particle cryoEM structure determination of membrane proteins.
Grant Chaperone Assisted Crystallography
Academic Article Engineered antigen-binding fragments for enhanced crystallization of antibody:antigen complexes.
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  • Crystallography