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Kossiakoff, Anthony

One or more keywords matched the following items that are connected to Kossiakoff, Anthony

Item Type	Name
Concept	Hormones
Concept	Human Growth Hormone
Concept	Growth Hormone
Academic Article	Human growth hormone and extracellular domain of its receptor: crystal structure of the complex.
Academic Article	Ternary complex between placental lactogen and the extracellular domain of the prolactin receptor.
Academic Article	Structural basis for cytokine hormone-receptor recognition and receptor activation.
Academic Article	Structure of a phage display-derived variant of human growth hormone complexed to two copies of the extracellular domain of its receptor: evidence for strong structural coupling between receptor binding sites.
Academic Article	Site2 binding energetics of the regulatory step of growth hormone-induced receptor homodimerization.
Academic Article	Functional promiscuity of squirrel monkey growth hormone receptor toward both primate and nonprimate growth hormones.
Academic Article	The functional binding epitope of a high affinity variant of human growth hormone mapped by shotgun alanine-scanning mutagenesis: insights into the mechanisms responsible for improved affinity.
Academic Article	Crystals of the complex between human growth hormone and the extracellular domain of its receptor.
Academic Article	Shotgun alanine scanning shows that growth hormone can bind productively to its receptor through a drastically minimized interface.
Academic Article	Dissecting the binding energy epitope of a high-affinity variant of human growth hormone: cooperative and additive effects from combining mutations from independently selected phage display mutagenesis libraries.
Academic Article	The high- and low-affinity receptor binding sites of growth hormone are allosterically coupled.
Academic Article	Alternative views of functional protein binding epitopes obtained by combinatorial shotgun scanning mutagenesis.
Academic Article	Comprehensive and quantitative mapping of energy landscapes for protein-protein interactions by rapid combinatorial scanning.
Academic Article	The role of protein dynamics in increasing binding affinity for an engineered protein-protein interaction established by H/D exchange mass spectrometry.
Academic Article	Intramolecular cooperativity in a protein binding site assessed by combinatorial shotgun scanning mutagenesis.
Academic Article	The X-ray structure of a growth hormone-prolactin receptor complex.
Academic Article	The crystal structure of affinity-matured human growth hormone at 2 A resolution.
Academic Article	Structure of the growth hormone-receptor complex and mechanism of receptor signaling.
Academic Article	Comparison of the intermediate complexes of human growth hormone bound to the human growth hormone and prolactin receptors.
Academic Article	Molecular recognition in biological systems: from activation to inhibition.
Academic Article	Determination of the energetics governing the regulatory step in growth hormone-induced receptor homodimerization.
Academic Article	The structural basis for biological signaling, regulation, and specificity in the growth hormone-prolactin system of hormones and receptors.
Academic Article	Principal determinants leading to transition state formation of a protein-protein complex, orientation trumps side-chain interactions.
Academic Article	Engineering synthetic antibody binders for allosteric inhibition of prolactin receptor signaling.
Grant	Energetics of cytokine-induced receptor signaling

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Hormones