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Search Results to Anthony Kossiakoff

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One or more keywords matched the following items that are connected to Kossiakoff, Anthony

Item TypeName
Concept Human Growth Hormone
Academic Article Human growth hormone and extracellular domain of its receptor: crystal structure of the complex.
Academic Article Ternary complex between placental lactogen and the extracellular domain of the prolactin receptor.
Academic Article Structure of a phage display-derived variant of human growth hormone complexed to two copies of the extracellular domain of its receptor: evidence for strong structural coupling between receptor binding sites.
Academic Article The functional binding epitope of a high affinity variant of human growth hormone mapped by shotgun alanine-scanning mutagenesis: insights into the mechanisms responsible for improved affinity.
Academic Article Crystals of the complex between human growth hormone and the extracellular domain of its receptor.
Academic Article Shotgun alanine scanning shows that growth hormone can bind productively to its receptor through a drastically minimized interface.
Academic Article Dissecting the binding energy epitope of a high-affinity variant of human growth hormone: cooperative and additive effects from combining mutations from independently selected phage display mutagenesis libraries.
Academic Article The high- and low-affinity receptor binding sites of growth hormone are allosterically coupled.
Academic Article Alternative views of functional protein binding epitopes obtained by combinatorial shotgun scanning mutagenesis.
Academic Article Comprehensive and quantitative mapping of energy landscapes for protein-protein interactions by rapid combinatorial scanning.
Academic Article The role of protein dynamics in increasing binding affinity for an engineered protein-protein interaction established by H/D exchange mass spectrometry.
Academic Article Intramolecular cooperativity in a protein binding site assessed by combinatorial shotgun scanning mutagenesis.
Academic Article The crystal structure of affinity-matured human growth hormone at 2 A resolution.
Academic Article Comparison of the intermediate complexes of human growth hormone bound to the human growth hormone and prolactin receptors.
Academic Article The structural basis for biological signaling, regulation, and specificity in the growth hormone-prolactin system of hormones and receptors.
Academic Article Principal determinants leading to transition state formation of a protein-protein complex, orientation trumps side-chain interactions.
Academic Article Engineering synthetic antibody binders for allosteric inhibition of prolactin receptor signaling.

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